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Essentials of Anesthesia & Critical Care
Anshul Jain
SECTION 1: ANESTHESIA
UNIT I:
Basics of Anesthesia
ROLE OF AN ANESTHESIOLOGIST
Intraoperative Anesthesia
Emergency Medicine
Critical Care
Pain Medicine
INTRAOPERATIVE ANESTHESIA
EMERGENCY MEDICINE
CRITICAL CARE UNIT
PAIN MEDICINE
CHAPTER 2:
History of Anesthesia
INTRODUCTION
INHALATION ANESTHESIA
LOCAL AND REGIONAL ANESTHESIA
INTRAVENOUS ANESTHESIA
STAGES OF ANESTHESIA
MUSCLE RELAXANTS
CHAPTER 3:
Respiratory Physiology
INTRODUCTION
ANATOMY
Nose
Pharynx
Larynx
Nerve Supply of Upper Respiratory Tract
Trachea
Bronchial Tree (Fig. 3.1)
Bronchopulmonary Segments (Fig. 3.2)
Pulmonary Circulation
Nerve Supply
BREATHING MECHANICS
Mechanics of Respiration
LUNG VOLUMES (TABLE 3.3 AND FIG. 3.3)
Tidal Volume
Inspiratory Reserve Volume
Expiratory Reserve Volume
Residual Volume
Forced Vital Capacity
Minute Volume
Functional Residual Capacity
Closing Capacity
DEAD SPACE AND UNEVEN VENTILATION
Effect of Anesthetics on Dead Space
VENTILATION-PERFUSION RELATIONSHIP (Fig. 3.4)
Ventilation
Perfusion
Ventilation-Perfusion Ratio
Hypoxic Pulmonary Vasoconstriction
REGULATION OF RESPIRATION
Pontine and Vagal Influences
Effects of Anesthetics on Respiratory Drive
MEASURING LUNG FUNCTION
Bedside Pulmonary Function Test
Breath Holding Time of Sabrasez
Snider Match Blowing Test
Spirometry
Forced Spirometry
Helium Dilution and Body Plethysmography
Diffusing Capacity
Flow Volume Curves
FITNESS FOR ANESTHESIA
CHAPTER 4:
Oxygen and Carbon Dioxide Transport
OXYGEN CASCADE
OXYGEN TRANSPORT
Reaction of Hemoglobin and Oxygen
Dissolved Oxygen
OXYGEN-HEMOGLOBIN DISSOCIATION CURVE (Fig. 4.2)
CARBON DIOXIDE TRANSPORT
CHAPTER 5:
Operation Theater
LOCATION
NUMBER OF OPERATION THEATERS
DESIGN
Sterile Zones
Clean Zone
Protective Zone
Disposal Zone
LAYOUT
Size
Doors
Ventilation
Humidity and Temperature
Floors
Walls and Ceiling
Lighting
OPERATION ROOM ASEPSIS
Cleaning and Disinfection
Sterilization
Microbial Monitoring
CHAPTER 6:
Anesthesia Machineand Vaporizers
INTRODUCTION
STANDARDS FOR AN ANESTHESIA MACHINE
ANATOMY OF AN ANESTHESIA MACHINE
High-Pressure Circuit
Oxygen Cylinder
Liquid Oxygen
Nitrous Oxide Cylinder
Cylinder Valves
Yoke Assembly (Fig. 6.3)
Pressure Reducing Valves
Intermediate-Pressure Circuit
Pipeline Supply Source
Second-Stage Oxygen Pressure Regulator
Low-Pressure Circuit
Flowmeter Assembly (Rotameter) (Figs 6.4A to C)
Proportionating System
Oxygen Flush Valve
TESTING ANESTHESIA MACHINE
High-Pressure System and Intermediate System
Low-Pressure System
VAPORIZERS
Classification of Vaporizers
Regulation of Output Concentration
Methods of Vaporization
Location of Vaporizer
Temperature Compensation
Agent Specification
Principle of Vaporization
Vapor Pressure
Boiling Point
Latent Heat of VaporizationQ
Specific Heat
Thermal Conductivity
Basic Operating Principle of a Variable Bypass Vaporizer
Factors Influencing a Vaporizer’s Output Concentration
Flow Rate
Temperature
Intermittent Back Pressure
Carrier Gas Composition
Aladin Cassette Vaporizer
Sequence of Vaporizers
SAFETY FEATUREs IN AN ANESTHESIA MACHINE
Safety Features of a Vaporizer
CHAPTER 7:
Anesthesia Breathing System
PROPERTIES OF AN IDEAL BREATHING SYSTEM
CLASSIFICATION OF BREATHING SYSTEM
MAPLESON SYSTEMS
Mapleson A (Magill Circuit and Lack Circuit)
Functional Analysis (Figs 7.1A to D)
Lack Circuit
Mapleson B and C Systems
Mapleson D System
Functional Analysis
Modification of Mapleson D System
Mapleson E and F Systems
Other Modifications
Hafnia System
ABSORBER BREATHING SYSTEM (CLOSED SYSTEM)
To-and-Fro System (Water’s System) (Fig. 7.5)
Circle System
CARBON DIOXIDE ABSORBENT
Soda Lime
Chemical Reactions
Signs of Soda Lime Exhaustion
Baralyme
Calcium Hydroxide Lime (Amsorb)
Complications of Carbon Dioxide Absorbents
Interaction with Inhalational Anesthetics
Carbon Monoxide Production
OTHER OXYGEN DELIVERY DEVICES
CHAPTER 8:
Airway Management
INTRODUCTION
AIRWAY ASSESSMENT
History
Physical Examination
Specific Airway Assessment Tests
Mallampati Classification (Fig. 8.1)
Mandibular Protrusion
Neck Movements
Thyromental Distance (Patil’s Test)
Who Require Airway Management?
