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Illustrated Medical Pharmacology SM Raju, AK Kapoor

SECTION 1: GENERAL PHARMACOLOGY
CHAPTER 1.1:Introduction and Terminology
- TERMINOLOGY
  - Pharmacokinetics
  - Pharmacodynamics
  - Pharmacotherapeutics
  - Clinical Pharmacology
  - Chemotherapy
  - Toxicology
  - Pharmacy
  - Pharmacopeia
  - Pharmaceutics
- NOMENCLATURE OF DRUGS
- SOURCES OF DRUGS
  - Products from Natural Sources
  - Synthetic Products
  - Products of Genetic Engineering
  - Prodrugs
- FACTORS AFFECTING DOSAGE AND THERAPEUTIC RESPONSE
  - Factors to Consider while Calculating the Therapeutic Dose
- EFFECTS OF DRUG INTERACTIONS
  - Secondary Effects
  - Drug-food Interactions
  - Drug-drug Interaction
  - Placebo Effect
  - Drug Dependency
  - Tolerance
  - Cross-tolerance
  - Tachyphylaxis
- DRUG THERAPY MONITORING
- LEGISLATION REGARDING NARCOTIC DRUGS
- DRUG DOSAGE CALCULATIONS
  - Formulae for Calculating Doses for Children
- BIOTRANSPORTATION OF DRUGS
  - Passive Diffusion
  - Carrier-Mediated Transport
  - Filtration
  - Pinocytosis
- DRUG ABSORPTION
  - Functional Groups Involved in Drug Absorption
    - Ionizable Groups on a Drug Molecule Alter their Absorption and Excretion
    - P-glycoprotein Expression Modulates Drug Absorption and Distribution
- DRUG ABSORPTION
  - Methods of Delaying Drug Absorption
  - Methods to Facilitate Absorption
  - First Pass Effect Alters the Bioavailability of Drugs
- DRUG DISTRIBUTION
  - Physiological Barriers of Drug Distribution
    - Blood-brain Barrier
    - Placental Barrier
- DRUG METABOLISM
  - Drug Transformation Reactions
    - Phase I Reactions
    - Phase II Reactions
  - Other Drug Interactions that Influence Drug Metabolism
- PEDIATRIC PHARMACOLOGY
- GERIATRIC PHARMACOLOGY
- PHARMACOGENETICS
  - Anticancer Drugs and Pharmacogenomics (Fig. 1.1.13)
- OTHER EXAMPLES OF GENETIC MUTATIONS AFFECTING DRUG RESPONSES
  - Vampire Syndrome
  - Hereditary Methemoglobinemia
- PEDIATRIC (NEONATE TO ABOUT 16 YEARS)
- GERIATRIC (AGED ABOVE 65 YEARS)
- WOMEN
  - Introduction to Drug Action
  - Disease Classification
  - Drug Classification
  - Drug Names
  - Mode of Drug Action
    - Killing Foreign Organisms
    - Stimulation and Depression
  - Sites of Drug Action
- ENZYME INHIBITION
  - Mechanisms of Drug Actions by Enzyme Inhibition
- DRUG RECEPTOR INTERACTIONS
  - Drug Interaction with Receptor Site
  - Drug Development and Approval Process
CHAPTER 1.2:Routes of Drug Administration
- ENTERAL ROUTE
- PARENTERAL ROUTE
- NASAL ROUTE
- CUTANEOUS OR TRANSDERMAL ROUTE
- TOPICAL (LOCAL) ROUTE
- OTHER ROUTES
  - Pulmonary Route (Inhalation)
    - Local Treatment
    - General Treatment
  - Ocular, Ear and Vaginal Routes
- PARTICULAR PREPARATIONS
  - Liposomes
  - Virus Vectors
- BIOAVAILABILITY
- BIOEQUIVALANCE
CHAPTER 1.3:Pharmacokinetics and Pharmacodynamics
- PHARMACOKINETICS
- PHARMACODYNAMICS
- REVIEW QUESTIONS
CHAPTER 1.4:Biotransformation of Drugs
- DRUG METABOLISM
SECTION 2: DRUGS AFFECTING AUTONOMIC NERVOUS SYSTEM
CHAPTER 2.1:Autonomic Nervous Systems
- NERVOUS SYSTEMS
  - Central Nervous System
  - Peripheral Nervous System
    - Afferent Division
    - Efferent Division
- NEUROTRANSMITTERS
  - Neurotransmitters of Autonomic Nervous System
    - Why are There so Many Brain Neurotransmitters?
