Systemic Drugs in Dermatology Kabir Sardana
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1Systemic Drugs in Dermatology
2 3Systemic Drugs in Dermatology
Kabir Sardana MD DNB MNAMS Professor Department of Dermatology and STD Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education & Research New Delhi, India
4
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Systemic Drugs in Dermatology
First Edition: 2016
9789385891243
Printed at
5Dedicated to
the divine grace of
Sri Ramana Maharishi
Who said that
All actions performed with unselfish devotion
With the aid of the three purified instruments
(body, speech and mind)
In the capacity of the servant of the Lord, became the Lord’s action
Thus one should stand free from the sense of “I” and “mine”
6
7Contributors 9Preface
There are a few dermatological drug books available in India, for the simple reason that there are so many drugs to be covered, unlike the West where getting regulatory clearance is difficult! My aim was to make drug reading enjoyable and quick. That is why, this book includes images of the mode of action of drugs, tabular listing of mode of action, indications, doses that are interspersed with a brief overview of guidelines. Wherever needed, brand names are mentioned, but I have no affiliation to any of the companies mentioned, they are just commonly used brands!
In India, unlike the West, almost all varieties of drugs are available, and this book discusses them in a prescribed format, which the reader can refer to depending on his/her needs (See How to Use the Book).
As no one can be an expert in all drugs, I have tried to involve experts in their fields. Some chapters are totally contributed by my brilliant contributors like the one on biological drugs. The chapters range in size depending on the controversies and importance attached to them. Thus, the chapter on immunosuppressants and steroids are long as they are probably the most commonly prescribed agents by dermatologists. The same is true of the chapter on antibiotics. The chapter on nutrition and skin is long only because there is so much data on it. Though I daresay not all of the drugs deliver results consistently, but as so many health supplements are consumed by the patient, a knowledge of these is important. A few chapters like the one on psychotropic drugs might seem an overkill, but a lot of our patients can be handled better, if we know how to use these drugs correctly. The miscellaneous drugs is probably wrongly titled but has many commonly used drugs.
A book of this nature was not easy to write and has been in progress for three years now! It went through a lot of hitches and I thank the publisher for tolerating them. I thank Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Group President), Mr Tarun Duneja (Director-Publishing), Mr PN Venkatraman (Director, International Marketing) and the entire production team of M/s Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, for their constant support and guidance in bringing out this book.
Though I have tried to make the book comprehensive and easy to refer and read, there may be drug or topics that I may have missed out. The reader can jot them down and maybe mail them to me for their incorporation in the next edition. We do plan to take out a handy drug book with the bare essentials and the readers suggestions are pertinent in this respect.
Kabir Sardana
10 11Acknowledgments
There is a saying that when the chips are down, of the three, colleagues, friends and family, the first to disappear are the first on the list! And sometimes or some say invariably, they are the reason for the problems!
Thats, when family and God, or the mystical force steps in. I could and would pen down my first hand experience in this regard, but for now I am fortunate to have seen the invisible hand of God, doing miracles, through the innumerable friends, that he sent along to help me along the way. This book is dedicated to them, some of whom may never read this book.
To my source of strength, my life partner and fellow dermatologist, Dr Supriya Mahajan who is always there for me even though I may not be able to reciprocate suitably.
My daughter Zoya
My Parents, Amba Sardana and Maj. Gen. KN Sardana in Dehradun
All my Teachers, Students
and Dermatologists, specially Dr RP Gupta and Dr HK Kar.
12
13How to Use the Book
The book can be referenced by the different readers in different ways depending on their needs.
  1. For the busy practitioner: Tabular list of uses, doses and drug monitoring.
    As most busy practitioners have little time to run through the book, an alphabetic listing of the drugs is given immediately after the Contents of the book.
  2. For the student, most chapters have a graphical depiction of the mode of action of drugs, with a table listing the same. Also an introductory section is given with graphics which serve as an overview of the chapter. This helps to give an understanding of the drug’s action and its clinical implications.
  3. For the reader who wants to read disease specific therapy, a good starting point, would be the Therapeutic Vignette where a listing of the various disorders being covered in this book are given. Also, in the index, common disorders are marked in bold.
  4. For the reader who is desirous of crosschecking the facts in the chapter, this book has done away with verbose referencing, though within the text under the section of uses, salient studies are mentioned with the lead author names. I feel this method of referencing gives credence to the authors work than just a numerical insert.
    A list of references is also given at the end of each drug, within which are the books that have been referenced. A mix of core pharmacology, rheumatology books and dermatological therapeutic books are listed in most chapters.
