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Chapter -04 Pathophysiology of Male Infertility

BOOK TITLE: Andrology Laboratory Manual

Author
1. Rao Kamini A
2. PA Baiju
ISBN
9788184489019
DOI
10.5005/jp/books/11172_4
Edition
1/e
Publishing Year
2010
Pages
31
Author Affiliations
1. Bangalore Assisted Conception Centre, Bangalore, Milann Fertility Centre, Bangaluru, Karnataka, India, Milann—The Fertility Center, Bengaluru, Karnataka, India, Milann (A Unit of BACC Health care Private Limited), Bengaluru, Karnataka, India, Milann (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann (A Unit of BACC, Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann Group of Fertility Centers, Bengaluru, Karnataka, India, Bengaluru, Karnataka, India, Bengaluru, Milann—The Fertility Center (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann—The Fertility Center (A Unit of BACC Health Care Pvt Ltd), Bengaluru, Karnataka, India, Bangalore Assisted Conception Centre, Bangalore, Karnataka, India, BACC Health Care Private Limited, Bengaluru, Karnataka, India, Bangalore Assisted Conception Center (BACC), Bengaluru, Karnataka, India, FOGSI-2001; Bangalore Assisted Conception Center (An ISO 9002 Organization), Karnataka, India, Bangalore Assisted Conception Center
2. Bangalore Assisted Conception Centre Pvt. Ltd. (BACC), # 6 / 7, Kumara Krupa Road, High Grounds, Bengaluru, Bangalore Assisted Conception Centre, 6/7, Kumara Krupa Road, High Grounds, Bengaluru, Karnataka, India
Chapter keywords

Abstract

Functions of human testes are steroidogenesis and spermatogenesis. Both these events are under the endocrine and paracrine control. Endocrine control is mediated through gonadotropins which are in turn controlled by pulsatile GnRH secretion from hypothalamus which reaches pituitary gland through hypophyseo-pituitary portal system. Paracrine control involves the mediation of many growth factors. Sertoli cells are the supporting cells in the seminiferous tubules, which has a major role in the spermatogenesis. They are also known as Sustentacular cells. Leydig cells are seen in the interstitium of testes produce testosterone and they also have an important role in the control of spermatogenesis. Tight junctions between the Sertoli cells also play a major regulatory role in spermatogenesis. In this the author concentrate on the physiological and pathological changes occurring in testes which contribute to infertility.

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