    - Acetylcholine
- CHOLINERGIC RECEPTORS
  - Muscarinic Receptors
  - Nicotinic Receptors
    - Nicotinic 1 (N1) Receptors
- EFFECTS OF DRUGS
- REVIEW QUESTIONS
CHAPTER 2.2:Adrenergic Drugs
- ADRENERGIC RECEPTORS
- ADRENERGIC STIMULANTS (AGONISTS)
- SUMMARY OF CLINICAL USES OF SYMPATHOMIMETIC AGENTS
- ADRENERGIC ANTAGONISTS (BLOCKERS)
- DRUGS AFFECTING NEUROTRANSMITTER RELEASE OR UPTAKE
- CONDITIONS THAT RESEMBLE MYASTHENIA GRAVIS
  - Neurasthenia
  - Associated Disorders
- REVIEW QUESTIONS
CHAPTER 2.3:Cholinergic Drugs
- CELLULAR EVENTS FOLLOWING CHOLINERGIC RECEPTOR ACTIVATION
- SECOND MESSENGER SYSTEMS
  - Muscarinic Receptor Activation by Nitric Oxide
    - Nitric Oxide Synthase
- STIMULATION OF CHOLINERGIC RECEPTORS
- ANTAGONISTS (INHIBITION) OF CHOLINERGIC RECEPTORS
  - Clinical Uses of Cholinergic Receptor Blockers
  - Antispasmodics
    - Smooth Muscle Spasm
- REVIEW QUESTIONS
CHAPTER 2.4:Antimyasthenic Drugs
- CLASSIFICATION OF ANTIMYASTHENIC DRUGS
- REVIEW QUESTIONS
SECTION 3: DRUGS AFFECTING CENTRAL NERVOUS SYSTEM
CHAPTER 3.1:Central Nervous System
- NEUROTRANSMITTERS
- CENTRAL NERVOUS SYSTEM STIMULANTS
  - Caffeine
  - Amphetamines
- ANTIDEPRESSANT
  - Tricyclic Antidepressants
    - Imipramine (Tofranil) and Desipramine (Norpramin)
  - Inhibitory Action of Antidepressants on Serotonin Uptake
    - Selective Serotonin Reuptake Inhibitors
    - Monoamine Oxidase Inhibitors
- HALLUCINOGENIC DRUGS
  - Mescaline and Psilocybin
  - Lysergic Acid Diethylamide
- CENTRAL NERVOUS SYSTEM DEPRESSANTS—SEDATIVE AND HYPNOTIC AGENTS
  - Barbiturates
  - Benzodiazepines
- NARCOTIC ANALGESIC DRUGS
- NARCOTIC ANTAGONISTS
- LOCAL ANESTHETICS
- REVIEW QUESTIONS
CHAPTER 3.2:Anxiolytics and Sedative–Hypnotics
- CLASSIFICATION OF ANXIOLYTICS AND HYPNOTIC DRUGS
- PHARMACOKINETICS
- MAJOR HYPNOTIC DRUG CLASSES
- BENZODIAZEPINE ANTAGONIST
  - Flumazenil (Romazicon)
    - Untoward Effects
    - Drug Interactions
- REVIEW QUESTIONS
CHAPTER 3.3:Antiepileptics
- EPILEPSY
- ANTIEPILEPTIC AGENTS
- SPECIAL CONSIDERATIONS FOR STARTING ANTIEPILEPTIC THERAPY
- REVIEW QUESTIONS
CHAPTER 3.4:General Anesthetics
- CLASSIFICATION OF DRUGS USED FOR GENERAL ANESTHESIA
- PROCEDURE FOR GENERAL ANESTHESIA
- STAGES OF ANESTHESIA
- CAUSES OF MORTALITY
- INTRAVENOUS ANESTHETICS
- INHALATION ANESTHETICS
- REVIEW QUESTIONS
CHAPTER 3.5:Local Anesthetics
- CLASSIFICATION OF LOCAL ANESTHETICS
  - Natural Local Anesthetics
