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Severe Acute Maternal Morbidity
Arulmozhi Ramarajan
PART I: ISSUES IN THE MANAGEMENT OF NEAR MISS IN OBSTETRICS
CHAPTER 1:
AN INTRODUCTION TO NEAR MISS IN OBSTETRICS
DEFINITIONS
There Are Various Definitions of Near Miss, All of Which Express The Same Thing
METHODS OF IDENTIFYING SEVERE MATERNAL MORBIDITY
There Are Essentially Three Methods of Identifying Severe Maternal Morbidity
CLINICAL CRITERIA RELATED TO A SPECIFIC DISEASE ENTITY
Intervention-based Criteria
Organ System Dysfunction-based Criteria
Disease-Specific Criteria by Filippi et al
1. Hemorrhage
2. Hypertensive Disorders in Pregnancy
3. Dystocia
4. Infection
5. Anemia
MORTALITY INDEX
Maternal Deaths—Beyond the Numbers
CHAPTER 2:
ESSENTIAL OBSTETRIC CARE
ESSENTIAL OBSTETRIC CARE
What is Essential Obstetric Care?
Basic Essential Obstetric Care
Comprehensive Essential Obstetric Care
What is the Aim of Providing Care During Pregnancy?
Aim of Antenatal Care
Evidence
Who Should Provide Care?
Evidence
What Would be Ideal Antenatal Care?
Frequency of Visits
The Booking Visit
Examination Should Include
Evidence
Screening Lab Tests
Evidence
Screening for Infections
Screening for Clinical Conditions
Ultrasound Scan
Evidence
Screening for Down's Syndrome
Second Trimester Care
Evidence
Medications
Third Trimester Care
Immunization During Pregnancy
Ideal Labor Room
The Labor Room Should be Well Equipped
Check List for Emergency Kit
PPH Tray
Grade Definition
Level Source of Evidence
CHAPTER 3:
SOCIOCULTURAL AND ECONOMIC ISSUES IN SAMM*
INTRODUCTION
CASE SCENARIO
This Happened in a City Hospital
ISSUES THAT BEG TO BE ADDRESSED
Too Soon to Marry, Too Soon to Carry
Unwed Mothers
Sex Selective Abortions
Mistrust and Minimal Use of Family Planning Services
Poverty and Low Social Class
Ill Health and Infections
Pregnancy is Not a Disease, So Why to Seek Medical Help?
Folk Medicine
INFLUENCE OF SOCIOCULTURAL MATTERS ON MATERNAL HEALTH
Delay in Deciding to Seek Care (Phase 1 Delay)
CASE SCENARIO
Delay in Identifying and Reaching a Health Facility (Phase 2 Delay)
Lack of Transportation
Delay in Receiving Adequate and Appropriate Care (Phase 3 Delay)
STEPS TOWARDS SAFER MOTHERHOOD
Before Pregnancy
During Pregnancy
The National Rural Health Mission
Other Innovative Schemes
CONCLUSION
CHAPTER 4:
CRITICAL CARE IN OBSTETRICS
INTRODUCTION
IDENTIFY THE PATIENT REQUIRING CRITICAL CARE
PRINCIPLES OF MANAGEMENT
Clinical Monitoring
Mental Status
Heart Rate
Blood Pressure
Respiration
Urine output
Electronic Monitoring and Invasive Hemodynamic Monitoring
Pulse Oximetry
Central Venous Pressure (CVP) Monitoring
Pulmonary Artery Catheterization
Blood Investigations
Hemoglobin
Coagulation Parameters
Electrolyte Imbalance
Respiratory Support in the Critically Ill
Clinical Criteria
Other Criteria
Hemorrhagic Shock
IV Access
Oxygenation
Fluid Replacement
Blood and Blood Products
Packed Red Blood Cells (PRBCs)
Use of Vasopressors or Inotropic Drugs
Norepinephrine
Dopamine
Ancillary Measures
Septic Shock
Management
Antibiotics
Recommended Antimicrobial Regimens for High-Risk Patients with Intra-Abdominal Infection
Genital Tract Infections
Correction of Hypotension
Newer Modalities of Therapy
Pre-eclamptic Toxemia
CONCLUSION
CHAPTER 5:
THE OBSTETRIC HIGH-DEPENDENCY UNIT (HDU)
LEVELS OF CARE AND THE CONCEPT OF HIGH-DEPENDENCY UNIT
Standard Maternity Ward
Intensive Care Unit
Obstetric High-Dependency Unit
How is Obstetric Critical Care/HDU Different From General Critical Care/ICU?
