The Protocol Book Soumitra Kumar
INDEX
A
Abciximab 37, 38
Aborted MI 12
ACE-inhibitors (ACEIs) 91
Acute cryptogenic organizing pneumonia 259
Acute eosinophilic pneumonia 259
Acute hypersensitivity pneumonitis 259
Acute interstitial pneumonia 258
Acute limb ischaemia 186
Acute tubular necrosis 289
Adenosine 131, 156, 356
Adenosine A1 receptor blocker 81
Adenosine receptor blockers 81
Adenosine triphosphate 81, 109, 152, 153
Adrenal crisis 300
Adrenaline 363
Aldosterone receptor antagonists 94
Aliskiren 105
Alprostadil 192, 357
Aminoglycoside 244, 248
Aminophylline 237
Amiodarone 96, 155, 356
Amphotericin B 352
Aneurysmectomy 105
Angiodysplasia 268
Angiogenesis 99
Angiotensin-receptor blockers 92
Anion gap 213
Anticonvulsants 276
Antimicrobial drugs 376
Antiphospholipid antibody syndrome 321
Aortic dissection 183
Apache II 342, 380, 381
Apache III 380, 381
Apixban 121
Arrhythmogenic right ventricular cardiomyopathy 142
Arrhythmogenic RV dysplasia 110
Aspirin 34, 119, 160, 275
Atenolol 359
Atropine 358
Azimilide 125
Aztreonam 340
B
B-type natriuretic peptide 68, 87
Balloon atrial septostomy 192
Balloon dilatation catheters 163
Barotrauma 251
Base excess 213
Basic life support 151
Beta-blockers 34, 93, 132, 160
Beta-blockers, acute 359
Bivalirudin 45
BNP (B-type natriuretic peptide) 31
Bosentan 97
Brugada syndrome 110, 143
Bundle-branch reentrant tachycardia 142
C
C-reactive protein 31
Calponin 185
Captopril 200
Cardiac index 54, 63, 66, 75
Cardiac rehabilitation 171
Cardiac resynchronization therapy 99
Cardiac transplantation 104
Cardioembolic stroke 270
Cardiogenic shock 54
Cardiomyoplasty 104
Cariporide 125
Carotid sinus hypersensitivity 111
Carotid sinus massage 109
Carvedilol 200
Catecholaminergic polymorphic ventricular tachycardia 145
Catheter ablation 123
Central venous pressure 73
Cephalosporin 340, 341, 350, 351
Cerebellar haemorrhage 280
Choline 31
Ciprofloxacin 247, 248, 249, 340
Clopidogrel 35, 160, 275
Coagulase negative staphylococci 345
Colloid 248, 335, 354
Congenital long Q-T syndrome 147
Congrelor 36
Conivaptan 97
Coronary artery bypass grafting 55
Coronary stenting 164
Corticosteroids 278
Creatine kinase-MB 30
Creatinine clearance 380
Crystalloid 335
Cyclophosphamide 325
Cyclosporine 326
D
D-dimer assay 177
Dabigatran 121
Darbopoetin 106
Dabigatran etexilate 121
Deep venous thrombosis 172
Dengue 353, 354
Diabetic ketoacidosis 309
Diazoxide 210
Dieulafoy's lesion 267, 268
Diffuse alveolar haemorrhage 259
Digitalis 94, 132
Digoxin 200, 360
Dilated cardiomyopathy 141
Diltiazem 132
Diltiazem 156
Diltiazem (IV) 361
Dipyridamole 275
Direct thrombin inhibitors 20
Disopyramide 122
Diuretics 78, 90
Dobutamine 79, 200, 361, 372
Dofetilide 118, 128
Dopamine 79, 200, 362, 372
Dressler's syndrome 27
Dronedarone 125
Drotrecogin 348, 349
Drotrecogin alfa 342, 343
E
Echocardiography portable 68
Eclampsia 206
Electrical cardioversion 117
Electrophysiology studies 109
Enalapril 200
Enalaprilat 210, 274
Endoaneurysmorrhaphy 105
Endoscopic therapy 266
Enoximone, vesanarinone 95
Enterococcus 350
Epinephrine 79, 363
Eplerenone 95
Eptifibatide 37, 38, 375
Esmolol 359
Esmolol hydrochloride 210
Etanercept 97
Euro heart failure survey II 85
Extended spectrum beta-lactamases 350
