Clinical En Face OCT Atlas Bruno Lumbroso, David Huang, Andre Romano, Marco Rispoli, Gabriel Coscas
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fm1Clinical En Face OCT Atlasfm2
fm3Clinical En Face OCT Atlas
Editors Bruno Lumbroso MD Former Head of Department and Director Rome Eye Hospital Director, Centro Oftalmologico Mediterraneo for Retinal Diseases, Rome, Italy David Huang MD PhD Professor of Ophthalmology Casey Eye Institute Oregon Health & Science University Portland, USA Andre Romano MD Department of Ophthalmology Federal University of Sao Paulo Voluntary Adjunct Professor, University of Miami Miller School of Medicine, and Director, Neovista Eye Center Americana, Brazil Marco Rispoli MD Ophthalmology Department Ospedale Nuovo Regina Margherita, and Centro Oftalmologico Mediterraneo for Retinal Diseases Rome, Italy Gabriel Coscas MD Professor of Ophthalmology Hôpital Intercommunal de Créteil Service d'Ophtalmologie, France Foreword James G Fujimoto
fm4
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Clinical En Face OCT Atlas
First Edition: 2013
9789350902967
Printed at Ajanta Offset
fm5Foreword
The Clinical En Face OCT Atlas is a bold and innovative step forward in the diagnosis and management of ocular disease. The pioneering efforts of the editors, Professors Bruno Lumbroso, David Huang, Andre Romano, Marco Rispoli and Gabriel Coscas, have made possible this publication, bringing together contributions from the world's leading clinicians and researchers in the field of ophthalmology and optical coherence tomography. En face OCT is an important new methodology which will play a key role in the clinical ophthalmological examination of ocular disease in the near future.
Recent advances in OCT technology have dramatically increased imaging speeds and now enable high density, three-dimensional volumetric OCT data sets to be acquired in clinical ophthalmic practice. Access to this threedimensional OCT data provides comprehensive information on retinal pathology, but presents clinical challenges in order to rapidly and decisively interpret this large amount of data.
This clinical atlas is the first of its kind, presenting new examination and diagnostic protocols for interpreting OCT imaging based on en face visualization. Organized into three main parts, this text covers the technology and interpretation of en face OCT images; presents an atlas of retinal pathologies to guide clinical interpretation and diagnosis; and surveys future developments in en face OCT. The en face OCT paradigm presented in this atlas represents a powerful and elegant approach which connects three-dimensional volumetric OCT to classic methods of ophthalmic imaging built on en face views of the retinal fundus. It promises to be a landmark reference for clinical ophthalmology practice as well as research.
James G Fujimoto PhD
Elihu Thomson Professor of Electrical Engineering
and Computer Science
Massachusetts Institute of Technology
USAfm6
fm7Contributors
  • Massimo Accorinti MD PhD
  • Uveitis Department
  • La Sapienza University of Rome, Italy
  • Micol Alkabe MD
  • San Giuseppe Hospital
  • University Eye Clinic, Milan, Italy
  • IMO (Instituto de Microcirugia Ocular)
  • Barcelona, Spain
  • Camilla Alovisi MD
  • San Giuseppe Hospital
  • University Eye Clinic, Milan, Italy
  • IMO (Instituto de Microcirugia Ocular)
  • Barcelona, Spain
  • Chrysanthi Basdekidou MD
  • Professor Sahel Department
  • Rothschild Ophthalmologie Fondation
  • Paris, France
  • Rubens Belfort Jr. MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo, Brazil
  • Member Academia Ophthalmologica Internationalis
  • Rubens N Belfort MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo, Brazil
  • Bernardo Cavalcanti MD
  • Post-doctoral Research Fellow
  • Cornea and Refractive Surgery Service
  • Massachusetts Eye and Ear Infirmary
  • Harvard Medical School, Boston, USA
  • Gilda Cennamo MD PhD
  • Eye Department
  • Federico II University
  • Naples, Italy
  • Salomon Y Cohen MD PhD