Manual Airway Maneuvers (Figs 8.2A to C)
EQUIPMENT FOR AIRWAY MANAGEMENT
Oral and Nasal Airways (Figs 8.3A and B)
Face Mask (Fig. 8.4)
Supraglottic Airway Devices
Laryngeal Mask Airway (Fig. 8.5)
Combitube (Fig. 8.6)
Infraglottic Airway Devices
Tracheal Tubes
TECHNIQUES OF DIRECT LARYNGOSCOPY AND INTUBATION
Preparation
Patient Position (Magill Position)
PreoxygenationQ
Direct Laryngoscopy
Technique of Laryngoscopy (Figs 8. 9A and B)
Confirming the Position of Tube
Difficulty with the Macintosh Technique
Nasotracheal Intubation (Fig. 8.10, Table 8.2)
Indications
Contraindications
Complications of Laryngoscopyand Intubation
Techniques of Extubation
Tracheostomy
Important Points about Tracheostomy
Cricothyrotomy
Emergency Airway Management (Flow chart 8.1)
RAPID SEQUENCE INDUCTION AND INTUBATION
Steps
CHAPTER 9:
Preanesthetic Evaluation
INTRODUCTION
GENERAL PRINCIPLES
IMPLEMENTATION of PREANESTHETIC ASSESSMENT
STEPS OF ASSESSMENT
Medical History
Physical Examination
Laboratory Evaluation
Guidelines for Preoperative Laboratory Testing
Routine Lab Test and Indication
Instructions after Preanesthetic Assessment
EFFECT OF PRE-EXISTING DRUG THERAPY ON ANESTHETIC MANAGEMENT AND MODIFICATIONS REQUIRED
Antihypertensive Drugs
Antianginal Drugs
Anticoagulants
Antiplatelet Drugs
Oral Contraceptive Pills
Oral Hypoglycemics
Steroids
Smoking
Antidepressants
Antiepileptic and Levodopa
Thyroid Supplement
Lithium
Herbal Medicine
PREMEDICATION
Drugs Used for Premedication
To Relieve Anxiety
To Reduce Chances of Aspiration
To Control Secretion
Antiemetic
UNIT II:
Anesthesia Pharmacology
INTRODUCTION
Classification
MECHANISM OF INHALATIONAL ANESTHESIA
Site of Action
MINIMUM ALVEOLAR CONCENTRATION
GENERAL PRINCIPLES OF INHALATIONAL ANESTHESIA
Inspired Concentration
Alveolar Ventilation
Anesthetic Uptake Factors
Other Factors Affecting FA/FI Ratio
Concentration Effect
Second Gas Effect
Absorption of Inhaled Anesthetic by Anesthetic Circuit
RECOVERY FROM INHALATIONAL ANESTHESIA
Diffusion Hypoxia (Fink Effect)Q
METABOLISM OF INHALED ANESTHETICS
ORGAN SYSTEM EFFECTS AND TOXICITIES
Liver
Hepatocellular Damage
Hepatitis
Kidney
Hematopoietic System
Neurotoxicity
Pregnancy
METABOLIC EFFECT
OTHER EFFECTS
Analgesia
Reaction with CO2 Absorbents
Inflammability
INDIVIDUAL ANESTHETIC AGENTS
Nitrous Oxide (Laughing Gas)
Manufacturing
Physical Properties
Metabolism
Anesthetic Properties
Systemic Effects
Other Effects
Contraindications
Side Effects
Uses of Nitrous Oxide
Entonox®
Xenon
Physical Properties
Anesthetic Properties
Metabolism
Organ System Effects
Halothane
Physical Properties
Anesthetic Properties
MetabolismQ
Systemic Effect
Uses
Contraindications
Drug Interactions
Isoflurane
Physical Properties
Anesthetic Properties
Systemic Effects
Metabolism
Contraindications
Enflurane
Systemic Effect
Metabolism
Sevoflurane
Systemic Effect
Metabolism
Contraindications
Desflurane
Physical Properties
Systemic Effects
Metabolism
Indications and Contraindications
Contraindications
AGENTS NO LONGER USED
Ether
Methoxyflurane
Cyclopropane
Trielene
Chloroform
NONANESTHETIC GASES IN ANESTHESIA
Oxygen
Physical Properties
Storage
Medical Air
Helium
Hyperbaric Oxygen
Indications
Therapeutic Principles
Contraindications
Limitations
CHAPTER 11:
Intravenous Anesthetics
BARBITURATES
History
Metabolism
Physicochemical Properties
Pharmacokinetics
Mechanism of ActionQ
Systemic Effects
Central Nervous System
Cardiovascular System
Respiratory System
Eyes
Other Effects
Dosing
Uses
Anesthetic Uses
Other Uses
Side Effects
Systemic
Local
Contraindications
Absolute
Relative
METHOHEXITONE
PROPOFOL
Physicochemical Characteristics
Mechanism of Action
Pharmacokinetics
DosesQ
Metabolism
Pharmacology
Central Nervous System
Effects on the Cardiovascular System
Effects on the Respiratory System
Ocular EffectsQ
Other Effects
Uses
Side Effects and Contraindications
Propofol Infusion SyndromeQ
KETAMINE
Physicochemical Characteristics
Pharmacokinetics and Metabolism
Mechanism of Action
Pharmacology
Central Nervous System
Cardiovascular System
Respiratory System
Eyes
Other Effects
Uses (Table 11.3)
Induction and Maintenance of Anesthesia
sedation
Other Uses
Side Effects
Contraindications
BENZODIAZEPINES
Pharmacokinetics and Metabolism(Table 11.4)
Mechanism of Action
Pharmacology
Central Nervous System
Cardiovascular System
Respiratory System
Muscular System
Uses
Sedation and Anxiolysis
Oral SedationQ
Induction and Maintenance of Anesthesia
Other Uses in Anesthesia
Side Effects and Contraindications
FLUMAZENIL
