Clinical OCT Angiography Atlas Bruno Lumbroso, David Huang, Andre Romano, Marco Rispoli, Ching J Chen, Yali Jia, Nadia K Waheed
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1Clinical OCT Angiography Atlas2
3Clinical OCT Angiography Atlas
Editors Bruno Lumbroso MD Director, Centro Italiano Macula Former Director, Rome Eye Hospital Rome, Italy David Huang MD PhD Peterson Professor of Ophthalmology Professor, Biomedical Engineering Casey Eye Institute Oregon Health and Science University Portland, USA Yali Jia PhD Research Assistant Professor Casey Eye Institute Oregon Health and Science University Portland, USA André Romano MD Department Ophthalmology Federal University Sao Paulo Voluntary Adjunct Professor University of Miami, Miller School of Medicine Director Neovista Eye Center Americana, Brazil Ching J Chen MD Professor and Chairman Director, Vitreoretinal Service Department of Ophthalmology University of Mississippi Medical Center Mississippi, USA Marco Rispoli MD Staff Ophthalmologist, Department of Ophthalmology Ospedale Nuova Regina Margherita Centro Italiano Macula Rome, Italy Nadia K Waheed MD MPH Assistant Professor in Ophthalmology Tufts University School of Medicine Boston, MA, USA ForewordJames G Fujimoto
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Clinical OCT Angiography Atlas
First Edition: 2015
9789351528999
Printed at
5Contributors
7Foreword
The Clinical OCT Angiography Atlas is a foremost guide for the understanding and interpretation of the powerful new imaging modality of OCT angiography or angio OCT. All the authors, Bruno Lumbroso, David Huang, Ching J Chen, Marco Rispoli, André Romano, Yali Jia and Nadia K Waheed have assembled and edited this landmark publication which includes contributions from internationally leading clinicians and researchers in ophthalmology and optical coherence tomography imaging.
OCT angiography is a new functional imaging modality for clinical ophthalmology and fundamental research. OCT angiography visualizes microvasculature by detecting motion contrast from blood flow. Unlike traditional fluorescein or indocyanine green angiography, it does not require injected contrast agents. Therefore, OCT angiography cannot detect vascular permeability changes which are manifested as dye leakage in traditional angiography, however, it can generate higher quality images because visualization is not impaired by diffuse hyperfluorescence. OCT angiography examinations can be performed rapidly, without patient discomfort and repeatedly; potentially on every patient visit to assess progression or treatment response.
OCT angiography uses high speed OCT structural imaging and provides three-dimensional data on microvascular structure, enabling separate en face visualization of retinal capillary plexuses as well as choriocapillaris, combined with coregistered en face and cross-sectional structural OCT. Although OCT angiography is a powerful modality, it can have imaging artifacts and provides information that is inherently more complex than structural OCT alone. Successful interpretation of OCT angiography findings requires an understanding of how OCT angiography works, the association of different ocular pathologies with their angiographic features, and integrated assessment of angiographic and structural OCT image data.
Consisting of more than 20 chapters, the Clinical OCT Angiography Atlas describes OCT angiography technology, methods and image interpretation. It provides a guide for interpreting OCT angiography in macular disease; covering age-related macular degeneration, diabetic retinopathy, macular telangictasia, myopia and other pathologies, as well as glaucoma and choroidal imaging. The atlas also discusses ongoing research in OCT angiography and its potential for future clinical practice. The Clinical OCT Angiography Atlas is an invaluable and comprehensive reference for clinicians and researchers to understand, interpret, and utilize this exciting new ophthalmic imaging modality.
James G Fujimoto PhD
Elihu Thomson Professor
Electrical Engineering and Computer Science
Massachusetts Institute of Technology
Cambridge, MA, USA8
9Preface
OCT angiography is a new high resolution imaging method for visualizing the retinal and choroidal circulation without the injection of any dye. By rapidly detecting intravascular flow when needed and being able to repeat the images, as often as necessary, at no risk to the patient, clinicians will come to appreciate OCT angiography as one of the most important applications of en face OCT imaging because of its ability to offer precise visualization of intravascular flow in the inner and outer retinal layers, as well as the inner choroid. An added advantage of this imaging strategy is that the same images acquired during OCT angiography can also be viewed as typical OCT B-scans. While it is no longer the domain of just a few privileged researchers and retina specialists, OCT angiography is now widely available to eye practitioners. As the quality of OCT angiography imaging improves and its availability becomes even more widespread, we predict that this noninvasive technology will become a new standard for imaging both the retinal and choroidal vasculature and anatomy.
The aim of this Clinical OCT Angiography Atlas is to show OCT users the utility of clinical OCT angiography imaging. The keyword is ‘clinical’. We hope to develop interest in the use of OCT angiography in everyday clinical activities and help users interpret OCT angiographic images. The operating principles and the future of OCT angiography are explained by some of the original developers of the technology, and well-known authors from around the world wrote the clinical chapters. This atlas should guide the general ophthalmologists to select the best OCT angiographic views and to be able to identify the typical and atypical features of the OCT angiographic images.
The everyday use of OCT angiographic imaging in the clinics has already generated enormous interest and its importance will grow rapidly in the next few years. Our atlas is designed to appeal a wide audience with interest in a variety disorders. We hope that this atlas fulfills a huge unmet clinical need to learn more about OCT angiography.
Bruno Lumbroso
David Huang
Ching J Chen
Yali Jia
Marco Rispoli
André Romano
Nadia K Waheed10