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Anesthesiology Updates for Postgraduates
Sampa Dutta Gupta
1: SPECIAL TOPICS
1:
Development of General Anesthesia
INTRODUCTION
TENTH CENTURY DOWNWARDS UP TO EIGHTEENTH CENTURY
NINETEENTH CENTURY
CHLOROFORM
Endotracheal Anesthesia
Intravenous Anesthesia
Premedication
Muscle Relaxants
ANESTHETIC MACHINE
ACKNOWLEDGMENTS
2:
Pediatric Anesthesia: An Overview
INTRODUCTION
Problems of Anesthesia in Neonates
Preoperative Assessment
FASTING GUIDELINES
Anesthetic Technique
Premedication
Induction
Intubation
REVERSAL CRITERIA
Monitoring
OPD ANESTHESIA
ANESTHETIC DRUGS
Propofol
Ketamine
Avoid in Children
SPECIAL CONSIDERATIONS
Cleft Palate Surgery
Gastroschisis or Exomphalos Surgery
Hypospadias and Circumcision
CONCLUSION
3:
Neurosurgical Anesthesia: An Overview
WHAT MAKES NEUROANESTHESIA DIFFERENT?
BASIC PRINCIPLES OF NEUROPHYSIOLOGY
Cerebral Blood Flow
Cerebral Blood Volume
Intracranial Pressure
CO2 Responsiveness
Cerebral Oxygen Metabolism
CLINICAL NEUROANESTHESIA
PREANESTHETIC EVALUATION AND OPTIMIZATION
BASIC PRINCIPLES
Induction of Anesthesia
Maintenance of Anesthesia
MANAGEMENT OF INTRACRANIAL PRESSURE
Hyperventilation
Anesthetic Drugs
Mannitol
Steroids
Head-up Position
Recovery
Postoperative Care
RECENT ADVANCES IN NEUROSURGERY
SUMMARY AND RECOMMENDATIONS
4:
Cardiovascular and Respiratory Physiology
RESPIRATORY PHYSIOLOGY WITH ANESTHETIC IMPLICATIONS
Lung Volumes during Anesthesia (Fig. 1)
Mechanism of FRC Reduction during Anesthesia
Prevention of Atelectasis during Anesthesia
Positive End-expiratory Pressure
Maintenance of Muscle Tone
Recruitment Maneuvers
Minimizing Gas Resorption
Compliance and Resistance during Anesthesia
Distribution of Ventilation during Anesthesia (Fig. 2)
Regional Blood Flow during Anesthesia
Ventilation-perfusion mismatching during Anesthesia
Hypoxic Pulmonary Vasoconstriction
Factors Increasing Pulmonary Vascular Resistance
Factors Reducing Pulmonary Vascular Resistance
Effects of Anesthetics on Respiratory Drive
Regional Anesthesia and Lung Function
Pneumoperitoneum and Lung Function
CARDIOVASCULAR PHYSIOLOGY WITH ANESTHETIC IMPLICATIONS
Blood Pressure
Factors Determining Blood Pressure
Control of Blood Pressure
Factors Modifying Systolic Blood Pressure
Factors Modifying Diastolic Blood Pressure
Measurement of Blood Volume
Fick Principle
Mixed Venous O2 Saturation
O2 Flux/Content
Arteriovenous O2 Difference
Oxygen Consumption
Ejection Fraction (EF) of Left Ventricle
Starling Forces in Capillaries
Starling Forces and Blood Loss
Autoregulation of Blood Flow
Valsalva Maneuver
Cardiac Action Potential
Phases for Depolarization
Pacemaker Cell Action Potential
Difference Between the Pacemaker and Myocyte Action Potential (Figs 5 and 6)
Coronary Circulation
Changes in the Fetal Circulation
5:
Role of Anesthesiologist in Pain Management in the Preoperative Period
ADVERSE PHYSIOLOGICAL EFFECTS
Hyperglycemia
Lipotoxicity
Protein Catabolism
Pain and Analgesia: Effects on Organ Dysfunction
Adverse Psychological Effects
UNIDIMENSIONAL TOOLS
Visual Analog Scale
Numeric Rating Scale
Verbal Descriptor Scale
Multidimensional Measures of Pain
FUNCTIONAL MEASUREMENT OF ACUTE PAIN
Outcome Measures of Pain
Pain:
Emotional Functioning
PAIN ASSESSMENT IN PEDIATRIC POPULATION
Pain Assessment in Intubated Postoperative Patients
Intramuscular Route
Intravenous Route
Subcutaneous Route
Transdermal/Iontophoretic Administration
Transmucosal Administration
Intrathecal Analgesia
Intra-articular Administration
Intrapleural Regional Analgesia
Paravertebral Blocks
PERIPHERAL NERVE BLOCK
Techniques
Adjuvant Drugs
Catheter versus Single-shot Techniques
Upper Extremity
Lower Extremity
LEVEL OF ADMINISTRATION—THORACIC VS LUMBAR
Drug used for Epidural Analgesia
Neuraxial Drugs and their Doses (Table 2)
Local Anesthetic Agents and Opioids
Adjuvant Drugs
Complications
IV PCA Drugs and Dose and Settings (Table 3)
Adjuvent Medications
Equipment
Complications Related to PCA
Equipment-related Complications
Patient and Staff Factors
Nursing and Medical Staff
Other Types of PCA
Midazolam
Neostigmine
Magnesium
Membrane Stabilizers
Gabapentin and Pregabalin
Antidepressant Drugs
Capsaicin
NONSELECTIVE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (nsNSAIDs)
Guide for Choosing NSAIDs
Guide for Administering NSAIDs
Adverse Effects
Cyclo-oxygenase-2 Selective Inhibitors (Coxibs)
Opioids
Buprenorphine
Codeine
Fentanyl
Hydromorphone
Methadone
Morphine
Analgesic Drugs in Patients with Renal Impairment (Tables 4 and 5)
Pharmacogenetics and its Influence on Pain Sensitivity and Drug Metabolism
Loss of Pain Sensation
Reduced Sensitivity to Pain
Drug Metabolism
Codeine
Tramadol
Methadone
NSAIDs
Clinical Implications of Opioid Tolerance and Opioid-induced Hyperalgesia and Plan of Acute Pain Management in these Groups of Patients
MANAGEMENT OF ACUTE PAIN
Effective Analgesia
Attenuation of Tolerance and Opioid-induced Hyperalgesia
Recovering Patients
Opioid Dose
Side Effects of Opioids
Local Anesthetics
Ketamine
Tricyclic Antidepressants
Anticonvulsants
Patient-controlled Analgesia
Epidural Analgesia
Intrathecal Opioid Analgesia
Other Regional Analgesia
Risk Factors for Progression from Acute Postoperative Pain to Chronic Pain
Post-thoracotomy Pain Syndrome
Postmastectomy Pain Syndrome
Posthysterectomy Pain Syndrome
Nonpharmacological Techniques for Postoperative Pain
Physical Therapy
Issues in the Pain Management in Children
6:
How to Write a Thesis?
INTRODUCTION
WHAT IS THESIS?
Essential Parts of a Thesis
Title
Acknowledgments
Abstract
Table of Contents
HOW TO WRITE THE INTRODUCTION AND BACKGROUND?
HOW TO WRITE AIMS?
HOW TO WRITE A REVIEW OF LITERATURE?
HOW TO WRITE METHOD SECTION?
HOW TO WRITE RESULTS?
Tables
Figures
HOW TO WRITE DISCUSSION?
HOW TO WRITE CONCLUSION?
HOW TO WRITE THE REFERENCE OR BIBLIOGRAPHY SECTION?
Author-Date System
Citation Order System
APPENDICES
General Points to be Followed while Writing the Thesis
Points to be Remembered while Revising the Thesis
Checklist for Revision
SOME IMPORTANT LANGUAGE POINTS
7:
Renal Physiology and Anesthetic Implications: An Overview
ANATOMY OF THE KIDNEY
FUNCTIONS OF THE KIDNEY
RENAL CIRCULATION
RENAL BLOOD FLOW
GLOMERULUS AND ITS FUNCTION
Normal Glomerular Filtration Rate (GFR)
Control of GFR
Permeability of Glomerular Capillaries
Hydrostatic and Osmotic Pressure
Factors Affecting the GFR
Filtration Fraction
TUBULAR FUNCTION
General Considerations
Mechanisms of Tubular Reabsorption and Secretion
Na+ Reabsorption
Glucose Reabsorption
Glucose Transport Mechanism
Other Secondary Active Transport
REGULATION OF GLOMERULAR BLOOD FLOW
Autoregulation
Sympathetic Nervous System
Renin-Angiotensin- Aldosterone System
Renal Prostaglandins
Atrial Natriuretic Peptide
FORMATION OF URINE
PROXIMAL TUBULE AND PERITUBULAR CAPILLARIES
LOOP OF HENLE AND VASA RECTA
Counter Current Multiplication
Counter Current Exchange
DISTAL TUBULE AND COLLECTING DUCTS
PERIOPERATIVE RENAL FUNCTION AND ANESTHETIC IMPLICATIONS
DIRECT ANESTHETIC EFFECTS ON RENAL FUNCTION
DIRECT SURGICAL EFFECTS ON RENAL FUNCTION
NEPHROTOXIC INSULTS IN THE PERIOPERATIVE PERIOD
CONCLUSION
8:
Anesthetic Considerations in Pregnant Patients with Cardiac Disease
INTRODUCTION
VALVULAR HEART DISEASE
MITRAL STENOSIS
MITRAL REGURGITATION
AORTIC STENOSIS
AORTIC REGURGITATION
CONGENITAL HEART DISEASE
Left-to-Right Shunts
Tetralogy of Fallot
EISENMENGER'S SYNDROME
COARCTATION OF THE AORTA
Prior Prosthetic Valve Surgery
INFECTIVE ENDOCARDITIS
9:
Anesthetic Considerations for Liver Transplantation
10:
Preanesthetic Evaluation
APPROACH TO A PATIENT IN PREANESTHETIC CLINIC
History Taking
Physical Examinations
Airway Assessment
Evaluation of the Cardiovascular System
Evaluation of the Respiratory System
Evaluation of Renal System
Evaluation of Hepatic System
Evaluation of Endocrine System
COAGULATION DISORDERS
PREOPERATIVE INVESTIGATIONS
ASSESSMENT OF A CHILD BEFORE ELECTIVE SURGERY
Upper Respiratory Tract Infection
Prematurity
RISK STRATIFICATION
American Society of Anesthesiologists Physical Status Classification (Table 5)
11:
Legal Aspects of Anesthesia: Knowledge of Postgraduates in Anesthesiology
LEGAL MASTER-SERVANT RELATIONSHIP
STANDARDS OF CARE
EXPERT WITNESS
HOW TO AVOID A LAWSUIT?
IF A TRIAL IS TO OCCUR?
Phase 1
Phase 2
Do's and don'ts at the Deposition
Phase 3: The Trial
How to Decrease the Likelihood of a Lawsuit?
