SECOND EDITION
Shirish M Kawthalkar MD (Pathology)
Associate Professor Department of Pathology Government Medical College
Nagpur, Maharashtra, India
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Essentials of Haematology
First Edition: 2006
Second Edition: 2013
9789350901847
Printed at
5Preface to the Second Edition
The second edition of Essentials of Haematology has become necessary because of continuous, fast-paced expansion of knowledge in laboratory techniques, immunology, molecular biology, and genetics that has directly affected the speciality of haematology. The task of preparing second edition was difficult as it was also important to maintain the concise and illustrated format of the book. I have tried to retain the basic intention of the book, i.e. to present haematology and blood transfusion in a concise and simplified manner which is mainly aimed at undergraduate students (MBBS) and residents of pathology and medicine. As stated in the preface of the earlier edition, the publication is not intended to be an all-inclusive textbook but rather a simplified and up-to-date introduction to haematology. I have not incorporated any new chapters but rather incorporated new and essential information in almost all chapters which is of significance and relevance in pathogenesis, diagnosis, and management of blood disorders.
In this edition, almost all the figures and illustrations have been maintained as in previous edition and many have been added and where required suitable modifications have been made in the text. Depiction of many figures is diagrammatic for easier understanding as actual images are somewhat difficult to understand at basic level of learning, especially figures of blood cells, genetics, and flow cytometry. I take full responsibility for any errors of omission and commission that may have occurred. All suggestions and constructive criticism are most welcome.
After many years of working and teaching in the field of haematology, I feel that there often appears to be a misconception among students that blood tests are all that is required for a haematological disease to be diagnosed. Understanding haematology requires knowledge of physiology, insight into pathogenesis and essential pathological processes, laboratory tests (with their limitations and strengths), and clinical medicine. For diagnosis of a haematological disease, integration of clinical examination findings and haematological tests is necessary and final evaluation and judgement has to come from co-ordination between the pathologist and the clinician. Essentials of Haematology is an effort to make understanding of haematology easier so that it will facilitate learning by students and help them solve haematological problems in their clinical practice.
I am thankful to Dr RM Powar, Dean, Government Medical College and Hospital, Nagpur and Dr DT Kumbhalkar, Professor and Head, Department of Pathology, Government Medical College, Nagpur, Maharashtra, India for their encouragement and valuable guidance.
I am eternally indebted to my parents for their constant encouragement, guidance, and blessings. It is not possible to express in words my feelings for the unwavering and inspirational support and patience of my wife Dr Anjali, a gynaecologist and of my children Ameya and Ashish.
I am indebted to Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director) and Mr Tarun Duneja (Director-Publishing) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India and his expert staff for excellent presentation of this book.
Shirish M Kawthalkar
7Preface to the First Edition
This book is an attempt to present haematology and blood transfusion in a concise and simplified manner and is primarily intended for undergraduate students (second and final year MBBS and BDS). At the same time, it will also be useful for postgraduate students of pathology, medicine, paediatrics, and obstetrics and gynaecology. One comes across a haematological problem frequently in all branches of medicine. Haematology and blood transfusion are closely related, and blood bank forms an integral and life-saving support system of a multidisciplinary hospital. A concise textbook of haematology and blood transfusion is needed for undergraduates who have to take on major subjects during their MBBS years. The coverage of haematology in available books is either too extensive or too short for their requirements. I have tried to strike a balance based on my experience in teaching and in diagnostic haematology.
This book was published in 1998 as Essentials of Haematology and Blood Transfusion. Changes are constantly occurring in haematology especially in molecular diagnostics, classification, and treatment of malignant disorders. I have tried to update each chapter to ensure that current knowledge and practices are reflected. Laboratory investigations play a major role in proper diagnosis and management of blood diseases. Therefore, laboratory aspects have been given relatively more coverage. As the scope of this book is limited, it has not been possible to give treatment of blood disorders in detail, especially dosages and drug schedules.
During preparation of this book help has been taken from various well-known textbooks and numerous journals that have been duly acknowledged at the end of each chapter. Figures of blood and bone marrow cells have been presented in a manner that highlights the important morphological details and helps in better understanding. Undoubtedly, there will be errors of omission and commission for which I take the full responsibility. Suggestions and constructive criticism are most welcome.
I am indebted to my parents for their constant support, value-based guidance, and blessings that I have received throughout my life. The friendship, love, care, and support of my wife Anjali, herself a gynaecologist, can never be adequately 8acknowledged and my children Ameya and Ashish, have made everything in life meaningful, worthwhile, and enjoyable.
I am thankful to Dr (Mrs) VS Dani, Dean, Government Medical College, Nagpur and Dr SK Bobhate, Professor and Head, Department of Pathology, Government Medical College, Nagpur, Maharashtra, India for their valuable guidance. I express my appreciation and gratitude to M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India for their sensible and valuable advice during publication of this book and also for bringing out the book in an excellent, easy-to-read format.
Shirish M Kawthalkar