  - Synthetic Local Anesthetics
- PROPERTIES
- MECHANISM OF ACTION OF LOCAL ANESTHETICS
- PHARMACOKINETICS
  - Absorption and Distribution
  - Metabolism and Excretion
- EFFECTS OF LOCAL ANESTHETICS
- PREPARATIONS
- CLINICAL USES OF LOCAL ANESTHETICS
  - Regional Anesthesia
  - Cocaine Toxicity
    - Untoward Effects of Acute Administration
    - Treatment of Cocaine Toxicity
- REVIEW QUESTIONS
CHAPTER 3.6:Parkinson's Disease
- CLINICAL MANIFESTATIONS
- MEDICATIONS FOR PARKINSON'S DISEASE
- REVIEW QUESTIONS
CHAPTER 3.7:Skeletal Muscle Relaxants
- SPASTICITY
  - Clinical Spasticity
- SPASMOLYTIC AGENTS
- NEUROMUSCULAR BLOCKING AGENTS
- NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS
- DEPOLARIZING NEUROMUSCULAR BLOCKING DRUGS
  - Succinylcholine (Anectine)
- SKELETAL MUSCLE SPASM
- CLINICAL PHARMACOLOGY OF NEUROMUSCULAR-BLOCKING AGENTS
  - Dose Guidelines
- REVERSAL OF NEUROMUSCULAR BLOCKADE BY ANTAGONIST
  - Special Considerations in Reversal of Neuromuscular Blockade
- REVIEW QUESTIONS
CHAPTER 3.8:Antipsychotic Drugs
- SCHIZOPHRENIA
- CLASSIFICATION OF ANTIPSYCHOTIC DRUGS (TABLE 3.8.1)
- CLINICAL USES OF ANTIPSYCHOTICS
- ANTIMANIC AGENTS
  - Lithium
- REVIEW QUESTIONS
CHAPTER 3.9:Central Nervous System Stimulants and Antidepressants
- STIMULANTS OF CENTRAL NERVOUS SYSTEM
- SEROTONIN ANTAGONISTS
- ANTIDEPRESSANT AGENTS
- REVIEW QUESTIONS
CHAPTER 3.10:Opioid Analgesic and Antagonists
- DISTRIBUTION OF OPIOID RECEPTORS AND THEIR INFLUENCE
- CLASSIFICATION OF OPIOIDS (TABLE 3.10.1)
- EFFECT OF OPIOID ANALGESICS ON THE CENTRAL NERVOUS SYSTEM
  - Morphine
  - Endogenous Opioid Peptides
- PHARMACOKINETICS
- PHARMACODYNAMICS
- NEUROCHEMISTRY OF PAIN
  - Abuse of Opioid
  - Tolerance/Physical Dependence
- ORGAN SYSTEM EFFECTS OF OPIOIDS
- ORGAN SYSTEM EFFECTS OF PENTAZOCINE AND OTHER AGONIST-ANTAGONISTS
  - Toxic Effects of Opioids
    - Nausea and Vomiting
  - Untoward Effects
- CLINICAL USES
- SPECIFIC DRUGS
- OPIOID ANTAGONISTS (PURE ANTAGONISTS)
  - Pharmacodynamics of Opioid Antagonists
  - Antagonist Drugs
- REVIEW QUESTIONS
CHAPTER 3.11:Ergot Alkaloids
- CLASSIFICATION
- ORGAN SYSTEMS EFFECTED BY ERGOT ALKALOIDS
- MIGRAINE
- REVIEW QUESTIONS
CHAPTER 3.12: Alcohols
- IMPORTANT COMMONLY ENCOUNTERED ALCOHOLS
- EFFECTS OF ALCOHOL
- PHARMACOKINETICS
- ALCOHOL ABUSE
- METHANOL ABUSE
  - Treatment
CHAPTER 3.13:Drug Abuse
- MEDICAL DEFINITIONS
- SIGNS AND SYMPTOMS
- DRUG ABUSE
SECTION 4: DRUGS ACTING ON CARDIOVASCULAR AND RENAL SYSTEM
CHAPTER 4.1:Antihyperlipidemic Agents
- LIPOPROTEIN METABOLISM
- STRATEGIES FOR TREATING HYPERLIPIDEMIAS
  - First Line of Agents
  - Second Line of Agents
    - Fibrates
    - Nicotinic Acid
- REVIEW QUESTIONS
CHAPTER 4.2:Anticoagulants
- ANTICOAGULANT DRUGS
  - Types of Anticoagulant Drugs
- CLASSIFICATION OF ANTICOAGULANTS
  - Parenteral Anticoagulants
    - Heparin and Low-molecular Weight Heparin
    - Heparin Antagonists
  - Oral Anticoagulants
    - Warfarin Antagonists
- CLINICAL USES OF ANTICOAGULANTS
- RECOMMENDED DOSAGE
- PRECAUTIONS
- UNTOWARD EFFECTS
- INTERACTIONS
CHAPTER 4.3:Thrombolytic Drugs
- THROMBOLYTIC THERAPY
CHAPTER 4.4:Antiplatelet Drugs
- ASPIRIN
  - Dose and Duration
  - Adverse Effects
- THIENOPYRIDINES
  - Clopidogrel
    - Clinical Uses
    - Adverse Effects
  - Ticlopidine
- GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGONISTS
- OTHER ANTIPLATELET DRUGS
CHAPTER 4.5:Antiarrhythmic Drugs
- THERAPEUTIC USE
- MECHANISM OF ACTION
  - Treatment of Arrhythmias
- CLASSES OF DRUGS USED TO TREAT ARRHYTHMIAS
- REVIEW QUESTIONS
CHAPTER 4.6:Vasoactive Drugs
- VASODILATORS
- PRESSOR DRUGS
- VASOCONSTRICTORS
- REVIEW QUESTIONS
CHAPTER 4.7:Cardioinhibitory Drugs
- THERAPEUTIC USES OF CARDIOINHIBITORY DRUGS
- DRUG CLASSES AND GENERAL MECHANISMS OF ACTION
CHAPTER 4.8:Cardiostimulatory Drugs
- THERAPEUTIC USE OF CARDIOSTIMULATORY DRUGS
  - Heart Failure and Cardiogenic Shock
  - Circulatory Shock
- DRUG CLASSES AND GENERAL MECHANISMS OF ACTION
CHAPTER 4.9:Diuretics
- FORMATION OF URINE
- THERAPEUTIC USES
  - Cardiovascular Effects of Diuretics
  - Pulmonary and Systemic Edema
- TYPES OF DIURETICS
- REVIEW QUESTIONS
CHAPTER 4.10:Antihypertensive Drugs
- HYPERTENSION
- RATIONALE OF REDUCING ARTERIAL PRESSURE
  - Reduce Cardiac Output
  - Reduce Systemic Vascular Resistance
- ANTIHYPERTENSIVE DRUGS
  - Diuretics
    - Chlorothiazide (Diuril)
  - Loop Diuretics
    - Untoward Effects
- SYMPATHOLYTICS
- ANGIOTENSIN CONVERTING ENZYME INHIBITORS
  - Angiotensin II Receptor Antagonists
- REVIEW QUESTIONS
CHAPTER 4.11:Antianginal Drugs
- ANGINA
- NITRATES
- β-BLOCKERS
- POTASSIUM-CHANNEL OPENERS
- MYOCARDIAL INFARCTION
  - Management of Myocardial Infarction
  - Action of IV Morphine in MI
- REVIEW QUESTIONS
CHAPTER 4.12:Cardiac Glycosides
- MECHANISM OF ACTION
- PHARMACOLOGICAL ACTIONS
  - Cardiac Effects
  - Extracardiac Effects
- TOXICITY OF DIGITALIS
- CONTRAINDICATIONS TO DIGITALIS THERAPY
- DRUG INTERACTIONS
- CLINICAL USES
- OUABAIN
- REVIEW QUESTIONS
SECTION 5: ENDOCRINE DRUGS
CHAPTER 5.1:Hypothalamic and Pituitary Hormones
- HYPOTHALAMUS
- PITUITARY GLAND
- PITUITARY HORMONES
- REVIEW QUESTIONS
CHAPTER 5.2:Thyroid and Antithyroid Drugs
- THYROID HORMONES
- ANTITHYROID DRUGS
- THYROID HORMONE DEFICIENCY
- REVIEW QUESTIONS
CHAPTER 5.3:Adrenocorti-costeroids and their Antagonists
- ADRENAL GLAND
- ADRENOCORTICOSTEROIDS
- INDICATIONS FOR CORTICOSTEROIDS
- ANTAGONISTS OF ADRENOCORTICAL AGENTS
  - Synthesis Inhibitors and Glucocorticoid Antagonists
  - Mineralocorticoid Antagonist
- REVIEW QUESTIONS
CHAPTER 5.4:Insulin
- INSULIN
  - Proposed Mechanism of Insulin Secretion
  - Proposed Mechanism of Insulin Action
    - Receptor Activation
    - Action of Insulin at Target Sites
- GLUCAGON
  - Clinical Uses
  - Untoward Effects
- INSULIN THERAPY
- ORAL HYPOGLYCEMICS AGENTS
- REVIEW QUESTIONS
CHAPTER 5.5:Gonadal Hormones and their Inhibitors
- GONADAL HORMONES
- OVARY
  - Puberty—Mechanism and Ovarian Function
    - Ovarian Cycle
  - Menopause
    - Anomalies in Ovarian Function
- ESTROGENS
- PROGESTINS
- OTHER OVARIAN HORMONES
- HORMONAL CONTRACEPTION
- ESTROGEN/PROGESTERONE INHIBITORS AND ANTAGONISTS
- OTHER OVARIAN INHIBITORS
  - Anastrozole
  - Letrozole/Fadrozole
- OVULATION-INDUCING DRUGS
  - Clomiphene (Clomifene)
- TESTES
- REVIEW QUESTIONS
CHAPTER 5.6:Agents Affecting Bone Mineral Homeostasis
- INTESTINAL ABSORPTION
  - Calcium
  - Phosphorus
- CALCIUM METABOLISM
- PHOSPHATE METABOLISM
- FLUXES OF CALCIUM AND PHOSPHATE
- HORMONAL CONTROL SYSTEMS
- OSTEOPOROSIS
  - Treatment
SECTION 6: DRUGS USED TO TREAT DISEASES OF BLOOD
CHAPTER 6.1:Drugs used in Disorders of Coagulation
- MECHANISM OF BLOOD COAGULATION
  - Sequence
  - Regulation Factors
- REGULATION OF COAGULATION AND FIBRINOLYSIS
  - Fibrinolysis
  - Drug Acting on Fibrinolytic System
- ANTICOAGULANT DRUGS
  - Heparin
  - Warfarin and Coumarin
- PHARMACOLOGICAL MANAGEMENT OF THROMBOSIS
- DRUGS USED IN BLEEDING DISORDERS
- REVIEW QUESTIONS
CHAPTER 6.2:Drugs used in Diseases of Hematopoietic System
- ANEMIA
  - Signs and Symptoms
  - Classification of Anemia
- DRUGS AFFECTING HEMATOPOIETIC SYSTEM
SECTION 7: DRUGS AFFECTING OTHER SYSTEMS
CHAPTER 7.1:Pulmonary Pharmacology: Asthma
- DEFINITION OF ASTHMA
- DIAGNOSIS
- LONG-TERM CONTROL
- QUICK RELIEF OF SYMPTOMS OR EXACERBATIONS SYMPTOMS
- DRUGS USED IN THE TREATMENT OF ASTHMA
- MEDICINES THAT LOOSEN LUNG SECRETIONS
  - Expectorants
  - Mucolytics
- POSTNASAL DRIP
  - Nasal Decongestion
- REVIEW QUESTIONS
CHAPTER 7.2:Gastrointestinal Drugs
- ACID-PEPTIC DISEASES
- GASTRIC PHYSIOLOGY
  - Physiological Stimulants
  - Physiologic Inhibition
- DRUGS USED IN ACID-PEPTIC DISEASE
- ANTIDIARRHEAL DRUGS
- LAXATIVES
- GASTROKINETIC (PROKINETIC) AGENTS
  - Bethanechol (Duvoid, Myotonachol and Urecholine)
    - Clinical Uses
    - Contraindications
  - Metoclopramide (Reglan) and Domperidone
- ANTIEMETIC DRUGS
  - Commonly used Antiemetic Drugs
- REVIEW QUESTIONS
CHAPTER 7.3:Anthelmintic Drugs
- CHEMOTHERAPY OF HELMINTHIC INFECTIONS
- DRUGS FOR THE TREATMENT OF NEMATODES
- DRUGS FOR THE TREATMENT OF CESTODES
  - Albendazole (Albenza, Eskazole, Zentel)
  - Niclosamide (Niclocide)
- DRUGS FOR THE TREATMENT OF TREMATODES
  - Oxamniquine
- DRUGS FOR THE TREATMENT OF TREMATODES AND CESTODES
  - Praziquantel
- DRUGS FOR THE TREATMENT OF FILARIASIS
SECTION 8: CHEMOTHERAPEUTIC DRUGS
CHAPTER 8.1:Antibacterial Drugs
- CLASSIFICATION
- PROPOSED COMMON MECHANISM OF BACTERICIDAL ANTIBIOTICS
  - Inhibitors of Cell Wall Synthesis
- CEPHALOSPORINS
  - Cephalosporins and their Spectrum of Pharmacological Action
- OTHER β-LACTAM CONTAINING ANTIBACTERIALS
- OTHER INHIBITORS OF CELL WALL SYNTHESIS
- AMINOGLYCOSIDES
- CHLORAMPHENICOL, TETRACYCLINES AND CLINDAMYCIN
- MACROLIDES
- DISRUPTERS OF NUCLEIC ACID SYNTHESIS
- SULFA DRUGS
- BACTERIAL RESISTANCE TO ANTIBIOTICS
- CATIONIC PEPTIDES
- REVIEW QUESTIONS
CHAPTER 8.2:Antimycobacterial Agents
- TUBERCULOSIS
- ANTITUBERCULAR DRUGS
- CLINICAL USES
- CLASSIFICATION
  - First-line Drugs
  - Other Drugs
- RATIONALE AND EVIDENCE FOR THE STANDARD REGIMEN
  - Monitoring, DOTS and DOTS-Plus
- DRUG-RESISTANT TUBERCULOSIS
- TUBERCULOSIS OF THE CENTRAL NERVOUS SYSTEM
- USE OF STEROIDS IN TREATING TUBERCULOSIS
- REVIEW QUESTIONS
CHAPTER 8.3:Antiviral Drugs
- ACTION OF ANTIVIRAL DRUGS ON LIFE CYCLE OF VIRUS
- LIMITATIONS OF VACCINES
- HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
- TREATMENT OF PNEUMONIA IN AIDS
  - Trimetrexate (Neutrexin)
- REVIEW QUESTIONS
CHAPTER 8.4:Antifungal Drugs
- FUNGAL INFECTIONS
  - Classes of Antifungal Drugs
- SYSTEMIC ANTIFUNGAL DRUGS FOR SYSTEMIC MYCOSES
- DRUGS FOR CUTANEOUS MYCOSES
- TOPICAL DRUGS
  - Imidazoles and Triazoles
  - Polyene Macrolide Antibiotics
- FUNGAL INFECTIONS IN HIV
- REVIEW QUESTIONS
CHAPTER 8.5:Antiprotozoal Drugs
- ANTIMALARIAL DRUGS
- PARASITIC LIFE CYCLE
- CLASSIFICATION OF ANTIMALARIAL DRUGS
- CLASSIFICATION BASED ON SITE OF DRUG ACTION AND PARASITE LIFE CYCLE
- MALARIA CHEMOPROPHYLAXIS
- TREATMENT OF MALARIA
- DRUGS AGAINST PNEUMOCYSTIS JIROVECII
- DRUGS AGAINST TRICHOMONIASIS
  - Orally used Drugs
  - Intravaginally used Drugs
- ANTIAMEBIC DRUGS
  - Life Cycle of E. histolytica
  - Drugs used to Treat Amebiasis
- DRUGS AGAINST LEISHMANIASIS
- DRUGS AGAINST GIARDIASIS
  - Pharmacological Management of Giardiasis
- CHEMOTHERAPY FOR TOXOPLASMOSIS
  - Treatment
  - Precaution
- REVIEW QUESTIONS
CHAPTER 8.6:Urinary Antiseptics
- NITROFURANTOIN (FURADANTIN, MACROBID, MACRODANTIN, NITRO MACRO AND URANTOIN)
- NALIDIXIC ACID (NEVIGRAMON, NEGGRAM, WINTOMYLON)
CHAPTER 8.7:Cancer Chemotherapy
- GOAL OF CANCER CHEMOTHERAPY
- PROBLEMS WITH CANCER CHEMOTHERAPY
- IMMUNOLOGICAL ASPECTS OF CANCER CHEMOTHERAPY
- CATEGORIES OF CHEMOTHERAPY DRUGS
- ANTIMETABOLITES
- ALKYLATING AGENTS
- ANTIBIOTICS
- MITOTIC DISRUPTORS
- ENZYME ANTICANCER AGENT
  - L-asparaginase
    - Clinical Uses
    - Untoward Effects
- HORMONES
- HORMONES ANTAGONISTS
  - Estrogen and Androgen Inhibitors (Tamoxifen and Flutamide)
    - Tamoxifen
    - Flutamide (Eulexin)
  - Gonadotropin-releasing Hormone Agonists (Leuprolide and Goserelin Zoladex)
    - Leuprolide and Goserelin
- MONOCLONAL ANTIBODIES
- OTHERS
  - Retinoic Acid Derivatives
    - Clinical Uses
    - Adverse Effects
  - Imatinib
- CELL CYCLE SPECIFIC CHEMOTHERAPEUTIC DRUGS
- REVIEW QUESTIONS
CHAPTER 8.8:Drugs Affecting the Immune System
- T HELPER 1—CELL-MEDIATED IMMUNITY
- INAPPROPRIATE IMMUNE RESPONSE
- ANTIBODY REAGENTS
- IMMUNOSUPPRESSANTS
- IMMUNOMODULATORS
SECTION 9: ANTI-INFLAMMATORY AND ANALGESIC DRUGS
CHAPTER 9.1:Anti-inflammatory Drugs
- NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
- REVIEW QUESTIONS
CHAPTER 9.2:Antirheumatic Drugs
- METHOTREXATE
  - Untoward Effects
- CHLOROQUINE AND HYDROXYCHLOROQUINE
- TUMOR NECROSIS FACTOR-ALPHA BLOCKING DRUGS
- GOLD COMPOUNDS
- PENICILLAMINE
- SULFASALAZINE
- GLUCOCORTICOIDS
  - Pharmacodynamics
  - Untoward Effects
CHAPTER 9.3:Drugs for Gout
- GOUT
- CLASSIFICATION OF DRUGS USED IN GOUT

INDEX

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Chapter Notes