FM4 Jaypee Brothers Medical Publishers (P) Ltd

The questions which are discussed here are a model of AIPGME/DNB conducted in Nov-Dec 2012 to 2015 and not obtained from NBE/DNB question bank, neither by force or compulsion by students, with due respect to the NDA (non disclosure agreement). If any similarities occur it may be due to mere coincidence and the author or the publisher is not to be blamed about. All questions discussed here can be found in one or the other question banks, guides and not any persons private property. The author is not related in anyway to the NBE/PGI/AIIMS exam conducting authority or agencies.

Jaypee Brothers Medical Publishers (P) Ltd.

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Jaypee Brothers Medical Publishers (P) Ltd.

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The views and opinions expressed in this book are solely those of the original contributor(s)/author(s) and do not necessarily represent those of editor(s) of the book.

All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission in writing of the publishers.

All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book.

Medical knowledge and practice change constantly. This book is designed to provide accurate, authoritative information about the subject matter in question. However, readers are advised to check the most current information available on procedures included and check information from the manufacturer of each product to be administered, to verify the recommended dose, formula, method and duration of administration, adverse effects and contraindications. It is the responsibility of the practitioner to take all appropriate safety precautions. Neither the publisher nor the author(s)/editor(s) assume any liability for any injury and/or damage to persons or property arising from or related to use of material in this book.

This book is sold on the understanding that the publisher is not engaged in providing professional medical services. If such advice or services are required, the services of a competent medical professional should be sought.

Every effort has been made where necessary to contact holders of copyright to obtain permission to reproduce copyright material. If any have been inadvertently overlooked, the publisher will be pleased to make the necessary arrangements at the first opportunity.

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First Edition: 2015

Second Edition: Digital Version 2017

Thrissur Medical College Alumni Association (TMCAA) is a CME Programme started in the year 2000 for Junior Doctors guiding and coaching for various PG entrance exams. Our principle is professionalism and structured orientation. Beyond guiding thousands of students to their dream PG and being one of the top institutes in the field we have also generated and promoted many deserving faculties and authors since the inception. Dr Rebecca had started her career as a PG guidance faculty from this institute four years back. Her teaching methodology and updated notes and techniques are well appreciated by students and her notes are of much demand as a “must for exam points”. We welcome and appreciate her effort in compiling her notes into students friendly entrance guide. Wishing all success to her and students reading second edition, Self Assessment and Review of Biochemistry.

It gives me immense pleasure to welcome the second edition of the book “Self Assessment and Review of Biochemistry” written by Dr Rebecca James. She is one of the best faculties in her subject in Calicut Medical College Alumni CME entrance guidance programme. The book comprises a vast collection of questions from the recent exams and thoroughly described. I am sure that now this book will become a necessity among the PG entrance Aspirant's books. Wishing all the success for the book.

The second edition of the book “Self Assessment and Review of Biochemistry” has been written as a course material for the various national level (NBE pattern), central institutes, state level, and private medical entrance exams. Dr Rebecca James has been a very keen and devoted teacher in her career. Her new and innovative visual and easy learning techniques have been much useful for her students. The references given are up-to-date and authentic and the presentation and charts are much students friendly. I do recommend this book for PG entrance aspirants. I heartily congratulate her and wish her all the success for this excellent piece of work.

After the overwhelming reception of the first edition of the book across India I am more than excited to release of the second edition. The responses from toppers of various PGMEE speak for the success of the first edition. In this edition we have incorporated the reviews and suggestions about the first edition from readers, yet the same format have been kept in order to remain it as a perfect book for PG aspirants.

