Editor
Meeta
MD
Co-Director and Consultant Tanvir Hospital
Hyderabad,
Andhra Pradesh,
India
President-2012, Indian Menopause Society Founder Secretary, Indian Menopause Society Hyderabad Chapter
Foreword
Wulf H
Utian
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Postmenopausal Osteoporosis: Basic and Clinical Concepts
First Edition:
2013
9789350900857
Printed at
fm5Contributors
- Ambrish Mithal md dm
- Chairman
- Division of Endocrinology and Diabetes
- Medanta Medicity
- Gurgaon, Haryana, India
- Board Member
- Chair, Nutrition Working Group of CSA
- Chair, Asia Pacific Advisory Council, International Osteoporosis Foundation
- Chief Advisor
- Indian Society for Bone and Mineral Research
- Ankita Narsaria rd
- Postgraduate Diploma in Clinical Nutrition and Dietetics
- Department of Food and Nutrition
- Sir Vithaldas Thackersey College of Home Science
- Shreemati Nathibai Damodar Thackersey University
- Mumbai, Maharashtra, India
- Anna Fenton bhb mbchb ccd ncmp phd fracp
- Gynecological Endocrinologist
- Christchurch Women's Hospital and Southern Cross Women's Health
- Christchurch, New Zealand
- Co-Editor-in-Chief of Climacteric
- The Journal of the International Menopause Society
- President-Elect of the Australasian Menopause Society
- Annil Mahajan md mams fellowship (rheumatology)
- Associate Professor
- Postgraduate Department of General Medicine
- Government Medical College
- Jammu, Jammu and Kashmir, India
- Ashok Vaidya md phd
- Research Director
- ICMR Advance Center of Reverse Pharmacology
- Traditional Medicine Medical Research Center
- Kasturba Health Society
- Mumbai, Maharashtra, India
- Ashwini Kumar Raut md
- Director Clinical Research
- Medical Research Center
- Kasturba Health Society
- ICMR Advanced Center for Reverse Pharmacology in Traditional Medicine
- Mumbai, Maharashtra, India
- Consultant Endocrinology
- Medanta Medicity
- Gurgaon, Haryana, India
- Beth Cartwright md
- Clinical Research Fellow in Gynecology
- King's College
- London, United Kingdom
- Beverley Lawton onzm
- Director
- Women's Health Research Center
- Department of Primary Health Care and General Practice
- University of Otago, Wellington South
- Wellington, New Zealand
- C Cooper dm frcp ffph
- Director and Professor
- Department of Rheumatology
- The MRC Epidemiology Resource Center
- Institute of Human Nutrition and Developmental Origins of Health and Disease Division
- School of Medicine
- University of Southampton
- Southampton General Hospital
- Southampton, United Kingdom
- Chandeep Singh md
- Consultant
- Max Institute of Orthopedics and Joint Replacement
- Max Superspeciality Hospital
- New Delhi, India
- Deepak Patkar mbbs md
- Director Radiology and Research
- Medical Research Center
- Kasturba Health Society
- ICMR Advanced Center for Reverse Pharmacology in Traditional Medicine
- Mumbai, Maharashtra, India
- Dilip Mehta phd
- CEO
- Viridis BioPharma Pvt Ltd
- Mumbai, Maharashtra, India
- Dinesh K Dhanwal dm
- Professor
- Department of Medicine and Endocrinology
- Maulana Azad Medical College
- New Delhi, India
- Edilfavia Mae Uy md
- Internal Medicine
- Farmington, Connecticut, USA
- Registrar Pediatrics
- Tanvir Hospital
- Hyderabad, Andhra Pradesh, India
- Heung Kim md phd
- Professor
- Department of Obstetrics and Gynecology
- College of Medicine
- Chief
- External Coopration and Partenership
- Kosin University
- Busan, South Korea
- Chief Editor
- Korean Osteoporosis Society
- Jagmeet Madan phd
- Principal and Professor
- Department of Food and Nutrition
- Sir Vithaldas Thackersey College of Home Science
- Shreemati Nathibai Damodar Thackersey University
- Mumbai, Maharashtra, India
- Janice Rymer md frcog
- Professor
- Department of Obstetrics and Gynecology
- King's College
- London, United Kingdom
- John C Stevenson mb bs frcp fesc mfsem
