Heart Failure: The Expert’s Approach Alan S Maisel, Gerasimos S Filippatos
INDEX
Page numbers followed by f refer to figure and t refer to table.
A
Ablation in
acute setting 235
chronic management of VT 236
Abnormal
mitral inflow Doppler echocardiography pattern 200
renal 240t
and liver function 240
Absence of structural heart disease 235
ACE See Angiotensin-converting enzyme
ACE inhibitors 393
ACEI See Angiotensin-converting enzyme inhibitors
Acetazolamide 119
Acetylsalicylic acid 155
Acquired immunodeficiency syndrome-induced heart failure 543
Actinomyces 507
Activated partial thromboplastin time 241
Active antiretroviral therapy, highly 542
Acute
agitation/anxiety 410
aortic regurgitation 59
atrial fibrillation 27
cardiac complications 500
cardiomyopathy trial 517
care 426
congestive heart failure, management of 19
coronary syndrome 44, 151, 154, 294, 299, 426, 494
in heart failure 152
treatment of 154
medications indicated in 156
prognostic value in 268
decompensated heart failure 9, 18, 41, 117, 120, 125, 284
national registry 151, 292, 372, 446
exacerbation of chronic obstructive pulmonary disease 44
fulminant myocarditis 509
heart failure 7, 8, 41, 54, 68, 120, 130, 294
biomarkers in 110
in emergency department, treatment of 15
inotropes in different clinical settings of 135t
management using systolic blood pressure 17
prognostic value in 268
role of ultrasound in management of 54
study 121
syndrome 16, 16t, 17, 18
treatment of 15
trial, biomarkers in 548
ischemic heart disease 199
kidney injury 47, 48, 141
maxillary sinusitis 84
mitral regurgitation 58
myocardial infarction 4, 87, 178, 226, 285, 291, 430, 508
myocarditis 506, 508, 509f
pericarditis 200
pulmonary
edema 5, 78
embolism 7, 17, 18
respiratory
distress syndrome 178, 179
failure 77
rheumatic fever 389, 390f
ST-elevation myocardial infarction 494
treatment of sustained ventricular tachycardia 235
valvular heart disease 57
Acutely decompensated heart failure 80, 127, 181183
and hypotension 182
and worsening renal function 181
Acutely destabilized heart failure 140
Adaptative-pressure-control 77
Adenosine
diphosphate 156, 341
monophosphate-activated protein kinase 343
triphosphat 343
Adenovirus 506, 507
Adequate blood pressure 124
ADH analogues 147
Adherence to guideline-based medications 375
ADHF
and hypotension 182
and worsening renal function 182
Administer sliding scale heparin infusion adjustment 171
Adrenergic system 535
Adrenocorticotropic hormone 144
Adrenomedullin 549
Adults with congenital heart disease 98
Advance care planning program 377
Advanced glycation end-products 341
Advanced heart failure 435, 443
AIDS-induced cardiac abnormalities and heart failure 541
Akinesia of mid-ventricle 497f
Alcohol
ablation therapy 492f
consumption, reduction in 394
septal ablation 491
Aldactone evaluation study, randomized 218
Aldosterone
antagonists 393
escape 219
Ambulatory capacity 103
AMC See Acute myocarditis
Amiloride 119
Amino N-terminal prohormone 37
Amino-terminal pro-B-type natriuretic peptide 71
Amiodarone 28
Amyloidosis 480
Amyotrophic lateral sclerosis 4
Anderson-Fabry disease 482
Anemia See Nutritional deficiencies
Angiotensin
AGT polymorphisms 534
converting 354
converting enzyme 115, 141, 156, 208, 259, 296f, 502
deletion polymorphism 534
inhibitors 489, 534, 542
doses of 438
in heart failure 214
insertion polymorphism 534
inhibitors 19, 48, 85, 119, 181, 188, 208, 213, 215, 218, 223, 245, 258, 268, 270, 276, 278, 281, 285, 286, 296, 299, 317, 328, 334, 348, 375, 373, 384, 399, 415, 421, 428430, 543
receptor blockers 141, 188, 208, 214, 258, 259, 268, 270, 271, 276, 281, 285, 296, 317, 328, 373, 375, 399, 415, 421, 429, 430, 438, 542
therapy 334
treatment algorithm 428
Antiarrhythmic
drugs 147, 228, 229
medications 228
Antibiotics 147
Anticoagulant 156
evaluation of long-term 242
Anticoagulation therapy in heart failure with sinus rhythm 242
Antidepressants 147
Antidiabetic agents 343
Antidiuretic hormone 118
Antihypertensives 147
Antineoplastic agents 147
Antipsychotic drugs 147
Antithrombotic therapy in heart failure patients in sinus rhythm, role of 246
Antiviral immunomodulation with interferon 517
Aortic
pressure 473
regurgitation 59
stenosis, regurgitation 274
valve 455
Apical hypokinesia 497f
Apixaban for reduction in stroke 242
Apoptotic myocardial cell death in heart failure 290f
Application of natriuretic peptide 109
in diagnostic algorithm for heart failure 111
Arbovirus 507
Arenavirus 507
Arginine vasopressin 144, 546, 549
Arrhythmias 9, 191
Arrhythmic right-ventricular cardiomyopathy/dysplasia 232
Arrhythmogenic
cardiomyopathy 533
right ventricular
cardiomyopathy 95, 477479, 526, 533
dysplasia 61
Arterial blood gases 6, 13
Artificial hearts 393
ARVC See Arrhythmogenic right-ventricular cardiomyopathy
