Recent Advances in Pediatrics (Special Volume 22): Immunology, Infections and Immunization Suraj Gupte
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fm1RECENT ADVANCES IN PEDIATRICS Special Volume 22 Immunology, Infections and Immunizationfm2
Jaypee's Other Titles by Prof (Dr) Suraj Gupte
  • Recent Advances in Pediatrics (RAP): Hot Topics (General/ Miscellaneous Pediatrics)
    Vol 21 (2013), Vol 20 (2011), Vol 19 (2010), Vol 18 (2009), Vol 17 (2007),Vol 16 (2006), Vol 15 (2005), Vol 14 (2004), Vol 13 (2003), Vol 12 (2002), Vol 11 (2001), Vol 10 (2000), Vol 9 (1999), Vol 8 (1998), Vol 7 (1997), Vol 6 (1996), Vol 5 (1995), Vol 4 (1994), Vol 3 (1993), Vol 2 (1992), Vol 1 (1991)
  • Recent Advances in Pediatrics (RAP): Special Volumes
    RAP Special Vol
    24
    :
    Respiratory Diseases
    RAP Special Vol
    23
    :
    Pediatric Gastroenterology, Hepatology and Nutrition
    RAP Special Vol
    21
    :
    Neonatal and Pediatric Intensive Care
    RAP Special Vol
    20
    :
    Nutrition, Growth and Development
    RAP Special Vol
    19
    :
    Developmental and Behavioral Pediatrics
    RAP Special Vol
    18
    :
    Pediatric Neurology
    RAP Special Vol
    17
    :
    Adolescence
    RAP Special Vol
    16
    :
    Pediatric Cardiology
    RAP Special Vol
    15
    :
    Nephrology
    RAP Special Vol
    14
    :
    Critical Care Pediatrics
    RAP Special Vol
    13
    :
    Pediatric Endocrinology
    RAP Special Vol
    12
    :
    Neonatal Emergencies
    RAP Special Vol
    11
    :
    Community Pediatrics
    RAP Special Vol
    10
    :
    Pulmonology
    RAP Special Vol
    09
    :
    Neurology
    RAP Special Vol
    08
    :
    Emergency Pediatrics
    RAP Special Vol
    07
    :
    Hematology
    RAP Special Vol
    06
    :
    Gastroenterology, Hepatology and Nutrition
    RAP Special Vol
    05
    :
    Neonatology – 2
    RAP Special Vol
    04
    :
    Neonatology
    RAP Special Vol
    03
    :
    Tropical Pediatrics – 2
    RAP Special Vol
    02
    :
    Tropical Pediatrics
    RAP Special Vol
    01
    :
    Nutrition, Growth and Development
  • Recent Advances in Pediatrics (RAP) Volumes in Pipeline
    • RAP 21: Hot Topics (General/Miscellaneous Pediatrics)
    • RAP Special Vol 25:Perspectives in Neonatology
  • The Short Textbook of Pediatrics, 11th edition, 2009
  • Differential Diagnosis in Pediatrics, 5th edition, 2009
  • Instructive Case Studies in Pediatrics, 5th edition, 2011
  • Pediatric Drug Directory, 8th edition, 2013.
fm3RECENT ADVANCES IN PEDIATRICS Special Volume 22 Immunology, Infections and Immunization
Academic Editor Suraj Gupte MD FIAP Professor and Head, Postgraduate Department of Pediatrics Mamata Medical College/Mamata General and Superspecialty Hospitals Khammam 507002, Andhra Pradesh, India E-mail: drsurajgupte@gmail.com, surajgupte@rediffmail.com, recentadvances@yahoo.co.uk, Website: www.drsurajgupte.com
Honorary Director: Pediatric Education Network
Editor: The Short Textbook of Pediatrics; Textbooks of Pediatric Emergencies, Neonatal Emergencies, Pediatric Nutrition, and Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Infectious Diseases, Influenza: Complete Spectrum, etc.
Author: Differential Diagnosis in Pediatrics, Instructive Case Studies in Pediatrics, Influenza, Perspectives in Influenza, Pediatric Drug Directory, Speaking of Child Care.
