Recent Advances in Pediatrics (Special Volume 26): Infectious Diseases I Suraj Gupte
INDEX
×
Chapter Notes

Save Clear


1Recent Advances in PEDIATRICS
(Special Volume 26)
Infectious Diseases I
Academic Editor Suraj Gupte Executive Editors Shamma-Bakshi Gupte Manu Gupte
2Jaypee's Other Titles by Professor (Dr) Suraj Gupte
  • Recent Advances in Pediatrics (RAP): Hot Topics (General/Miscellaneous Pediatrics)
    Vol 24 (2015), Vol 23 (2015), Vol 22 (2014), Vol 21 (2013), Vol 20 (2011), Vol 19 (2010), Vol 18 (2009), Vol 17 (2007), Vol 16 (2006), Vol 15 (2005), Vol 14 (2004), Vol 13 (2003), Vol 12 (2002), Vol 11 (2001), Vol 10 (2000), Vol 9 (1999), Vol 8 (1998), Vol 7 (1997), Vol 6 (1996), Vol 5 (1995), Vol 4 (1994), Vol 3 (1993), Vol 2 (1992), Vol 1 (1991)
  • Recent Advances in Pediatrics (RAP): Special Volumes
    RAP Special Vol 27: Infectious Diseases II
    RAP Special Vol 25: Perspectives in Neonatology
    RAP Special Vol 24: Respiratory Diseases
    RAP Special Vol 23 : Pediatric Gastroenterology, Hepatology and Nutrition
    RAP Special Vol 22 : Immunology, Infections and Immunization
    RAP Special Vol 21 : Neonatal and Pediatric Intensive Care
    RAP Special Vol 20 : Nutrition, Growth and Development
    RAP Special Vol 19 : Developmental and Behavioral Pediatrics
    RAP Special Vol 18 : Pediatric Neurology
    RAP Special Vol 17 : Adolescence
    RAP Special Vol 16 : Pediatric Cardiology
    RAP Special Vol 15 : Nephrology
    RAP Special Vol 14 : Critical Care Pediatrics
    RAP Special Vol 13 : Pediatric Endocrinology
    RAP Special Vol 12 : Neonatal Emergencies
    RAP Special Vol 11 : Community Pediatrics
    RAP Special Vol 10 : Pulmonology
    RAP Special Vol 09 : Neurology
    RAP Special Vol 08 : Emergency Pediatrics
    RAP Special Vol 07 : Hematology
    RAP Special Vol 06 : Gastroenterology, Hepatology and Nutrition
    RAP Special Vol 05 : Neonatology-2
    RAP Special Vol 04 : Neonatology
    RAP Special Vol 03 : Tropical Pediatrics-2
    RAP Special Vol 02 : Tropical Pediatrics
    RAP Special Vol 01 : Nutrition, Growth and Development
  • Recent Advances in Pediatrics (RAP) Volumes in Pipeline
    RAP 25: Hot Topics (General/Miscellaneous Pediatrics)
    RAP 26: Hot Topics (General/Miscellaneous Pediatrics)
    RAP Special Vol 28: Child Nutrition in Practice
    RAP Special Vol 29: Child Neurology and Developmental Pediatrics
    RAP Special Vol 30: Emergencies and Intensive/Critical Care
Jaypee's Other Books by Prof (Dr) Suraj Gupte
  • The Short Textbook of Pediatrics, 12th edition, 2015, in press
  • Differential Diagnosis in Pediatrics, 5th edition, 2009
  • Instructive Case Studies in Pediatrics, 5th edition, 2011
  • Pediatric Drug Directory, 8th edition, 2014.
  • Case-based Reviews in Pediatric Emergencies, 2015, in press
3Recent Advances in PEDIATRICS
(Special Volume 26)
Infectious Diseases I
Silver Jubilee Edition
Academic Editor Suraj Gupte MD FIAP Professor and Head Postgraduate Department of Pediatrics Mamata Medical College/Mamata General and Superspecialty Hospitals Khammam, Telangana, India recentadvances@yahoo.co.uk, drsurajgupte@gmail.com, surajgupte@rediffmail.com
Honorary Director: Pediatric Education Network
Editor: The Short Textbook of Pediatrics; Textbook of Pediatric Emergencies, Neonatal Emergencies, Pediatric Nutrition and Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Infectious Diseases, Influenza: Complete Spectrum Towards MRCPCH Part II (Theory) Examination, Pediatric Yearbook (Series), Newer Horizons in Tropical Pediatrics, etc.