Phase 4: Settling or Losing the Lawsuit
GOVERNMENT HOSPITALS
VEXATIOUS COMPLAINTS
PREVENTION
CONCLUSION
2: LONG CASES
12:
Mitral Stenosis during MD (Anesthesiology) Examination
13:
Anemia in Pregnancy
CASE SUMMARY
Pathological or Acquired Causes
Iron Deficiency Anemia (60%)
Macrocytic Anemia (10%)
Infections
14:
Anesthetic Management of a Patient with Permanent Pacemaker/Cardiac Implantable Electronic Device
ESTABLISHING WHETHER PATIENT HAS A CIED (MUST KNOW)
Pacemaker Interrogation
Clinical Examination
Investigations
Information from 12 Lead ECG (Fig. 3)
Evaluation of Cardiac Status
BASICS OF PACEMAKER AND CIED
Common Terminology used with Pacemaker (Good to know)
Pacing Threshold and Factors Affecting
Factors Important from Anesthesia Point of View
Implantable Cardioverter-defibrillator (ICD)
Indications
PREOPERATIVE AND INTRAOPERATIVE DEVICE FUNCTIONING (MUST KNOW)
Effect of the Magnet Application on Pacemaker Function
Reprogramming of the Implantable Cardioverter-defibrillator Preoperatively
Equipment to be Kept Ready in the Operating Room
Transesophageal
Intraoperative Monitoring for Patients with Pacemakers
Choice of Anesthesia Technique
Effect of Electrocautery on Pacemaker
POSTOPERATIVE CARE AND INSTRUCTIONS
Specific Clinical Scenarios
15:
Anesthetic Management of a Patient with Chronic Renal Failure Posted for Elective Surgery
PHARMACOLOGY1
CONCLUSIONS
16:
A Patient with Surgical Jaundice to Undergo Anesthesia for Laparotomy
HISTORY
SOCIAL HISTORY
Functional Units (Couinaud's Nomenclature)
Intrinsic Regulation
Extrinsic Regulation
17:
Diabetes Mellitus: Anesthetic Considerations
18:
A Patient with Lung Cyst Posted for Pneumonectomy
PATHOPHYSIOLOGY: CYSTS AND BULLAE
Patients with Cysts and Bullae
Perioperative Risks
Chronic Obstructive Pulmonary Disease
Chronic Bronchitis
Emphysema
Right Ventricular Dysfunction
Common Types of Lung Surgeries and their Indications: An Overview
Common Nonpulmonary Surgeries Performed by a Thoracotomy: An Overview
Problems of Thoracotomy
Evaluation of a Patient Posted for Lung Resection before Anesthesia
Specific Evaluation for Lung Resectability
Pulmonary Function Tests for Lung Resectability
Pulmonary Function Testing for Pneumonectomy
Preparing the Patient for Surgery
Types of Tube that may be used for Ventilation
Advantages of using DLTs
Types and Selection of DLT
Placement
Steps of DLT Placement
MANAGEMENT OF ONE LUNG VENTILATION
Initiating OLV
Hypoxia
TECHNIQUE AND STEPS OF ANESTHESIA
Steps
Perioperative Monitoring Parameters
Postoperative Pain Management Strategies
Strategies of Postoperative Care
STRATEGIES FOR POSTOPERATIVE MECHANICAL VENTILATION
Problems of Postoperative Ventilation after Pulmonary Surgery
Strategies
Possible Postoperative Complications
19:
Thyroid Swelling
CASE SUMMARY
Personal History
On Examination
Examination of the Neck
PALPATION
Special Examination: Eye Signs
Examination
General Examination
Local Examinations
20:
Abdominal Sepsis with Septic Shock, Posted for Exploratory Laparotomy for Source Control: An Approach
CASE
21:
Transurethral Resection of the Prostate Syndrome in Patient with Hypertension and Ischemic Heart Disease
22:
A 65-Year-Old Male Hypertensive Patient Posted for Elective Herniorrhaphy
HYPERTENSION
Classification of Hypertension for Adults
Other Causes of Secondary Hypertension (Table 1)
DRUGS FOR COMPELLING INDICATION
Treatment of Hypertensive Emergencies (Table 3)
Discuss Relevance of Commonly used Antihypertensive Drugs to Anesthesiologist
Discussion the Anesthetic Management in a Hypertensive Patient
Preoperative Evaluation
Induction of Anesthesia
Maintenance of Anesthesia
