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Textbook of Critical Care: Including Trauma and Emergency Care
Yatin Mehta, Jeetendra Sharma, Mukesh Kumar Gupta
SECTION 1: GENERAL PRINCIPLES
CHAPTER 1:
Recognition of Critical Illness
INTRODUCTION
ASSESSMENT OF A CRITICAL ILLNESS1,2
HISTORY AND PHYSICAL EXAMINATION
MONITORING THE ILLNESS AND INVESTIGATIONS
CRITICAL CARE WITHOUT WALLS2
CHAPTER 2:
Scoring Systems
INTRODUCTION
SEVERITY SCORES AIM
Describing Clinical Status at Intensive Care Unit Admission
Describing Patient's Clinical Status Evolution (e.g. SOFA and MODS)
Intensive Care Unit Scoring Models (Outcome)
Organ Failure Models
Organ Dysfunction Models
USE OF ORGAN FAILURE SCORING
OTHER ICU SCORING SYSTEMS FOR DAY-TO-DAY USE
SCORE COMPARISONS
BENCHMARKING
LIMITATIONS
RESOURCE USE
CONCLUSION
CHAPTER 3:
Resuscitation of Cardiac Arrest, Postresuscitation Care and Therapeutic Hypothermia
INTRODUCTION
History of Cardiopulmonary Resuscitation
BASIC LIFE SUPPORT AND ADVANCED LIFE SUPPORT ALGORITHMS OF CPR IN THE JAPANESE COUNCIL OF RESUSCITATION GUIDELINES2
The Chain of Survival
Advanced Life Support Algorithm
CAB (C: Chest Compression; A: Ensuring the Airway; B: Breathing) Not ABC
POST-CARDIAC ARREST SYNDROME4
Postresuscitation Disease to Post-cardiac Arrest Syndrome
Pathology of PCAS
Post-cardiac Arrest Brain Injury
Post-cardiac Arrest Myocardial Dysfunction
Systemic Ischemia/Reperfusion Response: Cytokine Responses, Coagulopathy, Endothelial Damage
Persistent Precipitating Pathology
Non-cardiac Origin Cardiac Arrest
Post-cardiac Arrest Care
General Measures
Monitoring
Early Hemodynamic Optimization
Management of Acute Coronary Syndrome
Blood Glucose Control
THERAPEUTIC HYPOTHERMIA: METHODS, REWARMING AND COMPLICATIONS
Induction and Maintenance of Therapeutic Hypothermia
Rewarming
Complications
SUMMARY OF THERAPEUTIC HYPOTHERMIA
CHAPTER 4:
Airway Management
INTRODUCTION
COMPLICATIONS OF AIRWAY MANAGEMENT IN INTENSIVE CARE UNIT
PREOXYGENATION IN CRITICALLY ILL PATIENTS
PREPARATION FOR AIRWAY MANAGEMENT IN INTENSIVE CARE UNIT
PREOXYGENATION AND VENTILATION
OTHER PREPARATIONS
ASSESSMENT FOR DIFFICULT INTUBATION
PROPOSED CHECKLIST BEFORE INTUBATION
Endotracheal Intubation
Principles of Laryngoscopy
Drug Therapy (Preintubation)
Rapid Sequence Intubation (RSI)
Confirm Tracheal Tube Placement
THE “INTUBATION BUNDLE”
Difficult Airway and Difficult Intubation
Supraglottic Airway Devices
Indications of Using SADs in ICU
Contraindications for Use as a Rescue Device
Video Laryngoscopes
CRICOTHYROIDOTOMY
Surgical Cricothyroidotomy
Needle (Narrow Bore) Cricothyroidotomy
Procedure
Ventilation through Needle Cricothyroidotomy
Wide Bore Cannula Cricothyroidotomy (>4 mm ID)
Complications of Cricothyroidotomy
Anticipated Difficult Airway
Unanticipated Difficult Airway
Complications of Intubation
Long-Term Complications of Intubation30
Extubation of the Airway31
Managing Displaced Tracheostomy Tube2
What Can Be Done to Improve Airway Management in ICU Safer
SUMMARY: KEY POINTS
CHAPTER 5:
Hemodynamic Monitoring
INTRODUCTION
BASIC HEMODYNAMIC MONITORING
Arterial Pressure Monitoring
Central Venous Pressure and Central Venous Oxygen Saturation
ADVANCED HEMODYNAMIC MONITORING
Pulmonary Artery Catheter
Pressures
Cardiac Output
Transpulmonary Thermodilution and Pulse Wave Analysis
Echocardiography
DERIVED CALCULATIONS
INTERPRETATION OF HEMODYNAMIC MEASUREMENTS
Characterization of the Type of Shock
Is Cardiac Output Adequate?
Evaluation of Preload Responsiveness
Evaluation of a Patient with Heart Failure
Evaluation of a Patient with Pulmonary Hypertension
Evaluation of a Patient with Respiratory Failure
CONCLUSION
CHAPTER 6:
Respiratory Monitoring
INTRODUCTION
BASIC RESPIRATORY MECHANICS
PHYSICAL EXAMINATION
MONITORING GAS EXCHANGE
Pulse Oximetry
Limitations of Pulse Oximetry
Recent Advances in Pulse Oximetry
Future Application
INVASIVE AND NONINVASIVE MONITORING OF CARBON DIOXIDE
Transcutaneous Carbon Dioxide Monitoring
Capnography and Dead Space Calculation
Volume Capnograph
Clinical Applications of Capnography
Limitations of Capnography
SYSTEMIC ARTERIAL BLOOD GAS ANALYSIS
Artefactual Changes in Arterial Blood Gas Values
Transcutaneous Blood Gas Monitoring
In-line Blood Gas Monitoring
CENTRAL AND MIXED VENOUS OXYGEN MONITORING
TISSUE OXYGENATION
CO-OXIMETRY
LUNG WATER ANALYSIS
BASIC RESPIRATORY MECHANICS
TRANSPULMONARY AND ESOPHAGEAL PRESSURES
INTRA-ABDOMINAL PRESSURE
STATIC COMPLIANCE
LUNG VOLUMES AND ALVEOLAR RECRUITMENT
PRESSURE/VOLUME CURVES
Static Pressure Volume Curves
STRESS INDEX
INTRATIDAL PRESSURE-VOLUME LOOP
VENTILATOR-PATIENT ASYNCHRONY, FLOW-VOLUME AND PRESSURE CURVES
MEASURING VENTILATION: MINUTE VENTILATION PLUS ALVEOLAR VENTILATION
ELECTRICAL IMPEDANCE TOMOGRAPHY
MEASURING RESPIRATORY DRIVE
MEASURING WORK OF BREATHING
PRESSURE TIME PRODUCT
BREATHING PATTERN (RAPID SHALLOW BREATHING INDEX)
MEASURING RESPIRATORY MUSCLE STRENGTH
DIAPHRAGMATIC FUNCTION
GASTRIC TONOMETRY
IMAGING
Quantitative Computed Tomography
Lung Ultrasound
DIAPHRAGMATIC ULTRASOUND
CARDIOPULMONARY INTERACTION
Hemodynamic Monitoring
Jugular Venous Bulb Oximetry
Bronchoalveolar Lavage Studies
CHAPTER 7:
Neuromonitoring
INTRODUCTION
NEUROLOGICAL ASSESSMENT
SYSTEMIC MONITORING
NEUROPHYSIOLOGICAL MONITORING
Electroencephalogram and its Derivatives
Evoked Potentials
CEREBRAL BLOOD FLOW MONITORING
MONITORING INTRACRANIAL PRESSURE
MEASUREMENT OF CEREBROVASCULAR REACTIVITY
TRANSCRANIAL DOPPLER
JUGULAR VENOUS OXIMETRY
PARENCHYMAL BRAIN TISSUE OXYGEN MONITORING
NEAR-INFRARED SPECTROSCOPY
CEREBRAL MICRODIALYSIS
CONCLUSION
CHAPTER 8:
Imaging in ICU
INTRODUCTION
X-RAYS IN ICU
LINES, TUBES AND OTHER DEVICES
The Endotracheal Tube
Thoracostomy Tube
The Feeding Tube
Central Lines
Monitoring of Pulmonary Capillary Wedge Pressure
Cardiac Pacing Devices
Intra-aortic Balloon Counterpulsation Device
PNEUMOTHORAX
PNEUMOMEDIASTINUM
PNEUMOPERICARDIUM
PLEURAL EFFUSIONS
PERICARDIAL EFFUSIONS
PNEUMONIA IN ICU
TRAUMATIC DIAPHRAGMATIC HERNIA
PULMONARY EDEMA
ABDOMINAL RADIOGRAPHY
X-RAY IN TRAUMA
ULTRASONOGRAPHY IN ICU
CARDIAC APPLICATIONS
THORACIC APPLICATIONS
AIRWAY APPLICATIONS
ABDOMINAL APPLICATIONS
VASCULAR APPLICATIONS
OPTIC ULTRASOUND
COMPUTED TOMOGRAPHY
CHAPTER 9:
Sedoanalgesia and Delirium
INTRODUCTION
PAIN
Diagnosis
Treatment
Pharmacological Therapy
Morphine
Hydromorphone
Fentanyl
Remifentanil
Ketamine
Non-steroidal Anti-inflammatory Drugs
Acetaminophen
AGITATION AND SEDATION
Management
Pharmacological Measures
Benzodiazepines
Propofol
Dexmedetomodine
DELIRIUM
Definition
Prevalence and Subtypes
Pathophysiology
Neurotransmitter Imbalance
Altered Tryptophan Metabolism
Impaired Oxidative Metabolism
Inflammation
Genetic Factors
Diagnosis of Delirium
Risk Factors
Evaluation and Workup
Prevention
Daily Spontaneous Awakening Trials (SAT) and Spontaneous Breathing Trials (SBT)
Choice of Sedation
Daily Delirium Monitoring
Early Mobility and Exercises
Treatment
Nonpharmacological Measures
Pharmacological Measures
CONCLUSION
REFERENCES
CHAPTER 10:
Fluids and Electrolytes
INTRODUCTION
FLUIDS AND ELECTROLYTES HOMEOSTASIS IN THE BODY
INTRAVENOUS FLUIDS IN COMMON USE
Electrolyte Solution (Crystalloids)
Colloids (Table 2)
Gelatins
Starches
Molecular Weight
Dextrans
Albumin
Effect of Fluid Therapy
Resuscitation Fluids: Points to Remember
DYSELECTROLYTEMIAS: A BRIEF DESCRIPTION
DISORDERS OF SODIUM
HYPONATREMIA
Symptoms and Etiology29,31
Diagnosis and Evaluation
HYPOVOLEMIC HYPONATREMIA
Management
A NOTE ON OSMOTIC DEMYELINATION SYNDROME
HYPERNATREMIA
Management of Hypernatremia
DISORDERS OF POTASSIUM
Hyperkalemia36,37
Hypokalemia37,38
DISORDERS OF CALCIUM40,41
Hypocalcemia
Hypercalcemia
DISORDERS OF MAGNESIUM
Hypomagnesemia
Hypermagnesemia
DISORDERS OF PHOSPHATE
Hypophosphatemia
Hyperphosphatemia
DISORDERS OF CHLORIDE
Hypochloremia
Hyperchloremia
Dyselectrolytemias: Learning Points
CONCLUSION
CHAPTER 11:
Acid-Base Balance and Disorders
INTRODUCTION
WATER, pH AND ACID-BASE
pH, PaCO2 AND ACID-BASE1,2
PaCO2/pH RELATIONSHIP
KIDNEY EFFECT
WEAK ACIDS
THE TWO APPROACHES
HOW TO APPROACH AN ACID-BASE DISORDER—A STEPWISE APPROACH BASED ON A CASE SCENARIO
Case Scenario
Step: 1
Important Steps in ABG (Arterial Blood Gas) Interpretation
Step: 2
Oxygenation Interpretation 12-14
Step: 3
Interpretation of pH12,13
Respiratory Alkalosis:15-18
Step: 4
Step: 5
Mind the Gaps
Osmolar Gap
CONCLUSION
CHAPTER 12:
Nutrition
INTRODUCTION
NUTRITIONAL ASSESSMENT IN THE CRITICALLY ILL
ROUTES OF NUTRIENT ADMINISTRATION
GENERAL STRATEGY FOR ICU PATIENTS
ENTERAL NUTRITION
Complications of Enteral Nutrition
REFEEDING SYNDROME
TOTAL PARENTERAL NUTRITION
