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Handbook of Pain Management in Practice
Sree Ranjani S
CHAPTER 1:
Basics of Pain
DEFINITION OF PAIN
NOCICEPTION AND NOCICEPTIVE PATHWAYS
Transduction of Pain
Nociceptors
Noxious Stimuli
Transmission of Pain
Perception of Pain
Reticular System
Somatosensory Cortex
Limbic System
Modulation of Pain
CLASSIFICATION OF PAIN
Depending on Major Site of Origin
Physiological Classification
Nociceptive Pain
Neuropathic Pain
Based on Occurrence
Based on Nature of Pain
Based on Intensity
Based on Anatomical Site of Origin
Temporal Classification
Chronic Pain
Acute Pain
EFFECTS OF UNTREATED PAIN
Untreated Acute Pain
Untreated Chronic Pain
CHAPTER 2:
Assessment of a Patient with Pain
HISTORY
EXAMINATION
Neurological Examination
Cranial Nerves Examination (Tables 2.1 and 2.2)
Posture and Gait Evaluation
Sensory Examination
Motor Examination
Reflexes
Coordination
Mental Status/Psychological Examination
CHRONIC PAIN ASSESSMENT TOOLS
Brief Pain Inventory1
McGill Pain Questionnaire2
Massachusetts General Hospital Pain Center's Pain Assessment Form3
Leeds Assessment of Neuropathic Symptoms and Signs4
IMMPACT Recommendation5
Categorical Scales6
Numerical Rating Scales
Verbal Numerical Rating Scale (Fig. 2.1)
Visual Form of Numerical Rating Scale9
Visual Analogue Scales
Pain Meter (PAULA)
Pain Assessment Forms/Card
CHAPTER 3:
Pharmacotherapy of Pain
PARACETAMOL
Mechanism of Action
Pharmacokinetics
Routes of Administration
Dosage2
Adverse Effects
Drug Interactions
Uses
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Classification7
Mechanism of Action
Pharmacokinetics
Indications
Adverse Effects
Gastrointestinal (GI) Effects8
Cardiovascular Effects
Renal Effects
Erectile Dysfunction Risk
Photosensitivity13
During Pregnancy
Others
Drug Interactions16
SKELETAL MUSCLE RELAXANTS
Classification
Adverse Effects (Table 3.2)
OPIOIDS
Classification
Pharmacokinetics and Pharmacodynamics
Pharmacological Actions
Contraindications
Uses
Morphine
Fentanyl Transdermal Patch
Codeine Dosage
Opioid Dosage
Immediate Release Preparations
Extended Release Preparations
Opioid Antagonists
Long-term Opioid Therapy
Addiction
Physical Dependence
Tolerance
ADJUVANTS
Antidepressants
Anticonvulsants
Antianxiety and Sedative Medications
Diazepam
Other Adjuvant Analgesics29
Adjuvant Analgesics for Bone Pain
Topical Agents
Other Adjuvants
STEROIDS
Secretion of Steroids
Injectable Synthetic Steroids
Action of Steroids
Corticosteroids
Uses of Corticosteroids in Interventional Pain Management
Uses of Corticosteroids in Other Conditions
Side Effects and Adverse Reactions
Equivalent Doses of Corticosteroids
Intra-articular Therapy
RADIOCONTRAST AGENTS
Dosage
Adverse Effects
LOCAL ANESTHETICS
Classification
Mechanism of Action
Concentration of Local Anesthetics
Epinephrine
Adverse Effects
Treatment of Local Anesthetic Toxicity
NEUROLYTIC AGENTS
Phenol
Alcohol
Hypertonic Saline
PLACEBO AND NOCEBO EFFECTS31
Placebo Effect
Nocebo Effect
CHAPTER 4:
Radiological Assessment of a Patient in Pain