Side Effects and Contraindications
ETOMIDATE
Physicochemical Characteristics
Pharmacokinetics and Metabolism
Dose
Mechanism of Action
Pharmacology
Central Nervous System
Cardiovascular SystemQ
Respiratory System
Endocrine Effects
Other Effects
Uses
Side Effects and Contraindications
NEUROLEPTANALGESIA(FLOW CHART 11.1)
Neuroleptanesthesia
DROPERIDOL
Uses
OPIOID ANESTHETICS
Physicochemical Properties
Opioid Receptors (Table 11.6)
Actions of Opioids on Other Receptors
Mechanism of Analgesia and Other Effects
Systemic Effects of Opioids
Central Nervous System
Respiratory System
Therapeutic Effects
Nontherapeutic/Deleterious Effects
Cardiovascular System (Table 11.7)
Endocrinologic Effects
Renal and Urodynamic Effects
Gastrointestinal Effects
Other Effects
Factors Affecting Pharmacokinetics of Opioids
Age
Renal Failure
Hepatic Failure
Anesthetic Uses
Sedation and Analgesia
Inducing Agent
As Adjuvant to Local Anesthetic
clinical pharmacology of important agonists
Morphine
Pethidine (Meperidine)
Fentanyl, Alfentanil and Sufentanil
Remifentanil
AGONIST-ANTAGONIST OPIOIDS
Pentazocine
Systemic Effects (Table 11.7)
Dose
Use
Butorphanol
Dose
Buprenorphine
Dose
Nalbuphine
OPIOID ANTAGONISTS
Naloxone
Naltrexone
α2 ADRENERGIC AGONISTS
Dexmedetomidine
Pharmacology
Central Nervous System
Respiratory System
Cardiovascular System
Other Effects
Uses and Doses
Clonidine
CHAPTER 12:
Local Anesthetics
INTRODUCTION
BASIC PHARMACOLOGY
Chemistry
Structure-Activity Relationships and Physicochemical Properties
Lipophilic-Hydrophilic Balance
Hydrogen Ion Concentration
MECHANISM OF ACTION (FIG. 12.1)
Few Interesting Facts
CLINICAL PHARMACOLOGY
Anesthetic Potency
Onset of Action
Types of Nerve Fibers
Duration of Action
Differential Sensory/Motor Blockade
FACTORS INFLUENCING ANESTHETIC ACTIVITY IN HUMANS
Dose
Addition of Vasoconstrictors
Carbonation and pH Adjustment of Local Anesthetics
Mixtures of Local Anesthetics
Pregnancy
CHOICE OF LOCAL ANESTHETICS
Infiltration Anesthesia
Intravenous Regional Anesthesia(Bier’s Block)
Dose
Peripheral Nerve Blocks
Central Neural Blockade
Topical Anesthesia
Tumescent Anesthesia
PHARMACOKINETICS
Absorption
Distribution
Biotransformation and Excretion
Pharmacokinetic Alterations by Patient Status
TOXICITY
Systemic Toxicity
Central Nervous System Toxicity
Cardiovascular System Toxicity
Direct Peripheral Vascular Effects
Autonomic Effects
Contributing Factors
Guidelines for Preventing and Managing Bupivacaine Cardiotoxicity
Methemoglobinemia
Allergies
Local Tissue Toxicity
LOCAL ANESTHETIC FAILURE
Inflammation at Site of Application
Genetic Variability
INDIVIDUAL AGENTS (TABLE 12.2)
Ester Group
Cocaine
Procaine Hydrochloride
Chloroprocaine
Amethocaine Hydrochloride
Oxybuprocaine
Amide Group
Lignocaine Hydrochloride
Prilocaine
Bupivacaine
Ropivacaine
OTHER LOCAL ANESTHETICS NOT IN ANESTHESIA PRACTICE
Dibucaine
Oxethazaine
NOVEL LOCAL ANESTHETICS
STERILIZATION OF LOCAL ANESTHESIA
CHAPTER 13:
Muscle Relaxants
INTRODUCTION
Mechanism OF ACTION OF NEUROMUSCULAR BLOCKERS AT THE NEUROMUSCULAR JUNCTION
Normal Physiology
Depolarizing Muscle Relaxants (Leptocurare)
Nondepolarizing Muscle Relaxants (Pachycurare)
Prejunctional Effects
DEPOLARIZING MUSCLE RELAXANTS
Succinylcholine
Pharmacokinetics and Pharmacodynamics
Side Effects
Clinical Uses
Interactions with Anticholinesterases
Contraindications
Nondepolarizing Neuromuscular Blockers
Individual Agents (Table 13.4)
Pancuronium
Tubocurarine
Vecuronium
Rocuronium
Atracurium
Cisatracurium
Mivacurium
Doxacurium
Pipecuronum
Gantacurium
Other Agents No Longer Used
Gallamine
Repacurium
Alcuronium
CLINICAL USES
Endotracheal Intubation
Maintenance of Relaxation
Other Uses
ADVERSE EFFECTS
Autonomic Ganglionic Blockade
Histamine Release
Hypotension
Tachycardia
Bradycardia
Respiratory Effects
Central Nervous System
Complications of Long-term Administration of Nondepolarizing Neuromuscular Blockers (as in Intensive Care Unit)
FACTORS AFFECTING RESPONSE TO NEUROMUSCULAR BLOCKERS
Drug Interactions
Temperature
Special Population
Coexisting Conditions (Table 13.5)
RECOVERY FROM NEUROMUSCULAR BLOCKADE
ANTAGONISM OF RESIDUAL NEUROMUSCULAR BLOCKADE
OTHER ANTAGONISTS OF NONDEPO-LARIZING NEUROMUSCULAR BLOCKERS
Sugammadex
CHAPTER 14:
Additional Drugsin Anesthesia
SYMPATHOMIMETICS
Adrenaline
Uses
Other Uses
Noradrenaline
Isoprenaline
Dopamine
Dobutamine
Ephedrine
Mephentermine
ANTIHYPERTENSIVES
ANTIEMETICS
UNIT III:
Perioperative Care
INTRODUCTION
CLINICAL MONITORING
CARDIOVASCULAR MONITORING
Arterial Blood Pressure
