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Color Atlas of Differential Diagnosis in Dermatopathology
Loren E Clarke, Jennie T Clarke, Klaus F Helm
CHAPTER 1:
Normal Skin Pattern: When the histology looks like normal skin
INTRODUCTION
FINDINGS WITHIN STRATUM CORNEUM
Disorders of Epidermis andStratum Corneum
Disorder Involving Epidermal Pigmentation
FINDINGS WITHIN THE DERMIS
Disorders Involving Subcutaneous Tissue
CHAPTER 2:
The Spongiotic and Psoriasiform Patterns
THE SPONGIOTIC PATTERN
Common Types of Spongiotic Dermatitis
Contact Dermatitis
Atopic Dermatitis (Figs 2.2A to C)
Nummular Dermatitis
Seborrheic Dermatitis
Dyshidrotic Dermatitis (Pompholyx) (Figs 2.5A to C)
Stasis Dermatitis (Figs 2.6A to D)
Xerotic (Asteatotic) Dermatitis
Pityriasis Rosea (Figs 2.8A to D)
Insect Bite Reaction
Polymorphous Light Eruption
Pruritic Urticarial Papules and Plaques of Pregnancy/Polymorphous Eruption of Pregnancy
Dermatophytosis (Tinea) (Figs 2.12A to D)
Grover's Disease (TransientAcantholytic Dermatosis)
Gianotti-Crosti Syndrome (Papular Acral Dermatitis of Childhood)
Parapsoriasis and Mycosis Fungoides
Psoriasis (Figs 2.16A to J)
Pityriasis Rubra Pilaris
Nutritional Deficiency Dermatoses and Glucagonoma Syndrome
Prurigo Nodule/Lichen Simplex Chronicus
CHAPTER 3:
The Interface and Perivascular/Periadnexal Patterns
INTRODUCTION
THE VACUOLAR PATTERN
Erythema Multiforme (EM) (Figs 3.5A to E)
Toxic Epidermal Necrolysis (Figs 3.6A and B)
Systemic Lupus Erythematosus (Figs 3.7A to C)
Subacute Cutaneous Lupus Erythematosus (SCLE) (Figs 3.8A to E)
Dermatomyositis (Figs 3.9A to E)
INTERFACE DRUG ERUPTION (FIGS 3.10A TO C)
Fixed Drug Eruption (Figs 3.11A and B)
Acute Graft-Versus-Host Disease (GVHD) (Figs 3.12A to C)
THE LICHENOID PATTERN
Lichen Planus (Figs 3.13A to G)
Lichenoid Keratosis (Lichen Planus-Like Keratosis) (Figs 3.14A to E)
Lichenoid Reactions to Neoplasms (Figs 3.15A to D)
Lichen Striatus (Figs 3.16A to C)
Lichen Nitidus (Figs 3.17A to D)
Chronic Graft-Versus-Host Disease* (GVHD) (Figs 3.18A to C)
Porokeratosis (Figs 3.19A to C)
Paraneoplastic Pemphigus (Figs 3.20A and B)
Lichenoid Pigmented Purpuric Eruption (Gougerot and Blum) (Figs 3.21A and B)
Lichen Sclerosus (Figs 3.22A and B)
THE PITYRIASIFORM PATTERN
Pityriasis Lichenoides Chronica(Figs 3.23A to D)
Pityriasis Lichenoides et Varioliformis Acuta (Figs 3.24A to C)
THE INTERFACE AND PERIVASCULAR/PERIADNEXAL PATTERNS
Discoid Lupus Erythematosus (Figs 3.25A to E)
Secondary Syphilis (Figs 3.26A to C)
Pernio (Figs 3.27A to D)
Erythema Migrans (Borreliosis, Lyme disease) (Figs 3.28A to C)
Chronic Actinic Dermatitis/Actinic Reticuloid (Figs 3.29A to D)
Other Conditions with an Interface Pattern
Mycosis Fungoides
Lichen Amyloidosis
Interface/Lichenoid Reactions to Tattoo
Polymorphous Light Eruption
Dermatophytosis/Tinea
CHAPTER 4:
The Blistering and Acantholytic Patterns
INTRODUCTION
THE INTRAEPIDERMALBLISTERING PATTERN