Author: Differential Diagnosis in Pediatrics, Instructive Case Studies in Pediatrics, Pediatric Drug Directory, Nutrition in NICU, Influenza, Perspectives in Influenza, Infant Feeding, Speaking of Child Care, The Baby Book: The Parents' Guide from Birth to Infancy
Co-editor: Asian Journal of Maternal and Child Health (Manila, Philippines)
Section and Guest Editor: Pediatrics Today (New Delhi)
Editorial Advisor: Asian Journal of Pediatrics Practice (New Delhi)
Editorial Advisory Board Member/Reviewer: Indian Journal of Pediatrics (New Delhi), Indian Pediatrics (New Delhi), Synopsis (Detroit, USA), Indian Journal of Pediatric Gastroenterology, Hepatology and Nutrition (Jaipur, Rajasthan) Maternal and Child Nutrition (Preston, UK), Journal of Pediatric Infectious Diseases (Turkey), Indian Journal of Child Health (Gwalior, Madhya Pradesh)
Examiner: National Board of Examinations (NBE) for DNB, All India Institute of Medical Sciences (AIIMS), New Delhi; Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh; Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar; Indira Gandhi National Open University (IGNOU), New Delhi, India, and several other universities
Pediatric Faculty Selection Expert: All India Institute of Medical Sciences (AIIMS), Punjab Public Service Commission, Jammu and Kashmir Public Service Commission, Union Public Service Commission, etc.
4
Jaypee Brothers Medical Publishers (P) Ltd
Headquarters
Jaypee Brothers Medical Publishers (P) Ltd. 4838/24, Ansari Road, Daryaganj
New Delhi 110 002, India
Phone: +91-11-43574357
Fax: +91-11-43574314
Overseas Offices
J.P. Medical Ltd.
83, Victoria Street, London
SW1H 0HW (UK)
Phone: +44-20 3170 8910
Fax: +44(0) 20 3008 6180
Jaypee-Highlights Medical Publishers Inc.
City of Knowledge, Bld. 237, Clayton
Panama City, Panama
Phone: +1 507-301-0496
Fax: +1 507-301-0499
Jaypee Medical Inc.
The Bourse
111, South Independence Mall East
Suite 835, Philadelphia, PA 19106, USA
Phone: +1 267-519-9789
Jaypee Brothers Medical Publishers (P) Ltd.
17/1-B, Babar Road, Block-B, Shaymali
Mohammadpur, Dhaka-1207
Bangladesh
Mobile: +08801912003485
Jaypee Brothers Medical Publishers (P) Ltd.
Bhotahity, Kathmandu, Nepal
Phone: +977-9741283608
© 2015, Shamma-Bakshi Gupte/Manu Gupte (Executive Editors)
The views and opinions expressed in this book are solely those of the original contributor(s)/author(s) and do not necessarily represent those of editor(s) of the book.
All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission in writing of the publishers/editors.
All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book.
Medical knowledge and practice change constantly. This book is designed to provide accurate, authoritative information about the subject matter in question. However, readers are advised to check the most current information available on procedures included and check information from the manufacturer of each product to be administered, to verify the recommended dose, formula, method and duration of administration, adverse effects and contraindications. It is the responsibility of the practitioner to take all appropriate safety precautions. Neither the publisher nor the author(s)/editor(s) assume any liability for any injury and/or damage to persons or property arising from or related to use of material in this book.
This book is sold on the understanding that the publisher is not engaged in providing professional medical services. If such advice or services are required, the services of a competent medical professional should be sought.
Every effort has been made where necessary to contact holders of copyright to obtain permission to reproduce copyright material. If any have been inadvertently overlooked, the publisher will be pleased to make the necessary arrangements at the first opportunity.