Noninvasive Arterial BP Monitoring
Invasive Arterial BP Monitoring
Technique
Electrocardiography
Central Venous Pressure
Selection of Veins
Waveform
Pulmonary Artery Catheterization
Clinical Uses
Complications
Cardiac Output
RESPIRATORY MONITORING
Stethoscope
Oxygen Saturation
Co-oximetry
Pulse Oximetry
CAPNOGRAPHY
Indication and Technique
Utilization
Applications
Other Applications
ANESTHETIC GAS ANALYSIS
Techniques
BLOOD GAS ANALYSIS
INTRAOPERATIVE SPIROMETRY AND AIRWAY PRESSURE MONITORING
NEUROMUSCULAR MONITORING
Patterns of Nerve Stimulation (Fig. 15.3)
Single Twitch
Train of Four
Tetany
Post-tetanic Count Stimulation
Double Burst Stimulation
Equipment and Technique (Fig. 15.4)
Selection of Nerve
TEMPERATURE MONITORING
Indications
Technique
Site
Mechanism of Heat Loss
MONITORING THE DEPTH OF ANESTHESIA
Specific Monitors
Bispectral Index
Patient State Index
Narcotrend
Evoked Responses
MONITORING BLOOD LOSS
Gravimetric Methods
Calorimetric Method
Arterial Blood Sampling
Sensitive Method
MONITORING COAGULATION
CHAPTER 16:
Perioperative Fluid Therapy andBlood Transfusion
INTRODUCTION
FLUID COMPARTMENTS(FLOW CHART 16.1)
Intracellular Fluid
Extracellular Fluid
INTRAVENOUS FLUIDS
Crystalloids (Table 16.1)
Important Crystalloids
Other Crystalloids
Colloid (Table 16.2)
Important Colloids
Choice of Fluid (Colloid versus Crystalloids)
PERIOPERATIVE FLUID THERAPY
Assessment of Surgical Fluid Losses
Blood Loss
Other Losses
Normal Maintenance Fluid Requirements
Pre-existing Deficits
Calculating Fluid Requirement
Intraoperative Fluid Replacement
Replacing Blood Loss
Replacing Redistributive and Evaporative Losses
Prevention of Over Infusion
BLOOD TRANSFUSION
Storage of Blood
Effect of Storage on Whole Blood
Blood Components (Tables 16.6 and 16.7)
Packed Red Blood Cells
Frozen RBC
Platelet Concentrates
Fresh Frozen Plasma (FFP)
Cryoprecipitate
Prothrombin Complex
Fluid Therapy in Special Situations
UNIT IV:
Regional Anesthesia Techniques and Complications
INTRODUCTION
APPLIED ANATOMY (FIGS 17.1 AND 17.2)
Vertebral Column
Spinal Cord
Blood Supply of Spinal Cord
Subarachnoid Space
Subdural Space
Epidural Space
Lumbar Puncture (Fig. 17.3)
Surface LandmarksQ
CENTRAL NEURAXIAL BLOCKADE
Mechanism of Action
SYSTEMIC EFFECTS OF NEURAXIAL BLOCKADE
Cardiovascular Manifestations
Hypotension
Bradycardia
Nervous System (Flow chart 17.2)
Respiratory System
Gastrointestinal System
Urogenital System
Metabolic and Endocrine Manifestations
Thermoregulation
SPINAL ANESTHESIA
Indications
Contraindications
Technique
Patient’s Position (Fig. 17.3)
Spinal Needles (Figs 17.4A to C)
Approach
Midline Approach
Lateral Approach (Paramedian Approach)
Taylor’s Approach
Saddle Block
Pharmacology
Drugs
Baricity
Level of Block
Factors Affecting Level of Block/Height of Block
Factors Affecting Duration of Block
Complications
Hypotension
Postdural Puncture Headache
Backache
Meningitis
Cranial Nerve Palsy
Neurological Injury
Transient Neurological Symptoms
Hypoventilation/Apnea
Nausea/Vomiting
Cardiac Arrest
Urinary Retention
EPIDURAL ANESTHESIA
Procedure
Thoracic Epidural
Cervical Epidural
Epidural Needles (Fig. 17.6)
Methods of Detecting Epidural Space
Test Dose
Pharmacology
Epidural Anesthetic Agents
Factors Affecting Level of Block
CAUDAL ANESTHESIA
Indications
Anatomy
Technique (Fig. 17.7)
Complications of Epidural and Caudal Block
Intravascular Injection
Subarachnoid Injection (Total Spinal)
Neurologic Injury
CHAPTER 18:
Nerve Blocks
INTRODUCTION
Techniques of Localizing Neural Structures
BLOCKS OF HEAD AND NECK
Trigeminal Nerve Block
Indications
Technique
Side Effect and Complications
Cervical Plexus Blockade (Figs 18.1A and B)
Indications
Technique
Complications
Stellate Ganglion Block
Technique
Side Effect and Complication
Phrenic Nerve Block
LOCAL ANESTHESIA OF THE AIRWAY
Superior Laryngeal Nerve Block (Fig. 18.2)
BLOCKS OF UPPER LIMB
Brachial Plexus Block
Interscalene Approach
Supraclavicular Approach
Infraclavicular Approach
Axillary Approach
Peripheral Brachial Block
Wrist Block
Intravenous Regional Anesthesia (Bier Block)
Clinical Applications
ContraindicationsQ
Technique
Complication and Side Effect
BLOCKS OF THORAX/ABDOMEN
Intercostal Nerve Blocks
Technique
Side Effects
Celiac Plexus Blocks
Technique
Side Effect and Complications
Ilioinguinal Block(For Repair of Inguinal Hernia)
Technique
Complications
Penile Block
Technique
BLOCKS OF LOWER EXTREMITY
Psoas Compartment Block
Perivascular Three-in-One (Femoral)Nerve Block
Modified Femoral (Fascial Iliaca)Nerve Block
