Handbook on Adverse Drug Reactions in TB Treatment Rajendra Prasad, Nikhil Gupta
INDEX
ABCDEFGHIJKLMNOPQRSTUVWZ
A
Abacavir 150
Abscesses 16
Acneiform eruption 56
Acquired immunodeficiency syndromes 149
Acyclovir 85, 88
Adefovir 88
Adverse drug reactions, epidemiology of 163, 179
Aggression 23, 26
Agranulocytosis 10, 14, 54
Alcohol 86, 89
dependence 139
excessive concurrent use of 23
Allergic reactions 27, 29, 31, 32, 42, 57, 58, 152
Allergy 27
Allopurinol 75, 83, 88
Alopecia 57
Aluminium hydroxide 81
American Academy of Pediatrics 17
American Thoracic Society 91, 94
Amikacin 2–4, 18, 56, 64, 85, 88, 93, 117, 147
drug interactions of 69
sulfate 18
Aminoglycosides 16–20, 85
coadministration of 69
Amiodarone 82
Amoxicillin 4, 46, 47, 59, 75, 94, 113, 118
clavulanic acid, drug interactions of 74
Amoxyclav 88
Amphotericin 69, 70, 83, 85, 88
Amprenavir 151
Analgesics 82
Anemia 10, 37, 44, 53, 59
aplastic 54
hemolytic 14, 53, 54
sideroblastic 53
Anorexia 25, 27, 36, 56–58, 102
Antacids 65–67, 70–74, 76, 77, 79, 81, 83, 85–88
Anticoagulants 86
Anticonvulsants 82
Antidepressants 87
Antipsychotics 82
Antiretroviral drug 149, 153
interactions 149, 155
Antiretroviral therapy 149, 157
adverse drug reactions of 157
Antitubercular drugs 1, 55, 81, 85, 135, 153
adverse drug reactions of 53, 56
doses of 1, 2
drug interactions of 65, 69
interactions 149
management strategies of 60, 144
pharmacology of 9, 16
regimen 1, 4
Antituberculosis
therapy 157
adverse drug reactions of 157
treatment 98
Anxiety 23, 24, 29, 31, 33, 35, 57
severe 23
Appetite, loss of 40, 49, 59, 150
Arrhythmias, ventricular 59
Arthralgia 25, 38, 53, 57, 64, 147, 161, 174
Ascitic fluid 16
Aspirin 27
Astemizole 88
Ataxia 10, 19
Atazanavir 151
Atracurium 69, 88
Audiometry 140
Auditory nerve
damage 54
impairment 14
Azole antifungal
agents 89
drugs 89
Azotemia 21
B
Bactericidal drug 14
Barbiturates 82
Bedaquiline 3, 48, 59, 64, 89, 94, 118, 147
drug interactions of 77
plasma protein binding of 48
Benzodiazepines 81, 82
Beta-lactam antibiotics 43
Bile 35
Bone marrow
depression 37, 59
suppression 160
Breastfeeding 17, 19, 21, 23, 25, 27, 28, 30, 32, 34, 35, 37–39, 41, 43–45, 47, 48, 50
British Thoracic Society 94
Bumetanide 69
Burning 36, 54
C
Calcium 21, 33
high concentration of 85
serum 140
Candida stomatitis 59
Capreomycin 2–4, 20, 56, 64, 85, 93, 113, 117, 147
drug interactions of 70
sulfate 20
Carbamazepine 81, 89
Carbapenem 45
intolerance 45, 46
Carboplatin 88
Carbothionamides 24
Central nervous system 29
toxicity 157
Cephalosporins 85
Cerebrospinal fluid 9
Cervical lymphadenopathy, tubercular 100
Chest
pain 49, 51
radiograph 140
X-rays 123, 125–127, 129, 130, 132, 133
Chills 22, 39
Cidofovir 69, 70
Cilastatin 2–4, 43, 44, 59, 77, 88, 94, 118
Cisapride 88
Cisplatin 85
Citric acid 87
Clarithromycin 2, 4, 42, 59, 64, 88, 93, 117, 147
drug interactions of 77
Clavulanate 3, 4, 46, 47, 59, 75, 113
Clavulanic acid 94, 118