X-RAY/RADIOGRAPH/ROENTGENOGRAPH
Physics of Radiation
X-ray Production
MAGNETIC RESONANCE IMAGING
Physics of Magnetic Resonance Imaging
Absolute Contraindications for MRI1
Relative Contraindications for MRI
COMPUTED TOMOGRAPHY
ULTRASOUND SCAN
Physics of Ultrasound
UPPER LIMB
Chronic Shoulder Pain
Shoulder Pathologies
Choice of Investigations
Chronic Elbow Pain
Causes
Choice of Investigations
Chronic Wrist Pain
Causes
Choice of Investigations
LOWER LIMB
Chronic Hip Pain
Causes
Choice of Investigations
Chronic Knee Pain
Causes
Choice of Investigations
Chronic Ankle Pain
Causes
Choice of Investigations
Chronic Foot Pain
Causes
Choice of Investigations
Spine
Causes
Chronic Neck Pain
Choice of Investigations (Figs 4.9A to F)
Low Back Pain
CHAPTER 5:
Acute Pain
DEFINITIONS
PREVALENCE3
CAUSES
FACTORS INFLUENCING PAIN
PATHOPHYSIOLOGY
CHARACTERISTICS
EFFECTS OF UNTREATED ACUTE PAIN
ASSESSMENT OF PAIN
TREATMENT
Pharmacological
Analgesics
Adjuvants
Anesthetics
Nonpharmacological
Psychological Management
Physical Therapies
Recommendations for Analgesics Use (WHO)
ASSESSING TREATMENT OUTCOME
PROGRESSION OF ACUTE TO CHRONIC PAIN
Risk Factors for Chronic Postsurgical Pain35
Mechanisms for the Progression from Acute to Chronic Pain
Methods to Prevent the Progression of Acute to Chronic Pain
Pre-emptive Analgesia
Preventive Analgesia
Choice of Anesthetic Drugs and Techniques
Surgical Approaches
Rehabilitation
CHAPTER 6:
Headache
EPIDEMIOLOGY
CLASSIFICATION
PATHOPHYSIOLOGY
Primary Headache
Secondary Headache
HISTORY AND PHYSICAL EXAMINATION
Aim
Headache History
Other Symptoms
Past History
Treatment History
Family History
Social and Personal History
Physical Examination
INVESTIGATIONS
Imaging in the Diagnosis of Headaches
Lumbar Puncture
Electroencephalography
Blood Investigations
ACUTE HEADACHE
Thunderclap Headache
Causes
Acute Primary Headache Disorders
Acute Secondary Headache Disorders
Red Flags of Acute Headache
Investigations
Treatment
PRIMARY HEADACHES
Migraine
Incidence
Clinical Presentation
Treatment of Acute Attacks
Prophylaxis
Cluster Headache
Epidemiology
Clinical Features
Treatment of Acute Attacks
Prophylaxis
Tension Headache
Epidemiology
Clinical Features
Treatment
Other Types of Headache
SECONDARY HEADACHE DISORDERS
Causes
Clinical Presentation
Treatment
CHAPTER 7:
Facial Pain
DEFINITION
CLASSIFICATION
TREATMENT
TEMPOROMANDIBULAR DISORDERS
Synonyms
Probable Etiopathology
Characteristics
Clinical Examination
Investigations
Treatment
TRIGEMINAL NEURALGIA
Definition5
Epidemiology
Etiopathogenesis
Clinical Presentation
Investigations
Treatment
IDIOPATHIC OR ATYPICAL FACIAL PAIN
Characteristics
Clinical Examination
Investigations
Treatment
GLOSSOPHARYNGEAL NEURALGIA
Types
Clinical Features
Treatment
POSTHERPETIC NEURALGIA
OCCIPITAL NEURALGIA
Etiology
Pathophysiology
Differential Diagnosis
Treatment
Interventions
Occipital Nerve Stimulator
HEMIFACIAL SPASM
Pathophysiology
Clinical Features
Investigations
Treatment
CHAPTER 8:
Backache
INTRODUCTION
EPIDEMIOLOGY
ANATOMY OF SPINE
ETIOLOGY AND RISK FACTORS
FUNCTIONAL BACK PAIN ASSESSMENT
Red Flags of Backache
EXAMINATION OF SPINE
Types of Examination
Inspection of the Spine
Tests for Range of Movements of Spine
Palpation
Provocative Test of Nerve Root Compression
Sensory Examination
Motor Examination
Tests for Sacroiliac Joint
INVESTIGATIONS
TREATMENT
Acute Low Back Pain
Conservative Treatment
Chronic Back Pain
Conservative Treatment
Interventional Pain Management
Surgery
Advanced Pain Therapies
SPECIFIC CONDITIONS OF THE BACK
Disk Prolapse
Stages of Disk Herniation
Clinical Features
Examination
Investigations Reveal the Pathology
Treatment
Diskogenic Pain
Radiculopathy
Facet Joint Arthritis
Clinical Presentation
Investigations
Treatment
Spondylosis
Epidemiology
Causes
Pathophysiology
Clinical Features
Investigations
Treatment
Surgery
Spondylolisthesis
Pathophysiology
Clinical Features
Investigations
Treatment
Spinal Canal Stenosis
Causes
Pathophysiology
Clinical Features
Investigations
Treatment
Sacroiliac Joint Pathologies
Causes of SI Joint Arthritis/SI Joint Inflammation/SI Joint Dysfunction
Clinical Features and Examination
Investigations
Diagnostic Block
Treatment
Infective Pathologies
Causes42
Epidemiology
Risk Factors44
Clinical Features
Physical Examination
Investigations
Treatment
Piriformis Syndrome
Anatomy of Piriformis Muscle
Etiology
Symptoms
Clinical Examination49
Investigation
Treatment
CONCLUSION
CHAPTER 9:
Abdominal Pain
TYPES
Acute Abdominal Pain
Chronic Abdominal Pain
ETIOLOGY AND CLINICAL FEATURES
Peptic Ulcer Disease
Biliary Tract Diseases
Malignancy
Bowel Obstruction
Diverticulitis
Appendicitis
Pancreatitis
Mesenteric Ischemia
Abdominal Aortic Aneurysm
Urogenital Disease
Miscellaneous
HISTORY
PHYSICAL EXAMINATION
INVESTIGATIONS
Laboratory Studies
Imaging Studies
MANAGEMENT
Functional Abdominal Pain
Chronic Intractable Abdominal Pain
TREATMENT
Other Modalities
CHAPTER 10:
Chronic Pelvic Pain
INCIDENCE1
ETIOLOGY
PATHOGENESIS
HISTORY
PHYSICAL EXAMINATION
MANAGEMENT
INVESTIGATIONS
Laboratory Studies
Imaging Studies
TREATMENT
RESISTANT CHRONIC PELVIC PAIN
CHAPTER 11:
Myofascial Pain
INTRODUCTION
MYOFASCIAL PAIN SYNDROME
Definition
Incidence
Etiology
Clinical Presentations
Differential Diagnosis
Investigations
Treatment
Physical Modalities
Medication
Needling and Infiltration
Exercise
FIBROMYALGIA
Incidence
Pathogenesis
Clinical Features
Associated Symptoms of Fibromyalgia
Investigations
Treatment
Physical Modalities
Medication
Exercises
CONCLUSION
CHAPTER 12:
Musculoskeletal Pain
PAIN ALONG SHOULDER JOINT
Anatomy of Shoulder Joint1
Causes of Pain Around the Shoulder2
Impingement Syndrome3–6
Rotator Cuff Tendinitis7,8
Symptoms
Clinical Examination
Investigations
Treatment
Operative Treatment
Long Head of Biceps Tendinitis9–11
Symptoms
Examination
Treatment
Surgical Treatment
Periarthritis Shoulder (Frozen Shoulder, Adhesive Capsulitis)
Investigation
Treatment
PAIN ALONG ELBOW
Lateral Epicondylitis (Tennis Elbow)12
Etiopathogenesis
Clinical Features