Sciatic Nerve Block
Ankle Block
UNIT V:
Anesthesia and Associated Diseases
INTRODUCTION
Risk Factors for Patients with Cardiac Disease (Table 19.1)
SYSTEMIC HYPERTENSION
Anesthetic Management
Preoperative Evaluation
Premedication
Intraoperative Blood Pressure Management
Choice of Anesthesia
Induction
Choice of Drugs
Monitoring
Postoperative Management
ISCHEMIC HEART DISEASE
Anesthetic Management
Preoperative Evaluation
Choice of Anesthesia
Perioperative Management
Monitoring
Postoperative Care
VALVULAR HEART DISEASE
Mitral Stenosis
Pathophysiology
Anesthetic Management (Table 19.3)
Mitral Regurgitation
Anesthetic Management
Choice of Drugs
Aortic Stenosis
Choice of Anesthesia
Management of Anesthesia
Choice of Drugs
Aortic Regurgitation
Management of Anesthesia
Tricuspid Regurgitation
Management of Anesthesia
Choice of Agents
CONGENITAL HEART DISEASE
Acyanotic Lesion
Anesthetic Management
Cyanotic Disease
Management of Anesthesia
CHAPTER 20:
Anesthesia for Patients with Respiratory Disease
INTRODUCTION
GENERAL CONSIDERATIONS
Preoperative Evaluation
Preoperative Preparation
Premedication
Choice of Anesthesia
Postoperative Care
SPECIFIC DISEASE
Asthma
Preoperative Preparation
Intraoperative Management
Chronic Obstructive Pulmonary Disease
Restrictive Lung Disease
Preoperative Evaluation
Intraoperative Management
Tuberculosis
Respiratory Tract Infection
CHAPTER 21:
Anesthesia for Patients with Hematological Disorders
ANEMIA
Preoperative PreparationQ
Anesthetic Considerations
Maximum Allowable Blood Loss
SICKLE CELL ANEMIA
PLATELET DISORDERS
COAGULATION FACTOR DISORDERS
Heredity Conditions
Preoperative Evaluation
Anesthetic Considerations
Iatrogenic Conditions
CHAPTER 22:
Anesthesia for Patients with Hepatobiliary Disease
INTRODUCTION
EFFECT OF ANESTHETIC AGENTS ON HEPATIC FUNCTION
Volatile Agents
Intravenous Anesthetics
Central Neuraxial Blockade
ANESTHETIC MANAGEMENT
Risk Assessment
Preoperative Considerations
Perioperative Considerations
Premedication
Induction
Maintenance
Monitoring
Perioperative Fluid
Precautions
Postoperative Care
BILIARY DISORDERS
Preoperative Considerations
Intraoperative Considerations
Monitoring
Postoperative Care
CHAPTER 23:
Anesthesia for Patients with Neuropsychiatric Disease
INTRODUCTION
EPILEPSY
Preoperative Considerations
Intraoperative Management
CEREBROVASCULAR DISEASE
Preoperative Management
Intraoperative Management
DEGENERATIVE AND DEMYELINATING DISEASE
Parkinson’s Disease
Anesthetic Considerations
Alzheimer’s Disease
Anesthetic Considerations
Multiple Sclerosis
Anesthetic Considerations
Guillain-Barré Syndrome
PSYCHIATRIC DISORDERS
Depression
Anesthetic Considerations
Mania
Schizophrenia
ANESTHESIA FOR ELECTROCONVULSIVE THERAPY
Anesthetic Management
CHAPTER 24:
Anesthesia for Patients with Musculoskeletal Disease
MYASTHENIA GRAVIS
Preoperative Evaluation
Choice of Anesthesia
Intraoperative Considerations
Induction
Maintenance
Monitoring
Postoperative Care
LAMBERT–EATON MYASTHENIC SYNDROME
Anesthetic Considerations
PERIODIC PARALYSIS (HYPERKALEMIC AND HYPOKALEMIC)
Anesthetic Considerations
MUSCULAR DYSTROPHIES
Anesthetic Considerations
Anesthetic Considerations in Myotonic Dystrophy
METABOLIC MYOPATHIES
Anesthetic Considerations
MALIGNANT HYPERTHERMIA
Etiology
Pathophysiology
Triggering Factors
Diagnosis
Intraoperative Management
Anesthesia in a Patient Susceptible to Malignant Hyperthermia
CHAPTER 25:
Anesthesia for Patients with Endocrinal Disease
INTRODUCTION
DIABETES MELLITUS
Diagnostic Criteria for Diabetes Mellitus (Adapted for American Diabetes Association)
Preoperative Evaluation
Choice of Anesthesia
Anesthetic Management
Intraoperative Glycemic Control
Monitoring
Postoperative Care
THYROID DISORDERS
Hypothyroidism
Anesthetic Considerations
Hyperthyroidism
Anesthetic Considerations
ADRENAL GLAND
Hypercortisolism (Cushing’s Syndrome)
Anesthetic Considerations
Adrenal Insufficiency
Management of Anesthesia
PHEOCHROMOCYTOMA
Anesthetic Considerations
Preoperative Preparation
Intraoperative Management
Postoperative Management
CHAPTER 26:
Anesthesia for Patients with Renal Disease
INTRODUCTION
EFFECT OF ANESTHETIC AGENT ON RENAL PHYSIOLOGY
Volatile Agents
Intravenous Agents
Direct Surgical Effects
EFFECT OF RENAL DISEASE ON ANESTHETIC AGENTS
Intravenous Agents
Inhalation Agents
Muscle Relaxants
PREOPERATIVE CONSIDERATIONS
Hematologic
Cardiorespiratory
Electrolytes
Preparation
Premedication
PERIOPERATIVE CONSIDERATIONS
Choice of Anesthesia
Induction
Maintenance
Fluid Therapy
Monitoring