Ascaris 507
Asthma 9, 215
Asymptomatic heart failure 417
Atrial
enlargement 274
fibrillation 21, 225, 227f, 229, 281, 313, 354, 358, 359, 373, 439
and heart failure 230
classifications 22
flutter 274
in acute setting 23
in patients with heart failure and preserved, management of 21
natriuretic peptide 32, 34, 41, 109, 110, 219
Atrioventricular dissociation 233f
Autoantibodies 513
Autosomal recessive 525f
Average volume-assured pressure support 77
AVRC See Arrhythmogenic right-ventricular cardiomyopathy
B
Balloon triggering and timing 469
Beats per minute 490
Benzafibrate infarction prevention 245
Beriberi 388
Beta blockers and proper dosing 216t
Beta-adrenergic
agonists 131
blocking agent 218, 223
Beta-blocker treatment algorithm 429
Bilateral renal artery stenosis 214
Bilevel positive airway pressure 19, 84
Bioelectrical impedance 66
vector analysis 71
Bioimpedance vector analysis 6, 166, 167
Biopsy 477
Bisoprolol 216
BIV function, assessments of 99
Biva in dyspneic patients, use of 68
Biventricular pacing 264
Bleeding 240, 456
history 240t
B-lines 70
Blood
cultures, multiple positive 200
metabolic profile 171
pressure 5, 8, 13, 16, 17, 74, 103, 372, 429, 447, 456
urea
and serum electrolyte 429
nitrogen 13, 17, 18, 82, 103, 174, 410
volume estimation 165
BNP See brain natriuretic peptide
Body mass index 44, 372, 448
Bone marrow mononuclear cells 398
Borrelia species 507
Bradycardia 216
Brain natriuretic peptide 16, 70, 71, 103, 104, 109, 189, 298, 298, 303, 316, 417, 488, 490
Breath, shortness of 543
Breathing 23
British National Health Service 365
Brockenbrough sign 487
Broken heart syndrome’ 494
Brucella species 507
Brugada criteria 234
B-type natriuretic peptide 3235, 37, 40, 44, 47, 56, 81, 109, 113, 153, 160, 165, 171, 220, 257, 274, 276, 278, 280, 281, 287, 292, 325
Building blocks of successful ultrafiltration therapy program 168
Bumetanide 119
Burden of heart failure 109
Bystander coronary disease 496
C
CAD See Coronary artery disease
Calcified mitral valve 60
Calcium channel blocker 191, 228
Captopril 180, 215
Carbohydrate antigen-125 302
Carbon monoxide 5
Carbonic anhydrase inhibitors 119
Cardiac
abnormalities associated with elevation of B-type natriuretic peptide 274t
arrhythmia 449
catheterization 495
chamber
enlargement 94
size 274
dysfunction 102
function
assessment of 104
heart failure with aldosterone antagonist trial, treatment of 329
implantable electronic devices 261
index 182
intensive care units 73
magnetic resonance 487, 495, 508, 525
diagnosis of myocarditis 512
findings in myocarditis, dynamics of 513f
imaging 8689, 92, 481, 482, 502, 515
in takotsubo cardiomyopathy 499f
myosin activators 134
output 167
rehabilitation ward 426
resynchronization 398
therapy 50, 189, 209, 261, 264, 265, 268, 271, 276, 281, 318, 329, 348, 393, 438, 454, 543
recommendation for 265
use of 209
siderosis 482
tamponade 111, 200, 542, 544
case of 57
transplantation 50
troponins 46, 290
in hospitalized patients, recommendations for 293
in management of patients with congestive heart failure 289
in outpatients with heart failure, recommendations for 294
release in patients with heart failure 289
use of 293
Cardiogenic
pulmonary edema 19, 78
sign of 62
shock 8, 130, 181, 182, 444
Cardiomems heart sensor 209
Cardiomyopathies 87, 92, 201, 264, 388, 478
classification of 478
restrictive 478, 480, 532
Cardiopulmonary exercise stress testing 188
Cardiorenal rescue study in acute decompensated heart failure 163
Cardiotoxic drugs, use of 47
Cardiovascular
diseases 101, 312, 387, 542
magnetic resonance 497
risk factors 369
Cardioverter defibrillator 515
therapy 398
Carvedilol 216, 228
CAST See cardiac arrhythmia suppression trial
Catecholaminergic polymorphic VT 232
Catheter ablation 229
CCB See Calcium channel blocker
Cell adhesion molecules 507
Central
nervous system 143
sleep apnea See also Obstructive sleep apnea
Cerebrovascular accident 246
Chest
pain 102
X-ray 16
CHF See Chronic heart failure
Chlamydia pneumonia 507
Chlamydophila psittaci 507
Chlorthalidone 119
Chlorthiazide 119
Chordal rupture 57
Chorea minor See also Sydenham's chorea
Chronic
constrictive pericarditis 387, 388, 389, 391
dilated cardiomyopathy 506
disease, role of 376
heart failure 19, 33, 38, 185, 273, 285, 286, 298, 322, 402, 549
cause of 151
definition of advanced 438
prognostic value in 267
therapy, outpatient tailored 353
ischemic heart disease 199
kidney disease 191, 219, 333, 388
obstructive pulmonary disease 4, 9, 44, 45, 71, 73, 77, 155, 256, 354, 359, 446, 549
progressive external ophthalmoplegia 532
pulmonary disease 12
renal insufficiency 89
symptomatic heart failure 399, 400
treatment of 400
valvular heart disease 57
ventricular tachycardia, treatment of 236
viral cardiomyopathy 517
