Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) Bruno Lumbroso, Marco Rispoli, Yali Jia, David Huang, James G Fujimoto
INDEX
×
Chapter Notes

Save Clear

1Clinical Guide to Angio-OCT: Non Invasive, Dyeless OCT Angiography2
3Clinical Guide to Angio-OCT: Non Invasive, Dyeless OCT Angiography
Authors Bruno Lumbroso MD Director, Centro Oftalmologico Mediterraneo for Retinal Diseases Rome, Italy Former Head of Department and Director Rome Eye Hospital, Rome, Italy David Huang MD PhD Professor Department of Ophthalmology Casey Eye Institute, Oregon Health and Science University Portland, Oregon, USA Yali Jia PhD Research Assistant Professor Department of Ophthalmology Casey Eye Institute, Oregon Health and Science University Portland, Oregon, USA James G Fujimoto PhD Professor of Electrical Engineering and Computer Science Department of Electrical Engineering and Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge, USA Marco Rispoli MD Staff Ophthalmologist Department of Ophthalmology Ospedale Nuovo Regina Margherita and Centro Oftalmologico Mediterraneo for Retinal Diseases Rome, Italy Contributors Luca Di Antonio MD PhD, Jay S Duker MD PhD, Adil El Maftouhi OD, Woo Jhon Choi PhD, James G Fujimoto PhD, David Huang MD PhD, Yali Jia PhD, Bruno Lumbroso MD, Leonardo Mastropasqua MD, Marco Rispoli MD, Maria Cristina Savastano MD PhD, Giovanni Staurenghi MD, Nadia K Waheed MD MPH
4
Jaypee Brothers Medical Publishers (P) Ltd.
Headquarters
Jaypee Brothers Medical Publishers (P) Ltd.
4838/24, Ansari Road, Daryaganj
New Delhi 110 002, India
Phone: +91-11-43574357
Fax: +91-11-43574314
E-mail: jaypee@jaypeebrothers.com
Overseas Offices
J.P. Medical Ltd.
83, Victoria Street, London
SW1H 0HW (UK)
Phone: +44-20 3170 8910
Fax: +44(0) 20 3008 6180
E-mail: info@jpmedpub.com
Jaypee-Highlights Medical Publishers Inc.
City of Knowledge, Bld. 237, Clayton
Panama City, Panama
Phone: +1 507-301-0496
Fax: +1 507-301-0499
E-mail: cservice@jphmedical.com
Jaypee Medical Inc.
The Bourse
111, South Independence Mall East
Suite 835, Philadelphia, PA 19106, USA
Phone: +1 267-519-9789
E-mail: jpmed.us@gmail.com
Jaypee Brothers Medical Publishers (P) Ltd.
17/1-B, Babar Road, Block-B, Shaymali
Mohammadpur, Dhaka-1207
Bangladesh
Mobile: +08801912003485
E-mail: jaypeedhaka@gmail.com
Jaypee Brothers Medical Publishers (P) Ltd.
Bhotahity, Kathmandu, Nepal
Phone: +977-9741283608
E-mail: Kathmandu@jaypeebrothers.com
Website: www.jaypeebrothers.com
Website: www.jaypeedigital.com
© 2015, Jaypee Brothers Medical Publishers
The views and opinions expressed in this book are solely those of the original contributor(s)/author(s) and do not necessarily represent those of editor(s) of the book.
All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission in writing of the publishers.
All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book.
Medical knowledge and practice change constantly. This book is designed to provide accurate, authoritative information about the subject matter in question. However, readers are advised to check the most current information available on procedures included and check information from the manufacturer of each product to be administered, to verify the recommended dose, formula, method and duration of administration, adverse effects and contraindications. It is the responsibility of the practitioner to take all appropriate safety precautions. Neither the publisher nor the author(s)/editor(s) assume any liability for any injury and/or damage to persons or property arising from or related to use of material in this book.
This book is sold on the understanding that the publisher is not engaged in providing professional medical services. If such advice or services are required, the services of a competent medical professional should be sought.
Every effort has been made where necessary to contact holders of copyright to obtain permission to reproduce copyright material. If any have been inadvertently overlooked, the publisher will be pleased to make the necessary arrangements at the first opportunity.