POSTOPERATIVE MANAGEMENT
CHAPTER 27:
Anesthesia for Obese Patients
INTRODUCTION
CLASSIFICATION
Obesity Hypoventilation Syndrome(Pickwickian Syndrome)
ANESTHETIC CONSIDERATIONS
Preoperative
Intraoperative Considerations
Choice of Anesthesia
Anesthetic Drugs and Dosing
Positioning
Postoperative Care
UNIT VI:
Anesthesia Practice
INTRODUCTION
ANESTHETIC MANAGEMENT
Anticipated Difficult Airway
Management
Other Options
UNANTICIPATED DIFFICULT INTUBATION
Cannot Intubate Cannot Ventilate Situation
AWAKE FIBEROPTIC INTUBATION
Indications for AFOI
Contraindications for AFOI
Preparations
Procedures
Anesthetizing the Airway
Endoscopy and Intubation
CHAPTER 29:
Anesthesia for Ophthalmic Surgery
INTRODUCTION
ANATOMY OF EYE
Blood Supply
Nerve Supply
OCULAR PHYSIOLOGY
Intraocular Pressure Dynamics
Oculocardiac Reflex
ANESTHETIC MANAGEMENT
Preoperative Evaluation
Laboratory Studies
Perioperative Management
Choice of Anesthesia
General Anesthesia
Anesthesia for Pediatric Ophthalmologic Procedures
CHAPTER 30:
Anesthesia for Ear, Nose and Throat Surgery
INTRODUCTION
EAR SURGERY
Anesthetic Management
Preoperative Assessment
Local Anesthesia
General Anesthesia
NASAL SURGERY
Preoperative Evaluation
Nasal Vasoconstrictors
Anesthetic Management
Choice of Anesthesia
Local Anesthesia
General Anesthesia
INTRAORAL SURGERY
Tonsillectomy
Preoperative Evaluation
Intraoperative Management
Postoperative Care
Laryngeal Procedures
Preoperative Evaluation
Anesthetic Techniques
CHAPTER 31:
Anesthesia forOrthopedic Surgery
INTRODUCTION
PREOPERATIVE EVALUATION
Choice of Anesthesia Technique
PERIOPERATIVE COMPLICATIONS
Cardiac Complications
Respiratory Complications
Neurologic Complications
Fat Embolism Syndrome
Treatment
Tourniquet-Related Complications
ANESTHETIC MANAGEMENT OF DIFFERENT Procedures
Lower Extremity
Arthroscopy
Hip Fractures
Pelvic Fractures
Hip and Knee Arthroplasty/Replacement
Upper Extremity Surgeries
Spinal Surgeries
Intraoperative Considerations
Complications
Postoperative Pain Management
CHAPTER 32:
Anesthesia for Genitourinary Surgery
INTRODUCTION
ANESTHETIC CONSIDERATIONS
Cystoscopy
Transurethral Resection of the Prostate
Choice of Anesthesia
Intraoperative Management
Monitoring
Radical Prostatectomy
Renal Transplantation
Preoperative Considerations
Intraoperative Considerations
CHAPTER 33:
Anesthesia forLaser Surgery
INTRODUCTION
LASER HAZARDS
Atmospheric Contamination: Laser Plume
Tissue and Vessel Perforation
Embolism
Energy Transfer to an Inappropriate Location
Eye
Endotracheal Tube
CHAPTER 34:
Anesthesia for Laparoscopy
INTRODUCTION
Subcutaneous Emphysema
Pneumothorax, Pneumomediastinum and Pneumopericardium
Endobronchial Intubation
Gas Embolism
Treatment
Hemodynamic Problems
Gastrointestinal Problem
Aspiration of Gastric Contents
Nausea and Vomiting
Problems Related to Patient Position
Postoperative Pain
ALTERNATIVES TO CO2 PNEUMOPERITONEUM
Inert Gases
Gasless Laparoscopy
ANESTHETIC MANAGEMENT
Preoperative Evaluationand Premedication
Anesthetic Techniques
General Anesthesia
Local and Regional Anesthesia
Choice of Drugs
Intraoperative Care
Patient Positioning and Monitoring
Monitoring
Recovery and Postoperative Care
LAPAROSCOPY IN CHILDRENAND DURING PREGNANCY
CHAPTER 35:
Anesthesia for Neurosurgery
INTRODUCTION
CEREBRAL PHYSIOLOGY AND PHARMACOLOGY
Cerebral Metabolism
Cerebral Blood Flow
Regulation of Cerebral Blood Flow
Intracranial Pressure
Diagnosis of Increased Intracranial Pressure
Effect of Anesthetic Agents on Brain Physiology (Table 35.1)
Inhalational Agents
Intravenous Agents
ANESTHETIC MANAGEMENT
Principles for Safe Anesthesia Management
Management of Increased Intracranial Pressure (Flow chart 35.1)
Diuretics
Steroids
SPECIFIC CONDITIONS
Head Injury
Preoperative Management
Intraoperative Management
Postoperative Care
INTRACRANIAL MASS LESIONS
Preoperative Evaluation
Anesthetic Management
Maintenance
Monitoring
Intravenous Fluids
Postoperative Management
POSTERIOR FOSSA PROCEDURES (CRANIOTOMY IN SITTING POSITION)
Problem of Posterior Fossa Surgery
Obstructive Hydrocephalus
Venous Air Embolism
INTRACRANIAL ANEURYSMS AND ARTERIOVENOUS MALFORMATION
SEIZURE SURGERY
Preoperative Evaluation
Intraoperative Management
CHAPTER 36:
Anesthesia for Cardiothoracic Surgery
INTRODUCTION
CARDIOPULMONARY BYPASS
Circuit
Accessory Pumps and Devices
Cardiotomy Suction
Left Ventricular Vent
Cardioplegia Solution
Composition
Physiological and Pharmacological Effects of Cardiopulmonary Bypass
ANESTHETIC MANAGEMENT OF CARDIAC SURGERY IN ADULTS