CICUS See Cardiac intensive care units
Circulation 23
CK-MB See Creatine kinase-MB
Classes of inotropes and mechanism of action 131
Claustrophobia 90
Clopidogrel 155
Clostridium tetani 507
CMR See Cardiac magnetic resonance imaging
Cohort studies, epidemiological 243t
Comet tails 70
Community, prognostic value in 268
Comorbidities, management of other 105
Complaint of dyspnea 4
Complete
blood count 113, 171, 455, 457
metabolic profile 171
Computed tomography 87, 89
Congenital
abnormalities 274
heart disease 87, 98
Congestion
management 208
symptoms of 191
Congestive heart failure 22, 24, 29, 29t, 48, 97f, 110, 179, 190, 198, 216, 225, 233, 258, 358, 373f, 420, 431
evaluation of mechanical assistance for treatment of 444
Randomized evaluation of mechanical assistance for treatment of 451
Constrictive pericarditis 97f
Continuous flow left ventricular assist device 458
Continuous positive airway pressure 19, 73, 76, 78, 84
Converting enzyme inhibitors 45
COPD See Chronic obstructive pulmonary disease
Coronary
artery
bypass grafting combines with
cell transplantation 398
hybrid strategy 398, 399
disease 16, 46, 92, 154, 155, 312, 373, 381, 387, 388, 398, 431, 455, 515, 528
premature 542
ischemia 274
care unit 425
heart disease 312, 314, 447
Corynebacterium diphtheria 507
Coxiella burnetii 507
Coxsackie B virus 506, 507
Coxsackie-adenovirus receptor 507
Coxsackievirus 507
B 512
C-reactive protein 141, 302, 543
Creatine kinase-MB 543
Creatinine 6, 13, 214
Critical pulmonary edema or hypercapnia 22
CRT, cardiac resynchronization therapy 264
CTN See Cardiac troponins
Current exacerbation of HF 215
CVD, prevention of 394
Cyanide 5
Cystatin C 301
Cytomegalovirus 507
Cytotoxic T lymphocytes 507
D
DCM See Dilated cardiomyopathy
DCMI See Dilated cardiomyopathy with inflammation
Decompensated chronic
aortic stenosis 60
valvular heart disease 60
Deep vein thrombosis 243
Delivery of ultrafiltration therapy
choice of location for 169
training of nursing staff in 169
Dengue virus 507
Deoxyribonucleic acid 341, 532, 536
Determining optimal heart failure therapy 317
Device and surgical procedures 393
Device-based therapies 329, 543
Diabetes 314
management in heart failure 340
mellitus 22, 24, 152, 155, 191, 225, 354, 359, 371, 373, 382, 431
Diabetic ketoacidosis 4
Diagnosis of chronic heart failure 298
Diagnostic algorithm for dyspneic patients, proposal of 71
Diastolic
compression of right ventricle 200
dysfunction 45, 274
in hypertrophic cardiomyopathy 486
Diet compliance, medication and 191
Digitalis 228
Digoxin 26, 228, 329, 393
Dilated cardiomyopathy 87, 201, 244, 261, 358, 389, 477, 478, 479, 508, 526, 532
with inflammation 508
Diltiazem 26, 228
Dipeptidyl peptidase-4 inhibitors 344
Direct-current cardioversion 227229, 235
Disability-adjusted life years 370
Discontinuation of ultrafiltration therapy 175
Disease, patterns of 495
Disposition of emergency department 8
Distal convoluted tubule 118
Distension of inferior vena cava 200
Diuretics 84, 147, 159
optimization strategies evaluation 158
pharmacokinetics and dosing of 119t
therapy in hospital 121
treated heart failure 159
Dizziness 11
DNA See Deoxyribonucleic acid
Dobutamine 131, 431
Dofetilide 28
Dopamine 131, 431
Driveline infection 457
Dynamic molecular targets in heart failure 535
Dyspnea 3, 11
causes of 4t
definition of 3t
in emergency department 34, 42, 49, 50, 268
resolution 12
E
Echinococcosis 507
Echocardiogram 226
Echocardiographic evaluation 487
Echovirus 507
Edema in lower extremities 410
Effect of mitral regurgitation 246
Effective regurgitant orifice 199
Ejection fraction 188, 219, 249, 313, 324, 328, 359, 376
preserved 312
Electrical cardioversion 28
Electrocardiogram 16, 113, 193, 226, 233, 294, 363, 495
Electrocardiography 487
EMB See Endomyocardial biopsy
Embolus, source of 201
Emergency
department observation
chart for patient 83f
unit 80
department patient with suspected acute heart failure syndrome 16
heart failure mortality risk grade 10, 10t
Enalapril 215
Encephalomyocarditis 507
End-diastole 497f
pressure 473
volume 473
End-of-life issues 465
Endomyocardial
biopsy 478, 515
histology of 510
immunohistology of 511
technique 510
fibrosis 383, 388, 389
Endothelial dysfunction 342
Endotracheal
intubation 76f
tube 16
End-stage heart failure 443
End-systole 497f
Entamoeba histolytica 507
Enteroviruses 506, 507
Epidemiology
of heart failure in India 387
study of heart failure in China 396
Epinephrine 131
Eplerenone 119
Eplerenone post-acute myocardial infarction heart failure efficacy and survival study 218
Epstein-Barr virus 506, 507
Erythema marginatum of acute rheumatic fever 390f
Erythrocyte sedimentation rate 543
Erythropoiesis-stimulating agents 337
Esmolol 26, 228
ESR See Erythrocyte sedimentation rate