Treatment13
Surgical Treatment
Golfer's Elbow (Medial Epicondylitis)
Etiology
Clinical Features
Treatment14
Triceps Tendinitis15
Clinical Features
Treatment
Olecranon Bursitis16
Clinical Features
Treatment
PAIN ALONG WRIST/HAND
de Quervain's Tenosynovitis
Clinical Features
Treatment17
Trigger Finger (Stenosing Flexor Tenosynovitis)
Clinical Features18
Treatment19
PAIN IN THE FOOT
Plantar Fasciitis
Clinical Features20
Investigations
Treatment20
Achilles Tendinitis21
Clinical Features
Treatment
Retrocalcaneal Bursitis22
Clinical Features
Investigation
Treatment
CHAPTER 13:
Arthritis
ANATOMY OF THE JOINT
TYPES
CLINICAL FEATURES
INVESTIGATIONS
TREATMENT
OSTEOARTHRITIS
Incidence
Risk Factors
Pathogenesis
Investigations
Treatment
RHEUMATOID ARTHRITIS
Incidence
Etiopathogenesis
Clinical Features
Investigations
Laboratory Tests
Radiography
Treatment
GOUTY ARTHRITIS
Pathogenesis
Symptoms
Acute Attack
Chronic Tophaceous Gout
Investigations
Treatment of Gout
Pseudogout
OTHER FORMS OF ARTHRITIS
Lupus Arthritis
Psoriatic Arthritis
Infectious Arthritis
Ankylosing Spondylitis
Hemorrhagic Arthritis
Juvenile Idiopathic Arthritis
CHAPTER 14:
Neuropathic Pain
NEUROPATHIC PAIN
Definition
Incidence
Etiology
Pathophysiology5,6
Clinical Features
Classification3 (Fig. 14.1)
Tools for Assessment
Laboratory Tests
Quantitative Sensory Testing8
Bedside Examination
Questionnaires
Treatment
Non-pharmacological Measures
Pharmacological Measures (Tables 14.1 and 14.2)
WHEN TO REFER TO A PAIN SPECIALIST?22
Interventions in the Treatment of Neuropathic Pain
DIABETIC NEUROPATHY
Definition
Incidence
Classifications27
Symptoms/Signs
Treatment
Step I
Step II (Management of Pain Symptoms)
COMPLEX REGIONAL PAIN SYNDROME
Incidence
Classification
Etiology
Clinical Features29
Pain
Skin Changes30
Swelling
Movement Disorders
Spreading Symptoms
Stages
Bone Changes in CRPS
Treatment29
Medications
Interventions Used in Treatment of CRPS
POSTHERPETIC NEURALGIA
Treatment of Herpes Zoster
Treatment of Postherpetic Neuralgia
CARPAL TUNNEL SYNDROME
Incidence
Risk Factors
Symptoms
Examination
Investigation
Treatment
Conservative Treatment
Oral Medications
Interventions
Prevention
PHANTOM LIMB PAIN
Incidence
Jensen and Nikolajsen Classification of Phantom Limb Pain48
Phantom Sensation
Phantom Pain
Stump Pain47
Predisposing Factors
Mechanism of Phantom Pain
Treatment
Prevention
CHAPTER 15:
Cancer Pain
INTRODUCTION
SYMPTOMS IN CANCER
APPROACH TO CANCER PAIN
Assessment of a Patient with Cancer
Eastern Cooperative Oncology Group Performance Status Assessment5
Different Types of Pain
TREATMENT GUIDELINES
METHODS OF CANCER PAIN MANAGEMENT
Pharmacotherapy
Essential Concept of WHO Approach
Morphine
Fentanyl Transdermal Patch
Disadvantages of Pharmacotherapy
Physical Methods
Counseling
Interventional Pain Management
Indications for Interventional Pain Management
Advantages of Interventional Pain Management
Commonly Performed Interventions
CONCLUSION
CHAPTER 16:
Peripheral Vascular Disease
ETIOLOGY AND RISK FACTORS