Complications of Total Parenteral Nutrition
IMMUNONUTRITION
L-Arginine
Omega-3 Fatty Acids
Glutamine
Selenium
NUTRITION IN SPECIAL SITUATIONS
Acute Pancreatitis
Acute Liver Failure
Nutrition Support in Acute Kidney Failure
Nutrition Support in Difficult-to-Wean Patients
CONCLUSION
CHAPTER 13:
Glycemic Control
INTRODUCTION
IMPORTANCE OF GLYCEMIC MANAGEMENT IN ICU
Prevalence of Hyperglycemia in ICU
Effect of Hyperglycemia in ICU
Target Blood Glucose
Transition from Insulin Infusion to Subcutaneous Insulin
Recommendations
BARRIERS TO GLYCEMIC MANAGEMENT IN ICU
MEDANTA INSULIN PROTOCOLS16,17
Glucometrics
CONCLUSION
CHAPTER 14:
Pressure Sore Prevention and Management
INTRODUCTION
INCIDENCE, MORTALITY AND COSTS
ETIOLOGY
RISK FACTORS
Risk Assessment Tool
Braden Scale
Norton Scale
HOW TO IMPLEMENT A PREVENTION PLAN
Skin Care
Mechanical Loading
Support Surface
Nutrition
MANAGEMENT OF PRESSURE ULCERS
Cleansing
Assessment and Staging
Four Stages System Used by Europeans40 (Figs 4 and 5)
Debridement
Bacterial Burden
Exudate Management
Nutrition
Pain Management
Monitoring Healing
ADJUNCTIVE THERAPIES
CONCLUSION
CHAPTER 15:
Principles of Mechanical Ventilation
INTRODUCTION
HISTORY OF VENTILATION
Negative Pressure Ventilation
Positive Pressure Ventilation
INDICATIONS FOR MECHANICAL VENTILATION
FUNCTIONING OF THE VENTILATOR
MODES OF CONVENTIONAL VENTILATION
Positive End-expiratory Pressure
Intermittent Positive Pressure Ventilation
Continuous or Intermittent Mandatory Ventilation
Synchronized Intermittent Mandatory Ventilation
Pressure-controlled Ventilation
Pressure Support Ventilation
Bi-level Positive Airway Pressure
Continuous Positive Airway Pressure
Inverse Ratio Ventilation
High-frequency Positive Pressure Ventilation
PATIENT MONITORING DURING VENTILATION
NONINVASIVE VENTILATION
CONCLUSION
CHAPTER 16:
Newer Modes of Ventilation
INTRODUCTION
CLASSIFICATION
Dual Control within a Breath
Merits
Demerits
Dual Control Breath to Breath: Pressure-limited Flow Cycled
Merits
Demerits
Dual Control Breath to Breath: Pressure-limited Time Cycled
Merits
Demerits
Dual Control Breath to Breath: Combined Time and Flow Cycled Ventilation
Merits
Demerits
Proportional Assist Ventilation
Merits
Demerits
Automatic Tube Compensation
Merits
Demerits
Neurally Adjusted Ventilatory Assist
Merits
Demerits
Adaptive Support Ventilation
Merits
Demerits
Knowledge-based Systems
Merits
Demerits
Airway Pressure Release Ventilation and Bilevel Positive Airway Pressure
Merits
Demerits
High Frequency Oscillatory Ventilation
Control on PaCO2
Control on Oxygenation
Weaning from HFOV
Use of Sedation and Neuromuscular Blockade
Merits
Demerits
Liquid Ventilation
Total Liquid Ventilation
Partial Liquid Ventilation
Merits
Demerits
CHAPTER 17:
Liberation from Mechanical Ventilation
INTRODUCTION
PHYSIOLOGY OF WEANING
Effect of Mechanical Ventilation and its Liberation on Respiratory System
Effect of Mechanical Ventilation and its Liberation on Cardiovascular System
Weaning: Protocolized or Personal Approach?
Difference between Extubation and Liberation of Mechanical Ventilation
Prediction of Weaning Success
Simple Measures of Capacity and Load
Complex Measurements of Capacity and Load
Integrative Indices
SPONTANEOUS BREATHING TRIAL (SBT)
Protocol for Liberation from Mechanical Ventilation and Extubation4
Screening the Patient for Readiness to be Liberated from Mechanical Ventilation
Give Spontaneous Breathing Trial
Assessment during a Spontaneous Breathing Trial
If the Patient Passes the SBT, Assess for Readiness for Extubation
THE CUFF-LEAK TEST
TREATMENT OF CORD EDEMA TO PREVENT EXTUBATION FAILURE
WEANING FAILURE
Group 1: Patients with Weaning Failure After the First SBT
Group 2: Patients with Weaning Failure1
Group 3: Patients with Weaning Failure and Prolonged Mechanical Ventilation1
ROLE OF NONINVASIVE VENTILATION IN WEANING23
CAUSES OF WEANING FAILURE, STRUCTURED AS “ABCDE”24
Airway and Lung Dysfunction
Brain Dysfunction
Cardiovascular Dysfunction
Diaphragm or Respiratory Muscle Dysfunction
Endocrine and Metabolic Dysfunction Causing Weaning Failure24
CHAPTER 18:
Extracorporeal Membrane Oxygenation (ECMO)
INTRODUCTION
AIMS OF ECMO
DEFINITION
HISTORY
TYPES OF ECMO
Veno-Venous ECMO
Carbon Dioxide (CO2) Removal with V-V ECMO
Veno-Arterial ECMO
CARDIAC INDICATIONS FOR ECMO
NONCARDIAC INDICATIONS FOR ECMO
ECMO IN ICU
ECMO and its Use in Sepsis
CESAR Study Conventional Ventilation or ECMO for Severe Adult Respiratory Failure9
ECMO IN H1N1 INFLUENZA
INTEGRATED ECMO IN CONGENITAL HEART DISEASE
Benefits of Integrated ECMO
Timing of ECMO is Important to Prevent End-organ Damage
CARDIOGENIC SHOCK AND ECMO
ECMO FOR HEART FAILURE
USE OF CONTINUOUS RENAL REPLACEMENT THERAPY IN SERIES WITH ECMO
Low Flow V-A ECMO
ECPR (ECMO CPR) HELICOPTER TRANSFER WITH CARDIOHELP
ECMO FOR DROWNING AND ACCIDENTAL HYPOTHERMIA
ECMO AND CATH LAB INTERVENTIONS
ECMO AND ORGAN PRESERVATION
ECMO COMPLICATIONS AND ITS MANAGEMENT
Mechanical Complication
Cannulation Related Complications
Management of Problems of A Blocked Cannula on ECMO
Pump Failure
Roller Pump Complications and Management
Causes
Management
Prevention of This Mishap
Heat Exchanger Complications (Fig. 20)
Causes
General Management of Circuit Complications
Complications in Patients
Neurological Complications Developing in Patients on ECMO
Pulmonary Complications on ECMO
Renal Complications on ECMO
Gastrointestinal Tract Complications on ECMO
Complications Resulting From Infection and Sepsis on ECMO (Fig. 23)
To Conclude, Complications of ECMO are Manifold, to Avoid them, we Need—
CONCLUSION
CHAPTER 19:
Transport of Critically Ill
INTRODUCTION
HISTORY
CLASSIFICATION OF MEDICAL TRANSPORTATION
EMERGENCY ON-SITE TRANSPORTATION/EVACUATION/PREHOSPITAL/PRIMARY TRANSPORTATION
THE GOLDEN HOUR RULE
AMBULANCE DESIGN STANDARDS
First Responders—Type A
Patient Transport Ambulance—Type B
Basic Life Support Ambulance—Type C
Advanced Life Support Ambulance—Type D
Ambulance Design
Equipment
PREHOSPITAL AIR MEDICAL TRANSPORTATION
INTRA- AND INTERHOSPITAL TRANSFER
Intrahospital Transfers
Preshifting Planning and Coordination
Equipment and Medications
Interhospital Transfer
Air Medical Interhospital Transportation
Equipment for Air Medical Transportation
MEDICOLEGAL ASPECT
SECTION 2: CARDIOVASCULAR SYSTEM
CHAPTER 20:
Pharmacology of Inotropes and Vasopressors
INTRODUCTION
CATECHOLAMINES
VASOPRESSORS
Dopamine
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Norepinephrine
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Epinephrine
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Phenylephrine
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Vasopressin
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Methylene Blue
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
INOTROPES
Isoproterenol
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Dobutamine
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Milrinone
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
Levosimendan
Introduction
Receptors
Effects
Side-effects
Dosing
Evidence
CHAPTER 21:
Acute Coronary Syndrome
INTRODUCTION
PRIMARY MANAGEMENT
MANAGEMENT OF ACUTE CORONARY SYNDROME
Reperfusion Therapy
Thrombolytic Therapy
Percutaneous Coronary Intervention
Adjunct Pharmacologic Treatment
CHAPTER 22:
Emergencies in Valvular Heart Diseases
INTRODUCTION
MECHANICAL VALVE MALFUNCTION/OBSTRUCTION
Epidemiology
Diagnosis
Clinical Presentation
Cinefluoroscopy
Transthoracic Echocardiography
Transesophageal Echocardiography
Other Techniques
Treatment
Nonobstructive left-sided PVT
Obstructive PVT
THROMBOLYSIS
Treatment Protocols
Streptokinase (STK)
Recombinant Tissue Plasminogen Activator (TPA)
Evaluation of Thrombolysis Outcome
PROSTHETIC HEART VALVE THROMBOSIS
Key Points
INFECTIVE ENDOCARDITIS
Microbiology
Clinical Symptoms and Signs
Acute Cardiovascular Complications
Diagnosis
Echocardiography
Management
Staphylococcal Infections
Streptococcal Infections
Fungi
Surgical Treatment: Indications and Optimal Timing of Surgery
EXCESSIVE ANTICOAGULATION AND BLEEDING
CHAPTER 23:
Arrhythmias and Heart Block
INTRODUCTION
DIAGNOSIS OF ARRHYTHMIAS
BRADYARRHYTHMIAS
Management of Bradycardias
Heart Blocks
Procedure of Temporary Pacing
TACHYARRHYTHMIAS
Approach to ECG Interpretation of Tachydysrhythmias
Accessory Pathway Mediated Tachycardia
Focal Atrial Tachycardia
Management of Narrow QRS and Regular Tachycardia
Acute Management
Adenosine in Supraventricular Tachycardia Treatment
ATRIAL FLUTTER
Acute Treatment
Atrial Fibrillation
Treatment of Atrial Fibrillation
Control of Ventricular Response
Wide Complex Tachyarrhythmias
Ventricular Tachycardia