Impetigo and Bullous Impetigo (Figs 4.2A to C)
Staphylococcal Scalded Skin Syndrome (Figs 4.3A to C)
Bullous Tinea/Bullous Dermatophytosis (Figs 4.4A to C)
Immunoglobulin A Pemphigus
Subcorneal Pustular Dermatosis(Sneddon-Wilkinson disease)
Infantile Acropustulosis
Bullous Diabetocorum
Pemphigus Foliaceus (Figs 4.8A to D)
Pemphigus Erythematosus
Hailey-Hailey Disease (Figs 4.9A to D)
Darier's Disease (Figs 4.10A to E)
Grover's Disease (Focal TransientAcantholytis Dyskeratosis) (Figs 4.11A to D)
Warty Dyskeratoma
Acantholytic Dyskeratotic Acanthoma (Figs 4.13A and B)
Herpes Virus Infection (Figs 4.14A to D)
Pemphigus Vulgaris (Figs 4.15A to G)
Pemphigus Vegetans
Paraneoplastic Pemphigus
THE SUBEPIDERMALBLISTERING PATTERN
Bullous Pemphigoid (Figs 4.18A to F)
Pemphigoid (Herpes) Gestationis
Cicatricial Pemphigoid (Figs 4.20A to D)
Epidermolysis Bullosa Acquisita (Figs 4.21A to C)
Porphyria/Pseudoporphyria (Figs 4.22A to E)
Bullous Lupus Erythematosus
Dermatitis Herpetiformis
Linear IgA Bullous Dermatosis (Figs 4.25A to C)
Bullous Arthropod Bite Reaction (Figs 4.26A to C)
Bullous Light Eruption
Bullous Erythema Multiforme
Blisters Due to Dermolysis
CHAPTER 5:
Follicular Processes
INTRODUCTION
INFECTIOUS BACTERIAL FOLLICULITIS
MAJOCCHI'S GRANULOMA
HERPES ZOSTER
NONINFECTIOUS CAUSES OF FOLLICULITIS (BOX 5.1)
Acne Vulgaris and Variants
Rosacea (Figs 5.5A to C)
Eosinophilic Folliculitis (Ofuji's Disease) and Eosinophilic Folliculitis of HIV Disease (Fig. 5.6)
ALOPECIA
Nonscarring Alopecia
Scarring Alopecia
CHAPTER 6:
The Nodular and Diffuse Dermal Infiltrative Patterns
INTRODUCTION
THE GRANULOMATOUS PATTERN (TABLE 6.1)
Sarcoidosis
Foreign Body Granulomatous Reactions (Table 6.2)
Granulomatous Rosacea
Lupus Miliaris Disseminatus Faciei (Acne Agminata)
Chalazion
Cheilitis Granulomatosa (Melkersson-Rosenthal Syndrome)
Cutaneous Crohn's Disease
Ruptured Cysts and Hair Follicles/Acneiform Papules
Granulomatous Reactions to Deep Fungal Infections (and Filamentous Bacteria) (Figs 6.9A to C)
Septated Hyphal Fungal Organisms
Nodular Granulomatous Perifolliculitis (Majocchi's Granuloma)
Aspergillosis
Hyalohyphomycosis
Chromomycosis (Chromoblastomycosis)
Phaeohyphomycosis
Alternariosis
Nonseptated Fungal Organisms
Zygomycetes
Mucorales (Mucor, Rhizopus and Absidia)
Entomophthorales
Granule-Forming Filaments (Mycetoma)
Actinomycotic Mycetoma (Bacteria)
Nocardiosis
Actinomyces, Streptomyces
Eumycotic Mycetoma (Fungi)
Brown Hyphae
Clear Hyphae
Yeast-Like Fungal Organisms with Pseudohyphae
Disseminated Candidiasis
Other Molds (with Septated or Nonseptated Hyphae)
Yeast without Pseudohyphae (Table 6.3)
Disseminated Candidiasis
Coccidiomycosis
Cryptococcosis
Histoplasmosis
Blastomycosis
Paracoccidioides
Sporothrix
Other Molds (Septate/Nonseptate Hyphae)
Granulomatous Reactions to Other Infections
Tuberculosis (Table 6.4)
Nontuberculous Mycobacterial Infections (“Atypical” Mycobacteria) (Table 6.5)
