Essentials in Hematology and Clinical Pathology Ramadas Nayak, Sharada Rai
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fm1Essentials in HEMATOLOGY AND CLINICAL PATHOLOGYfm2
fm3Essentials in HEMATOLOGY AND CLINICAL PATHOLOGY
Second Edition
RamadasNayak MBBS MD Professor and Head Department of Pathology Yenepoya Medical College Yenepoya University Mangaluru, Karnataka, India Formerly, Head Department of Pathology Kasturba Medical College Manipal University Mangaluru, Karnataka, India SharadaRai MBBS MD Associate Professor Department of Pathology Kasturba Medical College Manipal University Mangaluru, Karnataka, India Foreword KRamnarayan
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Essentials in Hematology and Clinical Pathology
First Edition: 2012
Second Edition: 2017
9789351524236
Printed at
fm5Dedicated to
Students who inspired us,
patients who provided the knowledge,
our parents and family members
who encouraged and supported us.
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fm7Foreword
“Some books are to be tasted, others swallowed and some few to be chewed and digested,” said Francis Bacon. This book, for which I am delighted to write the Foreword, has to be not merely tasted, chewed, swallowed and digested but also absorbed and assimilated for best results!
Clarifying concepts and inculcating the foundational tenets in hematology and clinical pathology are daunting tasks for any teacher. The teachers who have authored this book have admirably captured the core of the subject capping that with lucid explanations. The authors have expertize not only in the subject but also in the art of teaching. Willingness to share and the ability to convey convincingly are the veritable attributes of the authors. It is this wisdom of experience and expression that has percolated into this book. A book of this substance and style was long overdue and it could not have been timelier. I am certain that the contents of the book will mellow with each succeeding edition in the years to come. Let me congratulate and commend the authors for the pains they took to bring out a book, which deserves much more than just having a look.
K Ramnarayan
mbbs md (path) pg dip. higher education
Vice-Chancellor
Manipal University
Manipal, Karnataka, India
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fm9Preface to the Second Edition
Hematology is one of the rapidly expanding fields of medicine with new techniques. An extensive amount of time and effort is spent by the students in going through large volumes of various hematology textbooks. Hence, this second edition is a comprehensive book that has retained the total number of pages same as in the first edition and has also included updates on recent changes in hematology. Chapter 49 is renamed as “Automation in Hematology” and principles and uses of automations have been dealt with. A new Chapter 67 “Clinical Scenario” is added to help the student to solve the clinical-oriented questions asked in a few university examinations. New appendix 2 with laboratory values of clinical importance is also added.
Understanding hematology requires insight into the applied physiology and the pathophysiologic basis of these diseases in the context of relevant clinical features which is often neglected. Essentials in Hematology and Clinical Pathology emphasizes on building a strong foundation of both concepts. Clinical pathology section of the book deals with both hematological and nonhematological laboratory investigations done in routine practice.
The book has been organized into four sections namely Disorders of Red Cells, Disorders of White Cells, Disorders of Hemostasis and Clinical Pathology.
Essentials in Hematology and Clinical Pathology also features:
  • Molecular basis of common hematological disorders
  • About 135 illustrations, 27 photomicrographs, 18 photographs and 146 tables have been provided to facilitate easy and quick learning. Some of the illustrations and photomicrographs have been improved in quality
  • A summary of the important points at the end of each chapter
  • Essay questions, short note questions and more than 300 multiple choice questions (MCQs) to encourage self-evaluation of the important concepts by the students
  • Recent WHO classification (2016) of Tumors of Hematopoietic and Lymphoid Tissues
We hope that the textbook will provide a foundation to the students in hematology and clinical pathology and improve their understanding of the subject.
Ramadas Nayak
Sharada Rai
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fm11Preface to the First Edition
Hematology is one of the rapidly expanding fields of medicine. The extensive amount of time and effort spent by the students in going through volumes of the hematology textbooks encouraged us to write this comprehensive book. Understanding hematology requires insight into the applied physiology and the pathophysiologic basis of these diseases in the context of relevant clinical features which is often neglected. Essentials in Hematology and Clinical Pathology emphasizes on building a strong foundation of both concepts. Clinical pathology section of the book deals with both hematological and nonhematological laboratory investigations done in routine practice.
