Epidemiology of Ocular Tumors in Children & Adults Tamara T Mouratova
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fm1Epidemiology of Ocular Tumors in Children and Adultsfm2
fm3Epidemiology of Ocular Tumors in Children and Adults
Tamara T Mouratova Doctor of Medical Sciences Professor Ex-head of Uzbekistan's Onco-ophthalmologic Centre and Ophthalmologic Department of the Research Institute of Oncology and Radiology of Uzbekistan's Academy of Sciences Emeritus Member of the Belgian Societies of Ophthalmology Foreword Veniamin V Volkov
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This book has been published in good faith that the contents provide by the author contained herein are original, and is intended for educational purposes only. While every effort is made to ensure accuracy of information, the publisher and the author specifically disclaim any damage, liability, or loss incurred, directly or indirectly, from the use of application of any of the contents of this work. If not specifically stated, all figures and tables are courtesy of the author. Where appropriate, the readers should consult with a specialist or contact the manufacturer of the drug or device.
Epidemiology of Ocular Tumors in Children and Adults
First Edition: 2013
9789350259481
Printed atfm5
Dedicated to
My Mother
Valentina Efimovna Mouratovafm6
Foreword
fm7Every expert ophthalmologist who treats patients with ocular tumors would like to know how the disease develops, how much chance of survival do patients with malignant ocular tumors have, which gender suffers more frequently from various neoplasms, which countries have the highest incidence of some ocular malignancies, what mortality rate is the lowest with regard to one or other tumors, etc. An epidemiological study can give answer to these and many other questions. However, the existing information on incidence, mortality and survival rates of patients with benign and malignant ocular tumors, especially in children, ranges widely; and in some cases, one report contradicts the other.
The main purpose of this book is to show the wide spectrum of the existing scientific views on age, gender, percentage, incidences, mortality and survival rates of ocular tumors and the impacts of the environment on these rates. The book collects the results of many international researchers and compares international reports looking for epidemiological studies of benign and malignant ocular tumors in children and adults with the results of own epidemiological studies of these tumors in Uzbekistan. Moreover, very few studies deal with such important problems as environmental impacts (e.g. water and soil pollution, air emissions) on incidence and mortality of patients with malignant ocular tumors. Until today, there have not been published other studies on the subject. Author has also included chapter “Classification of Ocular Tumors”, because a universal classification unifying both histological and clinical signs of all ocular tumors still have not been established, therefore, she has described the majority of ocular tumor classifications to give as more information about ocular tumor classifications as possible. On the other hand, to compare results of research work between each other, it is necessary to use similar terms to be described in a classification and application of the similar terms for medical experts internationally. Until today, there have not been any published studies on the subject. The book is useful for clinical and scientific Ophthalmologists, Oncologists, Pediatricians, Epidemiologists, Social Workers, fm8Specialists of environmental areas, Journalists who are interested in relationship between incidence and mortality from malignant tumors and environment. The book is also suitable for graduate and postgraduate students and for those interested in epidemiology of ocular tumors.
Veniamin V Volkov
Doctor of Medical Sciences, Professor and Academician
Laser Academy of Sciences of the Russian Federation
Academy of Medico-Technical Sciences of the Russian Federation
Honoured Academician of Russian Academy of Natural Sciences
Honoured Scientist of Russian Federation
Honoured Doctor of Russian Military Academy
Hero of Socialist Labour
whose name is included into the Oxford IB Center Hall of Fame
fm9Preface
The idea of this book came to me many years ago but only now I have managed to put it into life. Ocular tumors are not infectious diseases being the usual topic of epidemiological studies. Nevertheless, research into the noninfectious diseases like malignant and benign tumors of the eye and ocular adnexa using epidemiological methods can reveal some uncontemplated aspects of tumor development process both in children and adults. Since such studies are essentially interdisciplinary crossing boundaries between ophthalmology, oncology and epidemiology, there are a few scientists worldwide involved with this topic. This is precisely why many epidemiological aspects in ophthalmo-oncology are not adequately studied, despite that numerous books on ophthalmology, oncology and especially ophthalmo-oncology contain information on patient's age, sex, number of patients with tumors in either right or left eye, and localization of the tumor according of anatomical sites. Yet there are still few studies of incidence, mortality and survival rates of patients according to the anatomical localization of an eye tumor per certain number of population, usually per 100,000 people. Clinical work even in large eye hospitals does not allow getting definitive numbers of incidence, mortality and survival rates of eye cancer patients, if one does not compare the cases among similar population group in terms of age and sex, because percentage frequently used in the relevant literature gives very rough picture which is quite hard to compare with the results of other studies. As a consequence, many reports do not often agree, or differ considerably or simply contradict each other.
The main objective of the book is to show the whole range of variations in numbers and views with regard to the epidemiology of the most commonly encountered benign and malignant ocular tumors in children and adults. Our research is based on the results of over 20 years’ work at the ophthalmological department—one of the 11 clinical departments within the Research Institute of Oncology and Radiology under Uzbekistan's Academy of Sciences. The department has been the only one in Uzbekistan with all necessary conditions to diagnose and treat children and adults with all types of benign and malignant tumors of the eye and its adnexa. In addition, I used my own professional experience of over 30 years’ treatment of eye cancer patients. The book provides comprehensive information on various factors such eyes and skin color, age, gender, influence of ultraviolet radiation, cellular phones radiation and environmental impacts on the development, incidence, mortality and fm10survival of ocular tumors in different geographical areas and countries across the globe comparing with the original results from Uzbekistan—the site of one of the largest environmental catastrophes in the world history known as the Aral Sea disaster. The most of our results were published in journals in English, in my Doctoral dissertation and publications in Russian, which based on my colleagues experience in the Institute of Oncology and Radiology of the Uzbekistan's Academy of Sciences, on my own more than 30 years’ experience in this institute as the founder and Head of Department of Ophthalmology and Head of Republic Onco-ophthalmological Center.
Tamara T Mouratova
fm11Acknowledgments
I am highly indebted to Professor Nariman Muratkhodjaev, Academician of the Uzbekistan's Academy of Sciences; Professor Alevtina Brovkina, Academician of the Russian Academy of Medical Sciences; Professor Elena Kremkova, Ophthalmological Chair of Russian State Medical University; Professor Raimund Hennekes, Vrije Universiteit Brussel; Valery Votrin, Environmental Resources Management (ERM); Ikhtibor Yuldasheva, Candidate of Geographical Sciences, Scientific Secretary of the Central Asian Regional Research Hydrometeorological Institute; Dr Galina Kozlovskaya, Dr Marfua Nigmanova, Dr Damira Khakimova, Candidate of Medical Sciences; Dr Naphisa Ubaidullaeva, Candidate of Medical Sciences, Department of Ophthalmology, Research Institute of Oncology and Radiology of Uzbekistan's Academy of Sciences; Natalya Griva, Mentral Regional Computing Center; Mikhail Chuprinin, the Institute of Nuclear Physics; Boris Konyukhov, Candidate of Geographical Sciences, the State Committee of Natural Protection; Alexei Tolmachev and Vladimir Rukavitsin for computer support, to all of my colleagues in the Department of Ophthalmology and in IOR, to my husband Guenrikh Votrin, my brother Alexander, our daughter Elena, our son Valery, our grand-daughter Ester, our grandson Matvei and all of our friends whose contribution made this book possible.fm12