Leprosy, Tuberculoid Type
Secondary or Tertiary Syphilis
Leishmaniasis (Chronic form)
Protothecosis
Cat-Scratch Disease
Pyoderma Vegetans (Blastomycosis-like Pyoderma)
THE PALISADING GRANULOMATOUSPATTERN (TABLE 6.6)
Granuloma Annulare (Figs 6.29A to F)
Interstitial/Incomplete Granuloma Annulare
Deep Granuloma Annulare
Necrobiosis Lipoidica
Necrobiotic Xanthogranuloma (Figs 6.31A to C)
Rheumatoid Nodule (Figs 6.32A to D)
THE NEUTROPHILIC/SUPPURATIVE DERMATITIS PATTERN (TABLE 6.7)
Arthropod and Arachnid Bite Reactions
Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis) (Figs 6.34A to D)
Pyoderma Gangrenosum (Figs 6.35A to C)
Behcet's Disease
Rheumatoid Neutrophilic Dermatosis
Interstitial Granulomatous Dermatitis and Palisaded Neutrophilic Granulomatous Dermatitis
Gastrointestinal Associated Neutrophilic Dermatosis (Bowel-Bypass Syndrome) (Figs 6.38A to C)
Hidradenitis Suppurativa (see Table 6.3)
Infectious Causes of Diffuse Suppurative/Neutrophilic Dermatitis
Bacillary Angiomatosis
Bartonellosis (Verruga Peruana)
Botryomycosis (Bacterial Pseudomycosis)
Toxic Shock Syndrome
Suppurative Folliculitis/Furunculosis
Ecthyma
Ecthyma Gangrenosum
Erysipelas/Cellulitis
Atypical Mycobacterial Infections
THE DIFFUSE HISTIOCYTIC DERMATITIS PATTERN (TABLE 6.8)
Juvenile Xanthogranuloma and Adult Xanthogranuloma
Reticulohistiocytoma and Multicentric Reticulohistiocytosis
Xanthoma Disseminatum
Generalized Eruptive Histiocytosis
Progressive Nodular Histiocytosis
Xanthomas
Rosai-Dorfman Disease
Infectious Causes of Diffuse Histiocytic Infiltrates
Histoplasmosis
Penicilliosis
Lepromatous Leprosy
Leishmaniasis
Trypanosomiasis
Malakoplakia
Rhinoscleroma
Rhinosporidiosis
THE LYMPHOPLASMACYTIC DERMATITIS PATTERN (TABLE 6.9)
Hematolymphoid Neoplasms
Infectious Causes of Lymphoplasmacytic Infiltrates
Secondary and Tertiary Syphilis
Lymphogranuloma Venereum
Chancroid
Granuloma Inguinale
Toxoplasmosis
Rhinoscleroma
DERMAL INFESTATIONS AND ARTHROPOD BITE REACTIONS
Onchocerciasis
Tungiasis
Larva Migrans
Schistosomiasis
Cysticercosis
Scabies
Tick Bite
CHAPTER 7:
The Vasculopathic Pattern
INTRODUCTION
THE OCCLUSIVE VASCULOPATHY PATTERN
Occlusive Vasculopathies with Minimal Vascular Damage
Severe Occlusive Vasculopathies (Vasculopathy with Extensive Vascular Damage, Hemorrhage and/or Necrosis)
Occlusive Vasculopathies with Characteristic Clinical or Histopathologic Features
Livedoid Vasculopathy/Atrophie Blanche (Fig. 7.3A)
Cryoglobulinemia Type 1 (Figs 7.4A to C)
Cholesterol Emboli
Calciphylaxis (Figs 7.6A and B)
THE ACUTE VASCULITIS PATTERN
Leukocytoclastic Vasculitis (Hypersensitivity Vasculitis, Small Vessel Neutrophilic Vasculitis)
Urticarial Vasculitis
Henoch-Schonlein Purpura (HSP) (Fig. 7.9)
Mixed Cryoglobulinemia (Types II and III)
Septic Vasculitis (Figs 7.10A and B)
Microscopic Polyangiitis
Polyarteritis Nodosa
THE FIBROSING VASCULITIS PATTERN
Erythema Elevatum Diutinum (Figs 7.13A to C)