Preoperative Evaluation
Premedication and Preparation
Intraoperative Management
Monitoring
Transesophageal Echocardiography
Transcranial Doppler
Intraoperative Course
Prebypass Period
Bypass Period
Ventilation
Cerebral Protection
Termination of Cardiopulmonary Bypass
Postbypass Period
Reversal of Anticoagulation
Postoperative Period
OFF-PUMP CORONARY ARTERY BYPASS SURGERY
ANESTHESIA FOR THORACIC SURGERY
PHYSIOLOGICAL CONSIDERATIONS
Lateral Position
The Open Pneumothorax
One-Lung Ventilation
Indications for One-Lung Ventilation
Patient-related
Procedure-related
Techniques for One-Lung Ventilation
Complications of Double-Lumen Tubes
ANESTHETIC MANAGEMENT OF LUNG RESECTION
Preoperative Considerations
Premedication
Intraoperative Management
Induction
Positioning
Maintenance of Anesthesia
Postoperative Management
Postoperative Analgesia
Anesthesia for Thoracoscopic Surgery
CHAPTER 37:
Geriatric Anesthesia
INTRODUCTION
PHYSIOLOGICAL CHANGES WITH AGING
Nervous System
Cardiovascular System
Respiratory System
Urinary System
Additional Problems
Risk Assessment
ANESTHETIC MANAGEMENT
Preoperative Evaluation
Frailty
Choice (Regional versus General Anesthesia)
Important Alteration in Pharmacology of Anesthetic Drugs
Inhaled Anesthetics
Intravenous Anesthetics
Opiates
Muscle Relaxants
Postoperative Considerations
Postoperative Pain
Postoperative Delirium
CHAPTER 38:
Obstetric Anesthesia
INTRODUCTION
PHYSIOLOGICAL CHANGES IN PREGNANCY AND THEIR ANESTHETIC IMPLICATIONS
Cardiovascular System (Table 38.1)
Anesthetic Implications
Hematologic System
Respiratory System (Table 38.3)
Anesthetic Implications
Gastrointestinal System
Anesthetic Implications
Renal System
Central Nervous System
Anesthetic Implications
PLACENTAL TRANSFER OF ANESTHETIC DRUGS
EVALUATION OF THE FETUS
ROLE OF INTRAUTERINE RESUSCITATION
ANESTHESIA FOR SPONTANEOUS VAGINAL DELIVERY (LABOR ANALGESIA)
Techniques for Labor Analgesia
Psychoprophylaxis
Transcutaneous Electrical Nerve Stimulation (TENS)
Systemic Medication
Inhaled Analgesia
Regional Analgesia
REGIONAL TECHNIQUES FOR LABOR ANALGESIA
Patient Evaluation and Preparation
Epidural Analgesia
Choice of Drugs
Epidural Test Dose
Spinal Analgesia
Combined Spinal-Epidural Analgesia
Paracervical and Pudendal Blocks
ANESTHESIA FOR CESAREAN SECTION
Choice of Anesthesia
Spinal Anesthesia
Advantages
Disadvantages
Choice of Drug
Epidural Anesthesia
Combined Spinal-Epidural Technique
Complications of Spinal and Epidural Anesthesia
General Anesthesia
SPECIFIC CONDITIONS
Pre-eclampsia and Eclampsia
Anesthetic Management
Antipartum Hemorrhage
Placenta Previa
Abruptio Placentae
Uterine Rupture
Management of Anesthesia
ANESTHESIA FOR NONOBSTETRIC SURGERY DURING PREGNANCY
BASIC LIFE SUPPORT IN PREGNANCY
ANESTHESIA FOR MANUAL REMOVAL OF PLACENTA
CHAPTER 39:
Pediatric Anesthesia
INTRODUCTION
ANATOMICAL AND PHYSIOLOGICAL DIFFERENCES
Airway
Respiratory System
Cardiovascular System
Hepatorenal System
Gastrointestinal System
Thermoregulation
Metabolic Differences
Central Nervous System
Neuromuscular Function
PHARMACOLOGICAL DIFFERENCE
Inhaled Anesthetic
Nonvolatile Anesthetics
Sedative Analgesics
Muscles Relaxant
ANESTHETIC CONSIDERATIONS
Preoperative Evaluation
Premedication
Induction
Laryngoscopy and Tracheal Intubation
Monitoring
Regional Anesthesia
Postoperative Care
Postoperative Pain Management
ANESTHETIC MANAGEMENT OF SPECIFIC DISORDERS
Tracheoesophageal Fistula
Preoperative Management
Anesthetic Management
Congenital Diaphragmatic Hernia
Anesthetic Management
Hypertrophic Pyloric Stenosis
CHAPTER 40:
Anesthesia at Remote Locations
INTRODUCTION
ANESTHESIA AT HIGH ALTITUDE
Patient Related Problem
Equipment Related Problem
Flowmeters
Vaporizers
Oxygen Delivery Systems
Use of Nitrous Oxide
Patient Response to Anesthesia and Surgery
Choice of Anesthetic Agent
Induction
Muscle Relaxants
ANESTHESIA AT HIGH PRESSURE (UNDER SEA WATER)
Problems and Principles of Anesthetic Management
ANESTHESIA IN DARK (RADIOLOGICAL PROCEDURES)
CHAPTER 41:
Anesthesia for Day Care Surgery
INTRODUCTION
Patients Suitable for Day Care Surgery
ANESTHETIC MANAGEMENT
Preoperative Evaluation
Premedication
Choice of Anesthesia
Intraoperative Management
Agents of Choice
Postoperative Period
Fast Tracking
CHAPTER 42:
Hypotensive Anesthesia
INTRODUCTION
Indications
Contraindications
METHODS FOR INDUCING HYPOTENSION
Nonpharmacological
Pharmacological
Clinical Considerations (Table 42.1)
OTHER TECHNIQUES TO REDUCE INTRAOPERATIVE BLEEDING
UNIT VII:
Pain Management
INTRODUCTION
TRANSMISSION OF PAIN