Polymorphic Ventricular Tachycardia
Treatment of Ventricular Tachycardia
CHAPTER 24:
Acute Decompensated Heart Failure and Cardiogenic Shock
INTRODUCTION
DIAGNOSIS AND CAUSES
Echocardiography
Plasma Biomarker
Brain-type Natriuretic Peptide
Troponin
PATHOPHYSIOLOGY
MANAGEMENT
General Approach to Patients with ADHF and Cardiogenic Shock
Hemodynamic Monitoring and Management
Fluid and Diuretic Therapy
Vasodilator Therapy
Inotropic Support
Mechanical Circulatory Support
Definitive Management
Reperfusion Therapy
Post-cardiotomy Heart Failure
RIGHT HEART FAILURE
CONCLUSION
CHAPTER 25:
Hypertensive Crisis
INTRODUCTION
DEFINITION
Accelerated Hypertension
Malignant Hypertension
HYPERTENSIVE URGENCY
HYPERTENSIVE EMERGENCY
Pathophysiology
Diagnosis of Hypertensive Emergency
Medical History
Physical Examination
Laboratory Evaluation
Treatment of Hypertensive Emergency
Pharmacologic Agents for Treatment of Hypertensive Emergency
Hydralazine
Nicardipine
Fenoldopam
Clevidipine
Enalaprilat
Sodium Nitroprusside
Nitroglycerin
Labetalol
Esmolol
Phentolamine
SPECIAL CONDITIONS
Neurological Hypertensive Emergency
AORTIC DISSECTION
HYPERTENSIVE EMERGENCY IN PREGNANCY
Hyperadrenergic State
MYOCARDIAL ISCHEMIA
ACUTE HEART FAILURE
ACUTE POSTOPERATIVE HYPERTENSION
CONCLUSION
CHAPTER 26:
Pulmonary Embolism and Deep Vein Thrombosis
INTRODUCTION
EPIDEMIOLOGY
PATHOPHYSIOLOGY
DIAGNOSIS OF DVT AND PE
D-Dimer Assay
Venous Ultrasound
Chest CT Scan
MANAGEMENT OF PULMONARY EMBOLISM
Primary Therapy of Pulmonary Embolism
Thrombolysis in Pulmonary Embolism
Interventions in Pulmonary Embolism
Surgical Management of Acute Pulmonary Embolism
Secondary Prevention of Recurrences
Anticoagulation Therapy
Inferior Vena Caval Filters
SEQUELAE OF DVT AND PE
PRIMARY PREVENTION OF VTE
FUTURE PERSPECTIVE
CHAPTER 27:
Aortic Dissection and Aneurysm
AORTIC DISSECTION
Introduction
Different Types
Stanford Classification
DeBakey Classification
Svensson Classification (Defines Type of Acute Aortic Syndrome)
Risk Factors
ANEURYSM
Natural History
Clinical Presentation
Dissection
Types
INDICATION FOR ICU CARE
COMPLICATIONS
MEDICAL MANAGEMENT AND ICU MANAGEMENT
Ascending Type A Dissection
Control Blood Pressure
Fluid Resuscitation
Type B Dissection (Management of BP with β-Blockers)
POSTOPERATIVE MANAGEMENT
Post-Bentall's Procedure/Arch Replacement
Post-thoracoabdominal Aneurysm Repair
BRIEF DESCRIPTION OF SURGICAL MANAGEMENT
Type A Aortic Dissection
Type B Dissections
Methods Available for Improving Spinal Cord Protection
BRIEF DESCRIPTION OF ENDOVASCULAR TREATMENT
CHAPTER 28:
Cardiac Tamponade and Constrictive Pericarditis
INTRODUCTION
ETIOLOGY AND PATHOPHYSIOLOGY OF PERICARDIAL TAMPONADE
CLINICAL PRESENTATION IN ICU SETTING
EVALUATION AND MANAGEMENT OF PERICARDIAL TAMPONADE
BRIEF DESCRIPTION OF SURGICAL MANAGEMENT OF CONSTRICTIVE PERICARDITIS AND RECURRENT PERICARDIAL EFFUSION
CONCLUSION
CHAPTER 29:
Anticoagulants, Thrombolytic and Antiplatelet Agents
INTRODUCTION
VITAMIN K ANTAGONISTS
Warfarin
HEPARIN AND HEPARINOIDS
Unfractionated Heparin
Low-molecular-weight Heparins
Pentasaccharides
Fondaparinux Sodium
Idraparinux Sodium
Factor Xa Antagonists
Rivaroxaban
Apixaban
Edoxaban
ANTIPLATELET AGENTS
Cyclooxygenase Inhibitors
Adenosine Diphosphate Antagonists (Thienopyridines)
Ticlopidine Hydrochloride
Clopidogrel
Prasugrel
Ticagrelor
Glycoprotein IIb/IIIa Inhibitors
Abciximab (ReoPro®)
Eptifibatide
Tirofiban
DIRECT THROMBIN INHIBITORS
Bivalirudin
Argatroban
Dabigatran
Comments on Direct Thrombin Inhibitors
FIBRINOLYTIC AGENTS
Streptokinase
Urokinase
Alteplase
Reteplase
Tenecteplase
PREVENTION AND MANAGEMENT OF COMPLICATIONS
CONCLUSION
SECTION 3: RESPIRATORY SYSTEM
CHAPTER 30:
Oxygenation and Respiratory Failure
INTRODUCTION
DEFINITIONS
PHYSIOLOGY OF OXYGENATION
Important Equations
TYPES OF RESPIRATORY FAILURE5,6
Type 1 Respiratory Failure
Type 2 or Hypercapnic Respiratory Failure
CAUSES OF RESPIRATORY FAILURE
CLINICAL PRESENTATION
APPROACH TO A PATIENT OF RESPIRATORY FAILURE
Arterial Blood Gas Measurement11
Pulse Oximetry
Pulmonary Function Tests
Chest Radiographs
Echocardiography
TREATMENT
Oxygen Supplementation
Noninvasive Ventilation
Invasive Mechanical Ventilation
CONCLUSION
CHAPTER 31:
Acute Respiratory Distress Syndrome
INTRODUCTION
DEFINITION AND CRITERIA
EPIDEMIOLOGY
Incidence
PATHOGENESIS
PATHOLOGY
MANAGEMENT
Ventilatory Techniques
Lung Protective Ventilation
Positive End-expiratory Pressure and Open Lung Ventilation
Pressure-controlled Ventilation
Inverse Ratio Ventilation
Airway Pressure Release Ventilation and Biphasic Positive Airway Pressure Ventilation
High Frequency Oscillatory Ventilation
Adjunctive and Rescue Therapies
Fluid Management
Corticosteroids
Neuromuscular Blockers
Prone Positioning
Inhaled Pulmonary Vasodilators
Extracorporeal Membrane Oxygenation
Mortality
CHAPTER 32:
Chronic Obstructive Pulmonary Disease and Acute Severe Asthma
INTRODUCTION
ETIOPATHOGENESIS
CLINICAL FEATURES
DIAGNOSIS
MANAGEMENT
Inhaled Bronchodilators
Oxygen Therapy
Corticosteroids
Antimicrobial Therapy
Other Adjunctive Therapy
Noninvasive Positive Pressure Ventilation
Mechanical Ventilation
COMPLICATIONS
CHAPTER 33:
Community-acquired Pneumonia
INTRODUCTION
RISK FACTORS
CLINICAL FEATURES
MICROBIAL ETIOLOGY
RISK STRATIFICATION
Criteria for Intensive Care Unit Admission
DIAGNOSTIC TESTS
Biological Markers
Antimicrobial Treatment
Nonantimicrobial Treatment
NONRESPONDING PNEUMONIA
PREVENTION
CONCLUSION
CHAPTER 34:
Nosocomial Pneumonia
INTRODUCTION
DEFINITIONS
EPIDEMIOLOGY
ETIOLOGY AND PATHOGENESIS
DIAGNOSIS
Nonbronchoscopic versus Bronchoscopic Specimens
Microscopy
Giemsa Stain
Cultures
Qualitative
Semiquantitative
Quantitative Culture
PREVENTION
TREATMENT
DURATION OF THERAPY
CONCLUSION
CHAPTER 35:
Massive Hemoptysis
INTRODUCTION
DEFINITION
EPIDEMIOLOGY
ANATOMY OF THE PULMONARY CIRCULATION
Pulmonary Circulation
Bronchial Circulation
Nonbronchial System Collateral Circulation
Pulmonary Venous Abnormalities
ETIOLOGY
PATHOPHYSIOLOGY5,6
Inflammatory Lung Diseases
Bronchiectasis and Cystic Fibrosis
Infections
Neoplasms
Cardiovascular Diseases
Pulmonary Embolism
Trauma
IATROGENIC CAUSES
Pulmonary Artery Catheterization
Bronchoscopy
Tracheostomy
CLINICAL APPROACH
INVESTIGATIONS
DIAGNOSIS
History and Physical Examination
Laboratory Studies
RADIOGRAPHIC STUDIES
Computed Tomography
Bronchoscopy
Multidetector CT Angiography
Bronchial Arteriography
MANAGEMENT
General Supportive Management
Definitive Medical Management
Lung Protection
Double Lumen Endotracheal Tubes
BRONCHOSCOPIC TREATMENT
Ice Cold Saline/Adrenaline Lavage
Endobronchial Infusion
Laser Photocoagulation
Endotracheal Balloon Tamponade
Bronchial Artery Embolization (BAE)
Surgical Management
MISCELLANEOUS CONDITIONS
OUTCOME
CONCLUSION
CHAPTER 36:
Pleural Effusion and Pneumothorax
INTRODUCTION
COMMON CAUSES OF PLEURAL EFFUSION IN ICU
ETIOLOGY
APPROACH TO PLEURAL EFFUSION IN ICU
PLEURAL FLUID EXAMINATION
MANAGEMENT OF PLEURAL EFFUSIONS IN ICU
Empyema
Hemothorax
Chylothorax
PLEURODESIS
Pleurodesis for Persistent Air Leak through Chest Tube
PNEUMOTHORAX IN ICU
Diagnosis
Undiagnosed Pneumothorax
Management of Pneumothorax in ICU
Tube Thoracotomy
BRONCHOPLEURAL FISTULAS
Etiology
Predisposing Factors192
Incidence
Clinical Features
Management
Bronchoscopic Treatment of Bronchopleural Fistulas
Mechanical Ventilation in the Presence of Bronchopleural Fistulas
SECTION 4: RENAL SYSTEM
CHAPTER 37:
Acute Kidney Injury
INTRODUCTION
DEFINITIONS
PATHOPHYSIOLOGY
Hypotension and Ischemia
Drug-induced Nephrotoxicity
Contrast-induced Acute Kidney Injury
Gadolinium-based Contrast Agents
Obstructive Uropathy
RISK FACTORS
Risk Models and Prediction Scores
Role of Biomarkers
Recognition (Table 5)
Response
Loop Diuretics
Natriuretics
Vasoactive Agents
Other Agents
Correction of Electrolytes and Acid-Base Status
Medication Dose Adjustments
Renal Support
Rehabilitation
CONCLUSION
CHAPTER 38:
Renal Replacement Therapy
INTRODUCTION
DEFINITION AND CLASSIFICATION OF ACUTE KIDNEY INJURY
MANAGEMENT OF PATIENTS WITH ACUTE KIDNEY INJURY
General Measures
Specific Measures
RENAL REPLACEMENT THERAPY
Indications for RRT in Critically Ill Patients with AKI
Life-threatening Indications
Non-emergent Indications
RRT for Overdose with Dialyzable Drug11
Inborn Errors of Metabolism12,13
Modality of RRT in ICU
Principles of RRT in IHD and CRRT14
Diffusion
Convection
Ultrafiltration
Principles of RRT in Peritoneal Dialysis15
Modes of Renal Replacement Therapy: IHD and CRRT
Hemodialysis
Continuous Renal Replacement Therapy
Sustained Low-efficiency Dialysis
Which Modality is Better—IHD versus CRRT versus SLED
What should be Dose of RRT?
Practical Aspects of RRT in ICU Setting
Extracorporeal Circuit
Vascular Access
Anticoagulation
Dialyzer Membrane
Buffer Solutions for RRT
Drug Dosing during RRT
Criteria for Stopping RRT
Complications of RRT
USE OF PERITONEAL DIALYSIS IN ACUTE KIDNEY INJURY
SECTION 5: GASTROINTESTINAL TRACT, PANCREAS AND HEPATOBILIARY SYSTEM
CHAPTER 39:
Upper Gastrointestinal Bleeding and Stress Ulcer Syndrome
INTRODUCTION
CAUSES OF UGIB
NON-VARICEAL BLEEDING
Peptic Ulcer and Gastroduodenal Erosions
Mallory-Weiss Tears
Vascular Anomalies
With Skin Lesions
Without Skin Lesions
Gastric Antral Vascular Ectasia
Dieulafoy's Lesion
Management of Non-variceal Bleeding
Risk Assessment and Stratification
Fluid Replacement
Gastric Lavage
Bleeding Diathesis
Pharmacotherapy in Non-variceal UGI Bleed
Pre-endoscopic Proton Pump Inhibitors
Tranexamic Acid
Somatostatin and Octreotide
Endoscopic Therapy in Non-variceal Bleed
Endoscopy in Peptic Ulcer Bleed
Thermal Approach
Injection Therapy
Mechanical Therapy
Combination of Various Approaches
Endoscopic Therapy for Patients with Adherent Clot
Repeat Second-look Endoscopy
Recurrent Bleeding
Surgery
Other Causes of Non-variceal UGI Bleed
Angiodysplasia
Dieulafoy's Lesion
Vasoenteric Fistula
Portal Hypertensive Gastropathy
Gastric Antral Vascular Ectasia
Hereditary Vascular Anomalies
Traumatic or Iatrogenic Bleeding
Mallory-Weiss Tear
Intramural Hematoma
Miscellaneous Causes of Bleeding
Hemobilia
Hemosuccus Pancreaticus
VARICEAL BLEEDING
Management of Variceal Bleed
Initial Resuscitation
Medical Management of Acute Variceal Bleed
Balloon Tamponade
Endoscopic Therapy
Rescue Therapies
CONCLUSION
CHAPTER 40:
Paralytic Ileus
INTRODUCTION
PATHOLOGY AND PATHOGENESIS
CLASSIFICATION
Gastroparesis
Small Bowel Ileus
Acute Colonic Pseudo-obstruction
POSTOPERATIVE ILEUS
SUMMARY OF EVIDENCE-BASED MANAGEMENT RECOMMENDATIONS
CONCLUSION
CHAPTER 41:
Mesenteric Ischemia
INTRODUCTION
MESENTERIC PHYSIOLOGY
PATHOPHYSIOLOGY
ACUTE MESENTERIC ISCHEMIA
Mesenteric Arterial Embolism
Mesenteric Arterial Thrombosis
Nonocclusive Mesenteric Ischemia
Mesenteric Venous Thrombosis
INHERITED HYPERCOAGULABLE STATES
Clinical Manifestation
Diagnosis
Laboratory Studies
Radiographic Studies
Treatment
Mesenteric Arterial Embolism
Mesenteric Arterial Thrombosis
Mesenteric Venous Thrombosis
Nonocclusive Mesenteric Ischemia
CONCLUSION
CHAPTER 42:
Fulminant Colitis and Toxic Megacolon
INTRODUCTION
ETIOLOGY
PATHOGENESIS
CLINICAL MANIFESTATIONS
DIAGNOSIS
TREATMENT
PROGNOSIS
CHAPTER 43:
Approach to Elevated Liver Enzymes
INTRODUCTION
ETIOLOGY OF DERANGED LIVER FUNCTION TESTS IN ICU PATIENTS
Ischemic-Congestive Hepatopathy or Hypoxic Liver Injury
Sepsis-induced Liver Dysfunction
Drug-induced Liver Injury
Parenteral Nutrition
Biliary Obstruction
Infiltrative Liver Disorders
CONCLUSION
CHAPTER 44:
Acute Liver Dysfunction and Hepatic Encephalopathy
INTRODUCTION
DEFINITION
ETIOLOGY
PATHOGENESIS
Role of Ammonia
Loss of Cerebral Autoregulation
Prognostic Models
MANAGEMENT
Complications and Causes of Death in ALF
Medical Therapy Directed to Control Encephalopathy and Cerebral Edema
Neurologic Support
Intracranial Pressure Monitoring
Jugular Bulb Venous Saturation Monitoring
Osmotherapy
Thiopentone
Hypothermia
Prophylactic Phenytoin
Hyperventilation
Ammonia-Lowering Strategies
L-Ornithine L-Aspartate
L-Ornithine Phenylacetate
Sodium Benzoate
Rifaximin
Miscellaneous Interventions to Lower Ammonia and Improve Encephalopathy
Therapies Directed toward Management of Complications
Prevention and Treatment of Infection
Hemodynamic Support
Coagulopathy
Mechanical Ventilation
Renal Support
Nutritional and Metabolic Support
Liver Transplantation and Bioartificial Liver Support
Liver Transplantation
Nontransplant Therapies for Liver Support
CONCLUSION
CHAPTER 45:
Acute Pancreatitis
INTRODUCTION
ETIOLOGY AND DEFINITION OF ACUTE PANCREATITIS
ASSESSING SEVERITY OF ACUTE PANCREATITIS
Local Complications
USE OF SCORING SYSTEMS IN ACUTE PANCREATITIS
MANAGEMENT OF ACUTE PANCREATITIS
Initial Management
Fluid Therapy
Choice of Fluid
Pain Control
Monitoring
Nutrition
Antibiotics
Persistent SIRS
Abdominal Compartment Syndrome
Early ERCP versus Late ERCP
Long-term Management
Timing of Cholecystectomy
Timing of Intervention for Necrosis
Testing in Cases of Recurrent Episodes of Pancreatitis
CONCLUSION
CHAPTER 46:
Hepatorenal Syndrome
INTRODUCTION
DEFINITION AND DIAGNOSTIC CRITERIA
CLINICAL TYPES
PATHOPHYSIOLOGY (FLOWCHART 1)
Renal and Systemic Hemodynamic Changes
Neurohumoral Abnormalities
RISK FACTORS
DIAGNOSTIC TESTING
Basic Metabolic Panel
PSEUDOHEPATORENAL SYNDROME
PREVENTIVE MEASURES
GENERAL APPROACH TO TREATMENT
Liver Transplantation
Pharmacotherapy
Transjugular Intrahepatic Portosystemic Shunt
OTHER THERAPEUTIC METHODS
CHAPTER 47:
Hepatopulmonary Syndrome
INTRODUCTION
CLINICAL FEATURES
PATHOGENESIS
PHYSIOLOGY OF HYPOXEMIA
LABORATORY EVALUATION
DIAGNOSIS
MANAGEMENT
Medical Therapy
Surgical Therapy
Natural History/Prognosis
KEY POINTS
CHAPTER 48:
Intra-abdominal Sepsis and Abdominal Compartment Syndrome
INTRODUCTION
PERITONITIS
Etiology
Primary Peritonitis
Secondary Peritonitis
Tertiary Peritonitis
Chemical Peritonitis
Peritoneal Abscess
Presentation
Management
Complications
INTRA-ABDOMINAL HYPERTENSION AND ABDOMINAL COMPARTMENT SYNDROME
Intra-abdominal Hypertension
Abdominal Compartment Syndrome
Diagnosis
Measurement of Intra-abdominal Pressure
Management
Outcomes
CHAPTER 49:
Approach to Portal Hypertension and Ascites
INTRODUCTION
ETIOPATHOGENESIS OF PORTAL HYPERTENSION
CAUSES OF PORTAL HYPERTENSION
EVALUATION OF PORTAL HYPERTENSION
VARICES
Managing Acute Bleeding
Resuscitation
ASCITES
Pathogenesis
Evaluation and Diagnosis
Relevant in Indian Setting
Management of Ascites
Diet and Diuretics
Refractory Ascites
Complications of Ascites
SECTION 6: NEUROLOGY
CHAPTER 50:
Approach to Unconscious Patient
INTRODUCTION
TERMS AND DEFINITIONS1
Consciousness
Coma
Vegetative State and Persistent Vegetative State
Brain Death
Locked-in Syndrome and Akinetic Mutism
Dementia
Minimally Conscious State
ETIOLOGY OF COMA
Primary (Neurological Causes)
Secondary (Systemic Causes)
Metabolic
CLINICAL APPROACH TO COMA
Initial Assessment and Management: ABCDE Approach
ABCs
Circulation
Blood Sugar Level
Focused History
General Examination
Temperature
Other Signs
Detailed CNS Assessment2
Evaluation of the Level of Consciousness
Cranial Nerve Examination
Pupils
Respiration
Limbs
Clinicoanatomical Correlation in Coma and Localization of Lesion
Bilateral Hemisphere Damage/Dysfunction
Supratentorial Mass Lesion with Secondary Brain Stem Compression
Midbrain Lesion
Pontine Lesion
Medullary Lesion
Investigations
Hypoglycemia
Hyponatremia
Uremic Encephalopathy4
Hepatic Encephalopathy5,6
Septic Encephalopathy7
Endocrine Encephalopathy
Toxicology
Cerebrospinal Fluid Examination8 (Table 2)
Role of Brain Imaging
Electroencephalography
Specific Treatment
Coma Cocktail for Poisoning9,10
Structural Brain Lesions
Drugs and Toxins
Neuroleptic Malignant Syndrome
Serotonergic Syndrome
Malignant Hyperthermia
Infections
Seizures
HYPOXIC ISCHEMIC ENCEPHALOPATHY
Introduction and Definition
Assessment and Prognostication in Hypoxic Ischemic Encephalopathy
Prevention and Treatment of Hypoxic Ischemic Encephalopathy
Use of Therapeutic Hypothermia
Use of Cerebral Protective Agents
Supportive Treatment
OUTCOMES FROM COMA14
Traumatic Coma
Nontraumatic Coma
CONCLUSION
CHAPTER 51:
Acute Ischemic Stroke
INTRODUCTION
ETIOLOGY
PATHOPHYSIOLOGY
Clinical Syndromes19
Internal Carotid Artery Syndrome
Middle Cerebral Artery Syndrome
Anterior Cerebral Artery
Posterior Cerebral Artery
Basilar Artery
DIAGNOSIS
Brain Imaging
Vascular Imaging
Perfusion CT and MRI
Laboratory Tests
Intravenous Thrombolysis
Endovascular Interventions
Blood Pressure Management Before and After Thrombolysis
ACUTE NEUROLOGICAL COMPLICATIONS IN INTENSIVE CARE
Brain Edema
Hemorrhagic Transformation
Seizures
Orolingual Angioedema
SUPPORTIVE AND PALLIATIVE CARE
Airway
Hyperthermia
Hypothermia
Intravenous Fluids
Hypoglycemia
Hyperglycemia
CONCLUSION
CHAPTER 52:
Acute Hemorrhagic Stroke
INTRODUCTION
INTRAPARENCHYMAL BLEED
Epidemiology
Sex
Age
Race
Mortality
Risk Factors and Causes
Diagnosis
Standard Recommendations2,3
Pre-hospital Care1,2
Emergency Management and Indication of Critical Care2
Blood Pressure Management
Facts2-5
Recommendations4
European Union Stroke Initiative Recommendations (EUSI)2
For Low Blood Pressure Management3,5
Anticoagulation Reversal2,3
Heparin Use2,3
Platelet Disorder3
Deep Venous Thrombosis Prophylaxis2,3
Intraventricular Hemorrhage Management
Management of Elevated Intracranial Pressure (ICP)3
Management of ICP
Intracranial Pressure Monitoring Device Insertion2,3
Surgery
SUBARACHNOID HEMORRHAGE
Severity of SAH10,11
Prehospital Care11
Emergency Department (ED) Care11
Diagnosis
Standard Recommendations10,11
Treatment
Monitor11,12
Fluids and Electrolyte
Pain
Nimodipine10-12,14
Deep Vein Thrombosis Prophylaxis10-12
Temperature10
Glucose
Antiepileptic Treatment10,11
Steroids
Magnesium11,12
Blood Pressure Management in SAH10,11
Surgical and Endovascular Methods
Timing of Intervention
Trial Revealed
Criticism
Recommendations10
Complications
Rebleeding10,11
Measures to Prevent Rebleeding after SAH
Delayed Cerebral Ischemia and Vasospasm14-17
Pathophysiology
Management of Vasospasm and DCI
Rescue Therapy for DCI
Hydrocephalus with SAH
Hypernatremia and Hyponatremia11-12
Cardiopulmonary Complications10,12
Unruptured Intracranial Aneurysm
Classification of Unruptured Intracranial Aneurysm10,18
Asymptomatic UIA18
Symptomatic UIA17
CONCLUSION
CHAPTER 53:
Seizure and Status Epilepticus
INTRODUCTION
DEFINITION OF STATUS EPILEPTICUS
CLASSIFICATIONS
Nonconvulsive Status Epilepticus
Subtle Status Epilepticus
TREATMENT OF STATUS EPILEPTICUS
Recognition of Status Epilepticus
Immediate Management
Work Up
Super-refractory Status Epilepticus
Continuous EEG Monitoring
How to Monitor Treatment in Status Epilepticus?