  • Hôpital Intercommunal de Créteil
  • Service d'Ophtalmologie
  • Créteil, France
  • Gabriel Coscas MD
  • Professor of Ophthalmology
  • Hôpital Intercommunal de Créteil
  • Service d'Ophtalmologie
  • Créteil, France
  • Umberto De Benedetto MD
  • Hôpital Intercommunal de Créteil
  • Service d'Ophtalmologie
  • Créteil, France
  • Giuseppe de Crecchio MD
  • Eye Department
  • Federico II University
  • Naples, Italy
  • Luca Di Antonio MD PhD
  • Ophthalmology Clinic
  • Department of Medicine and
  • Science of Ageing, University of “G. d'Annunzio”
  • of Chieti-Pescara, Italy
  • Ali R Djalilian MD
  • Associate Professor of Ophthalmology
  • Director, Limbal Stem Cell Biology &
  • Ocular Surface Transplantation
  • Department of Ophthalmology and Visual Sciences
  • University of Illinois at Chicago, Chicago, IL, USA
  • Lise Dubois
  • Orthoptist and OCT Specialist
  • Centre Ophtalmologique d'Imagerie et de Laser
  • Paris, France
  • Jay S Duker MD
  • Director, New England Eye Center
  • Professor and Chair of Ophthalmology
  • Tufts Medical Center
  • Tufts University School of Medicine
  • Boston, MA 02111, USA
  • Chiara M Eandi MD PhD
  • Department of Clinical Physiopathology
  • Eye Clinic, University of Torino, Italy
  • Adil El Maftouhi OD
  • Centre Explore Vision, Paris, France
  • Centre Hospitalier
  • National Ophtalmologique des XV XX
  • Service du Pr C Baudouin, Paris, France
  • fm8Edgar M Espana MD
  • Assistant Professor of Ophthalmology
  • Cornea Service, University of South Florida
  • Tampa, USA
  • Michel E Farah MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo
  • Brazil
  • Amani A Fawzi MD
  • Associate Professor of Ophthalmology
  • Northwestern University
  • Chicago, USA
  • Raimondo Forte MD PhD
  • Eye Department
  • Federico II University
  • Naples, Italy
  • James G Fujimoto PhD PhD
  • Professor of Electrical Engineering and Computer Science
  • Department of Electrical Engineering and Research
  • Laboratory of Electronics
  • Massachusetts Institute of Technology
  • Cambridge, USA
  • Marta Gilardi MD
  • Uveitis Department
  • La Sapienza University of Rome, Italy
  • Kyioko Gocho MD PhD
  • Clinical Investigation Center 503
  • Quinze-Vingts Hospital and University Pierre et Marie
  • Curie-Paris 6, Paris, France
  • Giovanni Gregori PhD
  • Bascom Palmer Eye Institute
  • Miami, Florida, USA
  • Federico M Grignolo MD
  • Professor and Chairman
  • Department of Clinical Physiopathology
  • Eye Clinic, University of Torino, Italy
  • Amod Gupta MD
  • Professor and Head
  • Advanced Eye Centre
  • Postgraduate Institute of Medical Education and
  • Research, Chandigarh, India
  • Vishali Gupta MD
  • Senior Vitreo-Retina Consultant
  • King Khaled Eye Specialist Hospital, Riyadh, KSA
  • Additional Professor, Advanced Eye Centre
  • Postgraduate Institute of Medical Education and
  • Research, Chandigarh, India
  • Pedram Hamrah MD
  • Director
  • Ocular Surface Imaging Center
  • Henry Allen Cornea Scholar, Cornea
  • and Refractive Surgery Service
  • Massachusetts Eye & Ear Infirmary
  • Visiting Scientist, Immune Disease Institute
  • Assistant Professor, Department of Ophthalmology
  • Harvard Medical School, USA
  • Mark Hathaway PhD
  • Senior Scientist
  • Optos, Inc, University of Kent
  • Canterbury, UK
  • Joachim Hornegger
  • Pattern Recognition Lab and
  • Erlangen Graduate School in Advanced Optical
  • Technologies (SAOT)
  • Friedrich-Alexander-University Erlangen
  • Erlangen, Germany
  • David Huang MD PhD
  • Professor of Ophthalmology
  • Casey Eye Institute
  • Oregon Health & Science University
  • Portland, USA
  • Yali Jia
  • Casey Eye Institute
  • Oregon Health & Science University
  • Portland, USA
  • Chunhui Jiang MD
  • Associated Professor
  • Ophthalmology Department
  • Eye & ENT Hospital of Fudan University
  • Shanghai, China
  • Martin F Kraus MD
  • Department of Electrical Engineering and
  • Computer Science, and Research Laboratory of