Inquiries for bulk sales may be solicited at: jaypee@jaypeebrothers.com
Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography)
First Edition: 2015
9789351523994
Printed at
5Contributors
6
7Preface
One of the most important present topics in medical retina is optical coherence tomography angiography (Angio-OCT). Certainly, the interest is growing almost exponentially, and it is discussed in all retina meetings. Several different Angio-OCT prototypes are developing, but only one device is clinically available such as XR-Avanti Optovue with split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. SSADA technology was created and developed by David Huang and Yali Jia. We are seeing interesting results that can be applied immediately to everyday clinical ophthalmology, i.e. probably the latest and exciting development in the retina field. It is currently a very exciting field. This technology is evolving very fast and will continue to gain even more widespread applicability.
Dyeless Angio-OCT is fast, easy and non invasive. Next software will still improve retinal disorders and choroidal neovascularization (CNV) diagnostic, highlighting the membrane and easing clinical work.
The aim of the Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) is to show everyday OCT user the clinical utility of Angio-OCT. The keyword is Clinical. The book presents the Angio-OCT principles. David Huang and Yali Jia present the SSADA algorithm and its applications, choroidal neovascularization (CNV), optic disk disorders and glaucoma. James G Fujimoto and Bruno Lumbroso propose the new terminology necessary to study this new technology. Clinical ophthalmologists, technicians and optometrists will then find a description of the vascular anatomy of retina and choroid, and an Angio-OCT Elementary Atlas of the general syndromes and clinical signs associations seen from vascular perspective. Then we present technological or scientific Angio-OCT progresses and try to understand their future clinical applications.
More work needs to be done to translate fully, the detail of Angio-OCT images into clinically useful information, and we still need to be cautious in interpreting the images and comparing them with histology data. We do not always have a significant idea of their true meaning. There is a debate from some specialists accustomed to fluorescein angiography, reluctant to adopt new technology.
The book discusses the clinical possibilities of Angio-OCT. It should guide the basic Ophthalmologist or Technician to understand the new imaging typical and atypical aspects. We hope to develop interest in using Angio-OCT in normal clinical work, show Angio-OCT users the practical clinical interest in day-to-day ophthalmology, and help them in understanding this new angiography.
Most imaging in the book (77 figures in Chapters 5, 7.1 and 10) has been performed with XR-Avanti Optovue SD-OCT device using SSADA algorithm. A few figures in chapters 3, 7.2 and 8 have been performed with a swept source OCT prototype using SSADA algorithm. Another technique is described in chapter 11, using ultrahigh speed, SS-OCT and its applications to optical coherence tomography-angiography (OCTA).
The book is fortunate to have outstanding contributions from scientific and clinical leaders in this field. We hope that it is a timely answer to a clinical need.
Bruno Lumbroso
Marco Rispoli
8
9Acknowledgments
The authors gratefully acknowledge Donata Piccioli for the beautiful drawings. It is with immense gratitude that we acknowledge the support of many outstanding experts.
We express our gratitude to M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India for their patience, encouragement and professionalism during the entire process. We are especially grateful to Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Group President), Mr Tarun Duneja (Director–Publishing), Ms Samina Khan (PA to Director–Publishing), Mr Sunil Kumar Dogra (Production Executive), Mr Neelambar Pant (Production Coordinator), Mr Pawan Kumar (Graphic Designer), Mr Himanshu Sharma (Proofreader) and Mr Manver Singh (Typesetter) for shaping up of the book and making all the changes, without any complaints.
13Introduction
In the last few years, structural and functional optical coherence tomography (OCT) technology has seen new and revolutionary developments. The most important of which is arguably an OCT angiography (Angio-OCT). Angio-OCT is already playing an important role in clinical ophthalmology as a new, non invasive and dyeless diagnostic tool, which serves as an adjunct to, or even a replacement for fluorescein and indocyanine green (ICG) angiographies. Angio-OCT is bringing multiple technical and clinical improvements in the study of retinal diseases, glaucoma and optic nerve disorders. It enables rapid, high-resolution visualization of vascular structure in three dimensions as well as ease of repeated imaging.
In the Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography), we offer a step-by-step guide for interpreting clinical images and data acquired by Angio-OCT. In this book, we present a logical method for interpreting ophthalmic images. The first phase is analytic. The second phase combines elementary components to synthesize the data, allowing an accurate diagnosis and treatment decision. We also update OCT terminology in order to have a standardized approach for assessing Angio-OCT features. The book explains similarities and differences between this new imaging method, and the classical fluorescein and ICG angiographies. Very soon new advances in technology will further improve Angio-OCT imaging, making day-to-day clinical work easier. We trust the book will help ophthalmologists, residents, ophthalmic technicians and optometrists to understand and appreciate the new possibilities offered by the latest Angio-OCT imaging technologies.
Bruno Lumbroso
David Huang
Yali Jia
James G Fujimoto
Marco Rispoli