- Consultant Physician and Reader
- Department of Metabolic Medicine
- National Heart and Lung Institute
- Royal Brompton Hospital
- Sydney Street, London, United Kingdom
- Kate Maclaran mb chb bsc
- Clinical Research Fellow
- Imperial College
- London
- Chelsea and Westminster Hospital
- Fulham Road, London and Royal Brompton Hospital
- Sydney Street, London, United Kingdom
- Marco Gambacciani md
- Department of Obstetrics and Gynecology
- Pisa University Hospital
- Via Roma, Pisa, Italy
- Meena P Desai phd msc
- Department of Molecular Immunodiagnostics
- National Institute for Research in Reproductive Health
- JM Street, Parel, Mumbai, Maharashtra, India
- Co-Director and Consultant
- Tanvir Hospital
- Hyderabad, Andhra Pradesh, India
- President-2012, Indian Menopause Society
- Founder Secretary, Indian Menopause Society
- Hyderabad Chapter
- Mohammed Ikram Khatkhatay (scientist e)
- Deputy Director
- National Institute for Research in Reproductive Health
- JM Street, Parel, Mumbai, Maharashtra, India
- Namyata Pathak md
- Research Associate
- Medical Research Center
- Kasturba Health Society
- ICMR Advanced Center for Reverse Pharmacology in Traditional Medicine
- Mumbai, Maharashtra, India
- Pamela Taxel md
- Associate Professor
- Department of Medicine
- Fellowship Director
- Department of Endocrinology and Metabolism
- University of Connecticut Health Center
- Farmington Avenue, Farmington, Connecticut, USA
- Prasun Deb dm
- Consultant Endocrinologist
- Yashoda Hospital
- Somajiguda, Hyderabad, Andhra Pradesh, India
- Rabindera Nath Mehrotra dm dnb ccd
- Certified Clinical Densitometry
- International Socity for Densitometris
- Senior Consultant
- Department of Endocrinology
- Apollo Hospitals
- Jubilee Hills, Hyderabad, Andhra Pradesh, India
- Raghava D Mulukutla ms frcs mch livuk
- Consultant Orthopedic and Spine Surgeon
- Udai Clinic and Apollo Health City
- Hyderabad, Andhra Pradesh, India
- Rama Vaidya md
- Dean and Head
- Division of Endocrinology and Metabolism
- Medical Research Center
- Kasturba Health Society
- Research Director
- Department of Reproductive Medicine
- BSES MG Hospital and Research Center
- Mumbai, Maharashtra, India
- Former Senior Deputy Director
- National Institute for Research in Reproductive Health
- Founder Secretary
- Indian Menopause Society
- Mumbai Chapter
- Mumbai, Maharashtra, India
- Ritu Trivedi phd
- Scientist
- Division of Endocrinology
- Central Drug Research Institute
- Chattar Manzil Palace, Lucknow, Uttar Pradesh, India
- SKS Marya ms dnb mch
- Chairman and Chief Surgeon
- Member
- Board of Directors of Asia Pacific Arthroplasty Society
- President-Elect Indian Arthroplasty Association
- Vice President
- Indian Orthopedic Association
- Indo-German Orthopedic Federation
- Indian Hip and Knee Society
- President
- Delhi Orthopedic Association
- New Delhi, India
- Sudhaa Sharma md
- Assistant Professor
- Postgraduate Department of Obstetrics and Gynecology
- Government Medical College
- Jammu, Jammu and Kashmir, India
- Sumeet Rastogi md
- Consultant
- Max Institute of Orthopedics and Joint Replacement
- Max Superspeciality Hospital
- New Delhi, India
- Tanvir md
- Consultant
- Tanvir Hospital
- Hyderabad, Andhra Pradesh, India
- URK Rao md medicine (aiims)
- Consultant Rheumatologist
- Sri Deepti Rheumatology Center
- Former President
- Indian Rheumatology Association
- Hyderabad, Andhra Pradesh, India
- Vipla Puri phd
- Consultant
- Department of Radioimmunoassay
- PD Hinduja Hospital and Research Center
- Mumbai, Maharashtra, India
- Consultant
- Postgraduate Department of Pharmacology and Therapeutics
- Government Medical College
- Jammu, Jammu and Kashmir, India
- Vivek Arya md dm
- Assistant Professor
- Department of Endocrinology
- Smt NHL Medical College and Sheth VS General Hospital