  • Electronics, Massachusetts Institute of Technology
  • Cambridge, MA, USA
  • Pattern Recognition Lab and Erlangen Graduate School
  • in Advanced Optical Technologies (SAOT)
  • Friedrich-Alexander-University Erlangen
  • Erlangen, Germany
  • Jean-Francois Le Rouic MD
  • Clinique Sourdille
  • Nantes, France
  • Mathieu Lehmann MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation
  • Rothschild, Paris, France
  • fm9Bruno Lumbroso MD
  • Former Head of Department and
  • Director, Rome Eye Hospital
  • Director, Centro Oftalmologico Mediterraneo
  • for Retinal Diseases
  • Rome, Italy
  • André Maia MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo
  • Brazil
  • Nadine Manasseh MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation, Rothschild
  • Paris, France
  • John Marshall PhD FRCPath FRCOphth (Hon)
  • Frost Professor of Ophthalmology and
  • Chairman of the Academic Department of
  • Ophthalmology at Kings College
  • St. Thomas’ Hospital, London, UK
  • Virginie Martinet MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation
  • Rothschild, Paris, France
  • Leonardo Mastropasqua MD
  • Professor and Chairman Ophthalmology Clinic
  • Department of Medicine and Science of Ageing
  • University of “G. d'Annunzio” of Chieti-Pescara, Italy
  • Carlos Mateo MD
  • IMO (Instituto de Microcirugia Ocular)
  • Barcelona, Spain
  • Alexandre Matet MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation
  • Paris, France
  • Martine Mauget-Faÿsse MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation, Rothschild
  • Paris, France
  • Cinzia Mazzini MD
  • Professor of Ophthalmology
  • Ophthalmic Ultrasound and Ocular Oncology Service
  • Eye Clinic of the University of Florence, Italy
  • Nalin J Mehta MD
  • The Colorado Retina Center
  • Lakewood, Colorado, USA
  • Ugo Menchini MD
  • Professor and Chairman
  • The Eye Clinic of the University of Florence, Italy
  • Paolo Nucci MD
  • Professor of Ophthalmology
  • University of Milan
  • Chairman, Eye Clinic, San Giuseppe Hospital, Italy
  • Michel Paques MD PhD
  • Clinical Investigation Center 503
  • Quinze-Vingts Hospital and
  • University Pierre et Marie Curie-Paris
  • Paris, France
  • Vanessa Pala MD
  • Epidemiologist
  • Centro Oftalmologico Mediterraneo
  • Rome, Italy
  • Swapnil Parchand MD
  • Advanced Eye Centre
  • Postgraduate Institute of Medical Education
  • and Research, Chandigarh, India
  • Lucia Pelosini MRCOphth
  • Ophthalmology Fellow
  • Western Eye Hospital
  • Imperial College, London
  • Fernando M Penha MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo
  • Brazil
  • Adrian Gh Podoleanu FInstP FOSA FSPIE
  • Professor of Biomedical Optics
  • Head of the Applied Optics Group
  • School of Physical Sciences
  • University of Kent
  • Canterbury, Kent, UK
  • Michel Puech MD
  • Centre Explore Vision
  • Paris, France
  • Maddalena Quaranta-El Maftouhi MD
  • Centre Rabelais
  • Lyon, France
  • Marco Rispoli MD
  • Ophthalmology Department
  • Ospedale Nuovo Regina Margherita, and
  • Centro Oftalmologico Mediterraneo
  • for Retinal Diseases
  • Rome, Italy
  • fm10Andre Romano MD
  • Vitreo-Retinal Surgeon
  • Department of Ophthalmology
  • Federal University of Sao Paulo
  • Voluntary Adjunct Professor, University of Miami
  • Miller School of Medicine, and
  • Director, Neovista Eye Center, Americana, Brazil
  • Richard Rosen MD FACS FASRS
  • Professor and Vice-Chairman
  • Surgeon Director, Chief of Retinal Services
  • Director of Research, Department of Ophthalmology
  • NY Eye & Ear Infirmary
  • New York Medical College, USA
  • Philip J Rosenfeld MD PhD
  • Professor of Ophthalmology
  • Bascom Palmer Eye Institute
  • Miami, Florida, USA
  • SriniVas R Sadda MD
  • Associate Professor of Ophthalmology
  • Director, Medical Retina Unit
  • Ophthalmic Imaging Unit
  • Doheny Image Reading Center
  • Doheny Eye Institute, Keck School of Medicine
  • University of Southern California, USA
  • José-Alain Sahel MD PhD
  • Rothschild Ophtalmologie Fondation