Who Needs High-dependency Unit Care?
What Does the High-dependency Unit Provide?
Facilities
Staffing
Operational policies
message
CHAPTER 6:
AUDIT IN OBSTETRIC NEAR-MISS SITUATIONS
WHAT IS AUDIT?
WHAT IS CLINICAL AUDIT?
CLINICAL AUDIT IN OBSTETRIC NEAR-MISS SITUATIONS
Stage 1: Identifying the Problem or Issue
Example
Stage 2: Setting Criteria and Standards
Audit criteria
Standards
Stage 3: Observing Practice and Data Collection
Stage 4: Comparing Performance with Criteria and Standards
Stage 5: Implementing Change
WHO SHOULD CONDUCT CLINICAL AUDITS?
Documentation
The Importance of Documentation
CHAPTER 7:
COMMUNICATION IN NEAR-MISS SITUATIONS
COMMUNICATION
Communicating Risks
Situation 1
Communication in an Emergency
Situation 2
Communication—Who and How?
Communication—Clear and Complete
Situation 4
Communication—Clear, Complete and Written Legibly
Situation 5
Communication That is Best Avoided
Situation 6
Communication Within the Team
Situation 7
Communication With the Referring Doctor
Situation 8
Communication When Referring a Patient
Situation 9
CHAPTER 8:
MEDICOLEGAL ISSUES AND LITIGATION IN OBSTETRIC MORBIDITIES
MEDICOLEGAL ISSUES
From the Perspective of the Judicial Authorities
The Informed Consent
LEGAL REDRESS
An Affected Party Can Seek Legal Redress Through Three Routes
Case I - Case Claimed under Consumer Protection Act
Case 2 - Case Claimed under Civil Law
Case 3 - Case Claimed Under Criminal Law
Maternal Morbidity Related Litigations
Acute Morbidity
Chronic Morbidity
How to Avoid Medicolegal Problems?
PART II: OBSTETRIC HEMORRHAGE
CHAPTER 9:
Antepartum Hemorrhage
PLACENTA PREVIA
Definition
Incidence
Risk Factors
Early Diagnosis and Expectant Management
Confirm Diagnosis, Exclude Placenta Accreta
Exclude Fetal Bleeding Due to Vasa Previa in a Low-Lying Placenta
Admit and Evaluate
Obtain Informed Consent for Expectant Management
During Expectant Management
Ongoing Counseling of the Woman and Her Family
Quick Correction of Anemia
Arrange for Adequate Blood Back-up
Antenatal Steroids
Antepartum Anti-D Prophylaxis
Plan Delivery in a Tertiary Center
Hospitalization Vs Ambulatory Care
Threatened Preterm Labor
Sign Out
Vaginal Delivery
Cesarean Section
Prerequisites for Cesarean Section
Problems That can be Encountered at Cesarean Section
ABRUPTIO PLACENTAE
Definition
Incidence
Risk Factors
Clinical features
Grades6
Maternal Complications
Management
Clinical Assessment
Laboratory Tests
Delivery
KEY POINTS IN APH
Advice
Advice to Women Who Have Been Diagnosed to Have Placenta Previa
CHAPTER 10:
POSTPARTUM HEMORRHAGE
PRACTICAL ISSUES IN POSTPARTUM HEMORRHAGE
PREDISPOSING FACTORS AND CAUSES
Tone
Placental Site Bleeding Due to Uterine Atony
Tissue
Retained Placental Tissue
Trauma
Thrombin
Coagulation Defects
MANAGEMENT OF POSTPARTUM HEMORRHAGE
Get Help—Shout for Help
Begin Basic Monitoring and Support
Attempt a Quick Assessment on the Cause of Hemorrhage
Tone?