- Senior Consultant
- Department of Endocrinology and Diabetes
- Center for Endocrine Disease and Diabetes
Osteoporosis is the most common bone disorder affecting humans. It is a skeletal disorder characterized by compromised bone strength, predisposing a person to an increased risk of fracture. The outcomes in morbidity and mortality can be devastating. Fortunately, over the last decade, there has been a revolution in understanding the problem, identifying individuals at risk, and of new pharmacotherapies to prevent further bone loss or actually restore bone.
But to take advantages of these developments, practitioners need to be educated about all the aspects relating to osteoporosis, and the public has to be made aware of the problem and the promise of new approaches and therapies.
Included in these needs are the following:
- An understanding of the effect of menopause and aging on bone health.
- An ability to identify risk factors that contribute to fracture risk.
- Knowledge to rule out secondary causes of osteoporosis.
- An understanding of nonpharmacologic and lifestyle approaches to prevent bone loss and fractures.
- A detailed understanding of the effects of various therapeutic agents on preventing osteoporotic fracture; comprehending their effects on bone density and turnover.
- An ability to develop and explain for patient's individual treatment strategies that may reduce morbidity and improve quality of life based on results of clinical trials.
- Understand the clinical effects of discontinuing different antiresorptive and anabolic therapies.
Recently, the North American Menopause Society addressed all these aspects in their 2010 osteoporosis position statement*. That paper is at best a summary of recommendations and certainly is recommended reading. However, a position statement is not a textbook, and does not have the luxury of long explanations or clear diagrams and illustrations. This new textbook takes that role, and achieves it admirably. The clinician will find detailed reviews and clinical recommendations on all the issues listed above.
____________
*Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause, 2010;17:23-56.
fm12Osteoporosis, especially prevalent among older postmenopausal women, increases the risk of hip and spine fractures, associated with particularly high morbidity and mortality in this population. Thus, the primary goal of osteoporosis therapy is to prevent fractures. This mandates slowing or stopping bone loss, maintaining bone strength and minimizing or eliminating factors that may contribute to fractures. The evaluation of postmenopausal women for osteoporosis risk requires a medical history, physical examination, and diagnostic tests. Major risk factors for postmenopausal osteoporosis (as defined by bone mineral density) include advanced age, genetics, lifestyle factors (such as low calcium and vitamin D intake, smoking), thinness, and menopause status. The most common risk factors for osteoporotic fracture are advanced age, low bone mineral density and previous fractures as an adult. Management focuses first on nonpharmacologic measures, such as a balanced diet, adequate calcium and vitamin D intake, adequate exercise, smoking cessation, avoidance of excessive alcohol intake, and fall prevention. If pharmacologic therapy is indicated, then government-approved options are bisphosphonates, selective estrogen-receptor modulators, parathyroid hormone, estrogens and calcitonin.
It is for me a privilege and pleasure to have been given this opportunity to provide this opening insight to a problem of such critical importance and relevance in a world with an aging population. Every practitioner should read, comprehend, and take into active practice the pearls of wisdom presented within the following pages.