Co-editor: Asian Journal of Maternity and Child Health (Manila, Philippines)
Section and Guest Editor: Pediatrics Today (New Delhi)
Editorial Advisor: Asian Journal of Pediatrics Practice (New Delhi)
Editorial Advisory Board Member/Reviewer: Indian Journal of Pediatrics (New Delhi), Indian Pediatrics (New Delhi), Synopsis (Detroit, USA), Indian Journal of Pediatric Gastroenterology, Hepatology and Nutrition (Jaipur), Maternal and Child Nutrition (Preston, UK), Journal of Pediatric Infectious Diseases (Turkey)
Examiner: National Board of Examinations (NBE) for DNB, New Delhi; All India Institute of Medical Sciences (AIIMS), New Delhi; Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh; Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar; Indira Gandhi National Open University (IGNOU), New Delhi, India
Pediatric Faculty Selection Expert: All India Institute of Medical Sciences (AIIMS), New Delhi; Punjab Public
Service Commission; Jammu and Kashmir Public Service Commission; Union Public Service Commission, etc.
Executive Editors Shamma-Bakshi Gupte Manu Gupte
fm4
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This book has been published in good faith that the contents provided by the contributors contained herein are original, and is intended for educational purposes only. While every effort is made to ensure accuracy of information, the publisher and the editors specifically disclaim any damage, liability, or loss incurred, directly or indirectly, from the use or application of any of the contents of this work. If not specifically stated, all figures and tables are courtesy of the editors. Where appropriate, the readers should consult with a specialist or contact the manufacturer of the drug or device.
Recent Advances in Pediatrics (Special Volume 22)
Immunology, Infections and Immunization
First Edition: 2013
9789350903667
Printed at
fm5Dedicated to
My dear Parents
whose inspiration, motivation, blessings
and moral support continue to contribute
a great deal of our academic endeavors
and
Everybody striving to contribute to
child health and welfare for a
brighter future globallyfm6
fm7Contributors fm13Preface
The trio, Immunology, Infections and Immunization, was dubbed as “inseparable” by the American Journal of Diseases of Children way back in 1980. Today, the unique relationship amongst the three components of the trio has assumed yet greater significance in the wake of advances made in the field of molecular biology. True, infections continue to be very much around. Nevertheless, thanks to the contribution made in immunology, our understanding in the field of infectious diseases stands considerably enhanced. Now, we are better prepared to face their challenge. The remarkable role of ever-expanding immunization in their prevention remains no secret.
This book is a unique blend of the best of reading matter concerning the trio. The 27 chapters of the treatise contributed by as many as 46 experts drawn from India, England, Ireland and the US attempt to review the depth and breadth of knowledge in the field of contemporary pediatrics in relation to immunology, infections and immunization with special reference to its applicability in the Indian subcontinent.
The state-of-the-art Chapters are presented in four groups, namely Part 1: Immunology; Part 2: Infections; Part 3: Immunization and Part 4: Pharmacotherapy of Infections Diseases and Immunologic Disorders.
Getting off the ground with a fine overview on immunology with accent on the fundamentals, the Part 1 deals with immunology, issues and concerns in immunology, primary and secondary immunodeficiency disorders, and diagnostic and therapeutic aspects of immunodeficiency disorders. Separate chapters on the topics immunotherapy, intravenous immunoglobulins (IVIGs), immunological basis for neonatal sepsis, acute disseminated encephalomyelitis and reactive hemophagocytic lymphohistiocytosis are also added.
Part 2 offers 10 excellent chapters, providing in-depth and crucial information on such matters as, central nervous system (CNS) infections, HIV, infective endocarditis, neonatal sepsis: Management beyond antibiotics, tuberculosis, bloody diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), meningococcemia, vector-borne diseases (VBDs) and infection control.
Part 3 is a down-to-earth approach to different aspects of immunization and vaccines with special emphasis on needs in the Indian subcontinent and other countries of the South-East Asian Region (SEAR). It deals with conventional vaccines, new and underutilized vaccines, adolescent vaccines, human papilloma virus (HPV) vaccine and immunization of the immunocompromised. The current recommendations of the IAP as well as EPI/UIP/GOI are given pride of place.fm14
Finally, Part 4 deals with pharmacotherapy in pediatric infectious diseases with a spotlight on new and not so new antimicrobials. An independent chapter provides a thought-provoking commentary on different facets of the growing and worrisome problem of antimicrobial resistance with a call for rejuvenated efforts at producing new antibiotics. Appropriate and rational antibiotic therapy stands out as a key pillar of combating antimicrobial resistance.
Each and every chapter stands out as “remarkable” for its excellence, providing a stimulating and, not infrequently, even provocative, mature and informed update. In keeping with the professed policy of the series, multidisciplinary approach with an eye on future continues to occupy a central spot in the volume. This well-tested approach is befitting when the goal is not only to inform but also to motivate discussion, interaction, research and innovation.
Here is wishing the galaxy of RAP readers a fruitful academic bonanza.
Suraj Gupte
Shamma-Bakshi Gupte
Manu Gupte
fm15Acknowledgments
Grateful acknowledgments are made to: