Practical Clinical Oncology Praful Desai, Suresh Advani, Rajendra Badwe, Anita Borges
INDEX
Page numbers followed by f refer to figure and t refer to table.
A
Abbe-Estlander flap 153
Abdominal wall reconstruction 601
Abdominoperineal resection 125, 130
Abiraterone 484
Abnormal mitoses 145
Accelerated fractionation 68
Acetaminophen 670
Acinetobacter baumannii 691
Acoustic neuroma 91
Acetate dehydrogenase 635
Acute
lymphoblastic leukemia 62
respiratory distress syndrome 663
Adenocarcinoma 183, 252, 265, 383, 405, 489
of stomach 203
Adenoid
basal carcinoma 383
cystic carcinoma 183, 383
Adenoma 250, 446, 450
of parathyroid 662
tubular adenomas 250
villous adenomas 250
Adenomatous
polyp with high-grade dysplasia 252f
polyposis coli 439
Adenosquamous carcinoma 383, 405
Adequate regional dissection 226
Adjuvant
chemoradiation 173f
chemotherapy 240, 353, 372, 390, 413, 497
concurrent chemoradiotherapy 413
drugs 671
external beam radiotherapy 400
postoperative radiation therapy 391
radiation therapy 412
radiotherapy after subtotal excision 571
therapy 262, 412, 465
in pancreatic cancer 319
treatment for GBC 299
Adrenal 661
androgen production 484
carcinoma 445
cortical carcinoma 448
cysts 446
glands 444f
mass 445
tumors 445
Adrenocortical carcinoma 91
Adrenocorticotropic hormone 79, 407, 444, 446, 588
Adriamycin 340, 628, 629, 630, 631
Adult lymphomas 644
Advanced
cancers, incidence of 674
germ cell tumors 506
nonseminoma 508
ovarian cancer 372
seminoma 508
stage
disease 390
lymphoblastic lymphoma 638
Airway obstruction 611
symptoms 612
treatment 612
Albicans Candida spp 691
Alcohol 234
Alendronate 556
Alpha fetoprotein 59, 507
American
Cancer Society 113, 331t
College of Radiology Imaging Network 332
Joint Committee on Cancer 406, 461t
Society
for Radiation Oncology 556
of Clinical Oncology 357
Urological Association 121
Aminoglutethimide 484
Amphipathic polyethylene glycol 104
Ampulla 205
of vater 209
Ampullary adenoma 213
Anal
canal tumor 130
carcinoma 62
intraepithelial neoplasia 265
Analgesic drug therapy 668
principles 668
Anaphylactic reactions to chemotherapeutic agents 610
Anaplastic
astrocytoma 563, 567
carcinoma 187
large cell lymphoma 634, 634f, 637, 638
lymphoma kinase 64, 403, 456, 634
oligoastrocytoma 561, 567
Anastomotic stricture at esophagogastric junction 217f
Anatomic areas within oropharynx 171f
Anatomical regions in hypopharynx 174f
Anatomy of pharynx 169f
Ancillary techniques 28
Andreas Vesalius 2f
Androgen
deprivation therapy 483
receptor 484
modulator 678
Anesthesia for head and neck surgery 660
Anesthetic problems in specific operations 660
Aneurysmal bone cyst 537
Angiosarcomas of chest wall 438
Ann Arbor
classification of Hodgkin lymphoma, modified 627t
staging classification for Hodgkin and non-Hodgkin lymphomas 647t
Anorexia 657
cachexia syndrome, pathophysiology 677f
of syndrome 677
Anterior
exenteration in females 494f
U cut 131
Antiandrogen withdrawal syndrome 80
Anti-angiogenesis therapy to control hematogenous metastasis 240f
Antibiotic prophylaxis for afebrile neutropenic patient 699
Antibody scan 44
Anticipation and treatment of side effects 671
Antidiuretic hormone 659
Anti-estrogen therapy 354
Antimicrobial
prophylaxis in surgical oncology 696
susceptibility testing 688
therapy, duration of 699
Antral adenocarcinoma 206f
Arcelona-clinic liver cancer staging 281t
Aromatase inhibitors 339, 346
Arterial blood gas analysis 441
Asbestos 404
Ascites 126
Asepsis and surgical technique 701
Asia-Pacific Association for liver treatment hepatocellular carcinoma 282
Aspergillus 689, 694
Scedosporium species 686
species 692
Aspirin 670
Asthenia 678
Asthma 662
Atypical
alveolar hyperplasia 405
lobular hyperplasia 338
small acinar proliferation 476
teratoid rhabdoid tumor 570
Autogenous reconstructions 605
Autoimmune diseases 650
Autologous bone marrow transplant 5
Automated DNA sequencing 95
Axillary lymph node 340, 342t
dissection 339, 342, 344, 352f
Axillary staging 340
B
Bacillus Calmette-Guérin therapy 492
Bacterial versus fungal blood culture positivity over three decades 692f
Balloon
dilation ablation 215f
dilation done 217f
Barium study of patient with lesion in ascending colon 253f
Barrett's
esophagus 202, 203f, 210
mucosa with polypoidal ulcerated adenocarcinoma 203f
Barriers to optimal
outcome in childhood cancers 621f
treatment of childhood cancers in India 621
Basaloid squamous carcinoma 382
Base tongue 171f
B-cell
lymphoma 57, 638
non-Hodgkin lymphoma, treatment and outcome of 637, 639t
BCG failure 493
Beatson-hormonal manipulation 339
Benign
and intracranial extra-axial tumors, management of 570
fibrous histiocytoma 537
lesions 436, 446
tumor 429
of follicular 186
Bereavement support 682
Beta-human chorionic gonadotropin 60, 503
Bevacizumab 63, 242, 415
Bilateral
breast cancer 346
gillies fan-flaps 593
nasolabial flap for submucous fibrosis 594f
ovarian tumors 369f, 375f
Bile duct 205
resection 299
Biliary
malignancies 291
stenting on of pancreaticoduodenectomy, effect of 312
Biological therapy 240
Biopsy 440, 646
interpretation 145
of bone tumors 538
or not to biopsy 280
Bipolar energy 127, 128
Birt-Hogg-Dube syndrome 454
Bismuth-corlette classification for hilar cholangiocarcinoma 302
Bisphosphonates 558
Bladder
cancer 488
carcinoma 62
Bleeding 679
management 679
Bleomycin 507, 509, 628, 629
Blood
biochemistry 647
culture 687
for fungus 689
loss 497
Bloodstream infection 690
trends 690
Bloom syndrome 90, 539
Blue dye 342
B-non-Hodgkin lymphoma, treatment of
advanced 638
limited stage 638
Body
fluid examination 647
mass index 363
Bone
and soft tissue 536
tumors 53
cuts for segmental 151f
forming neoplasm 35f
infarcts 537
marrow
aspiration and biopsy 627
biopsy 647
metastases 55, 59
sarcoma 91
scans 46, 47
tumors and soft tissue sarcomas 536
Borderline
ovarian tumors 375
resectable pancreatic cancer 318
Borrelia burgdorferi 650
Bortezumib 64
Bowel
leak and fistulae 497
obstruction 678
Brachytherapy 70, 71, 355, 357f, 483
in nutshell 71t
Brain
metastasis 581
management of 577
radiotherapy for multiple metastases, whole 580
tumor introduction 560
Brainstem gliomas 570
Branch vein umbilical fissure 297f
Breast 59, 711
cancer 44, 46, 6264, 76, 77, 91, 325, 326, 358t, 364, 438
and pregnancy 349
screening 18, 88, 93
conservation
surgery 338340, 341f, 345, 350, 357
therapy 603
conservative surgery, reconstructive surgery 603
conserving therapy 343, 352
imaging reporting and data system 334
implants 605
MRI 333
reconstruction 603
mastectomy 603
self-examination 19, 331
ultrasound 331
Bricker's
ileal conduit 495
technique 519
Brief pain inventory 668
Broad
spectrum drugs include 676
tongues of cohesive malignant hepatocytes wrapped by peripheral endothelium 280f
Bronchoalveolar carcinoma 405
Bruton's tyrosine kinase 64
Buprenorphine 670
Burden of hereditary cancers 84
Burkholderia species 694
Burkitt lymphoma 62, 633, 633f, 648
C
Cachexia syndrome 677
Cancer
anal canal 265f
antigen 59f, 349
cervix 380
chemotherapy 61, 662
control in developing countries 706
curable with combination chemotherapy 62
esophagus, radiotherapy response in 230t
for adult cancers 615t
for childhood cancers 615t
from an unknown primary site 585
of anal canal 250, 264
introduction 264
etiology 264
pathology 265
treatment 265
of colon 250
of esophagus 222
of head and neck region 62
of hypopharynx, staging of 176
of larynx 160
diagnosis 161
introduction 160
of pharynx 168
general features 168
goals of treatment 170
nasopharynx 169
results of treatment 171
surgical anatomy 168
of rectum 250
of thyroid
adjuvant radioactive iodine 191
etiology 186
introduction 186
investigations 188
management of neck nodes 190
pathology 186
staging 188
treatment 188
pain
analgesics in management of 669t
management 666
practical approach to a patient with 668
syndromes 667t
rectum variations in metropolitan cities 251
registry hub 15
research 112
type of 615
Candida 689
albicans 691
predominates 692
parapsilosis 692
species 689, 702
tropicalis 692
Carcinoembryonic antigen 349, 350, 365, 586
Carcinogenic embryonic antigen 59, 60
Carcinoid
crisis 534
tumors 662
Carcinoma 192
antigen 125 369
cervix 52
in situ 382, 384, 406, 488, 489, 490, 493, 504
of buccal mucosa 592f
of cervix 379
of colon 250
of rectum 255
etiology 255
introduction 255
surgery 257
concept of total mesorectal excision in rectal surgery 257
hand-sewn 257
of thyroid 186
stomach 233
epidemiology 233
introduction 233
Carcinosarcoma anterior lower gum with minimal cortical erosion 149f
Cardiac
dysfunction 390
failure 612
symptoms 612
treatment 612
multigated acquisition 44
problem 598
tamponade 612
symptoms 612
treatment 612
Cardioesophageal junction 236f
Cases of submucous fibrosis 593
Castration resistant prostate cancer 79, 484
Cat's eye reflex 621
Catecholamine receptor scanning 46
Causative agents 686
Cecostomy 518
Celiac
axis nodal clearance 225f
plexus
block 673
neurolysis 202, 215
Cell
carcinoma of esophagus 203
cycle
nonspecific agents 61f
progression 76
regulatory molecules 75
in mantle cell lymphoma 649f
in sarcomatoid pattern 187
lack nuclear features of papillary carcinoma 187
Cellular and nuclear pleomorphism 145
Celomic epithelium 365
Central
brain tumor registry of united states 560
nervous system 467, 624, 636, 637
tumors 560
venous pressure 661
Centralization of pancreatic resections 318
Cervical
axillary lymphadenopathy 407
cancer 62, 381
screening and prevention 15
esophagus 176
intraepithelial neoplasia 16, 380, 384
nodes 226
Cervicothoracic ganglion block 673
Cervix 711
Cetuximab 63, 416
Chemoradiotherapy 240, 387
definitive treatment 229
Chemosensitive tumors 441
Chemotherapy 60, 68, 229, 240, 353, 389, 428, 552
and hormonal therapy 558
and targeted therapy 565
cancer esophagus 230t
for locally advanced breast cancer 353
for metastatic breast cancer 353
induced nausea and vomiting 62
regimens in children with Hodgkin lymphoma 628
surgery-chemotherapy 238
Chernobyl disasters 186
Chest
radiography 440
wall postexcision reconstruction with goretex mesh repair 601f
wall reconstruction 598
wall resections and reconstructions 440
X-ray 425
Chevassu's maneuver 503f
Child with non-Hodgkin lymphoma 635t
Childhood
cancers, burden of 614
non-Hodgkin lymphomas 632t
Child-Pugh classification 278t
Children with non-Hodgkin lymphoma 635
Children's cancer group 629, 637, 639
Chlamydia psittaci 650
infections 635
Cholangiocarcinoma 299
introduction 299
Chondroblastoma 537
Chondroma 436, 537
Chondromyxoid fibroma 537
Chondrosarcoma 437, 441, 537, 542, 543f
Chordoma 537
Choriocarcinoma 59, 62367, 502
Choroid plexus tumor 91
Chromophobe 455
Chronic
hypercalcemia 194
lymphoblastic leukemia 64
lymphocytic leukemia 64, 647
myelogenous leukemia 63
myeloid leukemia 64, 86, 95
Circumferential margins 257
in surgery for rectal cancer 259f
Cisplatin 507, 509
Cladosporium 693
Classical
Hodgkin lymphoma 626, 645
seminoma 501
Classification of
carcinoma of breast 326
diffuse large B-cell lymphoma 32f
germ cell tumors of testis 501
lymphedema 352t
pap smear 384t
surface epithelial tumors 365t
Clear cell 367
adenocarcinoma 396
carcinoma 383
Clinical breast examination 19, 331
CNS tumors
complications of 564
histology of 561
Codeine 556, 670
Codman's triangle 35f, 539, 539f
Collecting duct tumors 455
Collimator shaped beam 66f
Colon
and rectal cancer 125
and rectum 50
cancer 63
Colonic and rectal nets 532
Colorectal cancer 27f, 126, 207, 364
surveillance 207
Colostomy 526
in infant or child 526
Colposcopy 384
Combination
chemotherapy 415
therapy for carcinoma stomach 240
Combined oral contraceptives 394
Common
malignant tumors 59t
symptoms, management of 564
Commonly occurring tumors of small bowel 245t
Community
based palliative care 682
cancer centers 707
empowerment 683
Complete response 563
Completion of
extensine D3 dissection 237f
total thyroidectomy 44
Complex heterogeneous mass in left kidney 457f
Complications of
BCG 493
colonic surgery 255
pancreaticoduodenectomy 314
Composite left cheek-mandible defect 154f
Comprehensive
cancer centers 707
list of documented infections 686f
Computed tomography 37, 39f, 42, 50f, 53, 71, 341, 345, 368, 440, 445, 502, 507, 509
of paraganglioma 452f
Concurrent chemotherapy 390
Condyloma 265
Condylomatous carcinoma 382
Confocal laser endomicroscopy, techniques of 203
Conformal radiotherapy 72
Conservation breast surgery 339
Constipation 676
management 676
non-drug measures 676
Contemporary
chemotherapy regimens for children with hodgkin lymphoma 629t
imaging modalities 561
management of bladder cancer 492
Continent urinary diversion 495
Continuity of care 683
Contralateral breast 604
Contrast
enhanced CT scan of chest 425
MRI of thorax 425
Controlled radial expansion 216
Conventional
clear cell 455
carcinoma 455
radical cystectomy 494
Core needle biopsy 335
over fine needle aspiration cytology 25
Corticosteroids 671
Cowden syndrome 88
Cranial nerve blocks 672
Craniopharyngiomas 571, 572
Creation of loop ileostomy 519f
Cribriform pattern with high-grade cytologic atypia 252f
Criteria of unresectability of HCC 284
Crizotinib 64, 640
Crohn's disease 127
Cumulative survival in locally advanced gastric cancer 239f
Cuncurrent chemoradiotherapy 69
Cushing's syndrome 405, 407, 432, 446, 533, 661
Cutaneous manifestations 589
Cyclin dependent kinases 75
Cyclo-oxygenase inhibitor 670
Cyclophosphamide 4, 339, 340, 628, 629, 630, 631, 639
oncovin methotrexate prednisone 639
Cylindroma 183
Cystectomy in males 494f
Cystitis cystica and glandularis 489
Cystocopy 385
Cystosarcoma phyllodes 347
Cystourethroscopy and transurethral resection 491
Cytogenetic analysis 586
Cytomegalovirus infections 693, 694
Cytoreductive surgery 371
Cytotoxic T-lymphocyte antigen 63
D
D'Amico risk stratification of carcinoma prostate 482t
Dacarbazine 448, 628
Deep
lobe 182f
vein thrombosis 407, 589
De-epithelized skin flaps 602
Dehydroepiandrosterone 77, 444
sulfate 445
Delayed gastric emptying 316
Delirium 679
management 679
Delivery of
hydrophobic drugs 104
nucleic acids 105
Deltopectoral flap 591f
Denonvilliers' fascia 130
Denosumab 556, 558
Dental rehabilitation 150f
Deoxyribonucleic acid 43, 60, 67, 85, 112, 358, 404, 625
Depiction of morphology of three classes of cholangiocarcinoma 301f
Dermoid cyst 367
Desmoids tumors 437
Desmoplastic fibroma 537
Determinants of nodal metastasis 199
Development of video capsule endoscopy 202
Diabetes and hypertension 395
Diagnosis and pretherapy workup 264
Diagnosis of digestive cancers 206
Diagnostic staging laparoscopy 210
Diarrhea 662, 677
Diclofenac 556, 670
Diet 234
and lung cancer 405
and obesity 476
Diethylstilbesterol 379, 381
Different neck compartments 191f
Diffuse
gastric body 206f
large B-cell
lymphoma 633, 648
NHL 644
large cell lymphoma 634f
Digestive
anastomosis 314
tract cancers 202
Digital
per-rectal examination 256
rectal examination 478, 478f
Dihydrotestosterone 79
Dilation done with controlled radial expansion balloon 217f
Disease
burden 15, 18, 20
free survival 121, 341, 552
free survival 226
of remaining colon 526
Dissection of
pararectal space 131
rectovaginal space 131
ureteric tunnel 132
Distant metastasis 126, 163
Division of
mediastinum 424f
rectum distal to tumor 130f
Donor sites 600
Dose of cetuximab 263
Double
balloon 207
strand break 67, 68
Doxorubicin 340, 629
Drop shaped rete ridges 145
Duct carcinoma in situ 327, 336
Ductal carcinoma in situ 19, 328f
Dysgerminoma 367
of left ovary 60f
Dysplastic lesions of digestive tract 203
Dyspnea 679
management 679
non-drug 679
E
Early
cardioesophageal lesion 224f
colon cancer 212
gastric cancer 212
menarche and late menopause 395
Elastofibroma dorsi 439
Electron microscopy 586
Eligibility criteria for using anti-EGFR drugs 263
Embryonal
carcinoma 60f, 367, 501, 502
rhabdomyosarcoma 62
Emergencies in oncology 609
Encapsulated tumor with cells in follicular pattern 187
Encasement of mesenteric vessels 248f
End colostomy 517
End ileostomy 518, 527
End of life care 572
Endocrine
and neuroendocrine tumors 44
combination therapy 81
Endocrinologic 659
End-of-life care 681
Endometrial
cancer 91, 394, 396
hyperplasia 396
Endometrioid
adenocarcinoma 383, 383f, 396f
carcinoma 366f
Endoscopic
evaluation 647
mucosal resection 202
technique
injection + band application 211f
injection + hood application 211f
injection + snaring 211f
palliative treatment 214
resection 211
submucosal dissection 202
steps of 212f
treatment 210
of postoperative 216
ultrasonography 202
ultrasound 408
Endothelial growth factor receptor 102
Endothelial-cell killing 566
Enneking system for malignant tumors 538t
Enteral feeding 677
Enterobacteriaceae 691
Enzyme cyclo-oxygenase 669
Eosinophilic granuloma 437
Ependymomas 570
Epidemiology for
cholangiocarcioma 300
gallbladder carcinoma 291
Epidermal
cells 183
growth factor receptor 5, 31, 33, 44, 60, 63, 64, 115, 580
Epidural
neurolysis 672
spinal cord compression 671
Epithelial dysplasia 142
Epithelioid type 274f
Erlotinib 416
Erythroplakia 142, 143
Esophageal
cancer 62, 214, 222
nets 532
Esophagus 122, 205, 206
Estrogen
and breast tumor 76
receptor 75, 76, 345, 351
Ethics
and palliative care 681
in end-of-life care 681
Ethnicity 235
diagnosis 235
genetics 235
investigations 235
pathology 235
symptomatology 235
treatment 236
lymph node dissection 237
surgery 236
Etoposide 507, 509, 629
plus cisplatin 507
Euronet pediatric Hodgkin's lymphoma 630
European
Organization for Research and Treatment of Cancer 563
Society for Medical Oncology 468
Evaluation of hereditary cancers 87
Event-free survival 637
Evidence-based medicine in oncology 653
Ewing's sarcoma 25, 438, 441, 536, 537, 541, 615
of femur 541f
Exogenous infections 685
Extended spectrum beta lactamase 687
Extension into parapharyngeal space 182f
Extent of lymph node dissection 388
External beam
radiation therapy 65, 356, 391
radiotherapy 400, 483
Extra-abdominal muscles 603
Extracranial course of facial nerve 181f
Extrahepatic 260
Extranodal marginal zone NHL 650
Extraperitoneal
radical cystectomy 495f
retrograde cystectomy 494
Extra-platysmal flaps 184
Extrathoracic metastases on positron emission tomography 51f
F
Facial telangiectasis 662
Familial
adenomatous polyposis 87, 89, 207
forms of large bowel cancer 252
familial adenomatous polyposis 252
hereditary nonpolyposis colorectal cancer 252
papillary RCC 454
retinoblastoma 537
Fanconi anemia 90
Fentanyl 670
transdermal 670
Fertility drugs 364
Fever 658
Fiberoptic bronchoscopy 409
Fibroma 367, 501, 537
Fibromatosis 439
Fibrosarcoma 537
Fibrous dysphasia 436, 537
Fibula 597
graft
front face 156f
open mouth 156f
profile 156f
Final transection area 297f
Fine needle aspiration 425
biopsy 202
cytology 25, 188, 192, 335, 369
gastrointestinal stromal tumor 275f
of moderately differentiated hepatocellular carcinoma 280
Fisher hypothesis 339
Five-year relative survival rates 711t
Flaps 602
donor site selection 596
elevation 599
requirements 599
Fluid-attenuated inversion recovery 565
Fluorescent in situ hybridization 25, 94
Fluorine-18 estradiol receptor scan 48
Fluorodeoxyglucose 37, 46
Follicle stimulating hormone 77
Follicular
adenoma 187
and carcinoma 186
lymphoma 57, 647, 649
international prognostic index score 648t
type 186
Front face 155f
Functional
adrenal mass 446
magnetic resonance imaging 38f
role of larynx 160f
Fungal
infections 689
in Indian scenario 691
serology 689
Fusarium 693
G
Galen's theory 1
Gallbladder 205
cancer before operation 295
carcinoma 291
introduction 291
with duodenal infiltration 294t
Gamma camera 43
Ganglioneuromas 446
Gardner syndrome 89
Gastric
cancer 50, 62, 214
carcinoids 62, 534
fundus with central ulcer and bleed 209f
pull-up 179f
tube conduit prepared for anastomosis 225f
ulcer 206
Gastrinoma 45
Gastroendocrine pancreatic neuroendocrine tumors 56
Gastroesophageal
junction 125f
reflux disease 223
Gastrointestinal 657
cancers 12, 50
carcinoids 533
lymphoma 209
stromal 252
tumors 25, 53, 64, 95, 209, 273, 589
introduction 273
management 275
pathology 273
pathology gross 273
pathology investigations 275
symptoms 675
tract 532
Geftinib 64
Gender adaptation 629
Gene expression profiling 28, 95
General principles in oncologic anesthesia 657
Genesis of rural cancer facility to major community cancer center 710t
Genetic
and cancer 84
disease 84
of sporadic and hereditary cancers 84
predisposition 625
syndrome 88, 89
testing 91
Genitourinary cancers 52
Geotrichum species 693
Germ cell 365
tumors 62, 367, 428, 500, 501, 537
Gerota's fascia 127
Gleason scoring 476
of prostate cancer 476
Glioblastoma 561, 565
in elderly patients 568
multiforme 563
Gliomatosis cerebri 567
Global burden of cancer 363
Glucagonoma 45
Glucose uptake ratio 53
Goals of care 675
Gonadal
stromal tumors 501
tumors 615
Gonadoblastoma 501
Gonadotropin releasing hormone therapy 484
Gorlin's syndrome 91
Grading of
breast carcinoma 328
human epidermal growth factor receptor 2 329t
Grafts material for structural support 600
Granulomatous carcinoma 346
Granulosa cell tumor 367, 501
Gross appearance of familial adenomatous polyposis 252f
Growing teratoma syndrome 508
Growth signal inhibitors 63
Guidelines for relative risk of malignant behavior 274t
Gynecologic surgery 364
Gynecological tract cystectomy with neobladder in females 495f
Gynecology oncology group 391
H
Hairy cell leukemia 647
Hand-assisted laparoscopic surgery 125
Hand-Schuller-Christian disease 437
Harmonic scalpel 127, 128
Harrington's classification for spinal metastases 557t
Hashimoto's thyroiditis 650
Head
and neck
cancer 53, 63
reconstruction techniques in 591
region, reconstructive options for 593
squamous cell carcinoma 67
Helicobacter pylori 203, 644, 650
infection 635
Hemangiomas 437
Hematological abnormalities 658
Hematopoietic stem cell transplant 687, 694
Hemi-body irradiation 556
Hemoclips applied 153f
Hemostasis achieved 207f
Hepatic malignancies 277
introduction 277
investigation 278
natural history of hepatocellular carcinoma 278
pretherapy workup 278
biochemistry 278
radiological imaging 279
tumor markers 279
staging 281
Hepatitis
and cancer 693
B 693
virus 688
C 693
Hepatocellular carcinoma 51, 277
introduction 277
with arterial enhancement and washout 279f
Herceptin 242
Hereditary
breast
cancer syndromes 326
ovarian cancer 91
syndrome 85, 88
cancer 84
syndrome 91f
leiomyoma RCC 454
nonpolyposis colon cancer 85, 91
syndrome 88, 89
retinoblastoma 90, 91, 539
High chance of high-grade dysplasia 203
High dose rate 71
High grade
prostatic intraepithelial neoplasia 476
squamous epithelial lesion 384, 385
High intensity focused ultrasound and cryotherapy 483
High nuclear grade 328
High prostate-specific antigen 37
High-dose methotrexate 638
Hilar 299
Hiroshima disasters 186
HIV and cancer 693
Hodgkin's
and non-hodgkin lymphoma 624t
disease 39f, 62, 63, 186
lymphoma 25, 62, 624, 628, 644, 646f, 650
classification of classical 626t
in children 631t
treatment of
high-risk classical 630
intermediate-risk classical 630
low-risk classical 630
reed-sternberg 625
Homogenous leukoplakia 142
Hopkins verbal learning test-revised 581
Hormonal
dependence of malignant cells 74
therapy 353, 354, 399, 484
Hormone
and contraceptives 394
and ovarian cancer prediction study 364
deprivation 75
in prostate cancer 79
induced cancers 80f
interference 75
receptor 329
replacement therapy 19
therapy 364
Hospice life care 572
Hounsfield units 445
HPV vaccination 17
Human
chorionic gonadotropin 507
epidermal growth factor receptor 345
immunodeficiency virus 380
papillomavirus 17, 142
infection 379
related lesions 265
testing 17
Huntington's disease 626
Hürthle cell 187
Hydroxydaunorubicin 639
Hypercalcemia 610, 658
pathophysiology 610
symptoms 610
treatment 610
Hypercalcemic crisis 195
Hyperthermic intraperitoneal chemotherapy 261, 374, 374f
Hyperviscosity syndrome 612
symptoms 613
treatment 613
Hypofractionation 68
Hypogammaglobulinemia 427
Hypoglycemia 589, 658
Hyponatremia 613
symptoms 613
treatment 613
Hypopharyngeal cancers
classification of 175
clinical features 175
epidemiology 175
incidence 175
physical findings 175
Hypopharynx
advanced disease 176
and cervical esophagus 174
introduction 174
early cancer 176
reconstruction 177
results of treatment 179
Hypothalamo-pituitary-gonadal axis 484
Hypoxia imaging 55
I
Ibrutinib 64
Ibuprofen 556, 670
Ifosfamide 507, 509
Ilium 596
donor site 598
Image-guided radiation therapy 37
Imatinib 64
Immature teratoma 367
Immune dysregulation 625
Immunocompromised cancer 685
Immunohistochemistry 24, 28, 274, 586
Important nodal groups 198f
In situ hybridization 28, 29, 531
In vitro fertilization, visions of 714
Incidence of stomas 512
Incidental carcinoma of gallbladder 295
Incision plan 177f
Increased nuclear-cytoplasmic ratio 145
Indian Cancer Cooperative Network 654
Individual tumors, management of 565
Indomethacin 670
Infections in
hematopoietic cell transplant recipients 697
patients with neoplastic disease 686
surgical oncology 694
Infective episode, diagnosis of 690
Inferior vena cava 444, 452f, 551
Infiltrating duct carcinoma 346
Inflammatory breast cancer 345, 346t
Infradeodenal common bile duct stricture 208f
Inhomogeneous leukoplakia 142
Inoperable
hilar cholangiocarcinoma 216f
midesophageal malignant stricture 214f
Insulinomas 45, 662
Intensity modulated
arc therapy 72
radiation therapy 4, 37, 71, 355, 356f, 391
techniques 401
radiotherapy 71
Intermediate cells 183
Internal mammary nodes 342, 355
International
Adjuvant Lung Cancer Trial 413
atomic energy agency 57
cancer genome consortium 95
collaborative ovarian neoplasm 373
Germ Cell Cancer Collaborative Group 507, 509
prognostic
index 648t
score for HL 651t
study group on pancreatic fistula definition of postoperative pancreatic fistula 315t
Interventions in pain management 672
Intestinal stoma surgery 515
Intracellular accumulation of nanoparticles 106f
Intractable pain 215
Intraductal
carcinoma 328
ultrasonography 208
Intraepithelial stage 382f
Intrahepatic cholangiocarcinoma 287
Intraoperative frozen section 304
Intraoral view 156f
Intraperitoneal chemotherapy 373
Intratubular germ cell neoplasia 500, 501
Intravascular
congestion, disseminated 658
device-related infections, prevention of 701
Intravenous pyelogram 496f
Intravesical therapy 492
Introduction of hormone therapy 63
Invasive
aspergillosis 689
breast cancer 326, 339, 352, 352t
carcinoma of cervix 385
ductal carcinoma 327f, 328f
lobular carcinoma 327
Iodine-131 metaiodobenzylguanidine therapy 56
Ionizing radiation 404
Ipilimumab 63
Irradiated chest wall 601
Irregular epithelial stratification 145
Irrigation 526, 527f
Irritable bowel syndrome 526
Ischemia of stoma 520
Isotope therapy of neuroendocrine tumors 56
Issues in salivary gland surgery nonsurgical treatment 185
Italian Association for Pediatric Hematology and Oncology 637
Ivor-Lewis technique 123
J
Janus kinase inhibitor 64
Jejunal ulcerated leiomyoma with bleed 153f
Jejunum in place 178f
K
Karapandzic technique 153, 153f
Karnofsky performance score 563
Ketoconazole 484
Ketoprofen 670
Ketorolac 670
Kidney 711
disorders 524
Killian's dehiscence 174
Kinesin spindle protein 106
Koch's lesion 49f
Kocher maneuver 125
Krukenberg's tumor 351, 375
Kudo's pit pattern 204f
L
Lactate dehydrogenase 368, 502, 503, 636, 637
Lactic acidosis 659
Lamina propria 490
Laparoscopic
assisted surgery 126
low anterior resection 127, 128
pancreatic resections 318
radical
hysterectomy 131
nephrectomy 462
right hemicolectomy 126
surgery 213
trans-hiatal esophagectomy 123, 123t
Large
cell carcinoma 405
gastrointestinal stromal tumor 209f
rectal villous adenoma 208f
ulcerated ampullary adenocarcinoma with intraductal extension 209f
Laryngeal
cancer 62
general principles 162
management of relapse and treatment failure 164
cavity, middle part of 161
Laryngopharyngectomy specimen 177f
Laryngopharynx 174, 593
Late toxicity, avoidance of 629
Latent membrane protein-1 626
Lateral mobilization of rectum 129f
Latissimus dorsi
muscle 599
myocutaneous flap 605
Layer of buccopharyngeal fascia 174
Left
gastric artery 225f
ilio-obturator lymph node dissection 132f
pararectal space 132
thoracoabdominal approach 224f
ureteric tunnel dissection 132f
Lesion in
buccal mucosa seen during surgery 592f
lower rectum postchemoradiotherapy 257f
Letterer-Siwe disease 437
Leukemia 501, 615
Leukokoria 621
Leukoplakia 142, 143
Leydig cell tumor 367, 501
Li-Fraumeni syndrome 86, 88, 91, 537, 539, 545
Ligation of
ileocolic vessels 128f
inferior mesenteric pedicles 129f
Lip split with cheek flap 150f
Lipoma 437
Liposarcoma 438
Lips 593
Liver 59
and pancreas 51
function tests 56
metastasis in colorectal cancers 260
resection 282
closure 284
drainage 284
postoperative care in cirrhotic patients 284
exposure and mobilization 283
for gallbladder cancers 296
inflow control 283
operative technique modifications for hepatic resection in cirrhotic patients 283
parenchymal transection 283
surgical principles for hepatic resection 282
transplantation 285, 306
LN dissection 132
Lobectomy versus total thyroidectomy in thyroid cancers 191
Lobular
carcinoma in situ 328, 338
neoplasia 328
Local
recurrence of rectal cancers 260t
tumor invasion 303
Localized esophageal cancer 224
Locally advanced breast cancer 48, 337, 339, 340, 344, 345, 345f
Locoregional therapy 285
Loop
colostomy 517
ileostomy 519, 527
Loss of
heterozygosity 85, 455
intercellular adherence 145
polarity of basal cells 145
Low
cervical 225
dose-involved-field radiation therapy 631
glomerular filtration rate 464
grade
dysplasia 208f
follicular lymphoma with nodules 649f
gliomas 567
intramedullary osteosarcoma 540
squamous epithelial lesion 384
molecular-weight heparin 564
nuclear grade 328
tumors of rectum 130
Lumbar sympathetic block 673
Lung 585, 711
cancer 48, 91, 407, 439
surgery 660
Luteinizing hormone releasing hormone 75, 102
Lutetium-177 dotatate therapy 56
Lymph node 121
biopsy 627
Lymphadenectomy 398
extent of 299
Lymphatic
dissemination 405
drainage
in ovarian cancer 370f
of stomach 237f
spread of laryngeal cancer 162f
Lymphedema 344, 351
Lymphoblastic lymphoma 634, 634f
Lymphocyte-predominant Hodgkin lymphoma, treatment of nodular 630
Lymphoma 59, 439, 501, 537, 615
in children 624
Lymphorrhea 497
Lynch syndrome 89, 394
M
Magnetic resonance imaging 37, 39, 42, 330, 341, 368, 375f, 385, 408, 437, 440, 459f, 479, 479f, 502, 533f, 537
of breast 335f
Malabsorption of vitamin B12 524
Male breast cancer 91, 347
Malignant
colorectal obstruction 215
fibrous histiocytoma 537, 546
germ cell tumors 429
lesions 437, 438, 445
liver tumors, classification of 277t
melanoma 63, 265
mixed Müllerian tumor 367, 397
mixed tumor 183
peripheral nerve sheath tumor 91
salivary gland tumors 183f
schwannoma 431
Mammalian target of rapamycin 468
Mammogram 352
Mammography 18, 35, 331
Management of
breast cancer 339
early stage I and II cancer of larynx 165
germ cell tumors of testis 504
laryngeal cancer 162
locally advanced breast cancer 345
lung cancer 403
metastatic
disease 547
neck 200
muscle invasive carcinoma bladder 494
pancreaticoduodenectomy 314
prostate cancer 486
recurrent disease 372
skeletal metastases 553
stage III and stage IV cancer of larynx 166
tumors of hypopharynx 176
Mandibular reconstructions 595
Mantle cell lymphoma 649
Marginal mandibulectomy 151f, 152f
Margins of resection 28
Maryland's forceps 132
Mastectomy 339f
site 604
Mature b-cell lymphoma 89 639
Mature cystic teratoma 367
McGill pain questionnaire 668
Mechlorethamine 628
Mediastinal
ganglioneuromas 431
tumors 424
Medical management of brain metastasis 579
Medicine obstacles to overcome 654t
Medullary
carcinoma 346, 455
thyroid cancer 45, 59, 64, 91
Medulloblastoma 568
Melanoma 64
Memorial
pain assessment card 668
sloan-kettering cancer center classification for hilar cholangiocarcinoma 302t
Mendelian
autosomal dominance 189
disorder 84
Meningiomas 570
Mesenchymal tumors 430
Mesna 507
Mesothelioma 439, 585
Metabolic
acidosis 524
scan 43
Metachronous bilateral breast cancer 346
Metaiodobenzylguanidine 532
scan 46f
Metastatic
and recurrent tumors 498
axillary nodes 336f
bone disease 57
brain tumors 577
breast cancer 350
disease 304, 484
neck 197
anatomy of fascia 197
anatomy spaces of neck 197
clinical features 199
introduction 197
N0 neck 200
N1 neck 200
N2 neck 200
N3 neck 200
neck levels 198
staging 199
triangles of neck 197
renal cell carcinoma 466
setting 262
Methicillin-resistant Staphylococcus aureus 686, 700
from different samples 696f
Methods of
reconstruction 595
skeletal stabilization 601
Methotrexate 339, 631
Methylguanine-methyl-transferase 562
Microbial pathogens and infection control in immunocompromised cancer patients 685
Microbiology of surgical site infections 694
Microinvasive squamous carcinoma 382
Microsatellite instability 94
Microsporidium species 697
Microsurgical breast reconstruction 606
Microvascular free
flaps 600
tissue transfer 594
Middle hepatic vein apex of transection 298f
Minimal
access surgery 135, 136f
in surgical oncology 138
deviation adenocarcinoma 383
invasive surgery 120, 259f, 482
for bladder cancer 498
Mini-mental state examination 564
Mirel's scoring system 557t
Mixed
adenocarcinoma 396
cellularity classical hodgkin lymphoma 645
tumors 501
Mode of
dissemination 405
spread 369
Modified
FIGO grading system 396
median lip split with Z's 151f
radical
mastectomy 339, 358
neck dissection 201
Scarff-Bloom-Richardson grading system 329
Molecular
biologic techniques 531
biology 310
of medulloblastoma 563
revolution 339
profiling 586
scan 44
targeted therapy 428
taxonomy of cancers 93
Monodermal teratoma 367
Mononuclear phagocyte system 104
Morphine 556, 670
Mouth opening 155f
Mucinous breast cancer 346
Mucoepidermoid carcinoma 183
Mucosa-associated lymphoid tissue 635
type lymphoma 186
Mucosal hyperplasia lower end of self-expandable metal stent in esophagus 215f
Mucous secreting cells 183
Multicentric disease 340
Multileaf collimators 72
Multinodular goiter 192
Multiple
basal cell carcinoma 91
daily fractions 68
endocrine neoplasia 90, 91, 186, 194
full-term pregnancies 381
myeloma 64
pulmonary metastases 460f
ligation-dependent probe amplification 91
Muscle flap 599
Musculocutaneous flaps 599, 603
Musculofascial flaps 602
Musculoskeletal tumor society 538
Mutually supportive and interactive system for cancer care 707f
Myasthenia gravis 426
Mycobacteria 686
Mycobacterial infections 693
Mycobacterium
fortuitum chelonei 693
tuberculi 4
Mycosis fungoides 589
Myelofibrosis 64
Myelolipoma 446, 450
Myeloma 537
Myocutaneous flap 602
Myoma screw 131
N
N0 neck 200
Nanotechnology application in cancer therapy 102
Naproxen sodium 670
Narrow band imaging
Kudo's IIIL pattern, malignant adenomatous polyp 204f
ulcerated dysplastic barrett's mucosa with stricture 203f
Nasogastric tube 125
Nasopharyngeal cancer 62
Nasopharynx 169f, 170
National
cancer
data base, evaluation of 191
Registry Programme 12
Institute of Health 114
nosocomial infections surveillance 690
Surgical Adjuvant Breast and Bowel Project 339, 340, 653
Natural orifice transluminal endoscopic surgery 137, 139, 202, 213
Nausea 675
management 675
Neck
levels 198f
residue and lymph node metastasis 55
Need for neoadjuvant chemoradiotherapy 256
Neoadjuvant
approaches in pancreatic cancer 319
chemotherapy 240, 263, 339, 369, 371, 389, 414, 497
contribution of 654
in colonic cancers 255
therapy 413
three-drug chemotherapy 176
treatment for GBC 299
Nephrogenic adenoma 489
Nephron sparing surgery 463
Neurilemoma 431
Neuroblastoma 45, 59, 431, 446, 615, 617
management algorithm in 618f
risk stratification in 618f
Neuroendocrine
carcinoma 383, 529
tumors 44, 59, 252, 529
of gastrointestinal tract 531
of jejunum 246f, 534f
of lung 532
Neurofibroma 431, 437
Neurofibrosarcomas 439
Neurogenic tumor 431, 437
Neurologic 659
Neurolytic celiac plexus block 673
Neuromuscular disorders 589
Neuropathic pain 667
Neurosurgery, principles of 564
Neutropenic sepsis 609
pathophysiology 609
symptoms 609, 610
treatment 609, 610
Newer concepts in pancreatic cancer 318
Nicotine derived nitrosamine ketone 404
Nipple
areola reconstruction 607
creation 607
discharge 349
N-methyl-D-aspartate 669
Nocardia species 686
Nodal
dissection 226
staging and fluorodeoxyglucose-positron emission tomography 49
Nodular
hyperplasia 446
lymphocyte-predominant Hodgkin lymphoma 626, 651
pattern of hepatocellular carcinoma on gross examination 283f
Nomenclature of neck dissections 200
Non-aeruginosa pseudomonas species 691
Non-albicans Candida 692
species 691
Non-germ cell tumors 501
Non-Hodgkin's lymphoma 62, 63, 624, 644
Nonhomologous end joining 67
Non-HPV cancers 171
Noninvasive
breast cancer 336
papillary carcinoma 490
Non-muscle invasive bladder cancer 492
Non-opioid analgesics 669
Nonseminoma 501f
Non-seminomatous germ cell tumor 430, 500, 501, 505, 505t, 507
Non-small cell
carcinoma 64
lung carcinoma 32, 48, 62, 101, 404, 580
Non-steroidal
anti-inflammatory
agents 677
drugs 555, 669, 670t
estrogen diethylstilbestrol 78
Nontuberculous mycobacterial 686
Normal cellular function 86
N-staging for all head and neck sites except thyroid 148t
Nuclear factor-kappa-B pathway 626
Nulliparity and infertility 395
NWTSG approach 619
O
Obesity 234, 363, 395
Obstructive
jaundice in resectable pancreatic head 312
rectal cancers 260
Odor 522
Oligo brain metastasis, management of 580
Oligodendroglioma 567
Oncocytoma 446, 450
Oncologic surgery, major 590
Oncology and hematology-Hodgkin lymphoma 630
Oncoplastic surgery 603
Oncovin 628, 630, 631
prednisone 639
Opening of peritoneum 127f
Opioid
analgesics 669
use, principles of 670t
Optic pathway glioma 91
Oral cancers 147
anatomical boundaries and subsites 147
approach to treatment 149
cheek flap 149
peroral 149
visor flap 150
cheek and gum 153
chemotherapy 159
floor of
mouth 157
tongue 157
general features 147
introduction 147
lips 153
managing mandible 150
mandible 154
radiotherapy 159
retromolar trigone 157
surgical approaches 149
Oral
cavity, subsites 147f
chemotherapy 262
contraceptives 381
lesions 145
lichen planus 142, 144
premalignant lesions 142
Oropharyngeal walls 171f
Oropharynx 171
clinical features 172
introduction 171
management 172
representative case 172
staging 172
Orthopantomogram of fibular reconstruction for mandibular defect 597f
Orthopantomograph weeks 157f
OSLO tomosynthesis screening trial 331
Osteoblastoma 537
Osteochondroma 436, 537
Osteogenic sarcoma 59, 62, 496f
Osteoid osteoma 537
Osteosarcoma 35f, 437, 441, 537, 538, 539f
Ovarian
cancer 52, 62, 91, 363, 364
screening 88, 93
tumors 351
Ovary 585
P
Paget's disease 347, 537, 539
Pain
measurement of 668
syndromes with
cancer therapy 667
tumor infiltration 667
to cancer therapy 668
types of 667
Palliation 229, 306
in pancreatic cancer 319
of intrathoracic disease 416
Palliative care 299, 572, 674, 675
definition of 675
Palliative chemotherapy 415
Pancreas 59, 205
cancer 62
Pancreatic
anastomosis 313
body and tail cancer 316
cancer, staging of 311
head 312
malignancies 310
Pancreaticobiliary 207
cancer 215
Papanicolaou smears 383
Papillae with characteristic nuclear features 187
Papillary
carcinoma 187, 346, 455
urothelial neoplasia 489
Papilloma 489
Paracetamol 556
Parafollicular cells 187
Paraganglioma 45
Paramedian mandibulotomy 152f
approach for lateral base tongue tumors 173f
Paranasal sinuses
orbit base 593
skull base 593
Paraneoplastic syndromes 425, 588
in cancer 588
Parastomal hernia 521, 526
and mesh repair 522
Parathyroid 662
adenoma of left inferior gland 196f
carcinoma 662
tumors 194
clinical features 194
introduction 194
investigations 194
management 194
Parenteral
feeding 677
nutrition 678
Paris classification 211f
Parosteal osteogenic sarcoma 540, 540f
Parotid gland 181f
Pars membranacea 125
Partial
breast
irradiation 339
radiation 355
response 563
Patch pharyngoplasty with adequate luminal diameter 177f
Pathology and patterns of spread 300
Pectoralis
major
muscle 600
myocutaneous flap 591
Pediatric
B-cell non-Hodgkin lymphoma 636t
cancer
unit model of care for childhood cancers in India 622f
units, creation of 621
CNS tumors, management of 568
Hodgkin lymphoma 624
risk stratification in 628t
treatment of 630
non-Hodgkin lymphoma 632
definitive therapy of 636
oncology 614
group 629, 637
palliative care 682
Pedicle latissimus dorsi flap 442f
Pelvic
and abdominal gist in male 276
lymph node dissection 480
lymphadenectomy 482
wall 259f
Peptide receptor radionuclide therapy 56
Percutaneous
ethanol injection 285
fine-needle aspiration 409
Periampullary cancer 312
Perineal radical prostatectomy 483
Perioperative chemotherapy 240
Periosteal osteogenic sarcoma 540
Peripheral
inserted central catheters 62
nerve
block 672
tumors 436
smear examination 647
vascular complication 497
Peristomal skin
lesions 522
protection 523f
Peritoneal
carcinomatosis 261
in stomach cancer 238
Peroral resectiion 149f
Peutz-Jeghers syndrome 8789, 207
Pharmacological management of cancer pain 668
Pharyngeal walls 174f
Pheochromocytoma 45, 59, 91, 445, 446, 451f, 611, 661
pathophysiology 611
symptoms 611
treatment 611
Phyllodes tumor 347, 347t
Piece meal polypectomy done 208f
Pilocytic astrocytoma 561
Piroxicam 670
Pituitary
adenomas 571
tumors 45
Platelet-derived growth factor receptor 562
Pleomorphic xanthoastrocytoma 561
Pneumatic compression stocking 497
Pneumocystis carinii 686, 688, 694
Poly methyl methacrylate 441f
Polyaromatic hydrocarbons 404
Polycythemia 589
Polyembryoma 501
Polymerase chain reaction 28, 30, 95
Polymeric nanoparticles 105
Polymethyl methacrylate 441
Polypoidal lesion in transverse colon 254f
Polyps adenomas 260
Port positions 122f
Portal vein
embolization 304
resections 305
touch technique 305
Positron emission
mammography 46, 48
tomography 39, 39f, 42, 43, 46f, 53, 341, 345, 425, 440, 448, 480
scan 46, 47f, 368, 440, 458, 502
Post nasolabial flap 594f
Postchemotherapy
management 508
pain syndromes 667
Postcolonic endoscopic submucosal dissection for intramucosal cancer 213f
Postcricoid pharynx 174f
Post-cystectomy urinary diversion 495
Posterior
lesion of tongue and oropharynx 152f
mediastinal tumors 432
U cut 131f
Postmastectomy radiation therapy 357t
Postoperative
dental rehabilitation 598
ileus 497
neck residual tissue 55
pancreatic fistula 315
radiation 400
radiotherapy 400, 412
Post-pancreatectomy hemorrhage 314
Post-radiotherapy
complex rectosigmoid resistant stricture 217f
complications 216
Postsurgical pain syndromes 667
Pouch of Douglas 129
Pramidronate 556
Preauricular skin crease 184
Precancerous squamous lesions 382
Precursor
B-lymphoblastic 632
t-lymphoblastic 632
lymphoma 637
Prednisone 628, 629, 630, 631
Premalignant
conditions 205
of digestive tract 203
Preoperative
biliary drainage 304
downstaging of rectal cancer 256
hand antisepsis 701
radiation therapy 413
Pretherapy work-up and investigation 223
Prevention
and management of anastomotic leaks 228
and surveillance 287
of colorectal cancer 202
Primary
abdominal tumor and nodal metastases 46f
bone tumors 536
brain tumors
imaging of 561
management of 560
breast reconstruction using latissimus dorsi flap and implant 606f
chemotherapy 62, 506
chondrosarcoma 542
hyperparathyroidism 194
inflammatory breast cancer 346
lymphoma with nodal mass in ileum 248f
malignant liver tumors 287
mucosal reapproximation 150f
neuroendocrine tumor 533f