Failure of Treatment15
CHAPTER 54:
Central Nervous System Infection
INTRODUCTION
BACTERIAL MENINGITIS
Epidemiology
Etiopathogenesis
Clinical Features
Diagnosis
Treatment
Antibiotic Therapy
Corticosteroid Therapy
Fluid Therapy
Osmotic Therapy
Recent Advances
VIRAL ENCEPHALITIS
Introduction
Clinical Features
Diagnosis
Treatment
CENTRAL NERVOUS SYSTEM MYCOSIS
Meningitis and Meningoencephalitis
Cryptococcal Meningitis
Intracranial Space Occupying Lesions
Rhino-Orbito-Cerebral Mycosis
Investigations for CNS Infections
Lumbar Puncture for CSF Analysis
Neuroimaging of Infections
Electroencephalography
Cerebrospinal Fluid Polymerase Chain Reaction
CHAPTER 55:
Neuromuscular Disorders
INTRODUCTION
GUILLAIN-BARRÉ SYNDROME
Clinical Features
Electrophysiological Diagnosis of Guillain-Barré Syndrome
Other Investigations
Treatment Strategies
Supportive Measures
Immunotherapy
MYASTHENIA CRISIS
Clinical Features
Laboratory Tests
Treatment
Cholinesterase Inhibitors
Immunotherapy in Myasthenic Crisis
Corticosteroid Treatment
Plasma Exchange
Intravenous Immunoglobulin
Conclusion
CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE ICU
Introduction
Clinical Features
Electrophysiological Features
Therapeutic Approaches
Prognosis
Diagnosis
Treatment
RHABDOMYOLYSIS
Laboratory Findings
Management
SECTION 7: ENDOCRINOLOGY
CHAPTER 56:
Glycemic Emergencies
INTRODUCTION
EPIDEMIOLOGY
DEFINITION
PATHOPHYSIOLOGY
ADVERSE OUTCOMES OF HYPERGLYCEMIA
OUTCOMES OF BLOOD GLUCOSE CONTROL
Leuven Studies
The Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation Trial
Other Trial of Glycemic Control in the Critically Ill
GLYCEMIC VARIABILITY
GLYCEMIC GOALS
BLOOD GLUCOSE MANAGEMENT (INSULIN) PROTOCOLS
HYPERGLYCEMIC EMERGENCIES
Epidemiology
Pathophysiology48-50
Risk and Precipitating Factors
Diagnostic Criteria
Indication for Admission to Intensive Care Unit
Treatment Guidelines
Fluid Therapy
Insulin Therapy
Potassium
Bicarbonate
Phosphate
Criteria for Resolution
Complications
Cerebral Edema
Pulmonary Edema
CHAPTER 57:
Thyroid Dysfunction in Critically Ill
INTRODUCTION
PATHOPHYSIOLOGY OF SICK EUTHYROID
Physiology1,2
Pathophysiology3-7
Characteristics and Laboratory Findings of Sick Euthyroid2,5-7
How to Differentiate Hypothyroidism from Sick Euthyroid Syndrome in Critically Ill Patient?3
Influence of Sick Euthyroid on Course of Illness
Management2,3,5-7
CHAPTER 58:
Adrenal Dysfunction in Critically III
INTRODUCTION
ADRENAL PHYSIOLOGY (TABLE 1)
CONTROL OF SECRETION
PHYSIOLOGICAL ACTION
FUNCTIONAL INADEQUACY
POSTULATED MECHANISMS OF GLUCOCORTICOID INSUFFICIENCY IN CRITICAL ILLNESS
DIAGNOSTIC CRITERIA
STEROID THERAPY IN CRITICAL ILLNESS (BOX 2)
Sepsis
Acute Respiratory Distress Syndrome31-33
Spinal Injury34,35
Head Injury36,37
Pneumonia38-42
Side-Effects of Steroid Therapy (Box 3)
CONCLUSION
CHAPTER 59:
Diabetic Insipidus and Syndrome of Inappropriate Antidiuretic Secretion
INTRODUCTION
Arginine Vasopressin
Regulation of Arginine Vasopressin Secretion (Flowchart 1)
Actions of Arginine Vasopressin
DIABETES INSIPIDUS
Causes of Diabetes Insipidus
Central Diabetes Insipidus
Nephrogenic Diabetes Insipidus11
Approach to a Patient Presenting with Polyuria in Intensive Care Unit
SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE HYPERSECRETION
Schwartz Criteria for Diagnosis of SIADH
Essential Criteria
Supplemental Criteria
Hyponatremia
Differential Diagnosis
Need for Management of Hyponatremia
Approach to Patient with Hyponatremia in Critical Care (Flowchart 3)
Treatment of Hyponatremia
SECTION 8: POST-SURGICAL CRITICAL CARE
CHAPTER 60:
General Principles
INTRODUCTION
HISTORY
OBJECTIVES OF POSTSURGICAL CRITICAL CARE
ADMISSION CRITERIA
POSTOPERATIVE EVALUATION
POSTOPERATIVE HYPOTENSION
UNCONSCIOUS PATIENTS AND BASIC GENERAL PRINCIPLES OF MANAGEMENT
Care of Artificial Airways
Oxygen Therapy
Common Procedures
Analgesia and Sedation
Opioids
Nonopioid Analgesics
STRESS ULCER PROPHYLAXIS
MONITORING
Basic Investigations
Cardiovasuclar/Hemodynamic Monitoring
Respiratory Monitoring
Prevention of Hospital Acquired Infections
NUTRITION
Routes of Nutrition
PREVENTION OF DEEP VENOUS THROMBOSIS AND VENOUS THROMBOEMBOLISM
Methods of Thromboprophylaxis
Temperature Control
Mechanical Ventilation
CARE OF THE SURGICAL SITE AND DRAINS
Drains
Antibiotics
ACKNOWLEDGMENT
CHAPTER 61:
Cardiac Surgery
INTRODUCTION
INITIAL GOALS IN THE IMMEDIATE POSTOPERATIVE PERIOD
CONCERNS AND MANAGEMENT
Hypothermia
Bleeding
Management of Postoperative Bleeding
POSTOPERATIVE MYOCARDIAL DYSFUNCTION
Preoperative Heart Failure
Perioperative Myocardial Dysfunction
Postoperative Heart Failure
Assessment of Volume Status
Inotropes and Vasopressors
Mechanical Circulatory Support
RENAL DYSFUNCTION
NEUROLOGICAL DYSFUNCTION
MANAGEMENT OF ARRHYTHMIAS
POSTOPERATIVE PAIN MANAGEMENT
Deep Vein Thrombosis (DVT)
CONCLUSION
CHAPTER 62:
Vascular Surgery
INTRODUCTION
SPECTRUM OF VASCULAR DISEASES REQUIRING CRITICAL CARE
Aortic Reconstructive Surgeries
Infrainguinal Reconstructive Surgeries
Acute Limb Ischemia
Acute Deep Venous Thrombosis
Diabetic Foot with Sepsis
Vascular Trauma
Carotid Endarterectomy
Mesenteric Ischemia
Endovascular Procedures
Preoperative Intensive Care Unit Care
Iatrogenic Vascular Trauma
Thrombotic Occlusion Following Arterial Line Insertion
Pseudoaneurysm Following Arterial Line Removal/Puncture
Venous Catheter-induced Deep Venous Thrombosis
Inotrope-induced Peripheral Digital Gangrene
Hemoptysis in Patients with Preexisting Pulmonary Disease
REQUIREMENTS OF VASCULAR PATIENTS IN ICU CARE
Hemodynamic Monitoring
Hypothermia
Electrolyte Management
Pain Management
Medications Specific to Vascular Surgeries
Heparin
Antihypertensives
Antiplatelets
Anticoagulation in Chronic Kidney Disease
Informed Consent One Stop Contact is not Enough
CHAPTER 63:
Neurosurgery
INTRODUCTION
GOALS OF POSTOPERATIVE NEUROSURGICAL CARE
Who Goes to and Who Stays in the Neurocritical Care Unit?
Effect of Anesthetic Agents on Neurosurgical Patients
Complications after Neurosurgical Procedures
Complications after Craniotomy
General
Specific Complications
Cerebrovascular Procedures
Medical Measures to Prevent Rebleeding after aSAH: Recommendations
Management and Prevention of Vasospasm Following aSAH
Management of Medical Complications Associated with aSAH: Recommendations
Basic Postoperative Neurosurgical Care
Postoperative Monitoring in Critical Care
Early Evaluation
Systemic Monitoring
Brain Specific Monitoring
Treatment of Acute Intracranial Hypertension
Cerebral Oxygenation and Metabolism
Electrical Monitoring
Biochemical Parameters: Electrolytes, Osmolarity, and Blood Glucose
Glucose
Neuroprotection
CONCLUSION
CHAPTER 64:
Renal, Heart and Lung Transplant
INTRODUCTION
KIDNEY TRANSPLANT
Early Postoperative Period
Assessment of Fluid Status
Monitoring
Guide to Fluid Replacement
Delayed and Slow Graft Function
Guide to Fluid Replacement
Biochemistry
Other Aspects of Early Postoperative Management
Surgical Prophylaxis
Acute Rejection
Surgical Complications
Medical Complications
Immunosuppression
Acute Graft Dysfunction
HEART TRANSPLANT
Post-transplant Monitoring
Hemodynamic Monitoring
Goals12,13
Volume
Vasoactive Drugs11
Bleeding and Coagulopathy
Predisposing Factors
Monitoring
Correction of Coagulopathy14,15
Heparin-induced Thrombocytopenia16
Hypertension
Arrhythmias
Pulmonary Vascular Resistance
Primary Graft Failure and Right Ventricular Dysfunction (Flowchart 2)
Mechanical Circulatory Support
Other Cardiac Abnormalities
Pericardial Effusion35,36
Graft Rejection
Hyperacute Rejection
Acute Rejection
Infection11,43,44
LUNG TRANSPLANT
Monitoring and Supportive Care
Respiratory Management45,46
COMPLICATIONS47-51
Treatment
Phrenic Nerve Injury
Native Lung Hyperinflation
Airway Complications
Early Allograft Dysfunction and Failure (Flowchart 3)
MANAGEMENT
Infection
Immunosuppression (Table 2)
Induction
Monoclonal Antithymocyte Antibody
Polyclonal Antithymocyte Globulin
IL-2 Receptor Antagonists
CONCLUSION
CHAPTER 65:
Liver Transplant Patient
INTRODUCTION
LIVER ALLOGRAFT FUNCTION
SYSTEMIC MANAGEMENT
Pulmonary System
Cardiovascular System
Fluid and Electrolytes
Renal System
Gastrointestinal System and Nutrition
Central Nervous System
Endocrine and Metabolic Acid-Base Issues
Coagulopathy
Infection
Immunosuppressive Therapy
POORLY FUNCTIONING GRAFTS
Graft Rejection
Primary Graft Failure
Small-for-Size Syndrome
Vascular Thrombosis
Biliary Complications
CONCLUSION
CHAPTER 66:
Immunosuppression in Solid Organ Transplant
INTRODUCTION
TRANSPLANT IMMUNOLOGY
TYPES OF SOLID ORGAN TRANSPLANT
PRINCIPLES OF IMMUNOSUPPRESSION
PHASES OF IMMUNOSUPPRESSION
Induction Therapy (0–7 Days)
Depleting Antibody Preparations
Nondepleting Antibody Preparations
Initial Therapy (First 3 Months)
Maintenance Therapy (After 3 Months)
ANTIREJECTION DRUGS
Corticosteroids
Mechanism of Action
Calcineurin Inhibitors
Mechanism of Action
The mTOR Inhibitors
Mechanism of Action
mTOR Inhibitors in Renal Transplantation
mTor Inhibitors in Liver Transplantation
Antimetabolites
Mycophenolate Mofetil
Azathioprine
Heart and Lung Transplantation
IMMUNOSUPPRESSION OF THE ICU PATIENT
CONCLUSION
SECTION 9: OBSTETRIC CRITICAL CARE
CHAPTER 67:
Approach to Critically III Pregnant Female
INTRODUCTION
PHYSIOLOGIC CHANGES OF PREGNANCY IMPACTING CRITICAL ILLNESS
AIRWAY
Airway and Anesthesia Challenges in Pre-eclampsia
Placenta Previa
Abruptio Plancentae
Acute Fatty Liver of Pregnancy
Renal Failure
CHALLENGES TO THE DIAGNOSTIC APPROACH OF THE PREGNANT ICU PATIENT
COMMON CONDITIONS REQUIRING ICU CARE IN OBSTETRIC PATIENTS
CONCLUSION
CHAPTER 68:
Pregnancy-induced Hypertension and HELLP Syndrome
INTRODUCTION
DEFINITIONS AND CLINICAL FEATURES
Chronic Hypertension
Gestational Hypertension
Preeclampsia
Superimposed Preeclampsia
ECLAMPSIA
HELLP Syndrome
Pathophysiology
EVALUATION AND WORK-UP
Maternal Work-Up
Fetal Work-up
MANAGEMENT
Severe Preeclampsia
Hypertensive Crisis
HELLP Syndrome
Eclampsia
CHAPTER 69:
Liver Dysfunction in Pregnant Female
INTRODUCTION
APPROACH TO LIVER DISEASE IN PREGNANCY