Granuloma Faciale (Figs 7.14A and B)
Localized Chronic Fibrosing Vasculitis (Figs 7.15A and B)
VASCULITIS WITH MACROPHAGES/GRANULOMAS
Wegener's Granulomatosis
Churg-Strauss Syndrome (Figs 7.17A and B)
CHAPTER 8:
Panniculitis
INTRODUCTION
SEPTAL PANNICULITIS
Erythema Nodosum (Figs 8.1A to E)
Differential Diagnosis of Lobular Lymphocytic Panniculitis
Subcutaneous T-Cell Lymphoma (Figs 8.2A to C)
Lupus Panniculitis (Figs 8.3A to D)
Differential Diagnosis of Neutrophilic Panniculitis
Pancreatic Panniculitis
Infectious Panniculitis
Alpha One Antitrypsin Deficiency
Differential Diagnosis of Lobular Histiocytic Panniculitis
Infectious Panniculitis
Erythema Induratum/Nodular Vasculitis (Figs 8.5A and B)
Subcutaneous Fat Necrosis of Newborn (Figs 8.6A to D)
NONINFLAMMATORY PANNICULITIDES
Calciphylaxis (Figs 8.7A to C)
Lipodermatosclerosis (Figs 8.8A to C)
CHAPTER 9:
Fibrosing Dermatitis
INTRODUCTION
Morphea/Scleroderma
Lichen Sclerosus
Chronic Radiation Dermatitis
Scleromyxedema/Lichen Myxedematosus/Papular Mucinosis
Nephrogenic Systemic Fibrosis
Erythema Elevatum Diutinum
Stasis Dermatitis
CHAPTER 10:
The Depositional Pattern
INTRODUCTION
AMYLOIDOSES
Systemic Amyloidoses
Systemic Light Chain Amyloidosis (Primary Systemic Amyloidosis, Myeloma-Associated Systemic Amyloidosis)
Systemic Amyloid A Amyloidosis (Secondary Systemic Amyloidosis)
Hemodialysis-Associated Amyloidosis (Systemic Beta-2 Microglobulin Amyloidosis)
Cutaneous Amyloidoses
Macular Amyloidosis
Lichen Amyloidosis
Nodular Amyloidosis
Juvenile Colloid Milium
Adult Colloid Milium (Papular Elastosis)
LICHEN MYXEDEMATOSUS
Scleromyxedema (Generalized Lichen Myxedematosus)
Localized Lichen Myxedematosus
PRETIBIAL MYXEDEMA (LOCALIZED MYXEDEMA)
GOUT (AND PSEUDOGOUT) (Figs 10.5A to E)
CALCINOSIS CUTIS (AND OSTEOMA CUTIS)
CHAPTER 11:
The Melanocytic Tumors
INTRODUCTION
CYTOLOGICALLY BANAL MELANOCYTES CONFINED TO THE EPIDERMIS
Simple Lentigo
Mucocutaneous Lentigo (Melanotic Macules)
Solar Lentigo (Figs 11.3A to D)
Junctional Melanocytic Nevus
Junctional Atypical Melanocytosis
(“Atypical Junctional Melanocytic Proliferation,” “Atypical Solar Lentigo”)
Persistent Nevus (Recurrent Nevus)
CYTOLOGICALLY ATYPICAL MELANO-CYTES CONFINED TO THE EPIDERMIS
Atypical Intraepidermal Melanocytosis
Melanoma In Situ, Lentigo Maligna Type
Melanoma (In Situ Other than Lentigo Maligna) Type (Figs 11.9A to E)
COMPOUND OR INTRADERMAL NEOPLASMS THAT ARE CYTOLOGICALLY BANAL
Criteria that Suggest a Benign Nevus
Classification of Melanocytic Nevi
The Common Subtypes of Compound and Intradermal Nevi
Miescher's Nevus (Common Plaque-like Nevus) (Figs 11.12A to D)
Unna's Nevus (Common Polypoid Nevus) (Figs 11.13A to D)
Zitelli's Nevus (Common Congenital Pattern Nevus, Superficial Type)
Mark's Nevus (Congenital Pattern Nevus, Deep Type) (Figs 11.15A to E)
Clark's Nevus (Dysplastic Nevus) (Figs 11.16A to H)
Nevus Spilus (Figs 11.17A to C)
