Textbook of Pediatric Hematology & Hemato-Oncology MR Lokeshwar, Nitin K Shah, Anupam Sachdeva, Bharat R Agarwal, Mamta Vijay Manglani, Asha Pillai
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1Textbook of Pediatric Hematology and Hemato-Oncology2
3Textbook of Pediatric Hematology and Hemato-Oncology
Editor-in-Chief MR Lokeshwar Consultant Pediatrician and Pediatric Hematologist Oncologist Shushrusha Citizens Co-operative Hospital and Lilavati Hospital and Research Centre, Mumbai, India Editors Nitin K Shah President, Indian Academy of Pediatrics, 2006 Consultant Pediatrician, PD Hinduja Hospital, Mumbai, India Bharat R Agarwal Head Department of Pediatric Hematology and Oncology BJ Wadia Hospital for Children Institute of Child Health and Research Centre, Mumbai, India Co-editors Mamta Vijay Manglani Professor and Head Department of Pediatrics Chief, Division of Hematology-Oncology Program Director, Pediatric Center of Excellence for HIV Care Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India Anupam Sachdeva Director, Pediatric Hematology-Oncology and Bone Marrow Transplantation, Institute for Child Health Sir Ganga Ram Hospital, New Delhi, India Recipient, Dr BC Roy Award Recipient, Silver Jubilee Research Award Publication Editor Asha Pillai Medical Officer Kashyap Nursing Home Mumbai, India Forewords SS Kamath Vijay N Yewale
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Textbook of Pediatric Hematology and Hemato-Oncology
First Edition: 2016
Printed at
5Dedicated to
Zinet Currimbhoy
Teacher of Teachers
in Pediatric Hematology and Oncology
for whom
Children with blood disorders and cancer were the greatest teachers!6
It is both a pleasure and a privilege to write a foreword for this first edition of Textbook of Pediatric Hematology and Hemato-Oncology. Immense advancement has been made over the past decade in the field of hematology and hemato-oncology providing not only enhanced accuracy in the diagnosis of inherited and acquired malignant and nonmalignant blood disorders but also new therapeutic strategies that have resulted in improved patient outcomes. The book with its illustrations, tables, figures and clinical photographs provides a concise yet thorough comprehension of pediatric hematology and will definitely become a reference book for the students and the practitioners.
I congratulate the Editor-in-Chief, MR Lokeshwar; Editors, Nitin K Shah and Bharat R Agarwal; Co-editors, Mamta Vijay Manglani and Anupam Sachdeva; Publication Editor, Asha Pillai and the 72 reputed and dedicated pediatric hematologists and hemato-oncologists from across the world who after 3 years of exhausting brainstorming sessions, brought out the remarkable book with 50 chapters spread over 7 sections.
I am sure that the information contained herein will be a benchmark in the understanding of the best approaches to the patients that we evaluate and manage.
SS Kamath
President, 2015
Indian Academy of Pediatrics (IAP)
I am delighted to write the foreword for the first comprehensive book Textbook of Pediatric Hematology and Hemato-Oncology. Postgraduate students look up to their teachers for a book by the editorial team of Doynes in the field of Pediatric Hematology and Hemato-oncology with their vast experience in the field and past experience in writing will fill in this void and meet the expectations of the postgraduate students. The Editor-in-Chief, MR Lokeshwar has been well supported by the other editors, Nitin K Shah, Bharat R Agarwal, Mamta Vijay Manglani and Anupam Sachdeva. The descriptive text along with clinical pictures make it an interesting reading material. It covers a vast spectrum of conditions making it very useful to the reader. I congratulate the entire team which includes the contributors, section editors, editorial board and M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, who have worked relentlessly to achieve this milestone for the book. Above all, my hearty congratulations to the ever-enterprising respected Dr MR Lokeshwar who thought of this brilliant idea of Textbook on Pediatric Hematology and Hemato-Oncology. I wish the best for the success and popularity of the publication among both postgraduate students and practitioners. It will be a landmark publication on Pediatric Hematology Oncology in the history of medical literature.
Vijay N Yewale
President, 2014
Indian Academy of Pediatrics (IAP)
Pediatric Hematology and Hemato-Oncology as a pediatric specialty has developed rapidly in the Western countries since last few decades and is now catching-up in developing countries. Gone are the days when the ‘adult’ hematologists and hemato-oncologists used to treat pediatric patients in need of specialized services. To begin with several pediatricians got self-trained in pediatric hematology and hemato-oncology and pioneered training in field of pediatric hematology and hemato-oncology in the form of several informal and formal courses throughout the country. This created interest in budding pediatricians to join this field by undergoing fellowships or even formal training in pediatric hematology and hemato-oncology abroad and now in India. The last step towards the growth of this specialty has been starting of 2 years of Post-Doctorate Fellowship in Pediatric Hematology and Hemato-Oncology by the National Board in India with several pioneering centers now offering this course since last 7 years, as well as 1 year Post-Doctorate Fellowship by the Maharashtra University of Health Sciences (MUHS) and even by the Indian Academy of Pediatrics (IAP). Several formally trained Pediatric Hematologists and Pediatric Hemato-oncologists are now providing the specialized services in private and public hospitals.
With the interest created in the field of pediatric hematology and hemato-oncology, there was also a felt need by the students as well as practitioners alike to have a dedicated textbook on pediatric hematology and hemato-oncology. While there are several reputed textbooks on pediatric hematology and hemato-oncology, many of them are also elaborate and at times bogged down with details of molecular science which may not necessarily fulfill the needs of students and practitioners who are looking at complete yet concise book.
With the single aim in mind of having a complete and yet easy-to-read textbook on pediatric hematology and hemato-oncology, we have attempted to bring out the first edition after 3 years of brain-storming and grueling process. The 50 chapters spread over 7 sections and authored by 72 reputed pediatric hematologists and hemato-oncologists from India and abroad make the book elaborate enough to give enough to all the readers, yet curtailing it to more than 500 pages making it concise enough! Further powered by illustrations, tables, figures and clinical photographs will make reading a unique and memorable event for the readers. Each chapter is further enriched by references at the end and is peer-reviewed making it scientifically as complete as possible. This being the first edition is bound to have some errors which might have escaped our attention in spite of our best efforts. We would request all our readers to send their feedback to us which will help us improve upon in the subsequent editions.
We are sure that the book will become a reference book for the students and a desk companion to the practitioners!
We would like to express our gratitude to many people who saw us sail through the publication of Textbook of Pediatric Hematology and Hemato-Oncology by providing support, talking things over, read, write, offering comments and helping us in bringing out the book.
We wish to especially thank the following people for their contributions:
  • Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Group President), Mr Tarun Duneja (Director-Publishing) without whom the book would have not found its way, Ms Samina Khan (Executive Assistant to Director-Publishing) for guiding us throughout, Mr KK Raman (Production Manager), Mr Sunil Dogra (Production Executive) and other staff of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, for assisting us in the editing, proofreading and designing skills.
  • All the authors/contributors mentioned in the list of contributors.
  • Special thanks to Mr Harish Raut for assisting us in the editing, proofreading and designing skills.
  • All the patients and families for allowing us to continue to learn the subject.
  • We would also like to thank our family members for their support.
    Last but not least, we beg forgiveness of all those who have been with us over the course of years and whose names, we have failed to mention.
Editorial Board22