Estimated glomerular filtration rate 89, 269
Estimation of
intracardiac pressures 198
jugular venous pressure 327f
Ethanol septal ablation 491
Euroheart failure survey 348, 359
Evaluating hyponatremia 146
Evidence-based markers of acute heart failure risk 10t
Exacerbation 216
Exercise regimen 191
Expiratory positive airway pressure 76
External jugular vein 327f
Extracellular
fluid volume 167
matrix remodeling 341
Extracorporeal membrane oxygenation 470, 514
F
Familial
cardiomyopathies 526
sarcomeric hypertrophic cardiomyopathy 530
Fatigue 410
Female sex category 24
Fibrosis 274
Filling pressures 274
Flavivirus 507
Flecainide 28
Fluid volume 324
assessment 326
Food and drug administration 46
Forrester's classification 62
Framingham heart study 311
Francisella tularensis 507
Frank-Starling curve 404
Furosemide 119
G
Galectin-3 49, 50, 269, 271, 299
Gastric inhibitory polypeptide 344
GCMC See Giant cell myocarditis
Genetic
and risk stratification 531
based risk stratification 529
diagnosis 531
of cardiomyopathy 524
diseases 522
heterogeneity 529
of sarcomeric hypertrophic cardiomyopathy 531
in heart failure caused by multifactorial diseases 534
test of cardiomyopathy 524
testing 526, 529, 531, 532, 533
in dilated cardiomyopathy 528
in heart failure, applications of 536
Geriatric syndrome model of heart failure 323f
Giant cell myocarditis 515
Glomerular filtration rate 44, 45, 221, 336
Glycemic control, role of 342
Glyceraldehyde-3-phosphate dehydrogenase 341
Glycoprotein 156
Good death, principles of 463
Guideline-directed medical therapy 265
Guiding heart failure care with natriuretic peptides 273
H
HAART-induced
cardiovascular disease 544
metabolic syndrome 542
Haemophilus influenzae 507
Handle
excessive diuresis 123
inadequate diuresis 123
HCM See Hypertrophic cardiomyopathy
Heart
attack 504
block 216
disease
preclinical structural 236, 370
right 201
failure 4, 27, 40, 48, 54, 80, 87, 89, 101, 104, 143, 182, 183, 198, 203, 204, 210, 213, 215, 219, 223, 238, 249, 261, 275, 284, 286, 292, 311, 322, 324, 325, 336, 337, 340, 347, 351, 353, 377, 388, 396, 402, 415, 426, 427, 429, 430, 439, 447, 451, 461, 522, 526, 536, 546, 549
advanced 377
and acute coronary syndrome 151
and atrial fibrillation 239
causes of 388
classification of 81
clinic 429
daycare 409, 432
disease management 410
in nursing homes 408
in nursing homes 408, 411
disposition 8
education 206
epidemiology 426
etiology 245, 312
in China 396
registery study of 396
in diabetes, pathophysiology of 341
in Europe 347
in hospital 107
in India 380, 387
in primary care 348
in southeast Asia 369
long-term antithrombotic study 246
management of 333
congestive 80
symptomatic 375, 376
managing adults with 417
morbidity, reduction of 220
multinational study in 268
outpatients with 348, 445
pathophysiology of 375
patient
daily review chart 430t
discharge planning 432
with symptomatic 420
prevention strategies 318
progressive 508
readmission 205f
relevant structural 256
risk
and mortality 534
stratification for inpatients with 446
rule out acute 37
signs
of advanced 439t
typical of 256
stage
B 370
C 371
surgical management of 398
survival score 446, 447
symptomatic 371
symptoms of 256
advanced 439t
therapies for 276t
to HIV/AIDS
diagnosis of 542
treatment of 542
treatment of 324
ultrafiltration therapy orders 170
with normal ejection fraction 257, 353
with preserved ejection fraction 255, 256, 256f, 259, 277, 374
management of patient with 255
treatment of 259
with preserved systolic function 56, 295
with reduced ejection fraction 223, 255, 437
rate 16, 399, 429, 490
rhythm abnormalities 274
transplant 366, 393
transplantation 443
in China 399
role of 377
Heartmate vented electric left ventricular assist system 377
Heartware ventricular assist device 377
Helminthic diseases 507
Hematocrit monitoring, technical aspects of 174
Hematologic function 449
Hemodynamics 56, 57, 448
and pulmonary congestion 62
congestion 62
instability/shock 197
Hemorrhagic shock 6
Heparin-induced thrombocytopenia 171, 173, 455
Hepatic function 449
Hepatitis
B virus 507
C virus 507
virus 507
Hepatojugular reflux 121
Heterophile-blocking tubes 290
HF See Heart failure
HFPEF, management of 329
High blood
glucose 370, 371
pressure 370, 371
High cholesterol 370, 371
High dependency unit 426
High flow nasal cannula 77
High sensitivity
cardiac troponin 300
troponins 46
High-dose chemotherapy 296
HIV See Human immunodeficiency virus
HIV-induced
cardiac abnormalities, pathophysiology of 542
cardiomyopathy 542
HNCM See Hypertrophic nonobstructive cardiomyopathy
HOCM See Hypertrophic obstructive cardiomyopathy
Home-based palliative disease management 377
Human
herpes-virus type 6 506
herpes-virus type 7 506
immunodeficiency virus 541, 543
Hydralazine 180
