Clinical Ophthalmology Anina Abraham, Sirisha Senthil
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Patient Evaluationchapter 1

 
EVALUATION OF GLAUCOMA
 
History
  • Pain, redness, watering
  • One/two-sided headache or brow ache
  • Haloes around bulbs; blurred vision
  • Nausea, vomiting
  • Use of topical/systemic steroids
  • Trauma
  • Frequent change of glasses
 
Family History
  • Diabetes mellitus/glaucoma/ocular disease
 
Past History
  • Similar complaints in the past
  • Diabetes, hypertension
  • Ocular surgery, laser
  • Uveitis, asthma
 
Treatment History
  • Glaucoma medication, use of homeopathy medications, inhalational steroids, antihypertensive (beta-blockers), antimigraine drugs (Topiramate)
 
Ocular Examination
  • Visual acuity for distance and near; vision improvement with pin hole
  • Refraction
  • Intraocular pressure with applanation tonometry
  • Gonioscopy—open angle, closed angle, occludable angle, goniosynechiae, blotchy pigments, angle recession, foreign body, new vessels, silicone oil, patency of the internal osteum
  • Pachymetry for central corneal thickness
  • Visual fields
  • Anterior segment examination
 
Cornea
  • Epithelial/stromal edema/scars
  • Pigment on endothelium
  • Krukenberg's spindle
  • Pseudoexfoliation (PXF)
 
Anterior Chamber
  • 2Depth (central and peripheral); regularity
  • Reaction
 
Iris
  • Color/pattern
  • Posterior synechiae
  • Peripheral anterior synechiae
  • Rubeosis iridis
  • Peripheral iridotomy/iridectomy
 
Pupil
  • Size, shape, reaction to light
  • Transillumination defects, sphincter atrophy
  • Pseudoexfoliation
 
Lens
  • Opacification, subluxation
  • Dislocation, glaucomflecken
  • Pseudoexfoliative material
 
Fundus Examination
  • Size/shape of optic disc
  • Neuroretinal rim (pallor/notching/thinning/ISNT rule)
  • Splinter hemorrhages
  • Peripapillary atrophy
  • NFL loss
  • PRPC (laser) marks
  • Vein occlusions
  • Choroidal detachment
 
Investigations
  • Central corneal thickness
  • Visual fields
  • GDx, OCT, HRT3
 
EVALUATION OF SQUINT
 
History
  • Onset, duration, intermittent/constant
  • Progression/regression
  • Ocular pain, headache (with aura)
  • Diplopia (variability), lid droop (variability)
  • Trauma to head/face/eye
  • Fever (viral meningitis)
  • Tremors, hemiparesis, weakness
  • Hearing loss, tinnitus, vertigo
  • Long standing early morning headache with nausea and vomiting (raised ICT)
  • Nasal symptoms
  • Defective vision
  • Tingling and numbness (multiple sclerosis)
 
Past History
  • DM/HTN/cardiovascular disease
  • Stroke, multiple sclerosis
  • Drug allergies
  • Ocular surgery
  • Previous episodes with remissions/exacerbations
  • Malignancy
 
General Examination
  • Including CNS examination and ENT examination
 
Ocular Examination
  • Best corrected visual acuity for distance and near; refraction
  • Color vision, visual fields
  • Compensatory head posture, facial symmetry
  • Lagophthalmos → any facial palsy
  • Ocular alignment—Hirschberg corneal reflex, cover/uncover/alternate cover test, Prism bar cover test, Krimsky test
  • Ocular motility—full/restricted
  • Diplopia charting
  • Forced duction test
  • IOP, gonioscopy
  • Anterior segment: if ptosis present—evaluate fully
  • Posterior segment → any papilloedema?
 
Cover Test
  • To detect heterotropia
  • Done for near and distance
  • Cover the apparently fixing eye and watch movement of suspected deviating eye
 
Cover-uncover Test
  • 4
    To detect heterophoria
  • Uncover the eye and watch its movement
  • If eye deviated under cover → on uncover, it will manifest a re-fixation movement on being uncovered
 
Alternate Cover Test
  • Interrupts binocular fusion
  • Reveals total deviation (phoria + tropia)
  • Phoria—patient will have straight eyes before and after test
  • Tropia—patient will have a manifest deviation
  • Quickly cover each eye alternately and watch behavior of each eye when cover is removed and transferred to the other eye
 
Krimsky Test
  • Prism in front of seeing eye which fixates a target
  • Increase strength of prism till corneal reflex is centered in blind eye
 
Prism Bar Cover Test
  • Precisely measures angle of deviation
  • Alternate cover test performed
  • Prisms of increasing strengths are placed in front of one eye with base opposite the direction of deviation
  • For esotropia—use a base out prism
  • For exotropia—use a base in prism
  • Amplitude of ocular re-fixation movements gradually decreases
  • End point is when ocular movements are negated
  • Then, angle of deviation = strength of prism
 
Hirschberg's Test
  • Light thrown into the eyes from 60 cm distance with an ophthalmoscope or focused light beam
  • Patient is asked to look at the light
    zoom view
  • 1 mm of deviation of corneal reflex = 7° deviation
  • If reflex is at the pupillary margin → deviation is 15°
  • If reflex is seen ½ way between center of pupil and limbus → deviation is 20°
  • Reflex ½ way between pupillary margin and limbus → deviation is 30°
  • If reflex seen at limbus → deviation is 45°5
 
Worth Four Dot Test
  • If all 4 lights seen → normal fusion or abnormal retinal correspondence (if—manifest squint)
  • 2 red lights seen → LE suppression
  • 3 green lights → RE suppression
  • 2 red + 3 green seen → diplopia
  • Red and green alternately seen → alternate suppression
 
Bagolini Striated Glasses
  • Glasses placed in front of both eyes
  • Patient is asked to look at a point source of light
    zoom view
 
Maddox Rod (When Placed in Front of Right Eye)
zoom view
 
Evaluation of Paralytic Squint
  • Determine cause—history, ocular examination orbital ultrasonography, neurological examination, CT-scan, MRI
  • Secondary deviation > Primary deviation
 
Diplopia Charting
6 Data obtained:
  • Areas of single vision and diplopia
  • Distance between 2 images in diplopia
  • Image tilt/erect
  • Image on same level or not
  • Crossed/homonymous diplopia
 
Park 3 Step Test
  1. Identify hypertropic eye
  2. Patient looks horizontally right and then left—deviation (and diplopia) increases in the direction of action of paralyzed muscle
  3. Tilt the head toward each shoulder and look for increase in deviation (in superior oblique palsy, deviation increases on tilting the head to the same side as the palsy)
 
Bielschowsky Head Tilt Test
For example: In right superior oblique palsy, right hypertropia increases when head is tilted toward the right shoulder; and disappears or decreases when head is tilted toward the left shoulder
 
EVALUATION OF UVEITIS
 
History
  • 7Onset, duration
  • Pain, photophobia, redness, watering
  • Blurred vision, floaters
  • Trauma
  • Viral infection, e.g. herpes zoster ophthalmicus
  • Fever, weight loss, night sweats, cough, shortness of breath (TB, sarcoidosis)
  • Diarrhea, constipation (inflammatory bowel disease)
  • Low back pain (ankylosing spondylitis)
  • Small joint pains (rheumatoid arthritis)
  • Orogenital ulcers (Behçet's disease)
  • Exposure (HIV, venereal disease)
  • Skin lesions like erythema nodosum, dermographia
 
Treatment History
  • Any long-term treatment for TB, leprosy
  • Any topical medication like steroids for similar episodes in the past
 
Past History
  • Diabetes/hypertension/tuberculosis/leprosy
  • Ocular surgery, previous recurrent attacks
  • Rheumatoid arthritis, SLE, ankylosing spondylitis
 
Ocular Examination
  • Best corrected visual acuity for distance and near
  • Refraction
  • IOP, gonioscopy
  • Anterior segment examination:
    • Conjunctiva—circumciliary congestion
    • Sclera—scleritis
    • Cornea—keratic precipitates (small/fine/white/stellate/medium- sized/mutton fat/greasy/inferiorly or throughout endothelium); disciform keratitis
    • Anterior chamber—cells, flare, hypopyon, hyphema, peripheral anterior synechiae
    • Iris—muddy, loss of crypts, heterochromia iridis, iris nodules, sector atrophy, new blood vessels, iris bombe’
    • Pupil—small, reaction to light, posterior synechiae, occlusion pupillae, seclusio pupillae, NVI, sphincter atrophy
    • Lens—cataract, subluxation
  • Posterior segment examination:
    • Vitreous cells
    • Snow banking, cystoid macular edema
    • Choroiditis, vasculitis, papillitis
 