Inquiries for bulk sales may be solicited at: jaypee@jaypeebrothers.com
Recent Advances in Pediatrics (Special Volume 26): Infectious Diseases I
First Edition: 2015
9789351529231
Printed at
5Dedicated to
My dear parents
whose inspiration, motivation, blessings
and moral support continue to contribute a great
deal to our academic endeavors
and
everybody striving to contribute to child health
and welfare for a brighter future globally
6
7Contributors
  • Zahida Akhtar
  • Senior Fellow
  • Division of Tropical Diseases
  • State University of New York
  • Stony Brook, New York, USA
  • Ch 10: Chikungunya
  • Farooq Amaan
  • Senior Consultant
  • Division of Infectious Diseases
  • State University of New York
  • Stony Brook, New York, USA
  • Ch 4: Antiviral Drugs in Influenza
  • Pankaj Anand
  • Senior Fellow
  • Department of Immunology
  • Institute of Child Health and Adolescence
  • London, UK
  • Ch 26: Pediatric HIV Infection/AIDS: Current Perspectives and New Guidelines
  • Joseph Andrew
  • Assistant Professor in Immunology
  • University of Maryland School of Medicine
  • Baltimore, Maryland, United States
  • Ch 26: Pediatric HIV Infection/AIDS: Current Perspectives and New Guidelines
  • Pooja Balasubramanian
  • Ex-Registrar
  • Department of Pediatrics
  • Seth GS Medical College and
  • King Edward Memorial (KEM) Hospital
  • Mumbai, Maharashtra, India
  • Ch 14: Leptospirosis
  • Sumeet R Dhawan
  • Senior Resident
  • Department of Pediatrics
  • Advance Pediatric Center
  • Postgraduate Institute of Medical
  • Education and Research (PGIMER)
  • Chandigarh, India
  • Ch 24: Pediatric Tuberculosis: Current Trends
  • Gloria Evert
  • Professor Emeritus in Infectious Diseases
  • University of Michigan, Michigan, USA
  • Ch 4: Antiviral Drugs in Influenza
  • Ch 6: Influenza Vaccines
  • Ch 7: Influenza: Future Perspectives and Directions
  • Novy Gupte
  • Senior Resident
  • Department of Pharmacology
  • Lady Hardinge Medical College and
  • Hospitals, New Delhi, India
  • Ch 1: Pediatric Influenza: Overview
  • Ch 4: Antiviral Drugs in Influenza
  • Ch 5: Influenza and Complementary and Alternative Medicine
  • Ch 6: Influenza Vaccines
  • Ch 7: Influenza: Future Perspectives and Directions
  • Ch 18: Adverse Events Following Immunization: Issues and Concerns
  • Ch 20: Future Vaccines
  • Ch 22: Antiviral Medications in Pediatric Practice
  • Suraj Gupte
  • Professor and Head
  • Postgraduate Department of Pediatrics
  • Mamata Medical College/Mamata
  • General and Superspecialty Hospitals
  • Khammam, Telangana, India
  • Ch 1: Pediatric Influenza: Overview
  • Ch 2: Seasonal Influenza: ABC and Beyond
  • Ch 3 : Influenza Pandemic 2009–10
  • Ch 5: Influenza and Complementary and Alternative Medicine
  • Ch 6: Influenza Vaccines
  • Ch 7: Influenza: Future Perspectives and Directions
  • Ch 9: A–Z Dengue
  • Ch 10: Chikungunya
  • Ch 11: Japanese Encephalitis: Issues and Concerns
  • 8Ch16: Cholera
  • Ch 18: Adverse Events Following Immunization: Issues and Concerns
  • Meera Hussain
  • Senior Fellow in Infectious Diseases
  • Harvard Medical School, Boston, USA
  • Ch 16: Cholera
  • CS Jyotirmanju
  • Associate Professor of Pediatrics
  • Department of Pediatrics
  • MS Ramaiah Medical College/Teaching Hospital
  • Bengaluru, Karnataka, India
  • Ch 23: Atypical Pneumonia
  • Neelesh Kapoor
  • Department of Community Medicine
  • Netaji Subhash Chandra Bose Medical
  • College (NSCBMC)
  • Jabalpur, Madhya Pradesh, India
  • Ch19: Immunization in India: 2015 and Beyond and the Need for Adopting ‘Health System’ Approach
  • BP Karunakara
  • Professor of Pediatrics
  • and Pediatric Intensivist
  • In charge of Pediatric Intensive Care units
  • Department of Pediatrics
  • MS Ramaiah Medical College/Teaching
  • Hospital, Bengaluru, Karnataka, India
  • Ch 8: Ebola Virus Disease
  • Ch 13: Rickettsial Infections
  • Ch 15: Acute Infectious Diarrhea
  • Ch 23: Atypical Pneumonia
  • Nancy Kennedy
  • Assistant Professor
  • Department of Immunology
  • Institute of Child Health and Adolescence
  • London, UK
  • Ch 26: Pediatric HIV Infection/AIDS: Current Perspectives and New Guidelines
  • William Kliegman
  • Assistant Professor in Infectious Diseases
  • Harvard Medical School, Boston, USA
  • Ch 16: Cholera
  • R Kumar
  • Senior Consultant in Infectious Diseases
  • Advanced Medical Center, Liverpool, UK
  • Ch 1: Pediatric Influenza: Overview
  • Ch 2: Seasonal Influenza: ABC and Beyond
  • Ch 3: Influenza Pandemic 2009–10
  • Ch 5: Influenza and Complementary and Alternative Medicine
  • CK Lahariya
  • Assistant Professor (Ex)
  • Department of Community Medicine
  • GR Medical College
  • Gwalior, Madhya Pradesh, India
  • Ch 19: Immunization in India: 2015 and Beyond and the Need for Adopting ‘Health System’ Approach
  • Sudhir Mishra
  • Senior Specialist and Head
  • Department of Pediatrics
  • Tata Main Hospital
  • Jamshedpur, Jharkhand, India
  • Ch 12: Typhoid: Is There Something New?
