Second Edition
Editor-in-Chief A Parthasarathy
Distinguished Professor of Pediatrics The Tamil Nadu Dr MGR Medical University,
Guindy, Chennai
Senior Clinical Professor of Pediatrics (Retired) Madras Medical College
Deputy Superintendent Institute of Child Health and Hospital for Children
Chennai, Tamil Nadu, India
Chief Academic Editor Anupama S Borker
Professor Department of Pediatrics In-charge Pediatric Hematology-Oncology Kasturba Medical College, Manipal University
Manipal, Karnataka India
Academic Editors MKC Nair
Professor of Pediatrics and Epidemiology Director Child Development Center Sree Avittom Thirunal (SAT) Medical College and Hospital
Thiruvananthapuram, Kerala,India
Swati Y Bhave
Senior Consultant Apollo Indraprastha Hospitals, New Delhi, India
Former Professor of Pediatrics BJ Medical College, Pune
Former Associate Professor of Pediatrics Grant Medical College, Mumbai
Former Consultant and Associate Professor Bombay Hospital Institute of Medical Sciences
Mumbai, Maharashtra, India
Foreword Mayil Vahanan Natarajan
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This book has been published in good faith that the contents provided by the contributors contained herein are original, and is intended for educational purposes only. While every effort is made to ensure accuracy of information, the publisher and the editors specifically disclaim any damage, liability, or loss incurred, directly or indirectly, from the use or application of any of the contents of this work. If not specifically stated, all figures and tables are courtesy of the editors. Where appropriate, the readers should consult with a specialist or contact the manufacturer of the drug or device.
Partha's Fundamentals of Pediatrics
First Edition: 2007
Second Edition: 2013
9789350903612
Printed at:
5Dedicated to
The revered memory of my mentor, friend, philosopher and guide, (Late) Professor V Balagopal Raju, Retired Professor and Head, Department of Pediatrics, Madras Medical College, Chennai and Director and Superintendent, Institute of Child Health and Hospital for Children, Egmore, Chennai, Tamil Nadu, India, whose compassion and concern for the health care of children in India, inspired many of his students and colleagues across the country, and to (Late) Dr Tapan Kumar Ghosh, Kolkata, West Bengal, India, for his untiring services in the field of infectious diseases in India6
7Contributors
- A Parthasarathy
- Distinguished Professor of Pediatrics
- The Tamil Nadu Dr MGR Medical
- University
- Guindy, Chennai, Tamil Nadu, India
- Senior Clinical Professor of
- Pediatrics (Retired)
- Madras Medical College, Chennai
- Deputy Superintendent
- Institute of Child Health and Hospital
- for Children
- Chennai, Tamil Nadu, India
- A Prahalad Kumar
- Professor
- Indira Gandhi Institute of Child Health
- Bengaluru, Karnataka, India
- Ajay Kalra
- Ex-Professor (Pediatrics)
- SN Medical College, Agra
- Uttar Pradesh, India
- Ex-Head (Pediatrics)
- Institute of Medical Sciences
- Saifai, Etawah, Uttar Pradesh, India
- Anju Gupta
- Associate Professor (Pediatrics)
- Postgraduate Institute of Medical
- Education and Research (PGIMER)
- Chandigarh, India
- Anupama S Borker
- Professor
- Department of Pediatrics
- In-charge, Pediatric Hematology-Oncology
- Kasturba Medical College
- Manipal University
- Manipal, Karnataka, India
- B Uma Maheshwari
- Assistant Professor
- Department of Neonatology
- Sri Ramachandra Medical College and
- Research Institute
- Porur, Chennai, Tamil Nadu, India