ACUTE FATTY LIVER OF PREGNANCY
Diagnosis
Management
INTRAHEPATIC CHOLESTASIS OF PREGNANCY
HYPEREMESIS GRAVIDARUM
VIRAL HEPATITIS
GALLSTONE DISEASE
BUDD-CHIARI SYNDROME
OTHER RARE LIVER DISORDERS ASSOCIATED WITH PREGNANCY
CONCLUSION
CHAPTER 70:
Amniotic Fluid Embolism
INTRODUCTION
EPIDEMIOLOGY
RISK FACTORS3-8
PATHOGENESIS
CLINICAL FEATURES9,14,20-23
DIAGNOSIS
MANAGEMENT9,20,21-23,31
Perimortem Cesarean Delivery
Other Treatment Modalities
RISK OF RECURRENCE
CONCLUSION
CHAPTER 71:
Ectopic Pregnancy, Antepartum and Postpartum Hemorrhage
INTRODUCTION
GENERAL PRINCIPLES
OBSTETRIC HEMORRHAGE
ANTEPARTUM HEMORRHAGE
Etiology
Placenta Previa
Abruptio Placentae
Management
POSTPARTUM HEMORRHAGE
Etiology
Management
Initial Assessment
Call for Help
Monitor
Resuscitation
Arrest the Bleeding
Management in Intensive Care after Control of Hemorrhage
RUPTURED ECTOPIC PREGNANCY
Risk Factors
Signs and Symptoms
Diagnosis
Management
Critical Care Management of Obstetrical Crisis (Antepartum and Postpartum): A Stepwise Approach
CONCLUSION
SECTION 10: HEMATOLOGY, RHEUMATOLOGY AND ONCOLOGY
CHAPTER 72:
Coagulation Disorders
INTRODUCTION
THROMBOCYTOSIS
THROMBOCYTOPENIA
Evaluation of Thrombocytopenia
DISSEMINATED INTRAVASCULAR COAGULATION
Causes of DIC
Clinical Manifestations
Acute versus Chronic DIC
Bleeding versus Thrombosis
Organ Dysfunction
Laboratory Abnormalities
Diagnostic Evaluation
Differential Diagnosis
Treatment
Prevention or Treatment of Bleeding
CHAPTER 73:
Thrombocytopenia in ICU
INTRODUCTION
DEFINITION
EPIDEMIOLOGY
CAUSES AND PATHOPHYSIOLOGY OF THROMBOCYTOPENIA
Spurious Thrombocytopenia
Increased Platelet Destruction
Nonimmune-mediated Causes
Immune-mediated Causes
Dilutional Thrombocytopenia
Distributional Thrombocytopenia
Decreased Platelet Production
Platelet Dysfunctions
Intrinsic Platelet Disorders
SEPSIS AND THROMBOCYTOPENIA7,6
HEPARIN-INDUCED THROMBOCYTOPENIA
THROMBOTIC MICROANGIOPATHY
Clinical Presentation
Disseminated Intravascular Coagulation
DIAGNOSTIC APPROACH
THERAPEUTIC ASPECTS10
CHAPTER 74:
Anemia in ICU
INTRODUCTION
ETIOLOGY OF ANEMIA IN CRITICALLY ILL
EFFECTS OF ANEMIA IN CRITICALLY ILL PATIENTS
PREVENTION
TREATMENT
Blood Transfusion
Infectious Risks
Noninfectious Risks
ROLE OF RECOMBINANT ERYTHROPOIETIN
BLOOD SUBSTITUTES
IRON SUPPLEMENTATION
CONCLUSION
CHAPTER 75:
Transfusion Therapy
INTRODUCTION
ANEMIA IN ICU AND RED BLOOD CELL TRANSFUSION
Safety Concerns and Risks of RBC Transfusion
Noninfectious Serious Hazards of Transfusions43
Leukodepletion or Leukoreduction of RBC
COAGULOPATHY AND FRESH FROZEN PLASMA TRANSFUSION IN ICU
Risks Associated with FFP Transfusion
THROMBOCYTOPENIA AND PLATELET TRANSFUSION IN ICU
Nonimmune Platelet Refractoriness
Risks of Platelet Transfusion
Strategies to Reduce Platelet Transfusion-related Adverse Effects
Strategy 1
Strategy 2
Strategy 3
Strategy 4
MASSIVE TRANSFUSION
TRANSFUSION-RELATED LUNG INJURY
CONCLUSION
CHAPTER 76:
Thrombotic Microangiopathy and Vasculitis
INTRODUCTION
CLINICAL FEATURES
Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Wegener's Granulomatosis (Granulomatosis with Polyangiitis)
Churg-Strauss Syndrome
Microscopic Polyangiitis
Polyarteritis Nodosa
Giant Cell Arteritis
Cryoglobulinemic Vasculitis
Drug-induced Vasculitis
Thrombotic Thrombocytopenic Purpura
DIAGNOSIS
Imaging
Histology
TREATMENT OF VASCULITIS
Plasma Exchange
Biological and Newer Therapies
DIFFERENTIAL DIAGNOSIS
CONCLUSION
CHAPTER 77:
Hemophagocytic Syndrome
INTRODUCTION
PATHOPHYSIOLOGY
CLINICAL FEATURES
LABORATORY INVESTIGATIONS
TREATMENT
CHAPTER 78:
Oncology Emergencies
INTRODUCTION
STRUCTURAL AND OBSTRUCTIVE ONCOLOGICAL EMERGENCIES
Cardiac Tamponade
SUPERIOR VENA CAVA (SVC) SYNDROME
Urinary Obstruction
Increased Intracranial Pressure
Spinal Cord Compression
Acute Airway Obstruction
METABOLIC OR HORMONAL EMERGENCIES
Hypercalcemia
Hyponatremia and SIADH
TUMOR LYSIS SYNDROME
CONCLUSION
CHAPTER 79:
Integrating Palliative Care in Intensive Care
INTRODUCTION
WHY PALLIATIVE CARE IS ESSENTIAL IN ICU?
BARRIERS TO PROVIDING EFFECTIVE PALLIATIVE CARE IN THE ICU
How to Integrate?
ICU—PALLIATIVE CARE MODELS
Consultative Model
Integrative Model
ADDRESSING INDIVIDUAL ISSUES OF PALLIATIVE CARE IN ICU
CONCLUSION
SECTION 11: INFECTIONS
CHAPTER 80:
Evaluation of Fever in ICU
INTRODUCTION
DEFINITION OF FEVER
METHODS USED FOR TEMPERATURE MEASUREMENT7,12-16
PATHOPHYSIOLOGY OF FEVER
CAUSES OF FEVER IN INTENSIVE CARE UNIT
Noninfectious Causes of Fever in Intensive Care Unit
Infectious Causes of Fever in Intensive Care Unit
Diagnostic Approach to Fever in the Intensive Care Unit (Flowchart 1)
Step-wise Approach to Fever in Intensive Care Unit
Infectious versus Noninfectious Causes
ACALCULOUS CHOLECYSTITIS
Causes (Table 4)
Pathogenesis
Management
Radiological Investigations
Ultrasonography
Computerized Tomography
Cholescintigraphy
Imaging Criteria for the Diagnosis of AAC
Treatment
Pharmacologic Treatment
Endoscopy
Interventional Radiology
Surgery
Complications
Gallbladder Gangrene
Emphysematous Cholecystitis
Perforation
CHAPTER 81:
Pharmacology of Antimicrobial Agents
INTRODUCTION
GENERAL PHARMACOLOGY OF ANTIMICROBIAL AGENTS
Mechanisms of Action
PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTIMICROBIALS
Pharmacokinetics
Beta-lactam Antibiotics
Fluoroquinolones
Aminoglycosides
Polymyxins
Macrolides
Glycopeptides
Linezolid
Daptomycin
Tigecycline
Polyenes
Triazoles
Echinocandins
Antimicrobial Uses in Specific Condition in ICU
CHAPTER 82:
Principles of Antimicrobial Use
INTRODUCTION
RATIONAL USE OF ANTIBIOTICS
Effective Therapy
Initial Choice
Appropriate Culture
Timing of Antibiotic Treatment
FUNGAL INFECTIONS
Epidemiology of Fungal Infections in the ICU
Empirical Antifungal Therapy
OPTIMIZING THE USE OF ANTIMICROBIAL AGENTS
Pharmacokinetics
Pharmacodynamics
Therapeutic Drug Monitoring
COMBINATION ANTIMICROBIAL THERAPY
FAILURE OF ANTIMICROBIAL THERAPY
DE-ESCALATION OF ANTIMICROBIAL THERAPY
ANTIMICROBIAL RESISTANCE
CHAPTER 83:
Severe Sepsis and Septic Shock
INTRODUCTION
DEFINITIONS
ETIOLOGY
PATHOPHYSIOLOGY
Molecular Basis
Physiological Derangements
MANAGEMENT
Initial Resuscitation of Hypovolemia, Hypoperfusion and Shock
Vasopressors
Corticosteroids
Bicarbonate
Diagnosis of Infection and Sepsis
Antibiotics
Source Control
TREATMENT OF ORGAN DYSFUNCTION AND SUPPORTIVE THERAPY IN SEPSIS
Acute Respiratory Distress Syndrome
Acute Kidney Injury
Hematological Changes and Use of Blood and Blood Products
Neurological Dysfunction
Hepatic Dysfunction
Gastrointestinal Tract
Cardiovascular Dysfunction
GENERAL INTENSIVE CARE
Glucose Control
Sedation, Analgesia and Neuromuscular Blockade
Nutrition Support
Deep Venous Thrombosis Prophylaxis
Stress Ulcer Prophylaxis
Other Measures
SETTING GOALS OF CARE
THERAPIES DIRECTED AGAINST INFLAMMATORY MEDIATORS
COMPENSATORY ANTI-INFLAMMATORY RESPONSE SYNDROME
PROGNOSIS
CHAPTER 84:
Clostridium difficile Colitis
INTRODUCTION
EPIDEMIOLOGY
RISK FACTORS
MICROBIOLOGY
Toxins
PATHOPHYSIOLOGY
CLINICAL MANIFESTATIONS
Usual Presentations
DIFFERENTIAL DIAGNOSIS
DIAGNOSIS
Specimen
Laboratory Diagnosis
Endoscopy
TREATMENT
General Principles16
PRIMARY CDAD
Nonsevere Disease16,19
Severe Disease
Antibiotics
Surgery
RECURRENT CDAD
Management of Recurrences
Antibiotic Therapy
Probiotic Therapy
Fecal Bacteriotherapy
Monoclonal Antibodies
PREVENTION
CHAPTER 85:
Prevention of Nosocomial Infections
INTRODUCTION
EPIDEMIOLOGY
DEFINITIONS OF HAIs
DETERMINANTS OF HAI
The Host-Patient Considerations
The Agent-Antibiotic Resistance in Microbes
The Environment—People
The Environment—Physical
SURVEILLANCE
ADMINISTERING INFECTION CONTROL
CONCLUSION
CHAPTER 86:
Fungal Sepsis
INTRODUCTION
CANDIDIASIS
Diagnosis
Treatment Choices for Candidemia13
CRYPTOCOCCOSIS14
Clinical Manifestations
Diagnosis
Treatment
ASPERGILLOSIS
Clinical Manifestations
Diagnosis
Treatment
MUCORMYCOSIS26
Clinical Manifestations
Diagnosis
Treatment
Approach to the Patient
CONCLUSION
ACKNOWLEDGEMENTS
CHAPTER 87:
ICU Care of HIV Infected Patient
INTRODUCTION
HISTORICAL PERSPECTIVE
PATHOPHYSIOLOGY OF HIV INFECTION
CRITICAL ILLNESS IN HIV
Spectrum of Diseases Requiring ICU Care
RESPIRATORY DISTRESS
Pneumocystis jiroveci Pneumonia
Bacterial Pneumonia
OTHER CAUSES OF OPPORTUNISTIC INFECTIONS
Fungal Pneumonia
Viral Pneumonia
Parasitic Pneumonia
Mycobacterium tuberculosis Infection
Epidemiology
Clinical Features and Diagnosis
Treatment
Multidrug-resistant Tuberculosis
Nontuberculous Mycobacterial Infection in HIV Positive Patients
Summary
Immune Reconstitution Inflammatory Syndrome
Sepsis
Neurologic Complications
Renal Injury
Hepatic Failure
Coinfection with Hepatitis C and HIV
Short-term Survival and Long-term Outcomes after Critical Illness
HIV AND HEALTH-CARE WORKERS
Occupational Exposures in Healthcare Settings
Postexposure Prophylaxis
Recommendations for the Selection of Drugs for HIV Postexposure Prophylaxis
Duration of Postexposure Prophylaxis
Follow-up of Exposed Healthcare Personnel
Postexposure Testing
Monitoring and Management of Postexposure Prophylaxis Toxicity
CHAPTER 88:
Infection in Immunocompromised Hosts
INTRODUCTION
THE IMMUNE SYSTEM
Splenectomy
Neutropenia
Resistance
Diagnosis of Invasive Aspergillosis8
Treatment of Invasive Aspergillosis
Management of Febrile Neutropenia
Choice of Empirical Antibiotic Therapy in High-risk Patients
Environmental Precautions in Febrile Neutropenic Patients7
T-cell Deficiency
Bacterial Infections
Fungal Infections
Parasitic Infections
Treatment of Toxoplasmosis12
Hypogammaglobulinemia3
Opportunistic Infections
Complement Deficiency
ELDERLY AS AN IMMUNECOMPROMISED HOST4
PREVENTING EARLY DISEASE (0–100 DAYS AFTER HCT)
Recommendations of CDC13
GENERAL PRINCIPLES OF INTENSIVE CARE FOR SEPSIS IN IMMUNOCOMPROMISED PATIENTS
CHAPTER 89:
Tropical Infections
INTRODUCTION
Some Points in the Differential Diagnosis of Tropical Infections
SEVERE FALCIPARUM MALARIA
Clinical Features of Severe Falciparum 2
Laboratory Findings in Severe Falciparum Malaria
Which is a Better Test for Diagnosing Malaria?