The book has been organized into four sections namely Disorders of Red Cells, Disorders of White Cells, Disorders of Hemostasis and Clinical Pathology.
Essentials in Hematology and Clinical Pathology also features:
  • Molecular basis of common hematological disorders
  • About 135 illustrations, 27 photomicrographs, 18 photographs and 146 tables have been provided to facilitate easy and quick learning
  • A summary of the important points at the end of each chapter
  • Essay questions, short note questions and 351 MCQs to encourage self-evaluation of the important concepts by the students
  • Recent WHO classification (2008) of Tumors of Hematopoietic and Lymphoid Tissues.
We hope that the textbook will provide a foundation to the students in hematology and clinical pathology and improve their understanding of the subject.
Ramadas Nayak
Sharada Rai
Astha Gupta
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fm13Acknowledgements
First and foremost, we wish to express our respects and deep gratitude to Dr Astha Gupta, for having been the author for the first edition of this book. Our sincere thanks to Ms Prathibha Bhat, for her untiring efforts, patience and excellent support in creating the illustrations for the first edition of this book.
  • We wish to express our gratitude to Mr Yenepoya Abdulla Kunhi, Honorable Chancellor, and Mr Farhaad Yenepoya, Director of Finance, Yenepoya University (Accredited by NAAC with “A” grade), Mangaluru, Karnataka, India, for their inspiration and encouragement.
  • We are grateful to Dr K Ramnarayan, former Vice-Chancellor, Manipal University, Manipal, Karnataka, for writing the foreword for the first edition, and encouragement and support.
  • We also wish to thank all our family members including Smt Rekha Nayak, Ms Rashmitha Nayak, Mr Ramnath Kini, Master Rishab Kini, Mr Ravidas Nayak (Engineer, Bengaluru), Dr Narendra Shetty, Master Jagrath, who have patiently accepted our long preoccupation with this work. Our sincere gratitude to our parents who will always remain our guiding light.
We would like to express our gratitude to all our friends, undergraduate and postgraduate students (Department of Pathology, Yenepoya Medical College, Mangaluru) and colleagues, who helped, inspired and supported us in the different stages of preparing the manuscript; to all those who provided support, talked things over, read, offered comments and assisted in the editing, proofreading and design.
  • Dr Rakshatha Nayak, Tutor, Department of Pathology, Yenepoya Medical College, a constituent of Yenepoya University (Accredited by NAAC with “A” grade), Mangaluru.
  • We are thankful to all our friends Dr Krishnaraj Upadhyaya (Professor), and Dr Krishna Prasad HV (Assistant Professor), Department of Pathology, Yenepoya Medical College, a constituent of Yenopoya University (Accredited by NAAC with “A” grade), Mangaluru.
  • A special thanks to Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Group President), Mr Tarun Duneja (Director–Publishing), and Ms Chetna Malhotra Vohra (Associate Director–Content Strategy) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, for publishing the book in the same format as wanted, well in time. We are grateful to Shri Jitendar P Vij, for unmasking our talent as authors.
  • We would like to offer a huge appreciation to the wonderful work done by Ms Sunita Katla (Publishing Manager), Ms Samina Khan (Executive Assistant to Director–Publishing), Mr Rajesh Sharma (Production Coordinator), Ms Seema Dogra (Cover Designer), Mr Laxmidhar Padhiary (Proofreader), Mr Rajesh Ghurkundi (Graphic Designer) and Mr Raj Kumar (DTP Operator) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India.
  • We thank especially Mr Venugopal V (Bengaluru) and Mr Vasudev H (Mangaluru) of M/s Jaypee Brothers Medical Publishers (P) Ltd, Bengaluru Branch, Karnataka, for taking this book to every corner of Karnataka.
  • Last but definitely not least, a thank you to our undergraduate and postgraduate students. Without you, we would not write. You make all our books possible.
There are many more people we could thank, but space, and modesty compel us to stop here.
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