- B Vishnu Bhat
- Professor and Head
- Department of Pediatrics and
- Division of Neonatology
- Jawaharlal Institute of Postgraduate
- Medical Education and Research
- (JIPMER)
- Puducherry, India
- Bharat Agarwal
- Head
- Department of Pediatric
- Hematology-Oncology
- Bai Jerbai Wadia Hospital for Children
- Parel, Mumbai, Maharashtra, India
- Bhavin Jankharia
- Consultant Radiologist
- Jankharia Imaging
- Mumbai, Maharashtra, India
- C Thangadorai
- Senior Clinical Professor of Pediatrics
- Madras Medical College, Chennai
- Pediatric Physician (Retired)
- Institute of Child Health and
- Hospital for Children
- Egmore, Chennai, Tamil Nadu, India
- D Gunasingh
- Professor of Pediatrics
- Madras Medical College
- Pediatric Physician
- Institute of Child Health and
- Hospital for Children
- Chennai, Tamil Nadu, India
- Deep Naveen Thacker
- Medical Officer
- Sahyadri Ramkrishna Super Speciality
- Hospital
- Gandhidham, Kutch
- Gujarat, India
- Deepa Bhaskaran
- Consultant Pediatrician
- Child Development Center
- Medical College
- Thiruvananthapuram, Kerala, India
- Devaraj V Raichur
- Professor of Pediatrics
- Karnataka Institute of Medical Sciences
- Hubli, Karnataka, India
- Dhanya Dharmapalan
- Consultant Pediatrician
- Dr Yewale's Multispeciality Hospital
- for Children
- Navi Mumbai, Maharashtra, India
- Digant D Shastri
- Pediatrician and CEO
- Killol Children Hospital
- NICU and Vaccination Center
- Takshashila Apartment, Majuragate
- Surat, Gujarat, India
- Divya Prabhat
- Head
- ENT Department
- Wadia Children's Hospital
- Mumbai, Maharashtra, India
- G Kumaresan
- Professor of Pediatric
- Neurology (Retired)
- Madras Medical College, Chennai
- Pediatric Neurologist
- Institute of Child Health and
- Hospital for Children
- Chennai, Tamil Nadu, India
- Govind Chavhan
- Pediatric Radiologist
- The Hospital for Sick Children
- Assistant Professor
- University of Toronto, Canada
- Hemchand Prasad
- Pediatric Endocrinologist
- Mehta Children's Hospital
- Chetpet
- Chennai, Tamil Nadu, India
- Hitt Sharma
- Additional Director (Medical Affairs)
- Serum Institute of India Ltd
- Hadapsar
- Pune, Maharashtra, India
- Jayakar Thomas
- Professor and Head
- Department of Dermatology and STD
- Sree Balaji Medical College
- and Hospital
- Chennai, Tamil Nadu, India
- Jaydeep Choudhury
- Associate Professor
- Department of Pediatrics
- Institute of Child Health
- Kolkata, West Bengal, India
- Jeeson C Unni
- Senior Consultant Pediatrician
- Dr Kunhalu's Nursing Home
- Kochi, Kerala, India
- K Nedunchelian
- Assistant Professor of Pediatrics
- Madras Medical College
- Pediatric Physician
- Institute of Child Health and Hospital
- for Children
- Chennai, Tamil Nadu, India
- K Pandian
- Pediatric Neurologist
- Visiting Consultant
- Kanchi Kamakoti Childs
- Trust Hospital (KKCTH)
- and KP Hospital
- Chennai, Tamil Nadu, India
- Ketan Parikh
- Consultant Pediatric Surgeon and
- Pediatric Laparoscopist
- Mumbai, Maharashtra, India
- KS Sanjay
- Professor of Pediatrics
- Indira Gandhi Institute of
- Child Health (IGICH)
- Bengaluru, Karnataka, India
- M Govindaraj
- In-charge, Director and Medical
- Superintendent
- Indira Gandhi Institute of
- Child Health (IGICH)
- Bengaluru, Karnataka, India
- M Indra Shekhar Rao
- Professor of Pediatrics
- Balaji Medical College
- Assistant Director of Medical
- Education (Retired)
- Government of Andhra Pradesh
- Head and Professor
- Department of Pediatrics
- Osmania Medical College
- Medical Superintendent