F
Facilitated PCI 14
Fascicular tachycardia 145
Fatty acid binding protein 31
Fenoldopam mesylate 209
Fibrinolytic agents 363
Flecainide 118, 122
Fluconazole 331, 352
Flucytosine 352
Fondaparinux 21, 40, 44, 183
Free wall rupture 26, 56, 81
Fungal infections 351
Furosemide 200
G
Glycerol 276
Glyceryl trinitrate 78
Glycoprotein IIb/IIIa inhibitors 21, 36, 160, 363
Grace risk score 32
Guiding catheter 161
H
Haemobilia 268
Haemodialysis 298
Haemofiltration 298
Hanta virus infection 353
Hemicraniectomy 276
Heparin 160, 363
Heparin-induced thrombocytopenia (HIT) 176
Hirudin 45
Hirulog 45
Hydralazine 95, 205
Hypercalcaemia 318
Hyperglycaemic hyperosmolar state 313
Hyperglycemia 316, 344
Hyperkalaemia 196, 224
Hypermagnesemia 227
Hypernatremia 222
Hypertensive crisis 202, 304
Hypertensive emergencies 202
Hypertensive urgencies 203
Hypertrophic cardiomyopathy 143
Hypocalcaemia 319
Hypokalemia 225
Hyponatremia 221
Hypotension 251
I
IABP 60
Ibutilide 122
Idraparinux 183
Imipenem 248, 249, 340, 378
Implantable cardioverter defibrillator 103
Implantable loop recorder 109
Infliximab 97, 327
Inotropic agents 79, 80
Intra-aortic balloon pump 169
Intracerebral haemorrhage 277
Ipratropium bromide 231
Isoprenaline 364
Isoproterenol 364
Istaroxime 81
Itraconazole 352
J
Japanese B encephalitis 354
L
Labetolol 274
Labetolol hydrochloride 210
Lacunar stroke 270
Left ventricular assist devices 169
Leptospirosis 353
Levosalbutamol 237
Levosimendan 79
Lignocaine 156, 364
Linezolid 340, 350, 351
Low molecular weight heparin 19, 42, 174, 183
M
Magnesium sulpate 231, 365
Malaria 353
Mallory-Weiss syndrome 265
Mannitol 276, 278
Mechanical ventilation 241
Meropenem 340
Metabolic acidoses 215
Metabolic alkalosis 215
Methicillin-resistant Staphylococcus aureus 350
Methylprednisolone 325
Metolazone 78, 200
Metoprolol 193, 359
Midodrine 112
Milrinone 79, 200, 365
Monobactam 340
Morphine sulfate 193, 366
MPM II 380, 381
Multivessel disease 51
Myeloperoxidase 31
Myocardial infarction 1
Myoglobin 31
Myxoedema coma 308
N
Neonatal lupus 326
Nesiritide 79
Neurally mediated reflex 107
Neurally mediated syncope 111
Nicardipine 274
Nicardipine hydrochloride 209
Nifedipine 274
NIH stroke scale 272
Nitroglycerine, acute 366
Nitroprusside 78, 200, 367, 373
Noninvasive ventilation 238
No-reflow 166
Non-sustained ventricular tachycardia 140, 146
Noninvasive ventilation 233
Norepinephrine 79, 368, 373
O
Obscure 283, 337
Omapatrilat 97
Open artery hypothesis 16
Orthostatic syncope 112
P
Pentasaccharides 183
Percutaneous coronary intervention 58
Percutaneous mechanical thrombectomy 189
Perhexiline 81
Pericarditis 26
Peritoneal dialysis 298
Phaeochromocytoma 304
Phenoxybenzamine 369
Phentolamine 210
Phenylephrine 193, 369
Piboserod 125
Piperacillin-tazobactam 340
Pituitary apoplexy 302
Plasmapheresis 326
Polymorphic VT 147
Potassuim sparing diuretics 91
Prasugrel 36
Prednisolone 231, 325
Pregnancy-associated plasma protein A 31
Pre-hospital thrombolysis 13
Primary PCI 7
Procainamide 157
Procalcitonin 339
Propranolol 193
Prostaglandin 192
Prostaglandin E1 357
Proton pump inhibitor 266
Pseudomonas aeruginosa 351
Pulmonary artery catheter 73
Pulmonary artery systolic pressure 72
Pulmonary embolism 177