Postoperative Management
23:
Renal Transplant Anesthesia
CASE SUMMARY
Infectious Diseases
HCV-positive Donor
HBsAg-positive Donor
HBc-antibody-positive Donor
Malignant Tumors
Vascular Conditions and Renal Function
Renal Functions
Marginal Donors
CARDIOVASCULAR SYSTEM
HEMATOLOGICAL SYSTEM
Management
RESPIRATORY SYSTEM
ELECTROLYTES AND ACID BASE STATUS
ENDOCRINE SYSTEM
COAGULATION
CENTRAL NERVOUS SYSTEM
GASTROINTESTINAL SYSTEM
DERMATOLOGICAL
PROBLEMS OF DIALYSIS
Premedication Drugs
Induction Agents
Thiopental
Propofol
Ketamine
Etomidate
OPIOIDS
MUSCLE RELAXANTS
NONDEPOLARIZING AGENTS
Volatile Anesthetic
Anticholinesterase Drugs
DRUGS MODIFICATIONS
Intraoperative Management
Goal
24:
Hypertensive Diseases in Pregnancy
CASE SUMMARY
Ganglion Blocking Agents
β-Adrenergic Blocking Agents
Calcium-channel Blocking Agents
Epidural Anesthesia
Spinal Anesthesia
General Anesthesia
25:
A Patient Suffering from Ischemic Heart Disease, have an Intracoronary Stent, on Beta Blockers, Calcium Channel Blocker and Statin Therapy, Posted for Elective Abdominal Surgery
CASE
Major Predictors
Intermediate Predictors
Minor Predictors
Nitrovasodilators (Nitroglycerin, Isosorbide Dinitrate)
β-Adrenergic Antagonists (Propranolol, Esmolol, Atenolol)
Calcium Channel Blockers (Verapamil, Diltiazem, Nifedipine, Nicardipine)
26:
Anesthetic Management of a Patient with Airway Disorder Posted for Upper Abdominal Elective Surgery
FEW ALGORITHM RELATED TO THE MANAGEMENT
Long-term Oxygen Therapy
3: SHORT CASES
27:
Hydrocephalus
CAUSES OF HYDROCEPHALUS
PATHOGENESIS
SIGNS AND SYMPTOMS
Newborns and Infants
Older Children and Adults
TREATMENT
Medical Therapy
ANESTHETIC MANAGEMENT
POSTOPERATIVE CARE
28:
Cleft Lip/Palate
29:
Role of Anesthesiologist in Acute Burn
30:
Postburn Contractures: Neck and Extremity
31:
Meningocele and Meningomyelocele
32:
Cyanotic Congenital Heart Disease: Tetralogy of Fallot
33:
Patent Ductus Arteriosus
34:
Anesthetic Management of a Diabetic Patient Posted for Emergency Laparotomy
4: MISCELLANEOUS
35:
Inhaled Anesthetics
HALOTHANE
Metabolism
Effects on Various Systems
ISOFLURANE
Sevoflurane
Effects on Various Systems
Desflurane
Effects on Various Systems
OTHER DRUGS RELATED TO ANESTHESIA
Sodium Bicarbonate
Potassium Chloride
Calcium Gluconate and Calcium Chloride
Magnesium Sulfate
Adrenaline
Vasopressin
Amiodarone
36:
Intravenous Fluids: Crystalloids and Colloids
GENERAL CONSIDERATION OF INTRAVENOUS FLUIDS
5% DEXTROSE SOLUTION
Type of Fluid
10% DEXTROSE SOLUTION
Type of Fluid
NORMAL SALINE (NS) SOLUTION
DEXTROSE NORMAL SALINE (DNS) SOLUTION
Type of Fluid
RINGER LACTATE SOLUTION
Type of Fluid
Uses
Contraindications
PEDIATRIC ELECTROLYTE SOLUTION (ISOLYTE P) MULTIELECTROLYTE SOLUTION IN 5% DEXTROSE
Type of Fluid
Uses
Side Effects
GELATIN SOLUTION (HAEMACCEL)
Type of Fluid
Indications/Uses of Gelatin Solution
Side Effects/Demerits
DEXTRAN 40 AND DEXTRAN 70
Type of Fluid
Contraindications
Side Effects
HYDROXY ETHYL STARCH (HES)
Type of Fluid
Contraindications
Side Effects
HUMAN ALBUMIN
Type of Fluid
Indications/Uses
Contraindications
Side Effects
37:
Surgical Airway
DEFINITION
INDICATIONS OF SURGICAL AIRWAYS
Anatomical Considerations
TECHNIQUES
Surgical Cricothyrotomy
Rapid Four Step Technique
PERCUTANEOUS CRICOTHYROTOMY
Cook Melker Cricothyrotomy Kit
Technique
Portex Cricothyrotomy Kit
Technique
Quick Trach 2 Device (Fig. 6)
Technique (Figs 7A and B)
PERCUTANEOUS TRACHEOSTOMY
Technique
Contraindications
Absolute
Relative
CRICOTHYROTOMY
Complications
Early
Late
Tracheostomy
Minor
Intermediate
Major
CONCLUSION
38:
How to Prepare Chest X-rays for MD/DA/DNB Examinations?
