Handbook of Lipidology Tapan Ghose
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1Handbook of LIPIDOLOGY2
3Handbook of LIPIDOLOGY
Tapan Ghose MD DNB (Med) DNB (Cardio) FNB MNAMS FCSI FIMSA FACC FSCAI Director and Head Department of Cardiology Paras Hospitals, Gurgaon, Haryana, India Foreword Upendra Kaul
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Handbook of Lipidology
First Edition: 2016
Printed at
5Dedicated to
The memory of
Mrs Purna Laxmi Ghose (Mother)
Mrs Rekha Chaudhuri (Mother in Law)
Mr GC Ghose (Father)
Dr Amitav Ganguly (Friend)
Dr Dinesh Chakraborty (Childhood Mentor)
All those patients who have left us6
My association with Dr Tapan Ghose, the worthy Editor of this handbook, has been of more than 18 years. He joined my team in Batra Hospital and Medical Research Centre, New Delhi, India, as a senior resident in the year 1997. Since then, he never looked behind and groomed into a mature cardiologist, adept in coronary and noncoronary interventions of international standards with numerous publications to this credit. He accompanied me to Fortis Network of Hospitals and helped me in setting up the Department at the Vasant Kunj facility and, finally, moved to his present place of work as Director Cardiology, Paras Hospital with my blessings.
His academic interests have been various including lipidology and management of lipid disorders. The first study on the efficacy of atorvastatin in this region was conducted and published by him under my guidance in 2000. It is, therefore, very logical that he has come out with a comprehensive Handbook of Lipidology. The book covers various aspects of the subject starting from history, molecular biology to various drugs and management of individual disorders precisely. It would become a very good and useful reference book on the subject for postgraduate students and clinicians, in general. I am sure Dr Ghose will come out with the updates of this handbook in the times to come.
Upendra Kaul
Awardee of Padma Shri and Dr BC Roy Award
Executive Director and Dean, Cardiology
Fortis Escorts Heart Institute
and Fortis, Vasant Kunj
New Delhi, India10
Coronary heart disease is the leading cause of death in the world. Each day, 30,000 people leave this planet because of coronary heart disease. Amongst the well-studied nine risk factors, dyslipidemia has the highest population-atributable risk factor and is modifiable. Since the initial description of thrombus as the cause of acute myocardial infarction by James B Herrick, many advances have taken place in the field of lipidology. One landmark achievement in the human history is the discovery of statin group of drugs. After penicillin and aspirin, these drugs are the third group of agents, which have an impact on the event-free survival of mankind.
There is an immense need of a comprehensive handbook on lipidology for the busy clinicians, which can serve as a desktop reference. Initially, I approached many people who are the known contributors from various countries, for this handbook. All of them had a long waiting time. Then, I approached leading physicians, who are involved in the day-to-day management of lipid disorders. All the contributors have tried to simplify the complex subject of lipidology into easily understandable language for the practitioners.
If a single life is saved and if a single episode of myocardial infarction or stroke is averted with the help of this handbook, then it would be presumed to be successful in serving its purpose.
Tapan Ghose
This work is the result of contribution made by many individuals.
I sincerely thank all the contributors of the various chapters of this handbook. In spite of being successful clinicians, all of them have taken out precious time from their busy work schedule for writing the chapters.
I would like to thank Prof Upendra Kaul, my mentor, for his constant guidance, help and for writing the Foreword for this handbook. This would not have been possible without his help.
I also thank Mr Manoj Sharma, Mr Priyawart Kumar, Ms Monika and Mr Praveen for helping me in the preparation of the manuscript. I sincerely thank all the team members of M/s Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, India, for their direct and indirect contribution to this handbook.
I also thank Mr SL Choudhury for his literary help and guidance. I would like to thank my brothers Mr Manik, Mr Ratan, Mr Swapan and Mr Tarun for their constant encouragement.
Finally, I would like to acknowledge the constant help of my wife, Dr Sutapa, and son, Tuhin, for their help, tolerating my irregular work schedule and helping me in spite of disturbing their many weekends.