Pulmonary thromboendarterectomy 175
Pulmonary vascular resistance 72, 74
Q
Quinidine 122
R
Recombinant factor VIIa 279
Reperfusion injury 168
Rescue PCI 12
Respiratory acidosis 215
Respiratory alkalosis 215
RF ablation 132
Right ventricular infarction 61
Rivaroxaban 121
Rotigaptide 125
rtPA 188
RV function assessment 72
S
Salbutamol 231, 237
SAPS 380, 381
SCD40 ligand 31
Scrub typhus 353
Septic shock 336
Short QT syndrome 150
Sodium nitroprusside 209
Somatostatin 266
Sotalol 118, 131
Spironolactone 95
Statins 97, 161
Steptokinase 188
Supraventricular tachycardia 132
Surgical ablation 124
Syncope
cardiac 108
neurally mediated reflex 108
orthostatic 108
Systemic inflammatory response syndrome 332
Systemic vascualr resistance 63, 74
T
Tedisamil 125
Teicoplanin 340
Tezosentan 97
Thrombin-receptor antagonists 36
Thrombolysis 181, 272
Thrombolytic therapy 4
Thrombophilias 172
Thrombus 166
Thyroid storm 305
Thyrotoxic crisis 305
Ticarcillin-clavulanate 340
Tilt-table testing 109
TIMI risk score 32
Tirofiban 37, 38, 374
Tissue Doppler echocardiography 100
Tolvaptan 97
Torsade de pointes 136
Transmyocardial laser revascularization 99
Troponins 30
U
Unfractionated heparin 18, 41, 174, 182
Urodilatin 81
Urokinase 188
V
Vancomycin 340
Variceal bleeding 266
Vasodilators 78, 80
Vasopressin 370
Vasopressin antagonists 81
Vasopressors 348
Vasovagal syncope 111
Ventricular associated pneumonia 246
Ventricular fibrillation 136
Ventricular flutter 136
Ventricular tachyarrhythmias 135
Verapamil 132, 156
Verapamil (intravenous) 370
Voriconazole 352
W
Warfarin 96, 119
Weaning 261
Wide complex tachycardia 133
X
Ximelagatran 121, 175
Z
Zoniporide 125
×
Chapter Notes

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1The Protocol Book
2The Protocol Book
Third Edition
Editor Soumitra Kumar MBBS MD DM Professor, Division of Cardiology Department of Medicine Vivekananda Institute of Medical Sciences Kolkata, West Bengal, India Foreword S Padmavati
3Published by
Jitendar P Vij
Jaypee Brothers Medical Publishers (P) Ltd
Corporate Office
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Fax: +91-11-43574314
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Branches
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The Protocol Book
© 2009, Jaypee Brothers Medical Publishers
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editor and the publisher.
First Edition: 2003 (by Editor)
Second Edition: 2008
Third Edition: 2009
9788184485615
Typeset at JPBMP typesetting unit
Printed at Replica Press
4
To
My family
Friends
and
Well wishers
5
Swami Vivekananda
The secret of religion lies not in theories but in practice.
To be good and to do good — that is the whole of religion.
6Contributors
Foreword
The Protocol Book represents guidelines for the diagnosis and management of common medical emergencies seen in hospitals. It covers mostly cardiac problems but also includes respiratory, gastrointestinal and renal diseases and diabetes. It has the same objectives as the American Heart Association/American College of Cardiology's Pocket Guidelines Updates compiled by the special Task Forces of these organisations, which are proving extremely useful for practising physicians.