Combined Nevus (Nevus with Phenotypic Heterogeneity) (Figs 11.18A to D)
Nevi with Inflammatory Reactions, Site-Specific Features and Other Incidental Findings
Nevus with Sutton's Reaction (Halo Nevus)
Nevus with Meyerson's Reaction (Eczematous Nevus)
Nevi on the Breast, Genital Region and Intertriginous Areas
Nevi on Acral Skin (Palms and Soles, Occasionally Elbows and Knees) (Figs 11.22A to D)
Nevi on the Ear (Figs 11.23A to D)
Malignant Melanoma Arising within a Compound Nevus (Figs 11.24A to D)
COMPOUND OR INTRADERMAL NEOPLASMS COMPOSED OF SPINDLED AND/OR EPITHELIOID MELANOCYTES: SPITZ'S AND REED'S NEVI
Spitz's Nevus (Nevus with Spindled and/or Epithelioid Cells) (Figs 11.25A to D)
Reed's Nevus (Pigmented Spindle Cell Nevus)
PREDOMINANTLY DERMAL TUMORS COMPOSED OF PIGMENT SYNTHESIZING MELANOCYTES: THE “BLUE NEVUS” VARIANTS
Tieche's Nevus (Common Blue Nevus) (Figs 11.27A to D)
Seab's Nevus (Deep Penetrating Nevus)
Carney's Nevus (Epithelioid Blue Nevus, Pigmented Epithelioid Melanocytoma)
Jadassohn's Nevus (Cellular Blue Nevus, Blue Nevus with Spindle Cell Component) (Figs 11.30A to C)
Masson's Nevus (Neuronevus of Masson)
Melanocytic Tumors of Uncertain Malignant Potential: Atypical Variants of Spitz's Nevi and the Blue Nevus Variants
COMPOUND OR INTRADERMAL NEOPLASMS COMPOSED OF MARKEDLY ATYPICAL MELANOCYTES
Lentigo Maligna Melanoma
Lentiginous Melanoma
Acral Lentiginous Melanoma
Superficial Spreading Melanoma (Figs 11.37A to D)
Nodular Melanoma (Figs 11.38A to D)
Desmoplastic Melanoma (Figs 11.39A to C)
Spindle Cell/Neurotropic Melanoma (Figs 11.40A to C)
Blue Nevus-Like Melanoma(Malignant Blue Nevus) (Figs 11.41A to C)
Nevoid Melanoma (Figs 11.42A to D)
Spitzoid Melanoma (Figs 11.43A to G)
CHAPTER 12:
Epithelial Neoplasms
INTRODUCTION
NON-NEOPLASTIC EPIDERMAL PROLIFERATIONS
Acanthosis Nigricans/Confluent and Reticulated Papillomatosis
Prurigo Nodularis/Lichen Simplex Chronicus
Pseudocarcinomatous Epithelial Hyperplasia
Verruca
BENIGN KERATINOCYTIC NEOPLASMS
Acanthomas
Acrokeratosis Verruciformis of Huff
Clear Cell Acanthoma
Epidermal Nevus
Flegel's Disease (Hyperkeratosis Lenticularis Perstans)
Porokeratosis
Seborrheic Keratosis
Solar Lentigo
Warty Dyskeratoma
MALIGNANT TUMORS ARISING FROM EPIDERMIS
Actinic Keratosis Versus Squamous Cell Carcinoma
Actinic Keratosis
Squamous Cell Carcinoma
Types of Squamous Cell Carcinomas
Keratoacanthoma Versus Squamous Cell Carcinoma
Basal Cell Carcinoma
CHAPTER 13:
Adnexal Neoplasms
INTRODUCTION
CRITERIA FOR SEBACEOUS DIFFERENTIATION
TYPES OF SEBACEOUS NEOPLASMS
Sebaceous Hyperplasia
Sebaceous Adenoma
Sebaceoma (Sebaceous Epithelioma)
Sebaceous Carcinoma
Nevus Sebaceus (Organoid Nevus)
Criteria for Follicular Differentiation
Types of Benign Follicular Neoplasms
FOLLICULAR NEOPLASMS DIFFERENTIATING TOWARDS INFUNDIBULUM AND ISTHMUS
Dilated Pore of Winer
Pilar Sheath Acanthoma
Trichoadenoma
Tumor of Follicular Infundibulum