Trauma?
Tissue?
Thrombin?
Replace Lost Blood Volume
Place an Indwelling Urinary Catheter
Inform Patient and Family About the Problem, Keep Them Updated
Start Blood Transfusion at the Earliest, to Prevent Dilutional Coagulopathy or ‘Washout Phenomenon’
If the Situation Does Not Come Under Control with These Measures, Consider Transfer to OT/Higher Center for Further Management
Remember, ‘Too Little, Too Late’ is What Kills the Mother
Not to Forget: Documentation and Debriefing
Clinical Assessment of Blood Loss
Shock index
Rule of 30
Recommended Laboratory Tests and Monitoring
Repeating of All Tests is Recommended
PREVENTION OF POSTPARTUM HEMORRHAGE AT VAGINAL DELIVERY
Active Management of the Third Stage of Labor (AMTSL)
Step 1
Step 2
Step 3
Uterotonic Drugs
Systematic Review of Effects of AMTSL Components
Uterotonic
Controlled Cord Traction
Uterine Massage
Other Interventions to Reduce Blood Loss
PREVENTION OF POSTPARTUM HEMORRHAGE AT CESAREAN DELIVERY
Measures That Can Help
MANAGEMENT OF POSTPARTUM HEMORRHAGE AT VAGINAL DELIVERY
Uterotonics
How to do Condom Tamponade?
How to do Bimanual Compression of the Uterus?
How to Give Aortic Compression?
How to Safely Transfer to a Higher Center?
MANAGEMENT OF POSTPARTUM HEMORRHAGE AT CESAREAN DELIVERY
Newer Developments in the Management of Postpartum Hemorrhage
Prohemostatic Therapy
Recombinant Factor VIIa (rFVIIa)
Antifibrinolitic Drugs
Desmopressin (DDAVP)
Non-pneumatic Anti-shock Garment (NASG)
PPH: KEY RECOMMENDATIONS
FURTHER MEASURES TO PREVENT POSTPARTUM HEMORRHAGE
CHAPTER 11:
CASE SCENARIOS IN POSTPARTUM HEMORRHAGE (PPH)
CASE 1. ATONIC POSTPARTUM HEMORRHAGE FOLLOWING NORMAL DELIVERY
Message
CASE 2. TRAUMATIC POSTPARTUM HEMORRHAGE FROM AN EPISIOTOMY
Message
CASE 3. PPH FOLLOWING REPEAT LSCS: INFERIOR EPIGASTRIC VESSEL RUPTURE
Message
CASE 4. POSTPARTUM HEMORRHAGE IN PLACENTA PREVIA—OBSTETRIC HYSTERECTOMY
Message
CASE 5. ATONIC POSTPARTUM HEMORRHAGE IN TWIN GESTATION: CONDOM TAMPONADE
Message
CASE 6. PLACENTA PREVIA—POSTPARTUM HEMORRHAGE ON TABLE
Message
CASE 7. A CASE OF DISSEMINATED INTRAVASCULAR COAGULATION
Message
CASE 8. MASSIVE HEMORRHAGE DURING LOWER SEGMENT CESAREAN SECTION
Message
CHAPTER 12:
SERIOUS HAZARDS OF TRANSFUSION (SHOT)
INTRODUCTION
INCORRECT BLOOD COMPONENT TRANSFUSION
ACUTE TRANSFUSION REACTIONS
Clinical Features of Adverse Transfusion Reaction
Allergic Reactions
Febrile Non-Hemolytic Transfusion Reactions (FNHTR)
Anaphylactic/Anaphylactoid Reactions
Hemolytic Reaction
DELAYED TRANSFUSION REACTIONS
POST-TRANSFUSION PURPURA (PTP)
Routine Work Up of a Transfusion Reaction
Prognosis
Illustration