Hydrochlorthiazide 119
Hydrogram 66
Hydrograph 66
Hyperglycemia, without 145
Hyperkalemia 214, 219
Hyperkinesia of apical and basal regions 497f
Hyperlipidemia 152
Hypertension 9, 22, 24, 44, 103, 152, 155, 182, 191, 225, 240, 240t, 311, 313, 326, 353, 358, 359, 373, 382, 389
Hypertensive
acute heart failure syndrome pathway 17
and normotensive acute heart failure, therapies for 19
heart disease 371
Hypertrophic
cardiomyopathy 87, 92, 201, 232, 262, 477, 478, 479, 485, 489, 490, 526, 529, 532
treatment of 490, 491
nonobstructive cardiomyopathy 491
obstructive cardiomyopathy 447, 485, 491, 492f
Hypertrophy 274
Hyperuricemia 125
Hypokalemia 6
Hyponatremia 143, 145
in heart failure 143
treatment of 146
in HF, presence of 146
in stage d heart failure 148
treatment of 145
Hypotensive acute heart failure syndrome pathway 18
Hypothalamic-pituitary-adrenal axis 547
I
ICD See Implantable cardioverter defibrillator
Iceberg phenomenon 190
Idiopathic
heart disease 526
pulmonary arterial hypertension 250
IHD See Idiopathic heart disease
Immunoadsorption 517
Immunohistological aspects of dilated cardiomyopathy with inflammation 511f
Immunomodulatory treatment 516
Immunosuppression 516
Impaired excitation contraction coupling 341
Impella 472, 473f
Implantable
cardiac-defibrillator 50, 528
cardioverter defibrillator 9, 189, 236, 250, 261, 262, 329, 376, 408, 438, 454, 459, 489, 510, 515, 532
Inappropriate antidiuretic hormone, syndrome of 146
Infectious agents 507t
Infective endocarditis 391f
Inferior vena cava 57, 198
Infiltrative
cardiomyopathies 480
diseases 274
Initiation of angiotensin-converting enzyme inhibitors 213
Inotropes 130
dependency, weaning of 136
in AHF 134
weaning of 136
Inotropic
agents, treatment with 136
contractile reserve 542
Inspiratory positive airway pressure 76
Intensive care unit 1618, 141, 179, 299
Internal
cardiac defibrillators 318
jugular vein 325
International
normalized ratio 221, 240, 455
registry for heart and lung transplantation 399, 447
Interpretation of natriuretic peptide values in ambulatory heart failure 274
Intra-aortic balloon 469
counterpulsation 468, 502, 503
pump 181, 182, 469f
support for myocardial infarction with cardiogenic shock 504
Intravenous
immunoglobulin treatment 517
nitroglycerin 127
non-potassium sparing loop diuretics 19
pyelogram 84
Invasive
blood pressure monitoring 136
diagnostics 488
Iodinated contrast for computed tomography 90
Iron
deficiency anemia 334
overload cardiomyopathy 97
Ischemic
cardiomyopathy 244, 262, 478
evaluation 234
heart disease 199, 274, 353, 354, 358, 359, 371
surgical treatment for 93
Isosorbide dinitrate 180
J
Jugular venous 71
distension 15, 16, 81, 121, 122
pressure elevation 419
pressure 16, 192, 324, 325
K
Kaplan-Meier
analysis 294f
curves 296, 440f
Kidney injury molecule 301
L
Labile international normalized ratios 240
Late gadolinium enhancement 94, 499
LBBB, left bundle branch block 264
Left
anterior descending 496
coronary artery 490
atrial, pressure 486
bundle branch block 261, 265, 318
sided HF 81
ventricular 94, 152, 315, 458, 502, 526, 532
aneurysm 246
assist device 183, 250, 451, 452f, 454, 458, 510, 515
candidacy evaluation 183
in China 399
infection 457
versus transplantation 443
diastolic function 56
dysfunction
studies of 244, 315
trial, studies of 341
ejection 359
fraction, reduced 218
fractions 63, 92, 236, 242, 255, 257, 262265, 268, 285, 294, 296, 313, 343, 374, 393, 399, 445, 454, 478, 485, 515
end diastolic
diameter 509
pressure 127, 257, 290, 486
volume index 257
end-systolic volume 478
filing pressures 62
hypertrophy 18, 226, 313, 315, 480, 486, 522
mass 370
masses and thrombus, evaluation of 97
noncompaction 479, 480, 533
outflow tract 56, 490
obstruction 486, 492f, 496, 502, 503
suction event 459
support 444
systolic
dysfunction 214, 225, 278, 348, 353, 354
function 55
thrombus 246
Legionella pneumophila 507
Leishmaniasis 507
Leptospira 507
Levosimendan 133
Lightheadedness 410
Lipid-lowering therapy 156
Lisinopril 215
Liver function 240t
Long QT syndrome 232
Low left ventricular ejection fraction 244
Low-density lipoprotein 156
Low-dose dobutamine stress magnetic resonance 93
Lower natriuretic peptide concentrations 281
Lupus erythematosus 152
Lutz frankenstein 364
LVAD See Left ventricular assist device
LVEDP See Left ventricular end-diastolic pressure
LVEF See Left ventricular ejection fraction
LVNC See Left ventricular
LVOTO See Left ventricular outflow tract obstruction
M
Magnetic resonance angiography 399
Major histocompatibility complex 511
Malaria 507
Malignant arrhythmias 507
Management and conventional heart failure treatment 514
Matrilineal inheritance of cardiomyopathies 525f
Matrix metalloproteinase-9 140
Mean
arterial blood pressure 509
corpuscular hemoglobin 336