17List of Drugs
β-lactam antibiotics
Acitretin
Acyclovir
Adalimumab
Albendazole
Alitretinoin
Alopecia
Alpha lipoic acid
Alprazolam
Amitriptyline
Amlodipine
Amphotericin B ,
Anidulafungin
Antioxidant
Apremilast
Aripiprazole
Aspirin ,
Azathioprine
Azithromycin ,
Aztreonam
Betamethasone
Bexarotene
Bilastine
Biotin
Bosentan
Brodalumab
Buspirone
Carbapenems
Carotene
Caspofungin ,
Cephalosporins ,
Certolizumab pegol
Cethromycin
Cetirizine
Chloroquine
Chlorpheniramine maleate
Chlroquine
Ciprofloxacin
Clarithromycin
Clindamycin
Clofazimine
Codeine
Coenzyme Q10 (Ubiquinone)
Colchicine
Colistin
Corticosteroids
Cortisone
Curcumin
Cyclophosphamide
Cyclosporine
Cyproterone acetate
Dalbavancin
Danazol
Dapsone
Daptomycin
Deflazacort
Desloratadine
Dexamethasone
Diazepam
Diltiazem
Diltiazem
Doripenem
Doxepin ,
Doxycycline , ,
Drospirenone ,
Duloxetine
Dutasteride
Erythromycin
Escitalopram
Essential fatty acids ,
Etanercept
Ethinyl estradiol
Famciclovir
Faropenem
Fexofenadine
Finasteride
Fluconazole
Fluoroquinolones
Fluoxetine
Gabapentin
Gabapentin
Gatifloxacin
Glutathione
Green tea
Griseofulvin
Guselkumab
Hydrocortisone
Hydroxychloroquine
Hydroxyzine hydrochloride
Idebenone
Imipenem
Infliximab
Inocoterone
Iron
Isotretinoin
Isotretinoin micronized
Isotretinoin-lidose
Itolizumab
Itraconazole
Ivermectin
18Ixekizumab
Ketoconazole
Ketotifen
Leflunomide
Lenalidomide
Leucovorin
Levocetirizine
Levofloxacin
Liarozole
Linezolid
Loratidine
Lycopene
Lymecycline
Mebendazole
Meropenem
Mesalamine
Metformin
Methotrexate
Methoxsalen
Methylprednisolone
Micafungin
Miltefosine
Minocycline , ,
Mirtazapine
Mizolastine
Moxifloxacin
Mycophenolate mofetil
Naltrexone
Naltrexone
Nifedipine
Nonsteroidal anti-inflammatory drugs
Norfloxacin
Nortriptyline
Ofatumumab
Ofloxacin
Olanzapine
Omalizumab
Oral contraceptives
Oritravancin
Oxybutynin hydrochloride
Paroxetine
Penicillamine
Penicillins
Pentoxifylline
Pimozide
Polymyxins
Pomalidomide
Posaconazole
Potassium iodide
Prednisolone
Pregabalin
Promethazine
Propranolol
Psoralen
Quetiapine
Quinupristin-dalfopristin
Retinoic acid metabolism
blocking agents
Rifabutin
Rifamycins
Rifaximin
Risperidone
Rituximab
Saw palmetto
Secukinumab
Serenoa repens
Sertraline
Sildenafil
Sodium stibogluconate
Sparfloxacin
Spironolactone
Sulfasalazine
Talarozole
Tapentadol
Telavancin
Telithromycin
Terbinafine
Thalidomide
Tigecycline ,
Tildrakizumab
Tofacitinib
Tramadol
Tranexamic acid
Triamcinolone
Trimethoprim-sulfamethoxazole
Valacyclovir
Vancomycin
Venlafaxine
Verapamil
Vitamin A
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin B6
Vitamin C
Vitamin D
Vitamin E
Vitamin K
Voclosporin
Voriconazole
Zinc salts
19Therapeutic Vignettes
Page numbers followed by f and t refer to figure and table, respectively
Acne, antiandrogens
Acne, diet in
Alopecia, antiandrogens
Alopecia, nutritional agents
Antidepressant, how to choose
Antifungal drugs, salient features
Antifungal drugs
Antihistamine use in clinical practice
Antiprotozoal drugs in dermatology t
Anxiety and panic disorders
Atopic dermatitis, antihistamines
Atopic dermatitis, nutritional agents
Bullous disorders, diet
Chronic neuropathic pain, management
Hemangioma, proponalol t
Herpes genitalis
Hirsutism, antiandrogens
Hirsutism, drugs therapy t
Hormonal acne
HSV infections, antiviral agents
Hyperandrogenic states, OCP
Immunopharmacological drugs, mode of action
Isotretinoin, dose regimens
Isotretinoin use for acne t
Male pattern alopecia, finasteride t
MRSA infections and treatment
NIH protocol of administering cyclophosphamide and steroids in lupus nephritis
Panic disorders
Pruritus, antihistamines
Psoriasis, biologicals
Psoriasis, nutritional agents
Psychiatric afflictions, treatment
Psychotic/Delusional, treatment
Steroid dosimetry and tapering schedule f
Urticaria, antihistamines
Urticaria, diet
Vitiligo, treatment, PUVA
Vitiligo, treatment