  • Neelam Mohan
  • Senior Consultant and Director
  • Pediatric Gastroenterology
  • Hepatology and Liver Transplantation
  • Medanta—The Medicity
  • Gurgaon, Haryana, India
  • Ch 17: Abdominal Tuberculosis
  • Divya Neha Pharasia
  • Registrar
  • Department of Pediatrics
  • Tata Main Hospital
  • Jamshedpur, Jharkhand, India
  • Ch 12: Typhoid: Is There Something New?
  • Rita Scott
  • Research Fellow
  • Department of Microbiology
  • and Immunology
  • St Louis Children's Hospital
  • St Louis, Missouri, USA
  • Ch 26: Pediatric HIV Infection/AIDS: Current Perspectives and New Guidelines
  • 9Farooq A Shaik
  • Senior Fellow
  • Division of Tropical Diseases
  • State University of New York
  • Stony Brook, New York, USA
  • Ch 9: A–Z Dengue
  • Ch 10: Chikungunya
  • Ahmar Shamim
  • Fellow
  • Department of Pediatric
  • Gastroenterology, Hepatology and Liver Transplantation
  • Medanta–The Medicity
  • Gurgaon, Haryana, India
  • Ch 17: Abdominal Tuberculosis
  • Sangeetha Shenoy
  • Associate Professor
  • Department of Pediatrics
  • MS Ramaiah Medical College/
  • Teaching Hospital
  • Bengaluru, Karnataka, India
  • Ch 15: Acute Infectious Diarrhea
  • Utpal Kant Singh
  • Professor and Head (Ex)
  • Department of Pediatrics
  • Nalanda Medical College and Hospital
  • Patna, Bihar, India
  • Ch 2: Seasonal Influenza: ABC and Beyond
  • Ch 3: Influenza Pandemic 2009–10
  • Ch 9: A–Z Dengue
  • Ch 10: Chikungunya
  • Ch 11: Japanese Encephalitis: Issues and Concerns
  • Priyanka Singh
  • Public Health Foundation of India
  • New Delhi, India
  • Ch 19: Immunization in India: 2015 and Beyond and the Need for Adopting ‘Health System” Approach
  • Praveen C Sobti
  • Professor
  • Department of Pediatrics
  • Christian Medical College (CMC) and
  • Hospital, Ludhiana, Punjab, India
  • Ch 25: Cerebral Malaria: Current Perspectives
  • Satish Tiwari
  • Professor
  • Department of Pediatrics, Medical College
  • Amravati, Maharashtra, India
  • Ch 12: Typhoid: Is There Something New?
  • Milind Tullu
  • Additional Professor
  • Department of Pediatrics
  • Seth GS Medical College and King Edward
  • Memorial (KEM) Hospital
  • Mumbai, Maharashtra, India
  • Ch14: Leptospirosis
  • Ch 21: Rational Antimicrobial Therapy
  • Namratha Upadhya
  • Assistant Professor
  • Department of Pediatrics
  • MS Ramaiah Medical College/
  • Teaching Hospital
  • Bengaluru, Karnataka, India
  • Ch 8: Ebola Virus Disease
  • Ch 13: Rickettsial Infections
  • Pankaj C Vaidya
  • Assistant Professor
  • Department of Pediatric Medicine
  • Advance Pediatric Center
  • Postgraduate Institute of Medical
  • Education and Research (PGIMER)
  • Chandigarh, India
  • Ch 24: Pediatric Tuberculosis: Current Trends
  • Charles White
  • Associate Professor in Immunology
  • University of Maryland School of Medicine
  • Baltimore, Maryland, USA
  • Ch 26: Pediatric HIV Infection/AIDS: Current Perspectives and New Guidelines
10
11Preface
Quick on the heels of global threat of the fatal Ebola virus infection/disease, the reputed British Medical Journal, in a recent editorial comment, has drawn attention to the growing menace of infectious/communicable diseases. Though smallpox got eradicated over three decades ago and polio eradication is around the corner, continuing as also emerging and re-emerging infectious diseases are having a field day notwithstanding herculean efforts by the WHO and other organizations to counter the trend. For instance, in the Indian subcontinent, over and above malaria, dengue is contributing to a significant morbidity and mortality as a consequence of poor control of the vector. Not just that. Chikungunya and even typhus have re-emerged. In certain endemic belts, Japanese encephalitis remains a huge threat. Food-borne diseases (say diarrhea) as also zoonosis (say, leptospirosis) and parasitic infestations (both intestinal and extraintestinal) are very much around. So are respiratory tract infections, tuberculosis, HIV/AIDS, and hepatitis B. To cap all that, the growing menace of antimicrobial resistance as also further emergence of drug-resistant bugs and superbugs is adding fuel to the fury.