corpuscular volume 336
pulmonary
artery pressure 182
capillary wedge pressure 257
rehospitalization equivalents 162f
Mechanical
circulatory support 250, 443, 447
duration of 452
ventilation in acute heart failure 73
Medication 268
exacerbate hyponatremia 147
optimization of 208
reconciliation 208
Messenger ribonucleic acid 303, 548, 549
Metallic implants 88
Metalloproteinase-9 140
Metastatic renal cell carcinoma 90f
Meteor 145
Metformin 343
Metolazone 119
Metoprolol 26, 228
CR/XL 216
Mid-region
proadrenomedullin 103, 300, 549
proatrial natriuretic peptide 32, 34, 109, 110
prohormone atrial natriuretic peptide 35
versus B-type natriuretic peptide 35t
Milrinone 133, 431
Mineralocorticoid
antagonists 438
receptor 223
antagonist 218, 270, 271, 274, 276, 278, 281
in patients with heart failure 218
Ministry of Health 425t
Minnesota living with heart failure questionnaire 376
Mitral
regurgitation 219, 359, 486
stenosis, regurgitation 274
valve 58, 455
Moderate-to-severe respiratory distress 76f
Molecular
genetics 488
pathways activated in heart failure and genetic testing, major 534
Monitor during diuresis 123
Monitoring
devices 194
of trends and determinants in cardiovascular disease 316
MRNA See Messenger ribonucleic acid
Mr-Proadm See Midregional proadrenomedullin
MR-ProANP See Mid-region proatrial natriuretic peptide
MRSA, methicillin-resistant staphylococcus aureus 457
Multicenter
automatic defibrillator implantation trial ii 262
INSYNC ICD randomized clinical evaluation 264
Multidisciplinary
chronic disease management program 376
teams 206
Multisystem organ failure 444
Myocardial
infarction 8, 29, 87, 140, 179, 198, 223, 244, 249, 263, 264, 284, 341, 353, 426, 431, 478
ischemia 9, 426
processes 274
Myocarditis 388, 506
management of 515
proof of 510f
with preserved ejection fraction 508
Myopericarditis 514
N
National
Cardiovascular Database 426
Health and Nutrition Examination Survey 109
Heart, Lung and Blood Institute 257, 311, 451
Natriuretic peptides 9, 10, 32, 40, 44, 69, 71, 109, 113, 152, 165, 274
for emergency department 43
for guiding heart failure management 276
function 42
in acute coronary syndrome 47
in Emergency Department 32, 35
in general inpatient setting 114
in inpatient setting 109
in intensive care unit, use of 114, 115
pathophysiology 41
role for 12
Nebivolol 216
Negative predictive value 43, 109
Neisseri 507
Nephrotic syndrome 143
Nesiritide 128
use of 19
versus dobutamine in heart failure 293
Neutrophil gelatinase-associated lipocalin 41, 47, 48, 102, 103, 139, 140, 141, 301
augments 140f
New biomarkers in emergency department 40
New cardiovascular disease biomarkers in hospital medicine 139
Newer inotropes 133
Next generation sequencing 528
Nicotinamide adenine dinucleotide phosphate 341
Nighttime
shortness of breath 410
urination, increase in See also Nighttime shortness of breath
Nitric oxide 182
inhaled 182
Nitroglycerin 17, 127, 128
Nitroprusside 128
NIV with acute pulmonary edema 78
Nomenclature of indication of mechanical circulatory support 453
Non-cardiogenic dyspnea 61
Noncommunicable diseases, prevalence of 426
Noncompaction cardiomyopathy 98
Noncompliance to medications 426
Noninvasive
ventilation 16, 19, 73, 78, 128
in acute heart failure 77
modalities of 75
role of 73
Nonischemic cardiomyopathies 94, 262, 479
treatment evaluation, defibrillators in 262
Nonpharmacological measures 394
Non-sarcomeric hypertrophic cardiomyopathy 531
Non-ST-elevation
acute coronary syndrome 47, 285
myocardial infarction 154, 285
Non-steroidal anti-inflammatory drugs 47, 48, 103, 215, 222, 439
Nonsteroidal anti-inflammatory drugs See also Calcium channel blocker
Non-ST-segment elevation myocardial infarction 46, 47
Nonsustained ventricular tachycardia 262
Nonsustained VT 232
Noradrenaline 431
Norepinephrine 131
Normal sinus rhythm 454
Normotensive acute heart failure syndrome pathway 18
Novel
anticoagulant agents 240
oral anticoagulants 240
NSAIDs See Nonsteroidal anti-inflammatory drugs
NSTEMI See Non-ST-segment elevation myocardial infarction
N-terminal 13
pro-brain natriuretic peptide 490
pro-B-type natriuretic peptide 34, 47, 110, 113, 269, 271, 299
prohormone
B-type natriuretic peptide 35
of brain natriuretic peptide 274t, 275, 276, 280
NT-ProBNP See N-terminal pro-B-type natriuretic peptide
Nuclear imaging 481
Nurse
management of asymptomatic heart failure 420
training and role 416
Nutrition 456
Nutritional deficiencies 388
markers of 456t
O
Obesity 45, 152, 314, 370
Obstructive
pulmonary disease 60
sleep apnea 190
Optimal
cutpoints for N-terminal pro-B type natriuretic peptide 43t
pharmacological therapy 262
Optivolemic B-type natriuretic peptide 45
Oral anticoagulants 229, 240, 244
Orthopnea 11, 102
Osler's nodes 391, 391f
Overweight 370
Oxidative stress 341