A Case of Respiratory Distress Following Blood Transfusion
TRANSFUSION-RELATED ACUTE LUNG INJURY (TRALI)
Etiology of TRALI
Pathogenesis of Pulmonary Edema
Diagnosis of TRALI
TRALI is a Diagnosis of Exclusion
Clinical Features
Chest X-Ray
Management of TRALI
POST-TRANSFUSION GVHD
Illustration
A Case of Fever With Skin Rash Following Blood Transfusion
Etiopathogenesis of PT-GVHD
Incidence
Clinical Features of PT-GVHD/TA-GVHD
Diagnosis
Risk Factors for PT-GVHD13
Prevention
CONCLUSION
PART III: HYPERTENSION AND ECLAMPSIA
CHAPTER 13:
COMPLICATIONS OF SEVERE PRE-ECLAMPSIA
INTRODUCTION
SYSTEMIC DERANGEMENTS
1. Cardiovascular
2. Hematologic
3. Renal
4. Hepatic
5. Central Nervous System
COMPLICATIONS
Eclampsia
Postpartum Eclampsia
HELLP Syndrome
Hematological Complications
Hepatic Complications
Antepartum Hemorrhage
Cardiovascular Dysfunction
Acute myocardial infarction
Cardiac Failure
Cardiomyopathy
Pulmonary Problems
Pulmonary Edema
Adult Respiratory Distress Syndrome (ARDS)
Neurological Complications
Pathogenesis of Cerebral Dysfunction
Renal Complications
Edema
Hyperuricemia
Renal Failure
Oliguria and Anuria
Pathophysiology
Gastrointentinal Complications
Musculoskeletal Complications
Fetal Complications
Fetal Distress/Fetal Demise
Ongoing Life Challenges
Mortality/Morbidity
Complications Due to Drugs
Long Term Effects
Pre-eclampsia and Subsequent Cardiovascular Risk
Pre-eclampsia and The Risk of End-Stage Renal Disease (ESRD)
Risk of Pre-eclampsia in a Subsequent Pregnancy
PREVENTION OF COMPLICATIONS
CONCLUSION
CHAPTER 14:
CASE SITUATIONS IN PREGNANCY-INDUCED HYPERTENSION (PIH)
CASE 1. ECLAMPSIA IN ALL ITS FLORIDITY
What are The Lessons Learnt?
CASE 2. MULTIPLE COMPLICATIONS—ECLAMPSIA/HELLP/DIC/OLIGURIA/PRES/PANCREATITIS
Could This SAMM be Avoided? Where and How Did The Errors Creep in? What Can be Done?
CHAPTER 15:
ECLAMPSIA
A CASE OF ECLAMPSIA
Discussion
Prevention and Treatment of Convulsions with Magsulf
1. Pritchard's Regimen
2. Zuspan's Protocol
3. Sibai's Protocol
Magnesium Toxicity
Treatment of Toxicity
Commonly Used Antihypertensive Drugs in Severe Pre-eclampsia and Eclampsia
Maternal Complications
CHAPTER 16:
THE ECLAMPSIA DRILL
AIMS
SEVERE PRE-ECLAMPSIA/IMMINENT ECLAMPSIA
MANAGEMENT OF ECLAMPSIA
ECLAMPSIA KIT
FURTHER MANAGEMENT OF ECLAMPSIA
Anticonvulsants
MgSO4
Monitoring Parameters
Antidote for MgSO4 toxicity
Management of Recurrent Convulsions
Second Line Anticonvulsant
Diazepam
Maintenance Dose
Antihypertensives
Labetalol
Nifedipine
INVESTIGATIONS
FLUID MANAGEMENT
DELIVERY
SHIFTING TO TERTIARY CARE CENTER
Indications
Rural Area
Urban Area
How to Shift?