Clofazimine 2–4, 35, 36, 56, 64, 87, 89, 93, 95, 107, 117, 136 147
drug interactions of 76
Clostridium difficile colitis 42
Cochlear ototoxicity 19, 56, 57
Colchicine 83
Colitis
hemorrhagic 59
pseudomembranous 44, 53, 59
Complete blood count 41
Confusion 12, 23, 24, 26, 29, 31, 33, 35, 55, 57
Contraception 114
Contraceptives 82
Corticosteroids 81, 82, 87
Cough 102, 153
Cramps 36
Cyclic polypeptide 20
Cycloserine 2–4, 22, 23, 57, 64, 81, 86, 93, 107, 113, 117, 147
doses of 23
drug interactions of 70
Cyclosporine 82, 83, 85, 86, 88
D
Dapsone 82, 86
Darunavir 151
Deafness, congenital 17, 20
Deep intramuscular injection 18
Delamanid 3, 49, 59, 64, 89, 94, 118, 117
drug interactions of 78
Delavirdine 151
Depression 23–26, 36, 57, 61, 145, 151, 157
Dermatitis, exfoliative 11, 37, 59
Diabetes
control, loss of 13
mellitus 116, 139
Diarrhea 25, 27, 29, 31–36, 42, 44, 46, 47, 57, 58, 59, 151–153, 158
bloody 46
severe 42, 43, 46, 47
watery 46
Diarylquinoline 48
Diazepam 81
Didanosine 33, 150
Digoxin 82, 86, 88
Diltiazem 82
Directly observed treatment short course 95, 110
Distress, epigastric 10
Disulfiram 81
Dizziness 10, 58, 12, 18, 23, 25, 26, 29, 31–35, 51, 55, 58, 59, 152
Dolutegravir 152
Drowsiness 23, 25, 54, 57, 151
Drug resistant tuberculosis 139
Drug susceptibility testing 106, 115, 137
Dry mouth 150
Dry skin 36, 56
Duloxetine 87
Dysarthria 53
Dysglycemia 34, 58, 161
Dysphoria 53, 151
E
Efavirenz 78, 82, 89, 151
Electrocardiography 141
Electrolyte
abnormalities 21, 54
disturbances 19, 56, 63, 147, 160
Eletriptan 87
Elvitegravir 152
Emtricitabine 150
Enalapril 82
Enflurane 81
Enfuvirtide 152
Eosinophilia 10, 19, 56
Ephedrine 76
Epilepsy 23
Ethacrynic acid 69, 83, 85
Ethambutol 1, 3–5, 9, 11, 12, 53, 55, 64, 67, 83, 93, 100, 102, 117, 122, 126, 136, 147, 163, 174
drug interactions of 67
overdosage of 12
Ethionamide 2–4, 24, 27, 57, 58, 64, 82, 83, 86, 87, 93, 107, 117, 147
drug interactions of 70
Etravirine 151
Euphoria 10
Extensively drug resistant tuberculosis, treatment of 112
Extracellular fluid 16
Eyes, yellow 29, 31, 33, 35, 36, 39, 4
F
Fainting 49, 51
Fat redistribution 151, 152
Fatigue 150
Fatigueness 153
Fever 11, 13, 22, 27, 39, 40, 56–58, 102, 150
Fine-needle aspiration cytology 100
First-line antituberculosis drugs 165
Fluconazole 82
Flue-like syndrome 53
Fluoroquinolones 2, 28, 29, 31, 33, 64, 85, 89, 113, 147
intolerance of 33, 34
Fluoxetine 87
Fosamprenavir 151
Foscarnet 69, 70
Furosemide 69, 85
Fusion inhibitors 152
G
Gallamine triethiodide 69
Gallbladder 28, 35
Gastric lavage 11, 12, 13
Gastritis 62, 146
Gastrointestinal
distress 49, 59
disturbances 24
intolerance 27, 29, 31, 32, 34, 37, 57–59
reaction 53
upset 11–13, 41, 54
Gatifloxacin 2, 33, 34, 58, 93, 117, 136
doses of 34
Gentamicin 88
Glomerular filtration 12, 14, 28
Glucose
monitoring 34
serum 140
Glutaryl pyruvate transaminase 96
Glycemic control 34
Granulocytopenia 150
Gums, inflammation of 23, 57