Oxygen 24
saturation 103
supplementation 82
therapy 78, 82
P
Painkillers 147
Palliation and end-of-life care 423, 461
during illness trajectory 462
in heart failure 461
Palliative care 329, 461, 465
in heart failure trajectory f 465
Paragonimus westermani 507
Parasternal long axis 57
Paroxysmal nocturnal dyspnea 81, 323, 543
Partial thromboplastin time 171, 455
PASP See Pulmonary artery systolic pressures
Patent foramen ovale 455
Pathogenesis of virus-induced acute cardiomyopathy 508f
Patient self care 206
Patient-centered heart failure care 466f
Peak expiratory flow rate 12
Pedigrees in autosomal dominant 525f
Percutaneous
coronary intervention 141, 155, 425
extracorporeal membrane oxygenator 470, 470f
mechanical circulatory support in cardiogenic shock 468
transluminal septal myocardial ablation 491
Pericardial
constriction 201
diseases 200, 274
effusion 57, 200, 544
pleural and 58f
Peripheral
arterial disease 29
artery disease 225
vascular resistance 501, 503
Pharmacologic cardioversion 28
Phosphodiesterase III inhibitors 133
Physical inactivity 370
Pleural effusion 6
Pneumonia 6, 48
Pneumothorax 6
Polyarteritis nodosum 152
Polymerase chain reaction 506
Polymorphic VT 233
Poor perfusion, symptoms of 191
Positive
end expiratory pressure 76, 78, 115
predictive value 43
Post HOC analyses of clinical trials 244
Postdischarge management 105
Post-myocardial infarction 218
Potassium-sparing diuretics 119
Potential
candidates for ultrafiltration 164
noncardiac of NPS in ICU 114
Prasugrel 155
Pressure assisted-controlled ventilation 76
Pressure support 76, 78
ventilation f 76
Pretransplant evalution 182
Primary care physician 354
Proadrenomedullin 548
Procainamide 28
Procalcitonin 48, 300, 546, 548, 549
Prohormone levels in heart failure 546
Propafenone 28
Proportional assist ventilation 76
Prothrombin time 455
and international normalized ratio 171
Proximal convoluted tubule 118
PTSMA See Percutaneous transluminal septal myocardial ablation
Pulmonary
arterial hypertension 98, 250
pathophysiology of 250
artery catheter 178, 179, 181, 182, 183
in heart failure 179
patients, uses of 182t
monitoring 136
trials of 179t
artery
systolic pressures 57
wedge pressure 33f
capillary wedge pressure 56, 180, 189
congestion 61, 62
disease 45
embolism 179
function 448
hypertension 121, 178, 250, 542
interstitial edema 62
vasodilator challenge 182
Pulmonic stenosis 274
Pulsatile index 458
Pump
endocarditis 457
pocket infection 457
thrombus 459
Q
Quality of life 179
R
RAAS See Renin-angiotensin-aldosterone system
Ramipril 215
Randomized controlled trial 179
Rapid
Emergency Department Heart Failure Outpatient 42
ventricular response 13
Rate
control efficacy in permanent atrial fibrillation 227
versus rhythm control 24
Reactive oxygen species 341
Recent European Society of Cardiology Guidelines 333
Recurrent congestion 125
Red blood cell 336
REDHOT See Rapid Emergency Department Heart Failure Outpatient
Reduced
ejection fraction 218, 312, 508
left ventricular ejection fraction 218, 508
Refractory heart failure symptoms 441
Regional wall motion abnormalities 198
Relative dyspnea score 4
REMATCH trial 162
Renal
biomarkers 301
dysfunction 45
use of 47
function 10, 268, 447
assessment 103
impairment 313
Renin-angiotensin
aldosterone 534
system 42, 110, 118, 143, 158, 218, 534, 536
system 314, 315
blockade 328
Resolution of giant cell myocarditis under immunosuppression 516f
Restrictive cardiomyopathy 477, 526
Reverse transcriptase inhibitors 542
Revolution acute respiratory failure 76f
RHD, prevention of 394
Rheumatic heart disease 382, 388, 389, 426
Rheumatoid arthritis See also Polyarteritis nodosum
Rhythm
control
agents 28t
treatment 27
diagnostics 488
Riet dierckx 363
Right ventricular 94, 458
presence of 61
stroke work index 183
support 444
systolic pressure 57
Right-sided
heart failure to pulmonary hypertension 544
versus left-sided heart failure 81
S
Sarcoidosis 481
Saturated oxygen 13, 24
Scar 274
Schistosoma species 507
Seattle heart failure model 446, 447
Secondary
comorbidities 102
medical issues, treatment of 103
Senile systemic amyloidosis 480
Serum
amyloid P component scintigraphy 481
neutrophil gelatinase-associated lipocalin levels, management based on 141t
sodium 149
Severe
asymptomatic hypotension 214
cases with cardiogenic shock 502
chronic heart failure 218
systolic dysfunction 400
Sex differences in
clinical presentation 315
heart failure 311
Short QT syndrome 232
Simpson's rule 55
Singapore heart failure outcomes and phenotypes 374
Single-nucleotide polymorphisms 536
Sinus rhythm
maintaining 228
restoring 228
Slow continuous ultrafiltration 167
Smoking cessation 394
SMT, standard medical therapy 264
SNPS See Single-nucleotide polymorphisms
Soap 431
Social welfare contribution 363