Primitive neuroectodermal tumor 536
Principles of
hormone treatment in
breast cancer 78
prostate cancer 81
nuclear imaging 43
Procarbazine 628, 631
lomustine 567
Procedure loop electro excision 385
Progesterone receptor 345, 351
Prognostic
factors for survival in high-grade gliomas 563
indices for brain metastasis 579t
Prokinetic agent 677
Proliferative
inflammatory atrophy 476
verrucous leukoplakia 142, 143f
Prophylactic surgery 365
Prostate 59
cancer 29f, 52, 62, 474, 476f, 477
inflammatory atrophy 476
specific antigen 59, 478, 482, 486, 586
density 478
velocity 478
Protocols of chemotherapy 263t
Pseudomonas 702
aeruginosa 690, 691, 698
Pseudomyxoma peritonei
chemotherapy 271
introduction 269
pathology 269
treatment 269
conservative approach 271
cytoreductive surgery 269
hyperthermic intraperitoneal pseudomyxoma peritonei chemotherapy 269
tumor
around transverse colon 271f
infiltration in transverse mesocolon 271f
P-staging 26
Psychological care 679
Pulmonary
artery 411, 440f
function test 441
metastases 55
osteoarthopathy 407
problem 598
Pylorus preserving pancreaticoduodenectomy versus classic whipple 313
Pyriform sinus 174f
Q
Quality of life in advanced cancer 674
Quantum
dots 100, 101
of node retrieval 226
R
Radiation therapy 340, 355, 387
oncology group 164, 563
Radiation-tumor-static 674
Radical
mastectomy 7, 339
neck dissection 200
nephrectomy 466f
prostatectomy 482, 482f
Radio sensitizer 68
Radioactive colloid 342
Radioembolization 57
Radio-frequency ablation 51, 202, 285, 415, 464
Radioiodine
scan of thyroid 45f
therapy for thyroid cancer 55
Radiology oncology system 33
Radiosurgery alone versus SRS with WBRT for oligo metastases 581
Radiotherapy 374, 391, 399, 427, 497, 556
Radius 596
Rare lymphomas in children 635
Rare primary liver tumors 288
Rationale for combination chemoradiotherapy 68
Rationale of treatment disease advancing 674
Recent advances in delivery of WBRT 581
Recessive hereditary colon cancer 89
Reconstruction
by bipaddled pectoralis major flap 154f
of chest wall 441
Reconstructive surgery in oncology 590
Rectum 711
Rectus abdominis muscle 602
Recurrent
carcinoma of
cervix 388
ovary 372f
disease 350, 485
glioblastoma, treatment of 568
laryngeal nerve 188
metastatic disease 240
Recursive partitioning analysis 563, 563t
Red cell aplasia 427
Reed-sternberg cells 625
Re-exploration complications of pancreaticoduodenectomy 316
Refractory disease 630
Regional lymph nodes 163, 504
Relapsed disease 630
Renal
and bladder cancer 52
cell carcinoma 454, 458f
dysfunction 659
failure 194
glomerular filtration rate 44
nephropathies 589
Results with surgery 238f
Retinoblastoma 91, 562, 615, 620
protein phosphorylation 75
Retroperitoneal
lymph node dissection 60, 371f, 506f
node dissection 506
sarcomas 550
Retropubic radical prostatectomy 480
Reverse transcription polymerase chain reaction 28
Rhabdomyosarcoma 438, 441
Rhizopus 693
Ribonucleic acid 105, 112
Right
and left hemicolectomy 125
cardinal ligaments 132f
hepatectomy specimen of large metastatic lesion 261
hepatic resection for hepatocellular carcinoma 283
lateral approach of superior mesenteric artery first technique 318f
posterior portal vein clamp 297f
Wilm's tumor, typical scan 619f
Rituximab 63
Road map after completion of dissection 133f
Robotic
open surgery for cancer rectum 259
pancreatic resections 318
surgery 125, 714
Role of
adjuvant chemoradiation 241
chemotherapy 399, 579
fulvestrant 354
oophorectomy 354
oral chemotherapy in adjuvant setting 262
prophylactic anticonvulsants 579
steroids 579
targeted therapy in
brain metastasis 580
management of colorectal cancer 263
metastatic cancer of stomach 242
Rothmund-Thomson syndrome 539
Rudolph Virchow 2f
S
Saccharomyces cerevisiae 693
Sacral nerve block 672
Sagittal anatomy of larynx 161f
Saline implants 605
Salivary gland surgery 185
facial nerve 185
Salivary glands tumors 180
diagnosis 181
introduction 180
management of neck 184
surgical anatomy 180
Salivary tumors
distribution 180
classification of 183
Salvage therapy 509
Sandwich technique 441f
Sarcomatoid carcinoma 382
Scapula 597, 598
Scintimammography 46
Sclerosing stromal tumor 367
Secondary
chondrosarcoma 543
to inoperable carcinoma head pancreas 208
Secretion of antidiuretic hormone 588
Segment of jejunum 178f
Segmental resection with clear margins 156f
Selection of surgical approach for mid-lower rectal cancers 260
Selective neck dissections 201
Self-expandable metal stent placed 216f
to alleviate jaundice 208f
to relieve dysphagia 214f
Seminoma 429, 501, 501f, 504
Sentinel lymph node 340, 343f, 344f
biopsy 338, 338f, 344
retrieval in breast cancer 343
Sentinel node mapping 46
Sequential chemoradiation 69
Seroma 344, 598
Serous
carcinoma 366f
papillary
adenocarcinoma 383
carcinoma 396, 397f
Sertoli
cell tumor 367, 501
Leydig cell tumor 367
Serum creatinine 56
Several hereditary cancer syndromes 91
Severe
acute respiratory syndrome 688
malena 126
Sex cord 365, 367, 501
Sexually transmitted diseases 476
Sigmoid loop colostomy 527
Silicone implant 605
reconstruction 601
Simplified classification system for common bone tumors 537t
Simulator training 136
Single
balloon 207
fan shaped structure 132f
hemoclip applied, hemostasis achieved 209f
incision laparoscopic surgery 137
nucleotide polymorphisms 92
photon emission computer tomography 42
port surgery 125
strand break 68
walled carbon nanotubes 102
Sjogren's syndrome 650
Skeletal
reconstruction 599
support, indications for 600
Skin
flaps 602
grafts 602
Sleeve lobectomy 409, 410
Small
bowel 206
carcinoids 534
enema of 246f
nets 532
cell
carcinoma 405
lung cancer 45, 405
lymphocytic lymphoma 649
malignant lesions 593
round cell tumors of childhood 616t
tissue 28
Smooth muscle tumors 252
Soft
palate 171f
tissue 91
sarcomas 25, 62, 545
tumors 615
Solitary
adrenal metastases 412
nucleotide polymorphisms 112
plasmacytoma 438
pulmonary nodule 48
thyroid nodule management algorithm 191
Somatic pain 667
Specimen of
esophagectomy with two-field dissection 227f
opened to mucosal extent of lesion 275f
total laryngopharyngectomy 179f
total thyroidectomy 189
Speckled leukoplakia 143f
Spermatocytic seminoma 501
Spinal
accessory nerve 197
cord compression 612
symptoms 612
treatment 612
hemangioblastoma 91
Spindle cell
carcinoma 382
type 274f
Spiritual care 680
Splenic marginal zone 650
lymphomas 647
NHL 650
Sporadic cancer 84
Spread of
metastases to brain 578
ovarian cancer 369f
Squamous
carcinoma 382
invading molar area of mandible 156f
lower lip 153f
cell carcinoma 206, 222, 265, 396, 405, 489
intraepithelial lesion 382
Stages of ovarian carcinoma 370t
Stagewise management of prostate cancer 486t
Staging
laparoscopy 304
of cancer of larynx 162
of digestive cancers 206
of lung cancer 406t
of neck based upon size, laterality and multiplicity 199t
of tumor, nodes and metastases 449t
Standard
median lip split incision 151f
resection versus adequate regional 227f
lymphadenectomy 227f
uptake value 47
versus extended lymphadenectomy 313
Staphylococcus
aureus 687, 700
species 685
Stapler anastomosis 257
Stellate ganglion block 673
Stenotrophomonas maltophilia 694
Stereotactic
ablative radiotherapy 412, 415
conformal radiotherapy 571
radiation 68