Gynecomastia 10, 25, 57
H
Hallucinations 12
Haloperidol 82
Headache 23–25, 29, 31, 32, 34, 42, 49, 57–59, 87, 150–153, 158
Hearing loss 42, 54, 61, 144
Hemoglobin 140
Hemorrhage, intracranial 152
Hepatic
disease 17, 19, 25, 29, 30, 36, 38, 40, 41, 43–45, 47, 49, 50
dysfunction 13
injury 59
insufficiency, severe 36
Hepatitis 10, 11, 13, 27, 37, 53, 56–59, 63, 97, 146, 153
drug induced 55
Hepatotoxicity 38, 40, 53, 159, 171
drug induced 96
Highly active antiretroviral therapy 149
Human immunodeficiency virus 139, 140, 149
treatment of 149
Hydrolysis, enzymatic 9
Hyperbilirubinemia, indirect 151
Hyperglycemia 34, 151, 152
signs of 35
Hyperlipidemia 160
Hypersensitivity 13, 47, 56, 57
reaction 10–12, 14, 40, 54, 59, 150, 152
Hyperuricemia 12, 13, 174
Hypocalcemia 54, 56
Hypoglycemia 26, 34
signs of 35
Hypokalemia 19, 54, 56, 63, 147
Hypomagnesemia 19, 54, 56, 63, 147
Hypotension 44, 59
postural 25, 57
Hypothyroidism 25, 27, 57, 58, 62, 146, 161
I
Ichthyosis 36, 56
Imipenem 2–4, 43, 44, 59, 77, 88, 94, 118
Indinavir 82, 151
Influenza-like syndrome 11
Insomnia 29, 31, 32, 34, 58, 150
International Union Against Tuberculosis and Lung Disease 91
Intrathoracic lymph node tuberculosis 4
Intrauterine devices 115
Iris 33, 152
Isoniazid 1, 4, 5, 7–13, 53, 54, 64, 65, 67, 81–83, 86, 87, 91, 93, 100, 102, 105, 117, 118, 122, 126, 135, 136, 147, 155, 163
drug interactions of 65
high dose 2–4, 94, 118, 136
overdosage of 10
plus pyrazinamide 11
Isonicotinic acid, hydrazide of 9
Itraconazole 82, 89
J
Jaundice 10, 23, 25, 55, 57
Joint pain 29, 31, 33, 35, 49, 54, 59, 153
Joint Tuberculosis Committee of British Thoracic Society 98
K
Kanamycin 2–4, 16, 17, 19, 20, 57, 64, 85, 88, 93, 103, 117, 124, 130, 136, 147, 180
drug interactions of 69
sulfate 16
Ketoconazole 81–83, 89
Kidneys 28
L
Lactation 139
Lactic acidosis 140, 150, 159
Lamivudine 150
Leukopenia 25, 38, 57, 59
Levodopa 81
Levofloxacin 2, 4, 28, 58, 93, 117
doses of 29
drug interactions of 72
Linezolid 2–4, 40, 59, 64, 87, 93, 107, 117, 147
drug interactions of 75
Lipase 140
Lipodystrophy 160
Liver 28
cirrhosis of 103
disease 45
acute 139
chronic 139
pre-existing 98
severe 51
disorders 118
failure, acute 172
function
monitoring 38, 40
test 26, 27, 32, 34, 58, 150–152
serum enzymes 140
toxicity 42
Lopinavir 78, 82, 151
Lung 28
Lupoid reaction 53
Lymphadenitis, tuberculous peripheral 4
Lymphatic fluid 16
M
Macrolide 89
antibiotic 42
Maculopapular rash 21, 56
Magnesium 21, 33
antioxidants 87
serum 140
Malabsorption syndrome 27, 58
Malaise 29, 31, 32, 34, 40, 58, 150
Maraviroc 153
Medical termination of pregnancy 113
Medroxyprogesterone 115
Memory, loss of 24
Meningitis 44, 45
tubercular 4
Mental illness 139
Meropenem 3, 45, 59, 94, 118
Methadone 82
Methotrexate 85
Methylphenidate 76
Migraine 87
Mirtazapine 87
Morphine 82
Moxifloxacin 2, 4, 29, 30, 31, 58, 93, 117, 136
drug interactions of 73
