Pranab Dey MBBS MD MIAC FRCPath
Professor Department of Cytology Postgraduate Institute of Medical Education and Research
Chandigarh, India
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Fine Needle Aspiration Cytology: Interpretation and Diagnostic Difficulties
First Edition: 2012
9789350256435
Printed at
5Dedicated to
Shree Shree Satyananda Giri My wife Rini and My daughter Madhumanti Dey
7Preface
Fine Needle Aspiration Cytology (FNAC) is now a well-recognized technique in diagnosis of various lesions. Increasing numbers of pathologists are now practicing cytology. Aspiration cytology is also included in the curriculum of the postgraduate training in pathology. Therefore, it is extremely necessary to know the various aspects of fine needle aspiration cytology.
In this book, Fine Needle Aspiration Cytology: Interpretation and Diagnostic Difficulties, I have discussed the important diagnostic features of aspiration cytology with multiple illustrations. The diagnostic problems of various lesions have been discussed in detail. I have mainly concentrated on the cytomorphology. However, the immunocytochemistry and other ancillary techniques have also been discussed. I hope that this book will help both the practicing cytologists and the pathology residents.
Pranab Dey
9Acknowledgments
I am thankful to M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, for giving me the opportunity and encouragement for publishing this book. My particular thanks to Mr Subrata Adhikari (Commissioning Editor) for his continuous support. I wish to thank my wife Rini and my daughter Madhumanti for their continuous cooperation and patience towards me whose mind was always preoccupied. Without their support, it was not possible to write the book at all.
11Abbreviations
AFB
Acid fast bacilli
AML
Acute myeloid leukemias
ACC
Adenoid cystic carcinoma
ALCL
Anaplastic large cell lymphoma
BCA
Basal cell adenoma
BCC
Basal cell carcinoma
BLL
Benign lymphoepithelial lesion
BAC
Bronchioloalveolar carcinoma
BL
Burkitt lymphoma
CEA
Carcinoembryonic antigen
CLL
Chronic lymphocytic leukemia
CT
Computerized tomography
CK
Cytokeratin
DFSP
Dermatofibrosarcoma protuberans
DSRCT
Desmoplastic small round cell tumor
DLBCL
Diffuse large B cell lymphoma
EMA
Epithelial membrane antigen
EBV
Epstein-Barr virus
ESR
Erythrocyte sedimentation rate
ER
Estrogen receptor
EWS
Ewing's sarcoma
FNAC
Fine needle aspiration cytology
FNS
Fine needle sampling
FCM
Flow cytometry
FCC
Follicular center cell
FN
Follicular neoplasm
FVPCT
Follicular variant of papillary carcinoma
GIT
Gastrointestinal tract
GIST
Gastrointestinal stromal tumor
GCT
Giant cell tumor of bone
GCTTS
Giant cell tumor of tendon sheath
GFAP
Glilal fibrillary acid protein
H&E
Hematoxylin and eosin
HCC
Hepatocellular carcinoma
HL
Hodgkin's lymphoma
IDC
Infiltrating duct carcinoma
IC
Insular carcinoma
IM
Intramuscular myxoma
LCH
Langerhans cell histiocytosis
LGL
Large granular lymphocytes
LCA
Leukocyte common antigen
LBL
Lymphoblastic lymphoma
L&H
Lymphocyte and histiocyte
MRI
Magnetic resonance imaging
MFH
Malignant fibrous histiocytoma
MPNST
Malignant peripheral nerve sheath tumor
MCL
Mantle cell lymphoma
MGG
May-Grünwald-Giemsa
MC
Medullary carcinoma
MEC
Mucoepidermoid carcinoma
MALTOMA
Mucosa associated lymphoma
NPC
Nasopharyngeal carcinoma
NB protein
Neuroblastoma protein
NSE
Neuron-specific enolase
NHL
Non-Hodgkin's lymphoma
PET
Pancreatic endocrine tumor
PAP stain
Papanicolaou's stain
PC
Papillary carcinoma
PNET
Peripheral neuroectodermal tumor
PGL
Persistent generalized lymphadenopathy
PLAP
Placental leukocyte alkaline phosphatase
PA
Pleomorphic adenoma
P-CEA
Polyclonal carcinoembryonic antigen
PLGA
Polymorphous low grade carcinoma
PR
Progesterone receptor
R-S
Reed-Sternberg
RCC
Renal cell carcinoma
REAL
Revised European American Lymphoma
RMS
Rhabdomyosarcoma
SHML
Sinus histiocytosis with massive lymphadenopathy
SLL
Small lymphocytic lymphoma
SRCT
Small round cell tumor
SCPN
Solid and cystic papillary neoplasm
Tdt
Terminal deoxynucleotidyl transferase
TSH
Thyroid stimulating hormone
TTF
Thyroid transcription factor
TCC
Transitional cell carcinoma
USG
Ultrasonography
WT
Wilms’ tumor
WHO
World Health Organization
ZN
Ziehl-Neelsen