  • Paris, France
  • Maria Cristina Savastano MD PhD
  • Catholic University School of Medicine
  • Rome, Italy
  • Andrea Sodi MD
  • Department of Ophthalmology
  • Eye Clinic University of Florence, Florence, Italy
  • Mahsa Sohrab MD
  • Ophthalmology Department
  • Northwestern University
  • Feinberg School of Medicine
  • Chicago, USA
  • Eric Souied MD PhD
  • Head of the Department of Ophthalmology
  • Hopital Intercommunal de Creteil and
  • Ophthalmology Department, “Henri Mondor”
  • Hospital, Creteil, Paris, France
  • Anderson Teixeira MD
  • Assistant Professor
  • Universidade Catolica de Brasilia
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo, Brazil
  • Federico Tridico MD
  • Department of Clinical Physiopathology
  • Eye Clinic, University of Torino, Italy
  • Vivien Vasseur
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation
  • Paris, France
  • Roberta Velletri MD
  • Department of Ophthalmology
  • Hospital São Paulo
  • Federal University of São Paulo
  • Brazil
  • Min Wang MD PhD
  • Associate Professor
  • Department of Ophthalmology
  • Eye and ENT Hospital of Fudan University
  • Shanghai, China
  • Jay Wei PhD
  • President & CEO
  • Optovue, Inc., Fremont
  • California, USA
  • Rishard Weitz
  • Senior Technical Advisor for Retinal Imaging
  • New York Eye and Ear Infirmary
  • USA
  • Benjamin Wolff MD
  • Professor Sahel Department
  • Rothschild Ophtalmologie Fondation
  • Paris, France
  • Gezhi Xu MD
  • Professor
  • Vice-President of Eye and ENT Hospital of
  • Fudan University
  • Vice-President of Shanghai EENT Hospital
  • Director of Retinal Department
  • Shanghai, China
  • Zohar Yehoshua MD
  • Bascom Palmer Eye Institute
  • 900 NW 17th St. Miami, FL 33136
  • Sonia H Yoo MD
  • Professor of Ophthalmology
  • Bascom Palmer Eye Institute
  • University of Miami
  • Miller School of Medicine, USA
  • Qienyuan Zhou PhD
  • Vice-President/Clinical Development
  • Optovue, Inc.,
  • Fremont, California, USA
fm11Preface
Current spectral domain optical coherence tomography (SD-OCT) devices already allow ophthalmologists to obtain good en face images of the retina and optic disk. En face OCT is no longer confined to a few retina specialists, but is widely available to all eye practitioners. As imaging speed and definition increases in the next generation of devices, the quality of en face views will further improve and their use will become even more important. All OCT users may get a different and new visualization of morphology, structure and topography of the eye. Everyday ophthalmologists will get an in vivo transverse layer-by-layer dissection of retina. This new way of seeing will help ophthalmologists localize and study lesions in individual layers of the retina.
The aim of the Clinical En Face OCT Atlas is to show everyday OCT users the utility of clinical en face imaging. The keyword is “clinical”. We hope to develop interest in the use of en face OCT in everyday clinical work, and help users interpret en face OCT images. This Atlas should guide the general ophthalmologists to select the best en face views and read easily the typical and atypical aspects of en face images. Most OCT devices already have en face visualization capabilities. The use of these capabilities should be increased and applied to more types of pathologies.
This book is fortunate to have outstanding contributions from leaders in the field. The operating principles and the future of OCT are explained by some of the original developers of the technology. The retinal and macular diseases chapters are written by well-known authors from around the world.
We believe that en face imaging has practical clinical interest for everyday clinical ophthalmology. Our atlas addresses a vast audience and describes how to diagnose diseases and plan surgery for a variety of disorders. We hope that this atlas gives a timely answer to a widely felt clinical need.
Bruno Lumbroso
David Huang
Andre Romano
Marco Rispoli
Gabriel Coscasfm12fm13fm14fm15fm16