Specific Antimalarial Treatment
Follow-up Treatment
Dosage in Organ Failure
Supportive Care4
Exchange Transfusion
SEVERE MALARIA IN PREGNANCY
SEVERE VIVAX MALARIA
DENGUE5,6
Management of Severe Dengue
LEPTOSPIROSIS
Diagnosis of Leptospirosis8
Treatment
SCRUB TYPHUS9
Laboratory Features of Scrub Typhus
Treatment of Scrub Typhus
CHAPTER 90:
Skin and Soft Tissue Infections
INTRODUCTION
IMPETIGO
ECTHYMA
ERYSIPELAS
FOLLICULITIS
FURUNCLE (FIG. 1)
CARBUNCLE (FIG. 2)
CUTANEOUS ABSCESS (FIG. 3)
CELLULITIS
BITE WOUNDS
Surgical Site Infections
NECROTIZING SOFT TISSUE INFECTIONS (FIG. 4)
Clinical Features
Investigations
Microbiology
APPROACH TO MANAGEMENT
Treatment
Fournier's Gangrene (Fig. 5)
Synergistic Necrotizing Cellulitis
Clostridial Myonecrosis (Gas Gangrene)
Fungal Infections (Fig. 6)
CHAPTER 91:
Acute Viral Syndrome
INTRODUCTION
SEVERE ACUTE RESPIRATORY SYNDROME
Diagnosis
Clinical Presentation
Indications for ICU Care
Management of Suspect and Probable SARS Cases
Complications2
KYASANUR FOREST DISEASE
Clinical Manifestations3
Indications for ICU Care
Management
Complications
SWINE FLU
Clinical Presentation3
Indications for ICU Care
Diagnosis
Clinical Management
Supportive
Respiratory Support4,5
Invasive Ventilation
Specific Therapy6
RABIES
Clinical Presentation7
Diagnosis8
Indications for ICU Care
Management
Vaccine
Rabies Immunoglobulin
Specific Treatment
JAPANESE B ENCEPHALITIS
Clinical Manifestations
Diagnosis
Indications for ICU Care
Management9
DENGUE FEVER
Clinical Presentation
Indications for ICU Care
Specific Management
HANTAVIRUS PULMONARY SYNDROME
Clinical Presentation
Indications for ICU Care
Specific Management
INFECTIOUS MONONUCLEOSIS
Clinical Presentation
Indications for ICU Care
Specific Management
SECTION 12: TOXICOLOGY AND ENVIRONMENTAL INJURIES
CHAPTER 92:
General Approach to Poisoning
INTRODUCTION
INITIAL GENERAL MANAGEMENT AND INDICATION OF ICU CARE (FLOWCHART 1)
History Taking and Initial Management
Clinical Examination and Identification of Toxidromes (Table 3)
DECONTAMINATION AND ENHANCED ELIMINATION
Decontamination
Enhanced Elimination
INVESTIGATIVE WORKUP
Biochemical Investigations
Radiological Investigations
STATUS OF VARIOUS TOXIN SCREENING TESTS
MEDICOLEGAL ASPECT RELATED TO POISONING
PROPER WAY OF DOCUMENTATION
CONCLUSION
CHAPTER 93:
Organophosphate Poisoning
INTRODUCTION
MECHANISM OF TOXICITY
Neurotoxicity
Nonneuronal Toxicity14
Genotoxicity and Carcinogenicity
PHARMACOKINETICS OF ORGANOPHOSPHATES
Absorption
BIOCHEMICAL CHANGES
Liver
Heart
Brain and Spinal Cord
Hormonal Imbalance
Kidney
DIAGNOSIS
CLINICAL FEATURES
Signs and Symptoms37
Central Nervous System Signs and Symptoms
Respiratory Signs and Symptoms
Cardiovascular Signs
Gastrointestinal Signs and Symptoms
Musculoskeletal Signs and Symptoms
Skin and Mucous Membrane Signs and Symptoms
INTERMEDIATE SYNDROMES38
MANAGEMENT
GENERAL MEASURES
CONTRAINDICATED DRUGS IN ORGANOPHOSPHORUS POISONING
Atropine
Atropine Toxicity
Glycopyrrolate
Magnesium Therapy
Oxime Therapy
VENTILATORY SUPPORT50
SPECIFIC MEASURES
CARBAMATES
Commonly Used Carbamates
ORGANOCHLORINE PESTICIDES
Commonly Used Organochlorine Compounds
HERBICIDES
Commonly Used Herbicides
Chlorophenoxyacetic Herbicides
Commonly Used Chlorophenoxyacetic Herbicides
Other Herbicides
Chlorates
Propanyl
RODENTICIDES
Commonly Used Rodenticides
Thallium
Warfarins
Superwarfarins
Aluminum Phosphide
Mechanism of Toxicity
Barium Compounds
Zinc Phosphide
INSECT REPELLENTS
Ethylene Dibromide
Pyrethrins and Pyrethroids
CHAPTER 94:
Common Poisoning
INTRODUCTION
PARACETAMOL POISONING
Introduction
Pathophysiology
Clinical Features
Stage 1
Stage 2
Stage 3
Stage 4
Investigations
Rumack–Matthew Nomogram (Fig. 1)
Management
Mechanism of Action of N-Acetylcysteine
Dose of N-Acetylcysteine
Indication of Liver Transplantation in Paracetamol Poisoning
Other Poor Prognostic Markers in Paracetamol Poisoning
Disposition
SALICYLATES POISONING
Introduction
Pathophysiology
Clinical Features
Acute Salicylate Overdose in Adults
Chronic Salicylate Overdose in Adults
Investigations
Serum Levels Correlation with Toxicity
Bedside Ferric Chloride Testing
Done Nomogram
Management
Maintenance of Airway, Breathing and Circulation
Gastrointestinal Tract Decontamination
Urinary Excretion and Alkalization
Hemodialysis and Hemoperfusion
Disposition
TRICYCLIC ANTIDEPRESSANT POISONING
Introduction
Pathophysiology
Clinical Features
Investigations
Management
Disposition
LITHIUM POISONING
Introduction
Pathophysiology
Clinical Features
Acute Intoxication
Acute-on-chronic Intoxication
Chronic Intoxication
Factors Precipitating Lithium Toxicity
Drug Interactions
Investigations
Management
Supportive Care
Gastrointestinal Decontamination
Enhanced Elimination
Disposition
SELECTIVE SEROTONIN REUPTAKE INHIBITORS POISONING
Introduction
Pathophysiology
Mechanisms of Serotonin Increase and Toxicity
Clinical Features
Acute Overdose Toxicity
Serotonin Syndrome
Complications of SSRI Poisoning
Investigations
Management
Acute Overdose
Serotonin Syndrome
Disposition
DIGITALIS POISONING
Introduction
Mechanism of Toxicity
Clinical Features
Investigations
Intensive Care Unit Admission
Management
Treatment of Electrolyte Imbalance
Management of Dysrhythmias
Digoxin Immune Fab Fragment
Miscellaneous
Prognosis and Disposition
CALCIUM-CHANNEL BLOCKERS POISONING
Introduction
Pathophysiology
Clinical Features
Investigations
Differential Diagnosis
Management
Maintenance of Airway, Breathing and Circulation
Gastrointestinal Decontamination
Intravenous Calcium
Catecholamines
Intravenous Glucagon
Insulin and Glucose Therapy
Lipid Emulsion Therapy
Phosphodiesterase Inhibitors
Other Measures to Support Circulation
Investigational Therapy
Therapeutic Goals in CCB Treatment
Patients Requiring ICU Admission
Prognosis
Disposition
BETA-BLOCKERS POISONING
Introduction
Pathophysiology
Clinical Features
Investigations
Management
Disposition
CHAPTER 95:
Snakebite
INTRODUCTION
SYMPTOMS
LOCAL SYMPTOMS
NEUROLOGICAL SYMPTOMS
VASCULOTOXIC SYMPTOMS
DIAGNOSIS
TREATMENT
First Aid for a Witnessed Bite
Assurance
To Prevent/Slow Down Systemic Absorption
Hospital Management
Anti-snake Venom
Indications for Anti-snake Venom
Monitoring after Anti-snake Venom Administration
Side-effects of Anti-snake Venom
Management of Anti-snake Venom Reaction
CONCLUSION
CHAPTER 96:
Hypothermia and Drowning
INTRODUCTION
THERAPEUTIC HYPOTHERMIA
Indications
Cardiac Arrest
Traumatic Brain Injury
Subarachnoid Hemorrhage
Ischemic Stroke
Spinal Cord Injury
Mechanism
Critical Care Management including Special Techniques of Cerebral Cooling
Intracranial Pressure Monitoring in Hypothermia Patients
Potential Alternative to ICP Management in Hypothermia Patients with Coagulopathy
Complications and Its Management
Shivering
Electrolyte Abnormalities
Acid-Base Status
Insulin Resistance
Kidney Dysfunction
Cardiac Function
Impaired Immune Function
Hematologic Effects
Current Status: Efficacy in Terms of Its Outcome
HYPOTHERMIA AS AN ENVIRONMENTAL INJURY
ETIOLOGY (BOX 3)
PATHOPHYSIOLOGY AND CLINICAL FEATURES
DIAGNOSIS
TREATMENT
DRUG THERAPY
REWARMING TECHNIQUES
APPROACH TO REWARMING
PROGNOSIS
CHAPTER 97:
Hyperthermia and Heat Stroke
INTRODUCTION
DEFINITIONS
TYPES OF HEAT STROKE
Classical Heat Stroke
Exertional Heat Stroke
INCIDENCE
RISK FACTORS
Extremes of Age
Environment
Sex
Physical Activity
Drugs
Miscellaneous
PATHOPHYSIOLOGY
THERMOREGULATION
ACCLIMATIZATION
CLINICAL FEATURES
Central Nervous System
Cardiovascular System
Gastrointestinal System
Kidney
Musculoskeletal System
TREATMENT
PROGNOSIS
CONCLUSION
CHAPTER 98:
Electric Injuries
INTRODUCTION
EPIDEMIOLOGY
BASICS OF ELECTRICITY8,9
EFFECTS OF ELECTRICAL CURRENT ON HUMAN BODY
TYPES OF ELECTRICAL INJURY
CLINICAL MANIFESTATIONS
Superficial Wounds
Cardiac
Respiratory
Renal
Nervous System
Other Effects
PREHOSPITAL CARE16,18
EMERGENCY DEPARTMENT CARE
MANAGEMENT IN ICU
INVESTIGATIONS31
CONCLUSION
SECTION 13: TRAUMA
CHAPTER 99:
Initial Management of Polytraumatic Patient
INTRODUCTION
Pre-event
Event
Post-event
EPIDEMIOLOGY
OUT-OF-HOSPITAL INITIAL MANAGEMENT
Objectives
Golden Hour
Scene Assessment
Patient's Assessment and Triage
Initial Evaluation and Management
Informing the Appropriate Facility
INHOSPITAL MANAGEMENT OF TRAUMA