EVALUATION OF PROPTOSIS
 
History
  • 8Onset, duration and progression of proptosis
  • Associated pain; nature of the pain
  • Decreased vision
  • Diplopia → in which gaze?
  • Field defects
  • Remissions/exacerbations
  • Diurnal variation; trauma
 
Systemic History
  • Fever, upper respiratory tract infection (sinusitis, lymphangioma, leukemia)
  • Any other cutaneous swellings (neurofibromatosis)
  • Epistaxis (nasal communication)
  • Dental infection
  • Skin lesions (café au lait spots in NF-1)
  • Allergies, nasal discharge, nasal polyps
  • Breast lumps, chronic cough, shortness of breath, hemoptysis (metastasis)
 
History Specific to Thyroid Orbitopathy
  • Increased/decreased appetite
  • Weight loss/gain
  • Palpitations, chest pain, shortness of breath
  • Hyperactivity/lethargy
  • Skin problems—dry skin, excessive sweating
  • Neck swelling
  • Hand tremors
  • Menorrhagia/amenorrhea
  • Sleep disturbances
 
Past History
  • Diabetes mellitus (DM) or hypertension (HTN)
  • Cardiovascular disease/CNS disorder/respiratory disorder
  • Previous ocular disease or surgery
 
Personal History
  • Diet/appetite/bowels/micturition
  • Smoking/alcohol intake
 
Family History
  • Similar complaints in the family
 
Treatment History
  • Use of steroids or other medication
 
General Examination
  • 9Conscious, coherent, moderately built
  • Pallor, icterus, cyanosis, clubbing, lymphadenopathy, pedal edema (PICCLE)
  • Dental and nasal examination
  • Thyroid (neck) and breast examination
  • Finger/hand tremors
  • Skin—dry/scaly; café au lait spots
Vital data
  • Temperature/BP/respiratory rate/heart rate
 
Systemic Examination
  • Heart—sounds; murmurs
  • Lung—breath sounds
  • Abdomen—hepatosplenomegaly; any masses
 
Ocular Examination
  • Best corrected visual acuity for distance and near
  • Refraction (high myopes → pseudoproptosis)
  • Visual fields, color vision
  • Ocular alignment—cover, uncover, alternate cover tests
  • Diplopia charting (if present); extraocular movements
  • Forced duction test (if any movement is restricted)
  • IOP; differential IOP; gonioscopy; applanation tonometry—check for pulsatile proptosis
  • Anterior segment evaluation; especially pupillary reaction
  • Fundus—any signs of optic nerve compression; CRVO; optic atrophy
 
Proptosis Evaluation
  • Facial symmetry; compensatory head posture
  • Lid retraction or lid lag, periocular fullness
  • If ptosis is present—evaluate levator function
 
Inspection
  • Naffziger's sign → on looking tangentially over the patient's forehead, palpebrae of the proptosed eye is seen first.
  • Bird's view or Worm's view can help in picking up subtle proptosis and differences between the two eyes.
  • Fullness or mass lesion in the orbit; visible pulsations or engorged veins
  • Lagophthalmos, Bell's phenomenon; corneal exposure
  • Conjunctival congestion over recti muscles (thyroid eye disease) diffuse congestion (vascular anomaly)
  • Change in size with Valsalva
 
Palpation
  • Orbital rim—any irregularity; mass lesion; can you insinuate your finger between the globe and orbital bones?
  • 10Size, shape, surface, margins, skin over-swelling, consistency, signs of inflammation, tenderness, reducibility and mobility
  • Variation with valsalva or bending down of the head
  • Resistance to retropulsion; pulsations, thrill
  • Corneal anesthesia, infraorbital/supraorbital anesthesia
 
Auscultation
  • Bruit over lesion/eyeball/ipsilateral forehead (Best heard with the bell of the stethoscope)
 
