Essentials in Hematology and Clinical Pathology Ramadas Nayak, Sharada Rai, Astha Gupta
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1Essentials in Hematology and Clinical Pathology2
3Essentials in Hematology and Clinical Pathology
Ramadas Nayak MBBS MD Professor of Pathology Kasturba Medical College, Mangalore Manipal University Karnataka, India askdr.nayak@gmail.com Sharada Rai MBBS MD Associate Professor of Pathology Kasturba Medical College, Mangalore Manipal University Karnataka, India Astha Gupta MBBS MD Assistant Professor of Pathology Kasturba Medical College, Mangalore Manipal University Karnataka, India Foreword K Ramnarayan
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© 2012, Jaypee Brothers Medical Publishers
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This book has been published in good faith that the contents provided by the authors contained herein are original, and is intended for educational purposes only. While every effort is made to ensure accuracy of information, the publisher and the authors specifically disclaim any damage, liability, or loss incurred, directly or indirectly, from the use or application of any of the contents of this work. If not specifically stated, all figures and tables are courtesy of the authors. Where appropriate, the readers should consult with a specialist or contact the manufacturer of the drug or device.
Essentials in Hematology and Clinical Pathology
First Edition: 2012
9789350255995
Printed at
5Dedicated to
Students who inspired us, patients who provided the knowledge, our parents and family members who encouraged and supported us.
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Foreword
“Some books are to be tasted, others swallowed and some few to be chewed and digested,” said Francis Bacon. This book, for which I am delighted to write the Foreword, has to be not merely tasted, chewed, swallowed and digested but also absorbed and assimilated for best results!
Clarifying concepts and inculcating the foundational tenets in hematology and clinical pathology are daunting tasks for any teacher. The teachers who have authored this book have admirably captured the core of the subject capping that with lucid explanations. The authors have expertise not only in the subject but also in the art of teaching. Willingness to share and the ability to convey convincingly are the veritable attributes of the authors. It is this wisdom of experience and expression that has percolated into this book. A book of this substance and style was long overdue and it could not have been timelier. I am certain that the contents of the book will mellow with each succeeding edition in the years to come. Let me congratulate and commend the authors for the pains they took to bring out a book, which deserves much more than just having a look.
K Ramnarayan
Vice Chancellor
Manipal University
Karnataka, India
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9Preface
Hematology is one of the rapidly expanding fields of medicine. The extensive amount of time and effort spent by the students in going through volumes of the hematology textbooks encouraged us to write this comprehensive book. Understanding hematology requires insight into the applied physiology and the pathophysiologic basis of these diseases in the context of relevant clinical features which is often neglected. Essentials in Hematology and Clinical Pathology emphasizes on building a strong foundation of both concepts. Clinical pathology section of the book deals with both hematological and nonhematological laboratory investigations done in routine practice.
The book has been organized into four sections namely Disorders of Red Cells, Disorders of White Cells, Disorders of Hemostasis and Clinical Pathology.
Essentials in Hematology and Clinical Pathology also features:
We hope that the textbook will provide a foundation to the students in hematology and clinical pathology and improve their understanding of the subject.
Ramadas Nayak
Sharada Rai
Astha Gupta
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11Acknowledgments
Our sincere thanks to Ms Prathibha Bhat for her untiring efforts, patience and excellent support in creating the illustrations. Acknowledgments are also due to Ms Rashmitha Kini, Mr Ramnath Kini, Ms Rakshatha, Dr Krishnaraj Upadhyaya, Professor of Pathology, Yenepoya Medical College, Mangalore, Karnataka, India; and Dr Raghupathi AR, Professor and Head Department of Pathology, Bangalore Medical College, Bengaluru, Karnataka, India; for their contribution in the preparation of the manuscript. We are grateful to Dr K Ramnarayan, Vice Chancellor of Manipal University, Manipal, Karnataka, India for his support and guidance.
We also wish to thank all our family members including Smt Rekha Nayak, Dr Narendra Shetty, Dr Amit Gupta and Master Jagrath who have patiently accepted our long preoccupation with this work. Our sincere gratitude to our parents who will always remain our guiding light. We are grateful to all our friends, undergraduate and postgraduate students who have inspired and supported us.
We acknowledge the wonderful work done by M/s Jaypee Brothers Medical Publishers (P) Ltd. team especially Mr Tarun Duneja (Director-Publishing), Mrs Samina Khan (PA to Director-Publishing), Mr Vasudev H, Mr KK Raman (Production Manager), Mr Akhilesh Kumar Dubey, Mr Ram Kumar, Mr Amitoj Singh, Mr Venu Gopal V and others.