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Chapter-59 Role of Aneuploidy Screening in Preimplantation Embryos

BOOK TITLE: Principles and Practice of Assisted Reproductive Technology

Author
1. Banker Manish
2. Gupta Reena
3. Aditi Kotdawala
ISBN
9789352705030
DOI
10.5005/jp/books/18020_60
Edition
2/e
Publishing Year
2019
Pages
12
Author Affiliations
1. Pulse Women’s Hospital, Ahmedabad, Nova IVF Fertility, Ahmedabad, Gujarat, India, Ahmedabad, Gujarat, India, Past President, ISAR, Pulse Women’s Hospital and Melbourne IVF, Ahmedabad, Gujarat, India, Nova IVI Fertility, India; Pulse Women’s Hospital, Ahmedabad, Gujarat, India; Indian Society for Assisted Reproduction (ISAR), Pulse Women’s Hospital, Ahmedabad, Gujarat, India; Indian Society for Assisted Reproduction (ISAR); Scientific Committee, IFFS 2016, NOVA IVI Fertility and Pulse, Women’s Hospital, Ahmedabad, Gujarat, India; Indian Society for Assisted, Reproduction (ISAR), Nova IVI Fertility, Ahmedabad, Gujarat, India, Nova IVI Fertility and Pulse Women’s Hospital, Ahmedabad, Gujarat, India, Ahmedabad, Nova IVI Fertility; Pulse Women’s Hospital; Scientific Committee, IFFS 2016, Ahmedabad, Gujarat, India, ASPIRE; ICMART and ASRM; Draft Committee for the ART Bill of India, ICMR; The Federation of Obstetrics and Gynecological Societies of India; Indian Society for Assisted Reproduction; Nova I
2. Nova IVI, Ahmedabad, Gujarat, India, Nova IVI Fertility, Ahmedabad, Gujarat, India, National Board of Examinations; Ahmedabad, Gujarat, India, Nova IVI Fertility, New Delhi, India
3. Nova IVI Fertility, Ahmedabad, Gujarat, India
Chapter keywords
Aneuploidy screening, preimplantation embryo, preimplantation genetic screening, chromosomal analysis, polar body biopsy, blastocyst stage biopsy, fluorescent in situ hybridization, whole genome amplification, advanced maternal age

Abstract

This chapter deals with the discussion on role of aneuploidy screening in preimplantation embryos. Aneuploidy is the presence of abnormal number of chromosomes, either extra or missing chromosomes, in the nucleus of a cell. It results from failure of separation of the paired chromosomes during cell division. Aneuploidy in preimplantation embryos can primarily arise during three developmental stages, i.e. the premeiotic divisions during gametogenesis, the meiotic division of gametogenesis, and the early mitotic divisions during embryogenesis stage. Preimplantation genetic screening (PGS) is performed in patients having no known chromosomal anomaly, mutation or other genetic abnormality. Proper counseling is very critical because in vitro fertilization patients planned for PGS do not have any specific identifiable genetic abnormality per se, and PGS is recommended in order to detect aneuploidies so that the chances of pregnancy may be increased in such patients. Techniques and limitations, different methods for chromosomal analysis, results of aneuploidy screening in various patient groups, concerns with preimplantation genetic screening, preimplantation genetic screening as universal screening are covered briefly in this chapter.

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