Wulf H Utian
mb
bch phd dsc (med) frcog facog fics llc
Professor Emeritus
Case Western Reserve University
Honorary Founding President and Executive Director Emeritus
North American Menopause Society
Honorary Past President
International Menopause Society
Chair Scientific Board
Rapid Medical Research Incorporation
Preface
With menopause and aging, there is a decrease in the bone mass and thinning of the trabecular bone. Paradoxically, there is deposition of calcium in the vessels seen in the picture of the postmenopausal uterus. Are these changes with aging preventable? Yes, to a great extent, if we can work on modifying the preventable factors leading to postmenopausal osteoporosis.
As a clinician looking after women's health, I realize that it is a daunting yet an essential task to instill the practice of preventive medicine in routine clinical care. Menopause is a biological and a recognizable event, hence, gives the clinician an opportunity to provide comprehensive health care at this stage.
The hypothesis that menopause transition accelerates the development of chronic disease is well supported by epidemiological, observational, clinical and randomized controlled trials. The average age at menopause in India is estimated as 46 years, much earlier as compared to 51 years in the Caucasian population. According to the World Health Organization health statistics for 2011 in India, the average female life-expectancy in 2011 is 68 years and is projected to increase to 73 years by 2021. It is also important to understand that the mean bone mineral density in the Indian women is about two standard denomination lower than the Caucasians. It is not surprising that osteoporotic fractures occur a decade earlier in Indian women. Another factor in India is the prevalence of malnutrition and vitamin D deficiency which adds to the increased prevalence of low bone mass. The prevalence of osteoporosis in the age group of 30–60 years is approximately 29% in India and the prevalence of low bone mass above the age of 50 years is estimated to be 50%.
fm14Faced with these figures and the increase in the aging population, it is important for the health care providers to be updated on the issues of management of chronic disorders, postmenopausal osteoporosis being one of them. Postmenopausal osteoporosis, unlike senile osteoporosis, is primarily due to estrogen deficiency leading to accelerated trabecular bone loss resulting in an increased risk of fractures in the wrist, spine and hip.
Osteoporosis is an evolving, complex, endocrinological disorder. Postenoppausal osteoporosis is called the silent epidemic, for it has a long window period and the first clinical manifestation of the disease is a fragility fracture. Treatment strategies are based on events which occur far in the future, hence, long-term compliance is a difficult issue to deal with. In the management of osteoporosis, the focus is to prevent the first fragility fracture and prevent further fracture if one has already occurred by stabilizing and increasing the bone mass.
Postmenopausal osteoporosis—is it a no man's land or responsibility of every health care provider dealing with women's health? Whose domain does it fall into? The endocrinologist, rhuematologist, physician, gynecologist, pediatrician, orthopedician, physiotherapist, nutritionist? All of them, since preventive measures start at an early age and being multifactorial, specialists from different specialities should be involved in the management of postmenopausal osteoporosis. Osteoporosis has long been considered as “A pediatric disease with a geriatric consequences” but now we need to rephrase and probably say that it is “An in utero disease with geriatric consequences”. This statement implies that its neither too early to start preventive measures nor too late to start treatment of osteoporosis.
In the Gail's model, the female life-expectancy by screening mammogram is increased by one month, occult blood testing by two months, Pap smear by three months, and by treating osteoporosis by six months to three years. All the above facts are intended to infuse interest to read, understand and manage postmenopausal osteoporosis.
I am fortunate to have a galaxy of distinguished contributors from different parts of the globe. Each one of them is an excellent academician and a dedicated clinician working in women's health. My sincere thanks to each one of them for their valuable time and contribution. I am fortunate and obliged to Dr Wulf H Utian, a legend in menopausal medicine, to have written the Foreword. I am grateful to my family for the unconditional support in my endeavors.
For any query, complement or advice, please mail at drmeeta919@gmail.com
Meeta