- Institute of Child Health and
- Nilofour Hospital
- Hyderabad, Andhra Pradesh, India
- M Zulfikar Ahamed
- Professor and Head
- Department of Pediatric Cardiology
- Sree Avittom Thirunal (SAT) Hospital
- Government Medical College
- Thiruvananthapuram
- University of Kerala
- Kerala, India
- Major K Nagaraju
- Senior Consultant in Pediatric Allergy
- Pediatric Allergist and Immunotherapist
- Kanchi Kamakoti Childs Trust Hospital
- Director
- VN Allergy and Asthma Research
- Center
- Chennai, Tamil Nadu, India
- Malathi Sathiyasekaran
- Consultant Pediatric Gastroenterologist
- Kanchi Kamakoti Childs
- Trust Hospital (KKCTH)
- Apollo Children's and SMF Hospital
- Chennai, Tamil Nadu, India
- Mayil Vahanan Natarajan
- Vice-Chancellor
- The Tamil Nadu Dr MGR Medical
- University, Guindy
- Chennai, Tamil Nadu, India
- Ex-Professor of Orthopedics and
- Director
- Institute of Orthopedics and
- Traumatology
- Madras Medical College and Rajiv
- Gandhi Government General Hospital
- Chennai, Tamil Nadu, India
- Meenakshi N Mehta
- Head and Consultant Pediatrician
- (Retired)
- Department of Pediatrics
- Mahatma Gandhi Memorial Hospital
- Parel, Mumbai, Maharashtra, India
- Head and Professor
- Department of Pediatrics
- (Retired)
- Lokmanya Tilak Municipal Medical
- College and LTMG Hospital, Sion
- Mumbai, Maharashtra, India
- Meenakshi Swaminathan
- Senior Consultant
- Department of Pediatric
- Ophthalmology
- Medical Research Foundation
- Chennai, Tamil Nadu, India
- MKC Nair
- Professor of Pediatrics and
- Epidemiology
- Director
- Child Development Center
- Sree Avittom Thirunal (SAT)
- Medical College and Hospital
- Thiruvananthapuram, Kerala, India
- Monjori Mitra
- Associate Professor of Pediatrics
- Institute of Child Health
- Kolkata, West Bengal, India
- MP Jeyapaul
- Director and Superintendent (Retired)
- Institute of Child Health
- and Hospital for Children
- Chennai, Tamil Nadu, India
- MR Lokeshwar
- Consultant Pediatrician and
- Pediatric Hematologist
- Lilavati Hospital and
- Research Center and
- Shushrusha Citizens and
- Cooperative Hospital Ltd
- Dadar, Mumbai, Maharashtra, India
- N Deivanayagam
- Former Professor of Pediatrics and
- Clinical Epidemiology
- Madras Medical College, Chennai
- Director-in-charge, Institute of Child
- Health and Hospital for Children
- Chennai, Tamil Nadu, India
- N Suresh
- Registrar in Pediatrics
- Kanchi Kamakoti Childs Trust Hospital
- Nungambakkam
- Chennai, Tamil Nadu, India
- N Thacker
- Director and Senior Consultant
- Deep Children Hospital
- Kutch, Gujarat, India
- NC Gowri Shankar
- Pediatric Pulmonologist and
- Bronchoscopist
- Deputy Head, Pediatrics
- Mehta Children's Hospital
- Chennai, Tamil Nadu, India
- Nigam Prakash Narain
- Associate Professor of Pediatrics
- I/C (PICU)
- Patna Medical College
- Patna, Bihar, India
- Nisarga
- Professor and Head
- Department of Pediatrics
- Adichunchanagiri Institute of
- Medical Sciences
- BG Nagar, Belluru, Mandya
- Karnataka, India
- NK Kalappanavar
- Vice-Principal, Professor and Head
- Department of Pediatrics
- SS Institute of Medical Sciences and
- Research Centre
- Davangere, Karnataka, India
- Nupur Ganguly
- Associate Professor
- Institute of Child Health
- Kolkata, West Bengal, India
- P Ramachandran
- Professor of Pediatrics
- Sri Ramachandra Medical College and
- Research Institute
- Porur, Chennai, Tamil Nadu, India
- Pankaj Deshpande
- Consultant Pediatric Nephrologist
- Hinduja Hospital, MGM Hospital
- Bethany Hospital
- Mumbai, Maharashtra, India