OBJECTIVES
LATERAL POSITIONING
POSITIONING
Reading the X-ray
Right Lung Atelectasis
Pleural Effusion
Pneumothorax
Pericardial Effusion (Fig. 15)
39:
How to Prepare ECG for Examination of Postgraduate Students of Anesthesiology?
NORMAL ECG AND THE 12-LEAD SYSTEM
BASIC ECG WAVEFORM
DETERMINATION OF THE ELECTRICAL AXIS
NORMAL RHYTHM OF THE HEART
Cardiac Dysrrhythmias
Factors
MECHANISM OF GENESIS OF DYSRRHYTHMIA
Pathogenesis
Action Plan—when Faced with an Abnormal Rhythm on the ECG Monitor
Practical Interpretation of Arrhythmias
A Systematic Approach to ECG Interpretation
Classification of Arrhythmias
Narrow Complex Rhythms
Broad Complex Rhythms
Narrow Complex Arrhythmias
Broad Complex Arrhythmias
Right Bundle Branch Block
Diagnostic Criteria for LBBB
Left Anterior Fascicular Block (LAFB)
Left Posterior Fascicular Block (LPFB)
Bifascicular Blocks
Trifascicular Block
Ischemic Heart Disease
Hyperkalemia
Hypokalemia
Hypothermia
EINTHOVEN'S TRIANGLE HYPOTHESIS (FIG. 35)
Lead System
NORMAL APPEARANCE IN PERICARDIAL LEADS
Normal Appearances in Limb Leads (Fig. 38)
Treatment of Symptomatic Brady Cardia
Sequence of Changes in Acute Myocordial Ischemia (Fig. 41)
Location of Changes in Myocardial Ischemia
Diagnostic Criteria for Myocardial Ischemia
Reciprocal Changes
True Posterior Myocardial Ischemia
Subendocardial Infarction
Changes in Myocardial Ischemia
ELECTROPHYSIOLOGY OF THE HEART
DIGOXIN
DIGOXIN TOXICITY
ICD THERAPY
40:
Cardiopulmonary Resuscitation Guidelines—the Science Behind Applications: What We Need to Know?
41:
Neonatal Resuscitation
STEPS OF RESUSCITATION
Initial Steps
Warmth
Dry, Stimulate Breathing, Clear Airway
Oximetry
Supplementary Oxygen
Ventilation
Positive Pressure Ventilation
CPAP/PEEP
Assisted Ventilation Device
Endotracheal Intubation
Chest Compressions
Drugs/Volume Expansion
Medications
Volume Resuscitation
Postresuscitation Care
Withholding and Discontinuation of Resuscitation
Educational Programs to Teach Neonatal Resuscitation
42:
Vaporizers
SALIENT FEATURES OF SOME VAPORIZERS
INDEX
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