Trichofolliculoma
Proliferating Trichilemmal (Pilar) Tumor
Pilomatricoma
Tricholemmoma/Inverted Follicular Keratosis
Trichofolliculoma
Trichoepithelioma and Trichoblastoma
Fibrous Papule
Trichodiscoma, Fibrofolliculoma and Neurofollicular Hamartoma
CRITERIA FOR APOCRINEDIFFERENTIATION
NEOPLASMS EXHIBITING FOLLICULAR-SEBACEOUS APOCRINE DIFFERENTIATION
Cylindroma
Spiradenoma
TUMORS EXHIBITING BOTH ECCRINE AND APOCRINE VARIANTS
Poroma (Figs 13.20A to C)
Hidradenoma
Mixed Tumor (Chrondroid Syringoma)
PURELY APOCRINE NEOPLASMS
Hidradenoma Papilliferum, Erosive Adenomatosis of Nipple and Syringocystadenoma Papilliferum
Tubular Apocrine Adenoma
CRITERIA FOR ECCRINE DIFFERENTIATION (DIAGNOSIS OF EXCLUSION)
ECCRINE NEOPLASMS
Syringoma
Malignant Adnexal Neoplasms
CYSTS
Follicular Cysts—Hair Follicle Related Cysts
Infundibulum Type/Epidermal Inclusion Cyst (Figs 13.31A to C)
Isthmus Catagen Type/Pilar/Trichilemmal Cyst
Steatocystoma (Cyst of Follicular-Sebaceous Duct)
Rarer Follicular Cysts (Not Illustrated)
Apocrine/Eccrine Cysts (Hidrocystomas)
Embryological Cysts
CHAPTER 14:
The Mesenchymal Tumors
INTRODUCTION
PAUCICELLULAR OR PATTERNLESS TUMORS
Scars and Keloids
Angiofibromas and Fibrous Papules
Superficial Fibromatoses
Deep Fibromatosis (Desmoid tumor, Desmoid fibromatosis)
Multinucleate Giant Cell Angiohistiocytoma
Tendon Sheath Fibroma
Desmoplastic Fibroblastoma
Neurofibroma and Variants
Sclerotic Fibroma (Storiform Collagenoma)
Perineurioma
Acral Fibrokeratoma
Elastofibroma
Pleomorphic Fibroma
THE FASCICULAR AND STORIFORM TUMORS
Nodular Fasciitis (and Other Fasciitis Variants)
Proliferative Fasciitis
Proliferative Myositis
Dermatofibroma and Variants
Cellular Dermatofibroma
Atypical Dermatofibroma (Dermatofibroma with Monster Cells)
Dermatomyofibroma
Dermatofibrosarcoma Protuberans
Solitary Fibrous Tumor
Traumatic Neuroma
Localized Interdigital Neuritis (Morton's Neuroma)
Palisaded and Encapsulated Neuroma/Solitary Neuroma
Schwannoma
Low Grade Fibromyxoid Sarcoma
Leiomyoma
Cutaneous Leiomyosarcoma
Myofibroma (and Myofibromatosis)
Infantile Digital Fibromatosis (Inclusion Body Fibromatosis)
Fibrous Hamartoma of Infancy
Plexiform Fibrohistiocytic Tumor
Neurothekeoma
Malignant Peripheral Nerve Sheath Tumor, Spindle Cell Pattern
Spindle Cell/Neurotropic Melanoma
THE MYXOID TUMORS
Cutaneous Focal Mucinosis
The Acral Myxoid Pseudocysts
Ganglion Cyst/Digital Myxoid Pseudocyst/Cutaneous Myxoid Cyst
Superficial Angiomyxoma/Cutaneous Myxoma
Myxoid Spindle Cell Lipoma
Acral Fibromyxoma (Figs 14.36A and B)
Nerve Sheath Myxoma (Figs 14.37A to D)
Myxoid Neurofibroma
Myxoid Dermatofibrosarcoma Protuberans
Myxofibrosarcoma
Myxoid Liposarcomas (Round Cell Liposarcoma)
Acral Myxoinflammatory Fibroblastic Sarcoma (Inflammatory Myxohyaline Tumor)
THE EPITHELIOID TUMORS
Myopericytoma/Myofibroma
Mixed Tumor (Myoepithelioma; Parachordoma)
Perivascular Epithelioid Cell Tumor
Glomus Tumor, Solid Pattern