In this Silver Jubilee year of RAP series, inspired by the need of the time, the RAP Special volumes 26 and 27 are devoted to the topical pediatric infectious diseases of particular interest in the Indian subcontinent and other South-East Asian Regions (SEAR).
The present volume (RAP Special Volume 26: Infectious Diseases I) presents 26 peer-reviewed state-of-the-art chapters contributed by as many as 26 experts drawn from India and abroad.
is a spotlight on influenza which afflicted the world in 2009–10 as a pandemic and continues to be around globally, including India, year after year as seasonal influenza. The issues discussed in the seven chapters devoted to influenza include antiviral influenza drugs, complementary and alternative medicine, influenza vaccines and influenza future perspectives and directions.
In the chapters of the remaining six parts, a plethora of topical issues such as vector-borne viral infections (Ebola virus disease, dengue, chikungunya, Japanese encephalitis), bacterial infectious diseases (typhoid, rickettsial infections, leptospirosis), gastrointestinal infections (diarrhea, cholera, abdominal tuberculosis), preventive pediatrics (adverse events after immunization, immunization in India), pediatric therapeutics (rational antimicrobial therapy, cerebral malaria) and miscellaneous issues (atypical pneumonia, cerebral malaria, pediatric tuberculosis) are discussed.
12The evidence-based chapters attempt to present the depth and breadth of knowledge in the field of contemporary pediatrics with special reference to its applicability in the Indian subcontinent and rest of the South-East Asian Region (SEAR).
In conformity with the policy of the RAP series ever since its inception and first appearance in 1991, each and every chapter is outstanding by its excellence, providing a stimulating, mature, informed, state-of-the-art and, at times, even provocative update. Such an approach is known to be befitting when the goal is not only to inform but also to motivate discussion, interaction, research and innovation.
Furthermore, all chapters are peer-reviewed, evidence-based and state-of-the-art with narrations that are reader-friendly, easy-to-understand and amply supported by highlighted illustrations, boxes, tables, algorithms and flow charts in order to drive home the important points effectively. Each chapter ends up with “Summary and Conclusion”, “Key Learning Points” and References.
Multidisciplinary approach with an eye on future, a well-tested and well-appreciated conviction with the RAP series, continues to occupy pride of place in the present volume too.
All-in-all, the galaxy of chapters focusing on the contemporary concepts, concerns, controversies and clarifications with emphasis on new and evolving concepts in children's infectious diseases as relevant in India and other South-East Asian countries form the lifeline of the volume.
Hopefully, the RAP readers will find the wealth of academic stuff concerning the contemporary scenario in pediatric infectious diseases in resource-limited countries enjoyable, fruitful, productive and useful in letter and spirit.
Suraj Gupte
Academic Editor
Shamma-Bakshi Gupte
Manu Gupte
Executive Editors
13Acknowledgments
Grateful acknowledgments are made to:
  • The distinguished contributors, both from India and abroad, for providing excellent state-of-the-art chapters on various topical issues in neonatology. They were gracious enough to repose confidence in our editorship.
  • The peer-reviewers, for critically reviewing the contributions, thereby providing us the benefit of their expertise.
  • The Advisory Editorial Board for providing inputs and advice in various editorial matters.
  • The Management (Mamata Education Society), especially Mr P Nageshwara Rao, Founder; Mr P Ajay Kumar, Chairman; Mrs Jayshree, Secretary; Dr G Venketeshwara Rao, Medical Director; and Dr K Koteshwer Rao, Dean and Principal, Mamata Medical College and Hospitals, for blessing this project.
  • Dr Gagan Hans and Dr Novy Gupte, for voluntarily helping us in various ways in taking the project to its logical conclusion over and above their own contributions.
  • Various periodicals and journals for editorial and critical reviews and for citing their references in the state-of-the-art chapters.
  • M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, and their dedicated staff for the skillful and admirable production qualities of the book.
1415161718192021