Second Edition
Editor Praveen Khilnani MD FAAP FCCM (USA) Senior Consultant and Incharge Pediatric Intensivist and Pulmonologist Max Hospitals, New Delhi, India
Editorial Board Rajiv Uttam
Vinay K Aggarwal
Sandeep Chopra
RK Mani
Rajesh Chawla
Yogesh Gautam
Mritunjay Pao
Jitendar P Vij
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Practical Approach to Pediatric Intensive Care
© 2009, Praveen Khilnani
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editor and the publisher.
First Edition: 2004
Second Edition: 2009
9788184486759
Typeset at JPBMP typesetting unit
Printed at
Late Smt Laxmi Devi Khilnani
Who left for heavenly abode on May 2001
She always knew I could do it whenever I thought I couldn't
She was the one who taught me to always be optimistic and hardworking
God will take care of the rest
5List of Contributors
- Aashna Treohan
- Research Fellow
- Apollo Center for Advanced Pediatrics
- IP Apollo Hospitals
- New Delhi, India
- Amit Varma md
- Pediatric Intensivist
- Director Critical Care
- Fortis Health Care
- Delhi, India
- Amit Gupta
- PICU Fellow
- Max Hospitals
- New Delhi, India
- Amita Mahajan md
- Senior Consultant
- Pediatric Hemoncologist
- IP Apollo Hospitals
- New Delhi, India
- Anil Sachdev md
- Senior Consultant
- Pediatric Intensivist
- Sir Gangaram Hospital
- New Delhi, India
- Anjali A Kulkarni md
- Senior Consultant Neonatologist
- IP Apollo Hospitals
- New Delhi, India
- A Sibal md
- Senior Consultant Pediatric
- Gastroenterology, Hepatology
- IP Apollo Hospitals
- New Delhi, India
- Arvind Bagga md
- Head Pediatric Nephrology
- AIIMS
- New Delhi, India
- Bala Ramachandran md
- Senior Consultant
- Pediatric Intensivist
- KKCT Hospital
- Chennai, Tamil Nadu, India
- Chhabi Ranu Gupta
- MCH Pediatric Surgery
- Consultant Pediatric Surgeon
- Holy Family Hospitals
- New Delhi, India
- Deepika Singhal md
- Consultant Pediatric Intensivist
- Pushpanjali Crosslay Hospital
- Vaishali, Ghaziabad, UP, India
- Dhiren Gupta md
- Consultant
- Pediatric Intensive Care
- Department of Pediatrics
- Sir Gangaram Hospital
- New Delhi, India
- Frank Zimmerman md
- Assistant Professor
- Children's Hospital
- University of Chicago
- Chicago, Illinois
- USA
- G Thomas Albrecht md
- Pediatric Cardiologist
- Richmond, Virginia
- USA
- Girish HC md
- Pediatric Intensivist
- Bangalore
- Karnataka, India
- Gurinder Pal Singh md
- Consultant PICU
- BL Kapoor Hospital
- New Delhi, India
- Harish Vyas mrcp (uk)
- Consultant PICU
- Birmingham, UK
- IC Verma md
- Incharge
- Department of Genetics
- and Metabolic Disorders
- Sir Gangaram Hospital
- New Delhi, India
- I David Todres md faap fccm
- Professor of Pediatrics, Anesthesia and Critical Care
- Harvard Medical School
- Massachussettes General Hospital
- Boston, Massachussettes, USA
- Jashua Caresky md
- Pediatric Surgery
- Indiana, Indianapolis, USA
- Jeffrey C Benson md
- Pediatric Intensivist
- Children's Hospital of Wisconsin
- Wisconsin, Michigan, USA
- John M Downey md
- Assistant Professor
- Children's Hospital
- University of Chicago
- Chicago, Illinois, USA
- Jose Irazzuzta md
- Director Pediatric ICU
- Children's Hospital
- Jacksonville, Florida, USA
- Jyotinder Kaur
- HOD Pediatrics
- Apollo Hospitals
- Ahmedabad
- Gujarat, India
- Krishan Chugh md
- Pediatric Pulmonologist and Intensivist
- Sir Gangaram Hospital
- New Delhi, India
- Leticia Castillo md fccm
- Associate Professor
- Pediatric Icu
- Baylor College of Medicine
- Houston, Texas, USA
- Madelyn Kahana md
- Director, Pediatric Intensive Care Unit
- Children's Hospital
- University of Chicago
- Madhulika Kabra md
- Department of Pediatrics
- AIIMS, New Delhi, India
- Mahajan V md
- Pediatric Cardiology
- Batra Hospital and Research Center
- New Delhi, India
- M Wadhawan md
- Consultant Hepatologist and Transplant Physician
- Multi-organ Transplant Unit