Sterile body sites and fluids, cultures from 687
Stoma retraction 521
Stomach 205, 206
cancer 63
Stomal
prolapse 521, 526
stenosis 521
Streptococcus pneumoniae 686
Stromal tumors 365, 367
Subarachnoid neurolysis 672
Subclassification of depth of superficial esophageal cancer 210f
Subependymal giant cell astrocytoma 91
Submandibular
and sublingual glands 182f
incision with access to anterior mandible 151f
salivary gland 180
Submucous fibrosis 142, 143, 593
resolution of 594f
Superficial esophageal cancer 211
Superior
hypogastric plexus block 673
sulcus tumors 411
vena cava 411
syndrome 611, 634
symptoms 611
treatment 611
Superparamagnetic iron oxide nanoparticle 101, 102
Supervoltage therapy 339
Supportive care 572
Supra-azygous mobilization of esophagus 125f
Supraglottic larynx 160
Supravital staining 143f
Surface
epithelial tumors 365
with electrocautery 297f
Surgery
for pancreatic cancer 312
for rectal cancer 259f
types of 603
Surgical
anatomy of
hypopharynx 174
larynx 160
nasopharynx 169
oropharynx 172
attire and drapes 701
coronal anatomy of larynx 161f
resection in hilar cholangiocarcinoma, principles of 304
treatment of hepatocellular carcinoma 281
Surveillance cultures 687
Survival rates 357, 395
Sympathetic nerve block 673
Synchronous bilateral breast cancer 346
Syndrome of inappropriate
antidiuretic hormone 405
secretion of antidiuretic hormone 659
Synthetic material for structural support 600
System for childhood non-Hodgkin lymphoma 635t
Systemic therapy
for colorectal cancer 261
of breast cancer 352
of epithelial ovarian cancer 371
of recurrent or metastatic disease 399
of uterine carcinoma 399
T
T2-weighted heterogeneously hyperintense lesion in left temporal region 578
Talcum powder 364
Tamoxifen 63
Targeted biological therapy 240
Targeted therapy 28, 63t, 64t, 287, 263, 263f, 353, 354, 415, 468
Taxanes 68
T-cell
lymphomas, management of 637
NHL 650
Technical modifications of
distal pancreaticosplenectomy 317
pancreaticoduodenectomy 313
Technique of
creation of stoma 516
identification of sentinel lymph nodes 342f
Telemedicine 714
Temporary colostomy 526
Tensin homolog 562
Teratomas 429, 501, 502
Testes 484
sparing surgery 504
Testicular
cancer 52
intraepithelial neoplasia 500, 504
tumors 500, 501t
Thalidomide 677
Thecoma 367, 501
Therapeutic
endoscopy in digestive tract malignancies 202
exploitation of mutations 86
impact of tumor markers in cancer 59
nuclear oncology 55
Therapy algorithm of colorectal cancer 264
Thermal ablation treatment of cancer 106
Thoracoscopic transthoracic esophagectomy 123
Thoracoscopy 122, 409
Thoracotomy 409
Thrombocytosis 589
Thrombophlebitis 589
Thrombotic manifestations 589
Thymic carcinoma 428
Thymoma 426
Thymus 426
Thyroglobulin 188
Thyroid 662
cancer 44
gland 186
stimulating hormone 44, 192
tumor composed of C-cells 187
Tissue diagnosis 688
TNM
classification of
CRCs 253t
extrahepatic bile duct tumors 302t
prostate cancer 481t
staging
of testicular tumors 504t
of thymic tumors 427t
system 538
Tobacco 234
Toluidine blue staining 21
Tomosynthesis 339
Tomotherapy 72
devices 72
Tonsillar pillars 171f
Tonsils 171f
Total
laryngectomy specimen 165
mesorectal excision 259f
pelvic exenteration 388
proctocolectomy 125
Toxicities of aromatase inhibitors 354
Toxoplasma gondii 697, 699
Tracheoesophageal fistula 231
Tramadol 556
Trans-activating transcriptional activator 106
Transanal
endoscopic microsurgery 260
adjuvant radiotherapy 260
Transarterial
chemoembolization 40, 40f, 286
radioembolization 286
Transbronchoscopic needle aspiration 409
Transesophageal ultrasonography 426
Transitional
carcinoma 489
cell 367
carcinoma 382, 488
Trans-oral robotic surgery 121
Transrectal ultrasound 486
guided biopsy of prostate 479f
guided needle biopsy 478
Transthoracic esophagectomy 123t
Transurethral resection 337, 489, 492
Transverse rectus abdominis myocutaneous flap 606
Trastuzumab 63, 242
emtansine 63
Treatment
goals and alternatives 184
of advanced disease 241
of localized renal cell carcinoma 462
of lung cancer 409
of primary tumor 503
of renal cell carcinoma 64
schedule 281t
Treponema pallidum 4
Trichosporon species 693
Tricyclic antidepressants 671
Trophoblastic tumor 501
T-staging for tumors of lip and oral cavity 148t
Tuberculosis of ascending colon 127
Tuberous sclerosis 87, 90, 91, 454
Tubular
adenoma composed of tubular glands 251f
carcinoma 346
Tumor
angiogenesis imaging 55
drug resistance imaging 55
exhibiting
c-cell differentiation 187
follicular differentiation: specific types 186
imaging in vivo 102
induced hypoglycemia 611
symptoms 611
treatment 611
induced osteomalacia 589
infiltration of plexus 667
invades
deep muscle 490
muscle 490
layer 259f
perivesical tissue 490
subepithelial connective tissue 490
superficial muscle 490
lysis syndrome 609
markers 349, 502, 586
necrosis factor 105, 626
node metastasis 461, 480, 481, 486
Node Metastasis
classification 163t, 172t
of cancers of hypopharynx 176t
of cancers of nasopharynx 170t
Staging 461t
system 162
of adrenal gland 444
of central nervous system 560
of chest wall 436
of endocrine gland 661
of small bowel 245
carcinoid tumors 245
clinical presentation 245
diagnostic work-up 245
etiology 245
introduction 245
treatment 246
adenocarcinoma 247
lymphoma 247
metastatic 248
sarcoma 247
related pain 668
spread in gallbladder cancer 293
suppressor genes 86
and oncogenes 86t
Type of
anastomotic disruptions 228
brachytherapy 71
endometrial carcinoma 397t
nuclear scans in oncology 43
Typical hypervascular hepatoma 40f
Tyrosine kinase inhibitor 32, 468, 579, 640
U
Ultrasonography 36, 333
guided celiac plexus block 215
of breast 334f
Uncommon pancreatic tumors 319
Undifferentiated carcinoma 187
Ureteral stenosis 524
Urinary tract infection 478, 523
Urostomy 519, 527
Urothelial cancers 488
Use of methylene blue stain 204
Usual sequence of events for development of mucosal cancers 205
Uterine artery and vein 132f
V
Vaccination 18
Vancomycin-resistant enterococci 687
Various premalignant conditions of digestive tract 205t
Vascular
anastomosis complete 178f
endothelial growth factor 5, 63, 106, 468, 562
resections 314
stroma and amyloid 188
Vemurafenib 64
Verrucous carcinoma 143f, 382
Vestibular schwannoma 571
Video-assisted thoracoscopy 409
Villoglandular papillary adenocarcinoma 383
Villous adenoma composed of villiform structures 251f
Vinblastine 628, 629, 631
Vincristine 567, 628, 629, 630, 631
Viral infections 688
Virtual reality simulators 136
Visceral pain 667
Vision 122, 514
Visor flap 151f
Volumes radiation therapy 401
Vomiting 675
management 675
Von Hippel-Lindau
disease 87, 90, 91, 454
factor 64
W
Warty carcinoma 382
Werner syndrome 539
Wertheim-Meigs radical hysterectomy 386f
Whipple's procedure 532
White light endoscopy 203
pink mucosa above Z-line 203f
WHO
2008 classification of lymphomas 645t
three-step analgesic ladder 669
Whole brain radiotherapy 565, 579
Wilms' tumor 62, 615, 619
management algorithm in 620f
Wound dehiscence 497
X
Xeroderma pigmentosum 87, 90
X-ray chest 408
Y
Yolk sac tumor 367, 501, 502
Z
Zoledronic acid 556, 558
Zonal anatomy of prostate 475f
Zones of adrenal cortex, adrenal medulla and adrenal hormones 444f
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