Multidrug resistant tuberculosis 64, 105, 112, 135, 179
treatment of 112, 122
Muscle
pain 153
relaxants, non-depolarizing 69
twitching 18, 20
weakness 18, 20, 22
Myasthenia gravis 14
Mycobacterium tuberculosis 102, 103, 105, 122, 124, 129–131, 135, 141
Myopathy 150
N
Narcotics 82
Nausea 10, 11, 19, 25–27, 36, 39, 40, 42, 44, 46, 47, 49, 51, 57, 59, 62, 146, 150–153, 158
Nelfinavir 82, 151
Nephrolithiasis 151, 159
Nephrotoxic agents 69, 70
Nephrotoxicity 14, 17, 19, 21, 54, 56, 57
Neuritis
peripheral 10, 53, 57
retrobulbar 53, 173
Neuropathy, symptoms of 41
Neurotoxicity 25, 56
Nevirapine 78, 151
Nifedipine 82
Nightmares 23
Nitrodihydro-imidazo-oxazole 49
Non-nucleoside reverse transcriptase inhibitors 149, 150, 151, 154, 155
Nonsteroidal anti-inflammatory drugs 85, 86
Nucleoside reverse transcriptase inhibitors 149, 150, 154
Nystagmus 19, 55
O
Ofloxacin 2, 31, 32, 58, 93, 117
doses of 32
drug interactions of 73
Ondansetron 89
Optic
neuritis 41, 53, 57, 63, 147, 160
neuropathy 41, 59
Oral
absorption 18, 21, 22, 24, 26, 28, 30, 32, 33, 35, 38, 39, 41, 45, 47, 48, 50
anticoagulants 74, 81, 82, 85, 88
bacteriostatic second line drugs 2
contraceptives 75, 88
hypoglycemic agents 82
paresthesias 151
ulcers 150
Ototoxicity 14, 21, 37, 59, 67, 173
Oxazolidinones 41
P
Pain 18, 20, 21, 29, 31, 33, 35, 42, 54
abdominal 11, 25, 36, 42, 49, 56, 57, 59, 152, 158
eye 23, 39, 57
severe abdominal 27
Pale skin 23, 57
Pancreatitis 49, 150, 158
Pancuronium 69, 88
Para-aminosalicylic acid 2, 4, 5, 25, 26, 64, 65, 82, 86, 97, 102, 113, 147
drug interactions of 71
Paracetamol 81
Parkinson's disease 76
Paroxetine 87
Pellagra 53, 57
Penicillins 69, 70
Pentamidine 88
Pericardial fluid 16
Peripheral neuropathy 17, 19, 29, 33, 41, 54, 56–60, 144, 150, 157, 172
Peritoneal fluid 16
Phagocytic cells 28
Phenazine derivative 35
Phenytoin 81, 82, 86
Phospholipidosis 49
Phospholipids, accumulation of 49
Photosensitivity 29, 31, 32, 34, 53, 57, 58
Phototoxicity 56
Pneumonia, bacterial 152
Polymyxins 85
Porphyria 25
Potassium 21
serum 140
Pregnancy 17, 19, 21, 23, 25, 27–39, 41, 43–45, 47, 48, 50, 139
Probenecid 67, 74, 86–88
Propafenone 82
Prostatic tissue 28
Protease inhibitors 149, 151, 154
Proteinuria 19, 21, 56
Prothionamide 2–4, 24, 57, 64, 86, 107, 136, 147
drug interactions of 70
Prothrombin time 58
Pruritus 40, 152
Pseudoadrenal crisis 53
Pseudojaundice 38, 59
Psychiatric disorder 172
Psychiatric disturbances 10, 57
Psychosis 10, 23, 120
Psychotic disturbances 25
Pulmonary tuberculosis 101, 103, 122, 124
Pyrazinamide 1, 3–5, 7, 9, 13, 53–55, 64, 82, 83, 92, 93, 100, 102, 108, 117, 118, 122, 126, 130, 136, 147, 163, 174, 175
drug interactions of 67
overdosage of 13
Pyridoxine 88
administration of 25
Q
Quinidine 82
R
Raltegravir 152
Ranitidine 81
Rash 10–13, 17–20, 22, 24, 29, 31, 33, 34, 37, 38, 40, 41, 43, 47, 56–59, 150–152
Refabutin 59
Renal disease 10–14, 17, 19, 21, 23, 25, 27, 29, 30, 32, 34, 35, 37–39, 41, 43, 44, 45, 47, 48, 50