- Parimalam Kumar
- Assistant Professor of Dermatology
- Stanley Medical College
- Chennai, Tamil Nadu, India
- Piyush Gupta
- Professor of Pediatrics
- University College of Medical Sciences
- Delhi, India
- PK Baskar
- Medical Director
- Sri Viveka Institute of Dental Health
- Chennai, Tamil Nadu, India
- Preeti Galagali
- Medical Director and Adolescent
- Physician
- Bangalore Adolescent Care and
- Counselling Center
- Bengaluru, Karnataka, India
- Prema Lakshminarayana
- Consultant Pediatrician and Geneticist
- Professor and Head of Department
- (Retired)
- Madras Medical College, Tamil Nadu
- Dr MGR Medical University
- Pediatrician, Genetic Consultant (Retired)
- Government Hospital for
- Women and Children
- Chennai, Tamil Nadu, India
- PSN Menon
- Former Professor of Pediatrics
- All India Institute of Medical Sciences
- New Delhi, India
- Consultant and Head
- Department of Pediatrics
- Jaber Al-Ahmed Armed Forces
- Hospital, Kuwait
- R Srikanth
- Fellow
- Department of Pediatric
- Ophthalmology
- Medical Research Foundation
- Chennai, Tamil Nadu, India
- Rajesh Patel
- Consultant Pediatrician
- City Hospital
- Mumbai, Maharashtra, India
- Rajeshwar Dayal
- Professor and Head
- Department of Pediatrics
- SN Medical College
- Agra, Uttar Pradesh, India
- Ramaswamy Ganesh
- Registrar in Pediatrics
- Kanchi Kamakoti Childs Trust Hospital
- Chennai, Tamil Nadu, India
- Ritabrata Kundu
- Professor of Pediatrics
- Institute of Child Health
- Kolkata, West Bengal, India
- Rohit Agrawal
- Director and Consultant Pediatrician
- Chandrajyothi Hospital
- Visiting Consultant
- Kohinoor Hospital
- Mumbai, Maharashtra, India
- S Balasubramanian
- Senior Consultant Pediatrician
- Kanchi Kamakoti Childs Trust Hospital
- Chennai, Tamil Nadu, India
- S Mahadevan
- Professor of Pediatrics
- Jawaharlal Institute of Postgraduate
- Medical Education and Research
- (JIPMER)
- Puducherry, India
- S Ramesh
- Consultant Pediatrician
- BRS Hospital
- Chennai, Tamil Nadu, India
- S Shivananda
- Director (Retired)
- Indira Gandhi Institute of Child Health
- Bengaluru, Karnataka, India
- S Thangavelu
- Head
- Department of Pediatrics
- Senior Consultant Pediatrician and
- Pediatric Intensivist
- Critical Care Unit
- Mehta Children Hospital
- Chennai, Tamil Nadu, India
- Sara Dhanawade
- Professor and Head
- Department of Pediatrics
- Bharati Vidyapeeth Medical College
- Sangli, Maharashtra, India
- SN Vani
- Emeritus Professor of Pediatrics
- including Neonatology
- Pramukhswamy Medical College and
- Sri Krishna Hospital, Karamsad, Anand
- Gujarat, India
- SR Kesavamurthy
- Emeritus Professor
- Kempegowda Institute of
- Medical Sciences
- Bengaluru, Karnataka, India
- Subhasish Bhattacharyya
- Associate Professor
- Department of Pediatrics
- Medical College
- Kolkata, West Bengal, India
- Surjit Singh
- Professor of Pediatrics
- Pediatric Allergy Immunology
- Unit, Advanced Pediatrics Center
- Postgraduate Institute of Medical
- Education and Research (PGIMER)
- Chandigarh, India
- Swati Y Bhave
- Senior Consultant
- Apollo Indraprastha Hospitals
- New Delhi, India
- Executive Director
- Association of Adolescent Child Care in
- India, Mumbai
- Former Professor of Pediatrics
- BJ Medical College
- Pune, Maharashtra, India
- Former Associate Professor of
- Pediatrics
- Grant Medical College
- Mumbai, Maharashtra, India
- Former Consultant and Associate
- Professor
- Bombay Hospital
- Institute of Medical Sciences
- Mumbai, Maharashtra, India
- T Ravikumar