Epithelioid Sarcoma
Epithelioid Hemangioendothelioma
Epithelioid Angiosarcoma
Malignant Peripheral Nerve Sheath Tumor, Epithelioid and Myxoid Pattern (Figs 14.50A and B)
THE LIPOMATOUS TUMORS
Nevus Lipomatosus Superficialis
Lipomas
Angiolipoma
Chondroid Lipoma
Myolipoma
Spindle Cell Lipoma/Pleomorphic Lipoma/Myxoid Lipoma
Hibernoma
Atypical Lipoma/Well-Differentiated Liposarcoma
THE VASCULAR TUMORS
Hemangiomas
Angioma (Cherry Angioma)
Infantile Type Hemangioma
Kaposiform Hemangioendothelioma
Vascular Malformations
Angiokeratoma
Lymphangiomas and Lymphangioma Circumscriptum
Venous Lake
Papillary Endothelial Hyperplasia (Masson's Tumor)
Pyogenic Granuloma (Lobular Capillary Hemangioma) (Figs 14.65A to C)
Glomeruloid Hemangioma
Arteriovenous Hemangioma (Cirsoid Aneurysm)
Hobnail Hemangioma/Targetoid Hemosiderotic Hemangioma
Angiolymphoid Hyperplasia with Eosinophilia/Epithelioid Hemangioma (Figs 14.69A to C)
Postradiation Atypical Vascular Proliferation
Glomus Tumor, Glomangioma Pattern (Glomulovenous Malformation)
Spindle Cell Hemangioma (Figs 14.72A to C)
Hobnail Hemangioendotheliomas (Figs 14.73A to C)
(Dabska Tumor, Papillary Intralymphatic Angioendothelioma and Retiform Hemangioendothelioma)
Kaposi's Sarcoma
Cutaneous Angiosarcoma (Figs 14.75A to E)
THE PLEOMORPHIC TUMORS
Atypical Fibroxanthoma (Figs 14.76A to E)
Pleomorphic Sarcoma
Pleomorphic Variants of Other Sarcomas
THE HISTIOCYTOID TUMORS
Giant Cell Tumor of the Tendon Sheath (Tenosynovial Giant Cell Tumor)
Granular Cell Tumor
Malignant Granular Cell Tumor
THE ROUND CELL TUMORS
Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma)
CHAPTER 15:
The Cutaneous Hematolymphoid Neoplasms
INTRODUCTION
THE EPIDERMOTROPIC/ADNEXOTROPIC PATTERN (TABLE 15.1)
T-Cell Pseudolymphomas (Figs 15.1A to D)
Mycosis Fungoides (Figs 15.2A to G)
Variants of Mycosis Fungoides
Sézary Syndrome
Adult T-Cell Leukemia/Lymphoma
Aggressive CD8+ Epidermotropic Lymphoma
THE DERMAL ± SUBCUTANEOUSPATTERN (see TABLE 15.1)
CD30+ Lymphomas/Lymphoproliferative Disorders
B-Cell Pseudolymphomas (Figs 15.7A to C)
Primary Cutaneous Marginal Zone Lymphoma
Primary Cutaneous Follicle CenterCell Lymphoma (Figs 15.9A to D)
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type (Figs 5.10A to E)
Lymphomatoid Granulomatosis
Extranodal Natural Killer (NK) /T-Cell Lymphoma, Nasal Type (Figs 15.12A to C)
Blastic Plasmacytoid Dendritic Cell Neoplasm (Figs 15.13A to D)
Gamma/Delta T-Cell Lymphoma
Myelogenous Leukemia
Langerhans Cell Histiocytoses (Other Histiocytic/Dendritic Cell Tumors)
Cutaneous Mastocytosis
Telangiectasia Macularis Eruptiva Perstans
Urticaria Pigmentosa (Maculopapular Cutaneous Mastocytosis)
Diffuse Cutaneous Mastocytosis
Solitary Mastocytoma
Mast Cell Immunophenotype
THE SUBCUTANEOUS PATTERN (see TABLE 15.1)
Subcutaneous Panniculitis Like T-Cell Lymphoma (Figs 15.18A to C)
INDEX
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