PATHOPHYSIOLOGY (Fig. 16.1)
DISEASES COEXISTING WITH PVD
CLINICAL FEATURES
Symptoms
Signs
INVESTIGATIONS
TREATMENT
CHAPTER 17:
Emergencies in Pain Practice
INTRODUCTION
VARIOUS EMERGENCIES
Vasovagal Syncope1
Local Anesthetic Toxicity2
Anaphylaxis3
Complications Inherent to the Procedure
MANAGEMENT OF COMPLICATIONS4,5
CONCLUSION
CHAPTER 18:
Pediatric Pain Management
INTRODUCTION
CAUSES OF PAIN IN CHILDREN
ASSESSMENT OF PAIN
Self-report Measures
Behavioral Measures
Physiological Measures
Assessment of Pain in Preterm/Neonates/Infants
Premature Infant Pain Profile7
Neonatal Facial Coding System
Neonatal Infant Pain Scale11
Maximally Discriminate Facial Movement Coding System12
Assessment of Pain in Toddlers and Preschoolers
Face, Legs, Activity, Cry, Consolability Scale13
Wong-Baker FACES Pain Scale14
Children's Hospital of Eastern Ontario Pain Scales15
Assessment of Pain in School-aged Children and Adolescents16
Visual Analog Scale17
McGill Pain Questionnaire18
TREATMENT OF PEDIATRIC PAIN
Non-pharmacological Methods
Pharmacological Interventions
Non-opioid Analgesics
Opioid Analgesics
CONCLUSION
CHAPTER 19:
Osteoporosis
DEFINITION
STATISTICS
CLASSIFICATION5 (Fig. 19.1)
Primary Osteoporosis
Type 1
Type 2
Secondary Osteoporosis
CAUSES
PATHOPHYSIOLOGY
SYMPTOMS AND SIGNS
EVALUATION/INVESTIGATIONS
Diagnosis of Osteoporosis
Routine X-ray
Dual-energy X-ray Absorptiometry Scan
TREATMENT OF OSTEOPOROSIS
Goals
Treatment Options (Fig. 19.3)
Exercise
Vitamin D
Calcium Supplements
Medications in the Treatment of Osteoporosis
PREVENTION/RISK REDUCTION
CHAPTER 20:
Physiotherapy and Rehabilitation
PHYSIOTHERAPY
Physiotherapeutic Modalities
Others
REHABILITATION
CHAPTER 21:
Interventions in Pain Management Practice
INTERVENTIONAL TECHNIQUES
Contraindications
ADVANCED INTERVENTIONAL TECHNIQUES
HEAD AND NECK PROCEDURES
Gasserian Ganglion Block
Indications
Anatomy
Procedures
Complications
Occipital Nerve Block
Indication
Anatomy
Procedures
Complications
Stellate Ganglion Block (Cervicothoracic Sympathetic Block)
Indications
Anatomy
Procedures
Complications
Sphenopalatine Ganglion Block
Indications
Anatomy
Procedures
Complications
SPINE PROCEDURES
Epidural Steroid Injections
Indications
Anatomy
Procedures
Various Approaches
Complications
Ozone Diskolysis (Fig. 21.2)
Indication
Anatomy
Procedures
Complications
Facet Joint Injections (Fig. 21.3)
Indication
Anatomy
Procedures
Complications
Sacroiliac Joint Injections (Fig. 21.4)
Indication
Procedures
Complications
Intrathecal Pumps
Anatomy
Indications
Procedures
Complications
Vertebroplasty (Fig. 21.5)
Indications
Procedures
Complications
Spinal Cord Stimulation
Indications
Mode of Action
Procedures
Trial Stimulation
Complications
INTERVENTIONS IN THE ABDOMEN
Celiac Plexus Block (Fig. 21.6)
Anatomy
Indications
Contraindications
Techniques
Complications
NEUROLYTIC TECHNIQUES IN PAIN MANAGEMENT
Chemical Neurolytic Block
Cryoablation Techniques
Radiofrequency Lesioning
Neuroablative Procedures
INDEX
TOC
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