Exophthalmometry
  • Reading > 21 mm or a difference of > 2 mm between the two eyes suggests proptosis
  • Reading of 10–12 mm suggests enophthalmos
  • Hertel's exophthalmometer reading, e.g. base reading 110 mm, OD 24 mm, OS 20 mm
zoom view
Measure horizontal displacement: Mark a point (P) on the center of the bridge of the nose; place a scale over the bridge; measure the distance between (P) and the nasal limbus of both eyes
Measure vertical displacement: Place a scale perpendicular to the lateral canthus; measure the vertical displacement with a scale held perpendicular to the first scale
 
EVALUATION OF PTOSIS
 
History
  • 11Sudden/gradual in onset
  • Duration → present since birth?
  • Trauma
  • Diurnal variation → worse in the evening?
  • Worse in sunlight
  • Diplopia
  • General fatigue
 
Past History
  • Diabetes mellitus, hypertension
  • Previous ocular surgery—under local anesthesia?
  • Similar complaints in the past
 
Family History
  • Others in the family affected?
  • Consanguineous marriage
 
Ocular Examination
  1. Visual acuity for near and distance, without and with correction is checked; refraction
  2. Facial symmetry
  3. Compensatory head posture
  4. Brow elevation
  5. Cover/uncover test, Hirschberg's corneal reflex, Prism bar cover test (test ocular alignment)
  6. Extra-ocular movements—full/restricted
  7. Lids:
    • MRD 1—margin reflex distance 1 → distance between upper lid margin and corneal reflection of a pen torch (patient looking directly at it) Normal = 4–4.5 mm
    • MRD 2—margin reflex distance 2 → distance between lower lid margin and corneal reflection of a pen torch
    • VFH—vertical fissure height → MRD 1 + MRD 2; Normal: 8–12 mm; Measure in upgaze/ downgaze/primary gaze
    • MCD—margin crease distance—distance between upper lid margin and lid crease in downgaze; Normal in female = 10 mm; male = 8 mm
    • MLD—margin limbal distance—distance between upper lid margin and lower limbus in upgaze
    • LPS function—place a thumb firmly against patient's brow to negate the action of the frontalis; then patient looks up as far as possible; measure the excursion of the lid
      • Normal function = 15 mm
      • Good function = 12–14 mm
      • 12Fair function = 5–11 mm
      • Poor function = < 5 mm
    • Bell's phenomenon—present if upward and outward rotation of the globe occurs on forceful closure of the lids; if absent—patient may develop post-operative exposure keratopathy
    • Herring reflex → in unilateral ptosis, manually elevate the ptotic lid and look for drooping of the fellow upper lid (it may show a subtle bilateral ptosis in which case surgery may induce ptosis in the fellow eye)
    • Marcus Gunn jaw winking phenomenon—when patient makes chewing movements with his jaw, the lid intermittently droops and elevates
    • Tests for ocular myasthenia (mentioned under neuro-ophthalmology)
  8. Anterior segment examination, gonioscopy, IOP
  9. Fundus examination
 
EVALUATION OF CORNEAL ULCER
 
History
  • 13Onset, duration
  • Symptoms—pain, watering, discharge
  • Trauma, fall of foreign body, chemical injury
  • Viral infection, conjunctivitis
  • Dry eyes, contact lens wear
  • Swimming in dirty pools
  • Topical steroid use or other medication (keratitis medicamentosa)
  • Itching (shield ulcer)
  • Facial weakness
 
Past History
  • Recurrence; similar episodes in the past
  • DM, HTN, ocular surgery
  • TB, leprosy (neurotrophic ulcer)
 
Ocular Examination
  • Visual acuity for distance and near; any improvement with pin hole; refraction
  • Digital tonometry (applanation tonometry should not be done when keratitis exists)
  • Syringing; reflux of material with pressure over lacrimal sac; any discharge
  • Anterior segment examination:
    • Lids—blepharitis, hordeolum, trichiasis, entropion, lagophthalmos
    • Upper palpebral conjunctiva—giant papillae
    • Corneal sensation
    • Corneal ulcer—location (central/marginal); surrounding edema/infiltrate; stromal haze; shape and size; margins/edge/base/floor; satellite lesions; Wessely ring; fluorescein staining
      • Pre-auricular lymphadenopathy
      • Anterior chamber reaction; hypopyon
      • Pupillary reaction
  • Fundus examination