- IP Apollo Hospitals
- New Delhi, India
- Manish Malik mrcp (uk)
- Consultant Neonatologist
- Max Super Specialty Hospital
- New Delhi, India
- Manish Vaish ms
- Senior Registrar, Neurosurgery
- Sir Gangaram Hospital
- New Delhi, India
- Guiseppe Marraro md
- Professor of Pediatrics and Anesthesiology
- Ophthalmic Hospitals
- Milan, Italy
- Mary L Falterman md
- Pediatric Cardiology
- Richmond
- Virginia, USA
- Meenu Singh md
- Pediatric Pulmonologist
- PGIMER, Chandigarh, India
- Meera Luthra mch (pediatric surgery)
- Senior Consultant
- Pediatric Surgeon
- Holy Family Hospital
- New Delhi, India
- Meera Ramakrishnan md
- Pediatric Intensivist and Emergency Incharge
- Manipal Hospital
- Bangalore, India
- Michael Hartenberg md
- Pediatric Radiologist
- Richmond, Virginia, USA
- Mritunjay Pao md
- Incharge
- Pediatric ICU
- GNRC Hospital, Guwahati
- Assam, India
- Mukta Mantan md
- Division of Nephrology
- AIIMS
- New Delhi, India
- N Jerath md
- Consultant Pediatric Intensivist
- IP Apollo Hospitals
- New Delhi, India
- Neelam Mohan md
- Senior Consultant
- Pediatric Gastroenterologist
- Sir Gangaram Hospital
- New Delhi, India
- N Wadhwa dnb
- Clinical Associate
- Pediatric Gastroenterology
- and Hepatology
- IP Apollo Hospitals
- New Delhi, India
- Nitesh Singhal md
- Consultant
- Pediatric Intensive Care Unit
- Max Hospitals
- New Delhi, India
- Pankaj Vohra md
- Pediatric Gastroenterologist
- Max Health Care
- New Delhi, India
- Pooja Verma ms
- Child Psychology
- Delhi, India
- Prasanna C Tellis md
- Pediatric Cardiology
- Narayan Hrudalya
- Bangalore
- Karnataka, India
- Praveen Khilnani
- Md faap fccm (usa)
- Senior Consultant
- Pediatric Intensivist and Incharge
- PICU Fellowship
- Max Hospitals
- New Delhi, India
- Prabhat Maheshwari mrcp
- Consultant, Pediatric Intensivist
- Artemis Health Sciences Institute
- Gurgaon, Haryana, India
- Prashant Pruthi md
- Consultant
- Pediatric Intensive Care
- Max Hospitals
- New Delhi, India
- Pushpendra N Renjen md
- Senior Consultant Neurologist
- IP Apollo Hospitals
- New Delhi, India
- Purnima Dhar md
- Senior Consultant Anesthesia
- IP Apollo Hospitals
- New Delhi, India
- S Radhakrishnan md
- Pediatric Cardiologist
- Escorts Heart Institute and Research Center
- New Delhi, India
- Rajesh Chawla md
- Senior Consultant
- Respiratory and Critical Care
- Medicine
- IP Apollo Hospitals
- New Delhi, India
- Rajesh Mehta md
- Professor
- Department of Pediatrics
- Safdarjung Hospital
- New Delhi, India
- Rajiv Uttam mrcp (uk)
- Senior Consultant
- Pediatric Intensivist and Pulmonologist
- Fortis Hospitals
- New Delhi, India
- Rajiv Chhabra mrcp (uk)
- Consultant
- Pediatric Intensivist
- Artemis Health Sciences Institute
- Gurgaon, Haryana, India
- Rakesh Aggarwal md
- Senior Consultant Neurologist
- IP Apollo Hospitals
- Rakesh Lodha md
- Department of Pediatrics
- AIIMS, New Delhi, India
- Ramesh Sachdeva md mba
- Pediatric Intensivist
- Vice President
- Children's Hospital of Wisconsin
- Wisconsin, Michigan, USA
- Reeta Singh md
- Consultant Pediatrics
- Sydney, Australia
- Riccardo Munoz md
- Director Cardiac ICU
- Children's Hospital of Pittsburgh
- Pittsburgh, Pennsylvania, USA
- RK Mani md
- Senior Consultant
- Respiratory and Critical Care Medicine
- Fortis Hospitals
- New Delhi, India
- RK Seth mch
- Senior Consultant Plastic Surgery
- IP Apollo Hospitals
- New Delhi, India
- RN Makroo
- Senior Consultant, Incharge
- Department of Transfusion Medicine
- IP Apollo Hospitals
- New Delhi, India
- RN Srivastava md
- Senior Consultant
- Pediatric Nephrologist
- IP Apollo Hospitals
- New Delhi, India
- Rohit P Rao md
- Pediatric Intensivist
- Children's Hospital of Wisconsin
- Wisconsin, Michigan, USA
- Ruchi Jain md
- Consultant Pediatric
- Faridabad
- S Ramesh md
- Pediatric Anesthesiologist
- KK Child Trust Hospital
- Chennai, Tamil Nadu, India
- Sandeep Chopra mch (Neurosurgery)
- Pediatric Neurosurgery
- Sir Gangaram Hospital
- New Delhi, India
- Sankaran Krishnan md
- Pediatric Pulmonologist
- Cornell University
- New York, USA
- Saroj Kumar Singh md
- Consultant Pediatric
- Nazreth Hospital
- Allahabad, UP, India
- Satish Deopujari md
- Consultant Pediatric Intensivist
- Child Hospital, Nagpur
- Maharashtra, India
- Shekhar T Venkataraman md
- Associate Director
- Pediatric Intensive Care Unit
- Children's Hospital
- Pittsburgh, Pennsylvania, USA
- Shiv Kumar Rajdev md mrcp
- Consultant Pediatrics
- London, UK
- Sidharth Luthra llb
- Advocate, High Court
- Delhi, India
- Sister Gracey BSc (Nursing)
- Head Nurse PICU
- IP Apollo Hospitals
- New Delhi, India
- Soonu Udani md
- Consultant Pediatric Intensivist
- PD Hinduja Hospital, Mumbai
- Maharashtra, India
- Suchitra Ranjit md
- Pediatric Intensivist
- Apollo Hospitals
- Chennai, Tamil Nadu, India
- S Gupta ms mch
- Senior Transplant Surgeon
- Multi-organ Transplant Unit
- IP Apollo Hospitals
- New Delhi, India
- Sujit Kumar Chowdhary ms mch
- Senior Consultant
- Department of Pediatric Surgery
- IP Apollo Hospitals
- New Delhi, India
- Sunil Gomber md
- Professor, Department of Pediatrics
- GTB Hospital
- New Delhi, India
- Sushil Kabra md
- Associate Professor
- Department of Pediatrics
- AIIMS, New Delhi, India
- Sukhmeet Singh md
- Consultant Pediatrics
- DMC, Ludhiana
- Punjab, India
- Ted A Williams md
- Pediatric Gastroenterologist
- Richmond
- Virginia, USA
- Uttara Babbar
- Advocate
- Delhi, India
- Utkarsh Kohli md
- Resident Pediatrics
- AIIMS, New Delhi, India
- Vidya Gupta mrcp (uk)
- Senior Consultant Neonatologist
- IP Apollo Hospitals
- New Delhi, India
- Vinay K Aggarwal mrcp (uk)
- Senior Consultant Pediatric
- Nephrologist
- Max Hospitals
- New Delhi, India
- Vikas Taneja md
- Consultant Intensivist
- Columbia Hospital
- Gurgaon, Haryana, India
- Yogesh Govil md
- Professor, Pediatrics
- KGMC College
- Lucknow, UP, India
Pediatric critical care is a relatively new subspecialty and has developed rapidly in many parts of the world. In India, it is still in infancy but over the last few years, it has made great strides. The standard of care for the critically ill or injured child is more or less at par with other countries. It is very gratifying to see that many institutions have excellent PICUs with current state of the art. The Indian Society of Critical Care Medicine and the Indian Academy of Pediatrics are to be commended for their lead and enormous input to disseminate the knowledge and skills to physicians, nurses and other health care personnel. With the explosion in current technology and monitoring techniques, many lives are being saved.
This book entitled Practical Approach to Pediatric Intensive Care edited by Dr Praveen Khilnani, Senior Consultant Pediatric Intensivist at Max Hospitals, New Delhi will be a valuable companion to all the medical and nursing personnel. Many areas and topics have been covered well by the author who is well experienced to conditions that prevail the world over.
A book like this cannot be exhaustive and complete. But, it contains practical guidance for the routine daily care of the sick child. I commend the editor for his efforts and venture.
N Janakiraman md faap fccm (usa)
Professor of Pediatrics and Critical Care
University of Illinois
Cookcounty Hospital
Chicago, Illinois, USA
9Preface to the Second Edition
As the field of pediatric critical care continues to grow, newer developments and guidelines have emerged. New resuscitation guidelines as well sepsis guidelines have been included, in addition to overall upgrading of latest information in the field of pediatric critical care. Practice oriented flow charts have been added to several chapters for common PICU problems.
It is hoped that this book will emerge as truly practical companion to any one taking care of a critically ill child.
Praveen Khilnani
10Preface to the First Edition
The field of pediatric critical care (pediatric intensive care) is rapidly advancing and new innovations and technologies are being frequently incorporated into the delivery of pediatric critical care. The role of the pediatric critical care specialist (pediatric intensivist) has become more defined as pediatrician who specializes in the field of diagnosis of critical pediatric illnesses and prompt management employing all—the principles of pediatric pathophysiology including hemodynamic disturbances, tissue oxygen delivery, septic process, trauma and surgical stress and systemic inflammatory response syndrome (SIRS). Treatment of critical illness involves a good grasp on ways to improve oxygen delivery for management of shock, respiratory failure and sepsis. Clinical reserve in a pediatric patient is far less compared to an adult patient, therefore, a timely detection of a clinically deteriorating patient as well as prompt institution of appropriate resuscitative efforts goes a long way. A pediatric intensivist must be well trained in emergency procedures such as central line placement, endotracheal intubation, bag mask ventilation, arterial line placement, sedation, ventilator management, chest tube placement, lumbar puncture, oxygen therapy, cardiopulmonary resuscitation, intraosseous line placement and above all the application of appropriate clinical judgement to use the above skills effectively and safely to improve patient outcome.
This book has been written and edited to emphasize practical aspects of pediatric intensive care contributed by various national and international authors involved in routine day-to-day management in the multidisciplinary pediatric intensive care unit with collaboration of a team of specialists including medical, surgical, nursing, and other important ancillary services. Ethical, legal, and nursing issues have also been included. I sincerely hope this book will be a resource to those practicing and training in the field of pediatric critical care medicine.
Effort has been taken to present currently accepted consensus on therapy rather than dogmatic opinions. I wish to thank all the contributors and my family members for their unconditional support.
Praveen Khilnani
Development of Pediatric Critical Care |
1889 | : | First infant respirator |
Egon Braun, Vienna | ||
1910 | : | First positive pressure ventilator |
1954 | : | Extracorporal circulation described |
1954 | : | First PICU, Goteburg, Sweden |
Closed chest defibrillation described | ||
ECMO described | ||
1957 | : | Severinghaus electrode: led to blood gas analysis |
1958 | : | First physician-directed multidisciplinary adult ICU, Baltimore City Hospital |
1963 | : | First liver transplant |
1964 | : | Theodore Striker, MD, becomes first pediatric critical care fellow, Philadelphia |
1967 | : | First US physician-directed PICU, Philadelphia |
: | Society of Critical Care Medicine (SCCM) established | |
1972 | : | First US Textbook of Pediatric Critical Care Clement Smith (Editor) |
1973 | : | First edition, Critical Care Medicine (CCM) |
1974 | : | Pulse oximetry developed |
1982 | : | Pediatric Section of Society of Critical Care Medicine established |
1983 | : | First advanced pediatric life support PALS copywritten |
: | Formation of section on critical care of AAP | |
1986 | : | US Guidelines published for pediatric air and ground transport |
1987 | : | First Comprehensive Textbook for Pediatric Critical Care–MC Rogers |
First pediatric critical care board examinations | ||
1988 | : | American College of Critical Care established |
: | Prism score described by Murrey Pollack | |
1989 | : | First pediatric critical care fellowship certified by American College of Graduate Medical Education (ACGME) |
1993 | : | US guidelines and levels of care for PICUs published |
1993 | : | Indian Society of Critical Care Medicine (ISCCM) established |
1993 | : | First Indian Academy of Pediatrics (IAP) intensive care conference, Delhi |
: | Manual of pediatric intensive care published–K Chugh and Praveen Khilnani | |
1997 | : | World congress and establishment of World Federation of Pediatric Intensive Care (WFPICC), Baltimore |
1998 | : | IAP intensive care chapter established |
1998 | : | 1st national congress on pediatric intensive care, Nagpur |
2000 | : | ISCCM pediatric section formed |
2001 | : | IAP and ISCCM PICU guidelines and levels of care published |
2002 | : | First pediatric critical care fellowship started |
2003 | : | First pediatric critical care fellowship exam, Surat |
2004 | : | First comprehensive Indian Textbook on Pediatric Intensive Care: Praveen Khilnani |
2007 | : | DNB pediatric critical care started in India. |