- Consultant Pediatrician
- Kanchi Kamakoti Childs Trust Hospital
- Nungambakkam
- Chennai, Tamil Nadu, India
- Tanmay Amladi
- Zahrat Al Nahda
- Doha Road, Behind Zulekha Hospital
- Al-Nahda, Dubai
- TS Surendran
- Director
- Ophthalmology
- Medical Research Foundation
- Chennai, Tamil Nadu, India
- V Goyal
- Consultant Pediatrician
- Vinayak Hospital
- Gandhidham
- Gujarat, India
- V Poovazhagi
- Assistant Professor of Pediatrics
- Institute of Child Health and
- Hospital for Children
- Egmore, Chennai, Tamil Nadu, India
- Vaman Khadilkar
- Pediatric Endocrinologist
- Jehangir Hospital, Pune and
- Bombay Hospital
- Mumbai, Maharashtra, India
- Assistant Professor
- Bharati Vidyapeeth Medical College
- Pune, Maharashtra, India
- Veena Kalra
- Head
- Department of Pediatric Neurology
- Apollo Indraprastha Hospital
- New Delhi, India
- Ex-Professor and Head
- Department of Pediatrics
- All India Institute of Medical Sciences
- Ansari Nagar, New Delhi, India
- Yeshwant Krishna Amdekar
- Medical Director
- BJ Wadia Hospital for Children
- Mumbai, Maharashtra, India
It is a great pleasure for me to write foreword for the book, Partha's Fundamentals of Pediatrics. The author of the book is known to me for a long time as a good teacher and academician dedicating most of his time for the betterment of children. As the children of developing countries differ from their counterparts in developed countries, the Indian Academy of Pediatrics plays a vital part in the health needs of children and the participation rendered by Senior Pediatricians like Dr Parthasarathy for the same is very immense in taking the child health to the next level.
The book is thoroughly written keeping in time with the rapidly changing concepts in pediatrics besides being evidence-based in that aspect. Apart from being an excellent textbook for undergraduates and postgraduates, the book has a quantum of knowledge to be cherished by the fellow pediatricians across the globe. I am sure that the book will continue to remain as a prestigious publication and serve the nation by helping the doctors engaged in the care of the children needing latest updates.
I congratulate Dr Parthasarathy on his stupendous efforts, and I wish him and the book all the best.
Mayil Vahanan Natarajan
Vice-Chancellor
The Tamil Nadu Dr MGR Medical University
Chennai, Tamil Nadu, India
Ex-Professor of Orthopedics and Director
Institute of Orthopedics and Traumatology
Madras Medical College and Rajiv Gandhi Government General Hospital
15Preface to the Second Edition
With dedication, we have published the second edition of this book in accordance with the revised Medical Council of India (MCI) and All India Institute of Medical Sciences (AIIMS) MBBS syllabus. Respective authors and chapter editors have taken great pains to revise and update the text in tune with the revised syllabus. Attempt has been made to include few additional topics not included in the syllabus but useful for the undergraduate student when he/she embarks practicing medicine after getting his/her degree.
Thus, the book is presented with the day-to-day management guidelines also to benefit the practicing pediatricians and family physicians who need to be updated on fundamentals useful for their practice. The book will, therefore, continue to be a reference volume for the undergraduates, even as they become practitioners of pediatrics, as a desktop-reference volume and ready-reckoner, because today's medical student is tomorrow's practitioner.
