Editor
GR Sridhar MD DM FACE FRCP
Director Endocrine and Diabetes Centre Visakhapatnam, Andhra Pradesh, India
Foreword
PV Rao
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Advances in Diabetes: Novel Insights
First Edition: 2016
9789351526452
Dedicated to
Professor GM Narayanaswamy and Professor G Nirmala
My parents and my teachers
Professor MMS Ahuja
A teacher of teachers, renowned clinician, dedicated researcher My mentor and guide.
9Contributors
Editor
- GR Sridhar MD DM FACE FRCP
- Director
- Endocrine and Diabetes Centre
- Visakhapatnam, Andhra Pradesh, India
Contributing Authors
- Yatan PS Balhara MD DNB MNAMS
- Assistant Professor
- Department of Psychiatry
- National Drug Dependence Treatment Centre
- All India Institute of Medical Sciences
- New Delhi, India
- Sarita Bajaj MD DM
- Consultant Endocrinologist
- Director-Professor and Head
- Department of Medicine
- Moti Lal Nehru Medical College
- Allahabad, Uttar Pradesh, India
- Dhanasekaran Bodhini MSc MPhil PhD
- Scientist
- Department of Molecular Genetics
- Madras Diabetes Research Foundation
- Chennai, Tamil Nadu, India
- Lakshmi Gumpeny MD
- Consultant
- Endocrine and Diabetes Centre Visakhapatnam, Andhra Pradesh, India
- KVS Hari Kumar MD DNB
- Associate Professor
- Department of Medicine and Endocrinology
- Command Hospital
- Panchkula, Haryana, India
- Esha Jafa MD
- Senior Resident
- Department of Medical Oncology
- Dr Ram Manohar Lohia Institute of Medical Sciences
- Lucknow, Uttar Pradesh, India
- Koona S Jyothi PhD
- Former Research Scholar
- Department of Botany
- Andhra University
- Visakhapatnam, Andhra Pradesh, India
- Sanjay Kalra MD DM
- Consultant
- Department of Endocrinology
- Bharti Hospital and BRIDE
- Karnal, Haryana, India
- Sadishkumar Kamalanathan MD DM
- Associate Professor
- Department of Endocrinology
- Jawaharlal Institute of Postgraduate Medical Education and Research
- Puducherry, India
- Sekar Kanthimathi MSc MPhil PhD
- Scientist
- Department of Molecular Genetics
- Madras Diabetes Research Foundation
- Chennai, Tamil Nadu, India
- Romesh Khardori MD PhD FRCP(C) FACP
- Professor of Medicine
- Division of Endocrinology and Metabolism
- Strelitz Center for Diabetes, Endocrine, and Metabolic Disorders
- Department of Internal Medicine
- Eastern Virginia Medical School
- Norfolk, Virginia, USA
- KD Modi MD DM DNB
- Senior Consultant
- Department of Endocrinology
- Care Hospital
- Hyderabad, Andhra Pradesh, India
- Viswanathan Mohan MD FRCP PhD DSc FNASc DSc
- Chairman and Chief Diabetologist
- Dr Mohan's Diabetes Specialities Centre
- President and Chief of Diabetes Research
- Madras Diabetes Research Foundation
- Chennai, Tamil Nadu, India
- Sathya Prakash MD
- Senior Resident
- Department of Psychiatry
- All India Institute of Medical Sciences
- New Delhi, India
- Venkatesan Radha MSc PhD
- Executive Scientific Officer and Head
- Department of Molecular Genetics
- Madras Diabetes Research Foundation
- Chennai, Tamil Nadu, India
- N Sudhakar Rao MD DM
- Former Professor and Head
- Department of Endocrinology and Metabolism
- Gandhi Medical College Secunderabad Telangana, India
Knowledge about diabetes is exploding. It threatens to overwhelm, rather than inform and educate. Attending any of the many conferences entails a careful choice of sessions of interest. The editor and contributors of this monograph have done a wonderful job in making some of the choices for its readers, who wish to read, rather than listen. From the topics and the expertise of the authors, these are choices well made; a synthesis of clinical and basic science and other topics that both educate and amuse.
This is an intriguing addition to the literature on diabetes.
PV Rao MD PhD FRCP (London)
Professor and Head
Department of Endocrinology and Metabolism
Nizams Institute of Medical Sciences
13Preface
Does diabetes need yet another publication? Ever since the ‘Progress in Medicine’ series edited by Professor MMS Ahuja, there have been similar efforts in various specialties of medicine. Diabetes seems to be relatively untouched by such efforts, and hence this monograph. Even with the proliferation and access to information, one sometimes wants a crystallized digest of the field, that as described in the Foreword both educates and amuses.
The genetic basis of diabetes, its relation with epigenetics and the limitations of genomics are well brought out, followed by an account of β cell development, which can be utilized to replicate and replenish lost pancreatic β cells. Insulin signaling pathway is then brought up, as a basis for the use of insulin and the perceived adverse effects that have been recently highlighted. Other molecules and ligands, which have come into mainstream such as incretins and dual peroxisome proliferator-activated receptors (PPAR) agonists are also covered, where basic science leads to newer drug molecules. In the management aspects, the status of bariatric surgery as a potential cure and its current limitations are highlighted.
To put into perspective that science and knowledge alone cannot change behavior, psychological stress, and relaxation response have been delineated; the role of physical exercise, often prescribed to prevent obesity and diabetes, also seems to preserve cognition. Depression, which is in close companionship with obesity and diabetes, finds a place. Scientific advances in society – the electric light have changed the distinction between day and night and its relation to sleep, and to diabetes completes the behavioral aspects.
There are some surprising associations with diabetes which have come to the fore; the close relation of bone and energy metabolism is being increasingly recognized. Oral health seems to be important in the pathogenesis of diabetes and has been highlighted. The field of bioinformatics provides new areas of investigation; sequences related to human insulin were found in plant kingdom, suggesting that plants may be a source of glucose modulating agents. Finally, if a bariatric surgeon can ‘cure’ diabetes, can hypertension be left off? Ablation of sympathetic nerves in the treatment of resistant hypertension, seen also in diabetes, is an emerging concept.
I thank all the contributors for sparing their time to share their expertise for this volume.
GR Sridhar