Communication
Triaging
Information Transfer
Trauma Team
INITIAL EVALUATION AND MANAGEMENT
Airway
Cervical Spine Protection
Breathing and Ventilation
Circulation and Bleeding
Disability
Exposure
ADJUNCTS TO PRIMARY SURVEY
Monitoring
Tubes and Catheters
Radiology
X-rays
Ultrasound
Diagnostic Peritoneal Lavage (DPL)
PATIENT TRANSFER
SECONDARY SURVEY
ADDITIONAL INVESTIGATIONS
Radiology
Blood Tests
TERTIARY SURVEY
PATIENT'S HANDOVER TO THE CONCERNED DEPARTMENT FOR DEFINITIVE CARE
CHAPTER 100:
Traumatic Head Injury
INTRODUCTION
PATHOPHYSIOLOGY OF HEAD INJURIES
Ischemic Brain Damage7
Traumatic Brain Edema8
ACUTE MANAGEMENT OF TRAUMATIC BRAIN INJURY9-13
NEUROMONITORING FOR TRAUMATIC BRAIN INJURY
Intracranial Pressure Monitoring14-17
Multimodality Monitoring
Jugular Venous Bulb Oximetry18-23
Transcranial Doppler Ultrasound24-29
Cerebral Function Monitoring30
Emerging Monitoring Technologies30
SURGICAL TREATMENT OF TRAUMATIC BRAIN INJURY31-34
Indications for Surgery in Head Injury
BARBITURATE COMA IN HEAD INJURY35,36
HYPOTHERMIA IN HEAD INJURY37,38
CONCLUSION
CHAPTER 101:
Thoracic Trauma
INTRODUCTION
PRIMARY SURVEY
DIAGNOSTIC TESTS
Chest Radiography
Computed Tomography
Ultrasonography
Echocardiography
Angiography
Indications for Angiographic Studies for Potential Thoracic Injuries
EMERGENCY DEPARTMENT THORACOTOMY
Indications and Contraindications for Emergency Room Thoracotomy
Accepted Indications
Relative Indications
Contraindications
BLUNT TRAUMA
Chest Wall
Rib Fractures
Flail Chest
Sternal Fractures
Clavicular Fractures
Scapular Fractures
Pulmonary Contusion
Laryngeal Injuries
Tracheobronchial Injuries
Great Vessels
Blunt Cardiac Injuries
Diaphragm
Esophagus
PENETRATING TRAUMA
Stab Wounds versus Firearm Injuries
Chest Wall Injury
Tracheal and Bronchial Penetrating Injuries
Pulmonary Injuries and Hemothorax
Cardiac Injuries
Air Embolism and Bullet Embolism
Great Vessels
Diaphragmatic Injuries
Esophageal Injuries
COMPLICATIONS OF THORACIC TRAUMA4
Pulmonary
Pleural Space
Vascular
Chest Wall
Mediastinum
ROLE OF VIDEO-ASSISTED THORACOSCOPIC SURGERY4
Indications
Relative Contraindications
Absolute Contraindications
CHAPTER 102:
Abdominal Trauma
INTRODUCTION
INITIAL MANAGEMENT
DAMAGE CONTROL SURGERY
EVALUATION OF AN ABDOMINAL INJURY
Blunt Trauma and Utility of CT Scan
Penetrating Trauma
Individual Organ Injury
Splenic Injury
Hepatic and Extrahepatic Bile Duct Injury
PANCREATIC AND DUODENAL INJURY
GASTRIC INJURY
SMALL BOWEL INJURY
COLORECTAL INJURY
ABDOMINAL GREAT VESSEL INJURIES
GENITOURINARY INJURIES
CHAPTER 103:
Spinal Injury
INTRODUCTION
EPIDEMIOLOGY
MECHANISM OF INJURY
Primary Mechanism
Secondary Mechanism
EMERGENCY MANAGEMENT AND TRANSPORT
ACUTE MANAGEMENT AND EVALUATION IN THE EMERGENCY DEPARTMENT
INTENSIVE CARE MANAGEMENT OF SPINAL CORD INJURY
Respiratory System
Cardiovascular System
Deep Vein Thrombosis and Thromboembolism
Gastrointestinal
Temperature Regulation
Supportive Care
CLINICAL EVALUATION
NEUROLOGICAL SYNDROMES
Anterior Cord Syndrome
Central Cord Syndrome
Brown Sequard Syndrome
Conus Medullaris and Cauda Equina Syndrome
SPINAL SHOCK
RADIOLOGICAL EVALUATION
Plain Radiography
Computed Tomography
Magnetic Resonance Imaging
Myelography
TWO TO THREE COLUMN CONCEPTS AND SPINAL STABILITY
CLOSED REDUCTION (TRACTION)
EXTERNAL ORTHOSIS
Halo
Minerva Jacket
SURGICAL MANAGEMENT OF SPINAL INJURIES
Occipitocervical Dislocation
Atlas Fracture
Axis (C2) Fracture
Atlantoaxial Dislocation
Subaxial Cervical Spine Fractures (C3-7)
Cervicodorsal Spine Injuries
Thoracic-Thoracolumbar Injuries
Sacral Injuries
Spinal Injuries in Children
REHABILITATION
CHAPTER 104:
Pelvic and Long Bone Injuries
INTRODUCTION
MODES AND MECHANISMS OF INJURY
EMERGENT MANAGEMENT/PREHOSPITAL CARE AND TRANSPORT
INTENSIVE CARE UNIT MANAGEMENT
COMPLICATIONS IN MULTIPLY INJURED
SURGICAL MANAGEMENT OF FRACTURES
CHAPTER 105:
Rhabdomyolysis and Fat Embolism Syndrome
INTRODUCTION
RHABDOMYOLYSIS
How to Identify Rhabdomyolysis: Different Definitions
Etiopathogenesis
Clinical Features
Diagnostic Aids
Serum CK
Serum and Urinary Myoglobin
Miscellaneous Findings
Differential Diagnosis
Complications
Identifying ARF and High-risk Patients in Rhabdomyolysis
Treatment Strategies
Hydration
Urine Alkalinization
Diuretics
Renal Replacement Therapy
Other Therapeutic Measures
FAT EMBOLISM SYNDROME
Etiopathogenesis
Mechanical Theory
Chemical Theory
Clinical Features
Diagnosis
Investigations
Blood Investigations
Radiological Features
Treatment
SECTION 14: MISCELLANEOUS
CHAPTER 106:
Immunological Emergencies
INTRODUCTION
ANGIOEDEMA
Presentation
Cause
ANAPHYLAXIS
Presentation
Cause
STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS5,6
Presentation
Cause
Differential Diagnosis
Causes in Intensive Care Unit Setting
Indications for ICU Admission if Occurring in Ward or Emergency
Evaluation, Monitoring and Management
GENERAL CARDIOPULMONARY SUPPORTIVE MEASURES
SPECIFIC PHARMACOLOGIC MEASURES
Adrenergic Agents
Antihistamines
Glucocorticoids
Others
SPECIFIC MANAGEMENT
Angioedema (ACEI-induced)
SJS and TEN5,6
COMPLICATIONS
CHAPTER 107:
Brain Death and Care of Patient for Organ Donation
INTRODUCTION
DIAGNOSIS OF BRAIN DEATH
Clinical Evaluation (Prerequisites)
Neurological Assessment
Confirmation of Coma
Assessment of Brain Stem Function
Apnea Test
Diagnosis of Brain Death in Children
Role of Ancillary Tests
How to Prepare Brain-Death Certificate (Fig. 1)
CARE OF POTENTIAL BRAIN-DEAD DONOR
Treatment Modifications after Brain Death Till Organ Procurement
Hemodynamic Instability
Respiratory System
Endocrine and Metabolic Dysfunction
Coagulopathy
Nutritional Support in Brain-dead Patient
Role of Organization
Medical Suitability for Organ and Tissue Donation
CONCLUSION
CHAPTER 108:
End of Life Care
INTRODUCTION
PRINCIPLES OF ETHICS
FOREGOING OF LIFE-SUPPORT THERAPY AND QUALITY OF DYING
INDIAN SCENARIO
PRESENT LEGAL POSITION OF FLST IN INDIA
CHAPTER 109:
Quality and Errors in ICU
INTRODUCTION
HISTORICAL BACKGROUND
DEFINITION OF QUALITY
WHAT EXACTLY IS PATIENT SAFETY?
Limiting Blame
Evolution of Quality in Healthcare
HEALTHCARE SAFETY—A NEW DISCIPLINE
WHERE DOES PATIENT SAFETY OCCUR AND HOW IS IT ACHIEVED?
METHODS FOR BRINGING ABOUT CHANGE
Quality Indicators in ICU19
Outcome Indicator
Morbidity Indicators
Errors and Patient Safety
Communication with Patient and Kin
Training Details of the Caregiver
Satisfaction Level of Staff
Resource Utilization, Cost-effectiveness and Revenue Generation
Trust of the Society
Action Plan for Quality Improvement19
Setting Up an Improvement Process
CONCLUSION
CHAPTER 110:
Intensive Care Design, Organization, Functions and Administration
INTRODUCTION
WHY NEED FOR A NEW ICU OR RENOVATION OF THE OLD ONE?
GOAL
ICU PLANNING
Initial Planning (Table 1)
Decision about ICU Level, Number of Beds, Design and Future Thoughts1,2,7-9
ICU–FUNCTIONAL MODEL (TABLE 3)1-4,8-10
Size and Arrangement of Critical Care Unit
Number of Beds and Number of ICUs as Needed for the Institution1,2,11-14
ICU Bed Designing and Space Issues1-5,11-15
Nursing Station Designing and Planning1-6
Equipment (Table 4)1,2,15-18
Design of Patient Care Zone
CLINICAL SUPPORT ZONE
UNIT SUPPORT ZONE
FAMILY SUPPORT ZONE
RECOMMENDATIONS FOR INDIAN ICUS FOR LEVEL 1 AND 2 (TABLE 7)
High Dependency Unit (HDU)
CONCLUSION1
CHAPTER 111:
Critical Care Research
INTRODUCTION
CONTEXT OF CRITICAL CARE RESEARCH
CHALLENGES AND OPPORTUNITIES
Collaborative Multiprofessional Research
Integration of Areas of Research
Patient Phenotypes and Critical Illness
Areas of Priority for Future Research
Modeling of Critical Illness in Preclinical Studies
Infrastructure
Newer Technology
Biomarkers
Clearer Definitions
Refined and Novel Research Methodology
FRAMEWORK OF CRITICAL CARE RESEARCH
Basic Sciences
Etiology and Patient Response
Microbiology
Recovery Phase of Critical Illness
TRANSLATIONAL RESEARCH
CLINICAL RESEARCH
Patient Pathways
Organ Support
General Supportive Critical Care Management
HEALTH SERVICES AND QUALITY IMPROVEMENT
Structures and Processes of Care
Safety and Quality Culture
Learning Culture
CONCLUSION
APPENDICES
Appendix-I: Cardiovascular Imaging
Appendix-II: Neuroimaging
Appendix-III: Respiratory Imaging
INDEX
TOC
Index
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