PART IV: SEPSIS
CHAPTER 17:
SEPSIS IN RELATION TO ABORTIONS
THE PROVIDERS
THE PROCEDURE
SEPTIC ABORTION
Uncomplicated Sepsis
Severe Sepsis
Multiple Organ Dysfunction Syndrome
Septic Shock
Diagnosis
Antimicrobial Treatment
Indications for Surgery
Surgical Management of Septic Abortion
Evacuation of the Uterus
Posterior Colpotomy
Laparotomy
Supportive Care
Pressor Agents
Anti-inflammatory Agents
Oxygenation
Immunotherapy
Prevention of Septic Abortion
Primary Prevention
Secondary Prevention
Tertiary Prevention
ADVANTAGES OF MEDICAL METHOD OF ABORTION18
STRATEGIES TO REDUCE UNSAFE ABORTIONS
CHAPTER 18:
PUERPERAL SEPSIS
INTRODUCTION
PUERPERAL SEPSIS
Incidence
Predisposing Factors
Bacteriology
Pathogenesis
Clinical Presentation
Differential Diagnosis of Puerperal Fever
Investigations
Treatment
Mild to Moderate Infections
Appropriate Treatment
Management of Puerperal Septic Shock
Intravenous Antibiotic Therapy
Complications of Puerperal and Postabortal Sepsis
Minor
Major
Septic Pelvic Thrombophlebitis
Toxic Shock Syndrome
Tetanus
Prevention of Infection
Prevention During Cesarean Section
Other Factors in Sepsis
CONCLUSION
PART V: OBSTRUCTED LABOR
CHAPTER 19:
DYSFUNCTIONAL LABOR
COMMON CAUSES OF DYSFUNCTIONAL LABOR
Cephalopelvic Disproportion
Abnormal Presentations
Incoordinate Uterine Action
USE OF OXYTOCIN
CASE SITUATIONS OF DYSFUNCTIONAL LABOR
CASE 1. PROLONGED LABOR, CPD
Lessons Learnt
What Would Have Helped?
CASE 2. RUPTURE UTERUS IN TRIAL OF LABOR AFTER CESAREAN (TOLAC)
Lessons Learnt
What Would Have Helped?
CASE 3: SHOULDER DYSTOCIA
Lessons Learnt
What Would Have Helped?
CASE 4. UNDIAGNOSED BREECH
Lessons Learnt
What Would Have Helped?
CASE 5: INSTRUMENTAL DELIVERY
Lessons Learnt
What Would Have Helped?
PRACTICE RECOMMENDATIONS
CHAPTER 20:
OBSTETRIC DRILLS
THE PARTOGRAM
The Following Details Are Recorded on The Partogram
Patient Information
Fetal Heart Rate
Amniotic Fluid
Moulding
Cervical Dilatation
Alert Line
Action Line
Descent Assessed by Abdominal Palpation
Hours
Time
Contractions
Oxytocin
Drugs Given
Pulse
Blood Pressure
Temperature
Urinary Protein, Acetone and Volume
Note
Purpose of The Partogram
FORCEPS AND VENTOUSE
SHOULDER DYSTOCIA
Risk Factors
Management
Avoid the P's
VAGINAL BREECH DELIVERY
Situations for Delivering a Breech
Prerequisites for Attempting Vaginal Breech Delivery
Situations Where Breech Delivery Should Not be Attempted
Technique and Tips for Assisted Vaginal Breech Delivery
CHAPTER 21:
RUPTURE OF THE UTERUS
ETIOLOGY
CLASSIFICATION
INCIDENCE
CLINICAL PRESENTATION
Differential Diagnosis
SITE OF RUPTURE
COMPLICATIONS
MORTALITY
CASE SCENARIOS
CASE I
Discussion
CASE 2
Discussion
CHAPTER 22:
CESAREAN SECTION
CAUSES FOR SAMM IN CESAREAN SECTION
Causes for Severe Bleeding
CASE HISTORY 1
PLACENTA PREVIA AND ABNORMAL PLACENTAL INVASION (API)
Risk Factors for API
Diagnosis
Type of Anesthesia
Timing of Delivery
Steps During Cesarean Section Which will Minimize Life-Threatening Bleeding
API Diagnosis During Antenatal Period
Conservative Treatment
Incomplete Removal
Surgical Conservative Management of API
Related Issues to be Kept in Mind
Uterine Lacerations
How Best Can We Prevent/Reduce the Morbidity?
CESAREAN DELIVERY OF A VERY PRETERM FETUS
Management
CASE HISTORY 2
CASE HISTORY 3
Complications in Pregnancy Due to Fibroid
Surgical Considerations
Skin Incision
Uterine Incision
CASE HISTORY 4
Management
Risk Factors for Rupture
CESAREAN HYSTERECTOMY
Common Indications for Emergency Hysterectomy
Surgical Considerations and Technique
A Total or Subtotal Hysterectomy
PART VI: BOLT FROM THE BLUE
CHAPTER 23:
AMNIOTIC FLUID EMBOLISM (Anaphylactoid Syndrome of Pregnancy)
INTRODUCTION
Clinical criteria3,5,8
PATHOPHYSIOLOGY
CLINICAL PRESENTATION
CASE 1
CASE 2
CLINICAL INDICATORS OF SEVERE ACUTE MATERNAL MORBIDITY
DIFFERENTIAL DIAGNOSIS
KEY INVESTIGATIONS
TREATMENT
Medical Care
Ventilation/Oxygenation
Limited Resource Setting
Medication
CONCLUSION
CHAPTER 24:
THROMBOEMBOLISM IN PREGNANCY
INTRODUCTION
CASE 1
CASE 2
PATHOPHYSIOLOGY
INCIDENCE
SEQUELAE
RISK FACTORS
PREVENTION
CLINICAL FEATURES
DIAGNOSIS
MANAGEMENT
Initial Treatment
Maintenance Treatment
Pregnancy
Labor and Delivery
Puerperium
Management in a Low Resource Setting
Management of Subsequent Pregnancies
CONCLUSION
CHAPTER 25:
ANESTHETIC NEAR MISSES IN OBSTETRICS
CHALLENGES
‘Nightmares’ for the Obstetric Anesthesiologist
COMMON OBSTETRIC PRESENTATIONS
CASE 1
Emergency Lower Segment Cesarean Section
Problem: General Anesthesia on Full Stomach—Aspiration
Preventive Measures
CASE 2
Traumatic Postpartum Hemorrhage on Table
Problem: Hemorrhage, Traumatic
Preventive Measures
CASE 3
Supine Hypotension Syndrome
Problem: Supine Hypotension and Cardiac Arrest
Preventive Measures
CASE 4
Cardiac Arrest Following Subarachnoid block
Problem: Peripartum Cardiomyopathy and Cardiac Arrest
Preventive Measures
CASE 5
Amniotic Fluid Embolism at Cesarean Section
Learning Points
Regional Anesthesia Techniques
Special Concerns for the Anesthetist
Making Regional Anesthesia Safer
Complications
Epidural Test Dose
LABOR ANALGESIA (LA)
Pain Relief
CASE 6
Labor Analgesia—Post Dural Puncture Headache (PDPH)
Problem: Post Dural Puncture Headache
Prevention
GENERAL ANESTHESIA
Special Concerns for the Anesthetist
Power Pearls for the Obstetrician
INDEX
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