Renal failure 14, 53, 59
Renal insufficiency 23, 116, 139
Renal toxicity 63, 147, 159, 175
Restlessness 23, 29, 34, 57, 58
Reverse transcriptase inhibitors 149
Revised National Tuberculosis Control Program 3, 164
Rifabutin 1, 4, 37, 38, 40, 91, 93, 117
Rifampicin 1, 4, 5, 7, 9–11, 13, 53–55, 64, 66, 67, 81, 83, 87, 89, 92, 93, 100, 102, 105, 117, 118, 122, 126, 135, 147, 163
drug interactions of 66
overdosage of 11
resistant tuberculosis 105, 135
Rifamycins 37–40, 153, 154
Rifapentine 39, 91, 93, 117
Ritonavir 78, 82, 89, 151, 152
Rocuronium 88
S
Salicylic acid 26
Saquinavir 82, 152
Seizure 24, 44, 46, 53, 57, 60, 59, 119, 144
Shock 55
anaphylactic 54
Sinuses, mucosa of 30
Skeletal muscle 30
Skin
blister fluid 30
discoloration 38, 59
rash 23, 27, 46, 53, 55, 57, 151, 159
reactions 53
yellow 26, 29, 31, 33, 35, 36
Sleep disturbances 23, 57
Sodium picosulfate 87
Sore throat 39
Speech, slurring of 10
Spleen 35
Statins 82
Stavudine 150
Steatorrhea 58
Steatosis 150
Stevens-Johnson syndrome 37, 59
Stomatitis 25, 57
Streptomyces
cattleya 43
griseus 14
mediterranei 10
Streptomycin 1–5, 7, 8, 14, 17, 19, 20, 54, 55, 64, 67, 85, 88, 91, 93, 117, 126, 147, 163, 173
drug interactions of 67
nephrotoxicity of 67
overdosage of 15
sulfate 14
Sucralfate 33, 85
Sulfonamides 82
Sulfonylurea 86, 87
Sumatriptan 87
Swelling 18, 20, 29, 31, 33, 35, 47
face 20, 46
joints 39, 40
lips 46
throat 46
Synovial fluid 16
T
Tachycardia 59
Tendon rupture 29, 31, 33, 34, 58
Tenofovir 150
Terfinadine 88
Terizidone 2–4, 22, 86, 93, 107, 117
drug interactions of 70
Theophylline 81, 82, 86
Thiacetazone 4, 5, 7, 8, 36, 55, 59, 85
Thionamides 25
doses of 25
Thiosemicarbazone 36
Thrombocytopenia 10–14, 38, 53, 54, 57, 59
Thrombophlebitis 44, 59
Thyroid
disease 139
enlargement 27, 58
stimulating hormone 140, 143
Tipranavir 152
Tobramycin 88
Topoisomerase 28
Torasemide 69
Toxic encephalopathy 10
Trazodone 87
Tremors 57
Tricyclic antidepressants 82
Trouble breathing 18, 20, 22, 46, 47
Tuberculosis 9, 16, 56, 65, 69, 149, 163
duration of treatment in 7
extensively drug resistant 112
in lactation, treatment of 91, 100
in liver diseases, treatment of 91, 96, 100, 102
in pregnancy, treatment of 91, 100
in renal insufficiency, treatment of 91, 93, 100, 101
osteoarticular 4
treatment of 5, 91, 93, 96
Tubocurarine 69
Tubular dysfunction 21, 56
Typhoid vaccine 88
U
Urinary retention 10
Urine 28
Urticaria 21, 56
Uveitis, anterior 38, 59
V
Vaginitis 59
Valproic acid 81, 88
Vancomycin 85, 88
Vasculitis 10, 53
Venlafaxine 87
Verapamil 82
Vertigo 19
Viral hepatitis 103
Vision tests 141
Vision, blurring of 10
Visual impairment 55
Vitamin 33
B12 87
B6 41, 86
Vomiting 10, 11, 19, 25–27, 36, 39, 40, 42, 44, 46, 47, 49, 51, 55, 57, 59, 62, 146, 150–152, 158
W
Wheezing 46
White blood count 140
Z
Zalcitabine 150
Zidovudine 82, 150
Zinc 33
×
Chapter Notes

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