This book has been compiled by the postgraduate students of the Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata under the guidance of senior consultants in these departments at the hospital and under the able Editorship of Dr Soumitra Kumar. The text is written in a typical ‘Senior Resident’ language that can be easily understood by their colleagues. The latest ‘state-of-the-art’ information and knowledge has been used in preparing the various sections. It is a very laudable effort on the part of the postgraduate staff.
I am sure The Protocol Book will prove very useful for all categories of physicians dealing with acute emergencies in hospitals.
S Padmavati
frcp (London) frcpe, facc, fams
PRESIDENT—All India Heart Foundation
DIRECTOR—National Heart Institute
9Preface to the Third Edition
The third edition of The Protocol Book in 2009 has come closer to the heels of the second edition in 2008. Significant changes in management guidelines of some leading acute problems (Acute coronary syndrome and pulmonary embolism in particular) have necessitated the publication of the new edition. The previous two editions (2003 and 2008) have been appreciated. The encouragement has continued to stimulate me and the contributors ever since and subsequent editions bear testimony to that.
To make things as lucid and conceivable as possible, data and guidelines have been presented in the form of simple algorithms, tables, etc. as it was done in the previous two editions and the facts and the figures are absolutely updated and evidence-based. Data presented at the important conferences held in 2008 (namely ACC 2008 and ESC 2008) have been incorporated in the new edition. The emphasis remains on successful “total management” of the patient, i.e. addressing all the major problems in a given patient.
I, on behalf of the team of contributors, would like to reiterate that ‘protocol’ for management of any particular medical problem should suffice for majority of the patients with that problem; but, at times, a special approach depending on the circumstances (patient's condition, skill and facilities available, financial situation, etc.) would still be necessary.
As editor, I am personally grateful to all the contributors of this edition for their sincere cooperation and hard work.
I am also thankful to the publishing team of M/s Jaypee Brothers Medical Publishers (P) Ltd., New Delhi for their sincere cooperation and support for the second and the current editions.
Last but not the least, I am grateful to my family members (my parents, wife and son) for their constant inspiration and for bearing with my academic endeavour often at the cost of my family commitments.
Soumitra Kumar
10Preface to the Previous Edition
The first edition of The Protocol Book in 2003 was a sincere and honest attempt to induce a scientifically rational approach in our day-to-day practice. The effort was appreciated and lauded widely and a senior cardiologist had commented as following: “I wonder why nobody has done this before”. Such encouraging words paved the way for the second edition. Thanks once again to M/s Zydus who have continued to extend their support and sponsorship and our endeavour has been significantly bolstered by the involvement of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, for the second edition.
These days, the practice of medicine is changing at such a pace that many of us find too fast and mind-blowing at times. To make things as lucid and conceivable as possible, data and guidelines have been presented in the forms of simple algorithms, tables, etc. as it was done in the first edition and the facts and figures are absolutely updated and evidence-based. However, as I had emphasized in the first edition, practice of medicine is as much an art as it is a science. Hence, ‘protocol’ for management of any particular medical problem should suffice for majority of the patients with that problem; but, at times, a special approach depending on the circumstances (patient's condition, skill and facilities available, financial situation, etc.) would still be necessary.
All the chapters of the first edition have been retained and four new chapters on “PCI in AMI”, “Rheumatological Emergencies”, “Vascular Emergencies” and “Acute Cardiac Care in Paediatric Practice” have been added along with sections on emergency cardiovascular drugs, antibiotics, etc. Apart from new additions, majority of the old chapters have been virtually rewritten and rest have been thoroughly revised. The focus has been on emergency cardiovascular medicine with near-equal emphasis on common medical emergencies that one comes across in high-dependency units. The emphasis needless to say is on successful “total management” of the patient because a patient undergoing primary PCI will return home only if his hyperglycaemia, azotaemia and dyselectrolytaemia have been addressed as successfully as his PCI has been.11
As editor, I am personally grateful to all the contributors of this edition for their sincere cooperation and hard work. I am thankful to the team of M/s Phildon for their unstinting help in the composition of the manuscript. I am grateful to my family members (my parents, wife and son) for their constant inspiration and for bearing with my academic endeavours often at the cost of my family commitments.
Soumitra Kumar