Socioeconomic factors 204
Sodium 13, 175
nitroprusside 128
Soluble
guanylyl cyclase 375
transferrin receptor 337
Sotalol 28
Spironolactone 119, 219
Stage heart failure 369
Stamatia prapa 365
Standard operational procedures 427
Staphylococcus aureus bacteremia 201
Steady-state free precession 88
ST-elevation myocardial infarction 154, 284, 285
Stenotic lesions 274
Stepped pharmacologic therapy 163
Stroke 22, 24, 240, 240t
prevention 29
Strongyloides stercoralis 507
ST-segment elevation myocardial infarction 16, 291
Suboptimal TTE images 201
Subxiphoid of pericardial effusion 7f
Sudden cardiac death 95, 232, 261, 398, 486, 490, 507
in heart failure 262
trial 244, 245
prevention 514
Sudden death in heart failure trial 262
Sulfa-based diuretics 181
Sulfonylureas 343
Supraventricular tachycardias 233, 234, 486
Sydenham's chorea 390
Sympathico-adrenergic system 315
Symptomatic
hypertrophic
nonobstructive cardiomyopathy patients 489
obstructive cardiomyopathy patients 491
hypervolemic hyponatremia 148
hypotension 214
Systemic vascular resistance 180, 182
Systolic
anterior
motion 201
movement 486
blood pressure 13, 17, 18, 82, 84, 128, 130, 183, 214, 354, 429
dysfunction 274
function, preserved 312
heart failure 92
pulmonary artery pressure 198
versus diastolic dysfunction 82
T
Taenia solium 507
Takayasu arteritis 383
Takotsubo cardiomyopathy 494, 497f, 504
complicated by cardiogenic shock 503
management priorities in 502
Tandemheart 471
Tandemheart® system and pump 471f
TASH See Transcoronary ablation of septal hypertrophy
Teach-back method concepts 194
TEE, transesophageal echocardiography 457
Telemonitoring 209
Telemonitoring to improve heart failure outcomes 209
Therapeutic
algorithms 488
range 240
window for noninvasive ventilation 76f
Therapy-related factors 204
Thiazide diuretics 119
Thiazolidinediones 343
Thibaud damy 363
Thick ascending limb 118
Thoracis ultrasound 71
Thromboembolic events 242
Thrombolysis in myocardial infarction 155
score for unstable angina 155t
Ticagrelor 155
Tissue Doppler imaging 56
Tolvaptan 119
Torsades de pointes 28, 317, 495, 500
Torsemide 119
Toxic conditions with acute myocarditis 507t
Toxoplasma gondii 507
Traditional biomarkers 298
Trajectories of decline 462f
Trandolapril 215
Transcoronary ablation of septal hypertrophy 491
Transesophageal echocardiogram 98, 197, 201, 227, 229
Transient ischemic attack 29
Transition
care nursing roles 422
from intravenous to oral drug regimens 125
to end-of-life care 412
Transthoracic echocardiogram 54, 193, 54, 200
Triamterene 119
Trichinella spiralis 507
Trichinosis 507
Tricuspid
annular plane systolic excursion 61
regurgitation 55, 198, 274
velocity of 198
valve 455
Troponin peptide 9
Troubleshooting left ventricular assist device patients 183
Trypanosoma cruzi 507
Tuberculosis prevention 394
U
Ultrafiltration 159
clinical specialist, role of 168
in fluid-overloaded heart failure patients 160, 162
therapy in heart failure in china 398
United Network for Organ Sharing 1a Status, maintenance of 183
Universal health literacy principles 194
US carvedilol heart failure program 215
Utility in emergency department 42
V
VAD, ventricular assist device 457
Valsartan heart failure trial 268
Valvular
abnormalities 274
disease 455
disorders 45
dysfunction 57
function 197
heart disease 199, 201, 388
Vascular
abnormalities. 239
disease 22, 24, 225, 342
Vasodilator-heart failure trial 244, 245
Vasodilators 19, 85
in acute heart failure 127
induced
decrease in blood pressure, management of 129
hypotension 129
recommended dose of 128t
Vasopressin
and heart failure 144
antagonists 119
levels of 144
receptor antagonists 120
role of 144
Venoarterial extracorporeal membrane oxygenation 504
Venous access 172
Ventilator associated pneumonia 74
Ventricle, right 61, 163
Ventricular
arrhythmias 459
assist device 393, 443, 448, 543
role of 377
enlargement 274
fibrillation 263
function, right 448, 454, 456
rate control 227
systolic function 197
tachycardia 232, 233f, 234, 235, 263, 447, 490
done right 232
types of 236
Ventriculography of
classic apical pattern of takotsubo cardiomyopathy 496f
midventricular variant of takotsubo cardiomyopathy 497f
Verapamil 26, 228
Veterans health administration 402
Virological analyses of endomyocardial biopsy 512
Vital signs 4
Vitamin K antagonists 240
W
Warfarin
and antiplatelet therapy in chronic heart failure 247
in nonvalvular atrial fibrillation 242
versus aspirin in reduced cardiac ejection fraction 247
Well's criteria 7t
Wet versus dry natriuretic peptide levels 113t
Wide complex tachycardias 233, 234
Wolff-Parkinson-White syndrome 226
Worsening renal function 9, 181, 182
WPW syndrome See Wolff-Parkinson-White syndrome
Z
Zidovudine 336
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