The contents include a wide range of pediatric topics starting from Pediatric Care in Developing Countries, National Rural Health Mission, History Elicitation and Physical Examination, Newborn Care, Growth and Development, Infant and Young Child Feeding, Community Pediatrics, Immunity, Immunization and Infectious Diseases, Systemic Diseases of Neurology, Cardiology, Pulmonology, Gastroenterology, Hepatology and Pancreatology, Nephrology, Hematology, Oncology, Endocrinology, Genetics, Allergy and Rheumatology, and chapters related to allied subspecialties in Pediatrics like Ophthalmology, Otorhinolaryngology, Dentistry, Orthopedics, Learning Disabilities, Child Labor and Neglect, Adolescent Health, Poisoning and Toxic Ingestion, Essentials of Pediatric and Neonatal Intensive Care, Surgery, Rational Drug Therapy, Medical Research, Pediatric Procedures, Radiology and Imaging in 33 Chapters including 9 Miscellaneous Topics, viz. Vital Statistics, IMNCI Strategy, Rights of Children, Drugs and Drug Dosages, Interpretation of Laboratory Values and Allergy Tests, Safe injection Practices and the MCI/AIIMS-MBBS syllabi for ready reference.
It is our fervent hope that the readers of the book will appreciate the fluency and readability of the text and will find the topics covered useful for undergraduate examination and day-to-day pediatric practice. Your valuable suggestions are earnestly welcomed to improve the contents and quality of future editions of the book.
A Parthasarathy
Anupama S Borker
MKC Nair
17Preface to the First Edition
The long-pending recommendation of the Indian Academy of Pediatrics (IAP) and the dream of many senior teachers in Pediatrics, became a reality when the Medical Council of India (MCI) announced the inclusion of Pediatrics as a separate examination subject in the year 1997. The IAP Education Center and the MCI, based on the recommendations of the IAP experts, executed a very concise and need-based syllabus.
The need for a concise textbook to impart fundamental knowledge of pediatrics to the graduate medical students was felt and the Indian Academy of Pediatrics brought out a comprehensive textbook for the first time titled IAP Textbook of Pediatrics. The academy's venture was warmly welcomed by students, teachers and practitioners alike. However, due to its comprehensive nature, the contributors could not restrict the text and hence it became voluminous. Several topics which were not the part of MCI syllabus were also included. Soon the IAP Textbook of Pediatrics became a true desktop companion of postgraduates and practitioners. Several reprints were brought out and the third edition has been published in 2006.
A much smaller version became the need of the hour and hence this book at the request of undergraduates. Though we cannot claim a state-of-the-art presentation, we have strived our best to include all the topics as delineated by the Medical Council of India and the IAP Education Center in their syllabus and also a few selected topics of practical importance.
It is our fervent hope that this textbook will fulfill the fundamental needs of the undergraduates. Your suggestions are most welcome to improve the quality of the contents for future editions.
A Parthasarathy
PSN Menon
MKC Nair
19Acknowledgments
The Editor-in-Chief is indebted to the following, for timely assistance in accomplishing this project on schedule:
- All learned contributors, chapter editors and members of the editorial board.
- Dr Anupama S Borker for her dedication and hard work, and the “eagle's eye” scrutiny and editing of the whole book.
- Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Mr Tarun Duneja (Director-Publishing), Ms Samina Khan (PA to Director-Publishing), Dr Richa Saxena (Chief Editor), Dr Anchal Kaushik and Ms Jagriti Kundu (Medical Editors), Mr KK Raman (Production Manager) and his production team of graphic designers, proofreaders and typesetters, M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, and Mr Pradeep Ratan Mukherjee (Branch Manager), Mr Jayanandan (Author Coordinator) and their dedicated team of Chennai Branch Office, Mr CS Gawde (Branch Manager), Mr Ramesh (Author Coordinator) and their dedicated team of Mumbai Branch Office, and Mr Venugopal (Branch Manager) Bengaluru, Karnataka, India, for their coordination and assistance from time to time.
- Mrs Nirmala, Mr R Janardhanan, Dr (Mrs) Prathibha, Ms Shruthi Pavana, Ms Swathi Pavana, Mr P Balaji, Mrs Kavitha, Ms Kavya, Ms Mahiya, for their valuable suggestions and coordination and to Mr D Prakash, Mr Ajay Kumar, Mr Shukla, Mrs Uma Devi Sathish and Mr Sathiyathasan of Chennai, Tamil Nadu, India, for their secretarial assistance.