THEORIES OF PAIN
CLASSIFICATION OF PAIN (FIG. 43.3)
EVALUATION OF PAIN
Visual Analog Scale Score
McGill’s Pain Questionnaire
Evaluation of Pain in Neonate and Children
CHAPTER 44:
Postoperative Pain Management
INTRODUCTION
ASSESSMENT OF PAIN
METHODS OF POSTOPERATIVE PAIN MANAGEMENT
Pharmacological Methods
Systemic Analgesics
Local Anesthetics
Nonpharmacological Techniques
Multimodal Analgesic Approach
CHAPTER 45:
Chronic Pain and Palliation
INTRODUCTION
ASSESSMENT AND MANAGEMENT
MANAGEMENT ACCORDING TO PAIN TYPES
Diabetic Neuropathy
Trigeminal Neuralgia
Post-herpetic Neuralgia
Phantom Pain
Scar Pain
Treatment
Complex Regional Pain Syndrome
Treatment
Low Backache
Treatment
Cancer Pain
COMBINING PAIN MANAGEMENT WITH PALLIATIVE CARE
Principles of Palliative Care
SECTION 2: CRITICAL CARE
UNIT VIII:
Practice and Management in ICU
INTRODUCTION
INTENSIVE CARE UNIT ORGANIZATION
Structure
Numbers of Intensive Care Unit Beds
Input
ASSESSMENT OF SEVERITY OF ILLNESS
CLINICAL MANAGEMENT
Shock (Table 46.1)
Classification (Table 46.2)
Management (Flow chart 46.2)
Monitoring
Choice of Medications
Additional Measures
Respiratory Failure
Management (5S)
COMPLICATIONS IN INTENSIVE CARE UNIT
Infections
Deep Venous Thrombosis
Ulcers
Impaired Glycemic Control
Neurologic Dysfunction
Multiorgan System Failure
Intensive Care Unit Acquired Weakness
CHAPTER 47:
Cardiopulmonary Resuscitation
INTRODUCTION
SUDDEN CARDIAC ARREST
2010 AMERICAN HEART ASSOCIATION GUIDELINES FOR CPR
Conceptual Framework for CPR
Rescuer
Victim
BASIC LIFE SUPPORT SEQUENCE (FLOW CHART 47.1)
Immediate Recognition of Cardiac Arrest and Activation of Emergency Response System
Chest Compression
Rescue Breath
Defibrillation
ADVANCED CARDIOVASCULAR LIFE SUPPORT
2010 Acls Guidelines
Defibrillation Strategies
Cardiopulmonary Resuscitation before Defibrillation
Waveform and Energy
Automated versus Manual Mode
Drug Therapy
Ventricular Fibrillation/Pulseless Ventricular Tachycardia
Pulseless Electric Activity/Asystole
MONITORING DURING CPR
Mechanical Parameters
Physiologic Parameters
Pulse Check
End-Tidal CO2
Central Venous Oxygen Saturation
CHAPTER 48:
Principles of Mechanical Ventilation
INTRODUCTION
Physiology of Mechanical Ventilation
Total Ventilator Controlled Ventilatory Support
Partial Patient Controlled Ventilatory Support
Indication of Mechanical Ventilation
Other Indications
WORKING AND OPERATION OF VENTILATOR
Terminology Used (Flow chart 48.1)
VENTILATOR MODES
Controlled Mandatory Ventilation or Continuous Mandatory Ventilation
Indication
Complication
Assist-Controlled Mode Ventilation (Fig. 48.2A)
Trigger
Cycle
Intermittent Mandatory Ventilation
Synchronized Intermittent Mandatory Ventilation (Fig. 48.2B)
Triggering Mechanism
Synchronization Window
Advantages of Synchronized Intermittent Mandatory Ventilation Mode
Limitation
Pressure Control Ventilation (Fig. 48.2C)
Pressure Support Ventilation (Fig. 48.2D)
Dual Mode Ventilation
NONINVASIVE VENTILATION
Noninvasive Ventilation Modes
Limitation of Noninvasive Ventilation
POSITIVE-END EXPIRATORY PRESSURE
Indications
Physiology of Positive-End Expiratory Pressure (Flow chart 48.2)
Safe Level
Complications
COMPLICATION OF MECHANICAL VENTILATION
Respiratory Complication
Cardiovascular System
Gastrointestinal System
Musculoskeletal System
Skin
Central Nervous System
Financial
WEANING FROM VENTILATION
Weaning Criteria (Table 48.2)
Weaning Procedure
CHAPTER 49:
Acid–Base andElectrolyte Imbalance
INTRODUCTION
NORMAL ACID–BASE HOMEOSTASIS
ACID–BASE DISTURBANCES
Diagnosis
Rule 1
Rule 2
Rule 3
Prediction of Compensation (Table 49.1)
Rule 4
Mixed Acid–Base Disorders
Rule 5
Metabolic Acidosis
Management
Metabolic Alkalosis
Pathogenesis
Treatment
Respiratory Acidosis
Treatment
Respiratory Alkalosis
Treatment
ELECTROLYTE DISTURBANCES
Disorders of Sodium Balance
Hyponatremia
Hypernatremia
Disorders of Potassium Balance
Hypokalemia
Hyperkalemia
Disorders of Calcium
Hypercalcemia
Hypocalcemia
CHAPTER 50:
Nutritional Support in Intensive Care Unit
INTRODUCTION
INDICATION OF NUTRITION SUPPORT (FLOW CHART 50.1)
NUTRITION REQUIREMENT
Routes of Nutrition (Flow chart 50.2)
Enteral Nutrition
Parenteral Nutrition
Peripheral Parenteral Nutrition
Complications of Parenteral Nutrition
CHAPTER 51:
Brain Death
INTRODUCTION
MECHANISM OF BRAIN DEATH
Criteria and Tests for Determining Brain Death
Loss of Consciousness and Unresponsiveness
Pupils
Brainstem Responses
Apnea Test
Rule out the Mimics
INDEX
TOC
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