Writing a book for Postgraduate Medical Entrance in Biochemistry was a dream for me when I was doing my PG career. But when I started Postgraduate medical entrance coaching, gradually I recognised how hard it was for students to learn the subject. There is no subject expert written book in biochemistry for the major exams like PGI, AIIMS, AIPGME, JIPMER, or even state entrance exams. None of the students had learned biochemistry properly or were not taught properly in their MBBS course and for entrance. Students were forced for learning from books not by a subject expert which are just to pick some points from standard books without explanation or internet reference. Biochemistry comprises up to 8% in NBE exams and up to 30% in PGI exams and lots of researches and updates are coming up in this field. My students often would come asking with doubts quoting some of these guides in which many answers I found wrong. As four years passed in postgraduate medical entrance coaching I made my own notes based on standard textbooks with clinical scenarios and emphasised on teaching to think and correlate rather than mugging up biochemistry. Gradually students from other institutes started asking for my notes and requested me to write a book so that they could also read it. This book is meant for it. I approached Jaypee Brothers Medical Publishers (P) Ltd., and they accepted my proposal, the remaining is in front of you.

Writing this book has never been easy to me. “No tears in the writer, no tears in the reader. No surprise in the writer, no surprise in the reader.” — Robert Frost.

Staff and Residents of Department of Biochemistry, Government Medical College, Kozhikode

Dr Akhil K, Dr Goutham Nallaiyan for their mental support

Mr Praveen TMCAA staff

Dear students,

I consider you as one of my students by using this book and I believe it is my responsibility to guide you through in your postgraduate medical exams and I wish you all the best to come out with flying colors. I know that many of you feel that Biochemistry is one of the most boring subjects you have learned in MBBS. This is primarily due to the methodology you have been taught and you tend to think of it as a subject of cycles and test tubes. But the fact is that if it was taught with all clinical correlations and the practical applications the subject becomes interesting and beautiful. I hope you will have a renewed perception about biochemistry after reading this book.

“I consider myself fortunate to have attended Dr Rebecca's high yield lectures at TMCAA. She is a very dedicated teacher and makes the core concepts in Biochemistry simple and interesting. Her book, Self assessment and review of Biochemistry is a must read for all entrances especially for PGI as they ask almost 20 + questions from biochemistry and related topics. The book will compensate for those who cannot attend her classes as it is well written, updated, error free and revision friendly.”

“I heard about Dr Rebecca's Self assessment and review of Biochemistry during my PG preparation time, when I was confused about what book to read for Biochemistry. I feel this book as a perfect example of how an entrance preparation book should be. This helped me a lot especially during the last few days before the exam, as it is concise and at the same time high yielding”

“Madam, I am your student in TMCAA. I want to thank you so much. All the questions that came from Biochemistry was covered by you. Your classes made the difference.”

“Thank you for your valuable teaching and guidance.”

“Thanks a lot for your classes and wonderful book. I could answer many questions from Biochemistry. Madam's class and book matter a lot to me.”

“Thank you mam…Your classes and book have always given us the extra edge. Whatever we know about Biochemistry is only because of you.”

“Thank you so much mam. All biochemistry questions were from your class and book only. I attended all biochemistry questions with confidence. That is the success of a good teacher like you mam. God bless u”

“Mam got 250 rank in AIIMS. Your page and information provided by you helped me a lot”

“I got 27th rank in JIPMER Nov 2015. Your classes were excellent and inspiring and everything you taught only was asked. Your last minute revision in the facebook group was really useful. Thank you so much mam”FM15

“It is written in my fate that I should understand the true core of biochemistry after MBBS through your book. In Islam it is told that to sustain your life even after death is to give charity and to teach the ignorant. Mam you are one who deserves that place. Hats off to you mam to give us knowledge of Biochemistry through your book”

“ Hello mam this is Nikhil from Banglore. I am preparing for PG entrance, I bought your book. I usually hate biochemistry, but after reading the first chapter itself I fell in love with biochemistry. It is an awesome way of explanation you have given mam”

“ Thank you mam for such a wonderful book. You have just simplified everything. Mentioned all must know topics. The high-yielding points represented very well. I was always having fear for Biochem, it was a nightmare for me. Your book boost up my confidence for preparation. Thank you mam for such big help”

“Thank you mam for your book and forum in facebook. I attempted all biochem questions correctly in AIPGMEE and DNB”

“Biochem was the dreadful subject in my career. I am very poor in basics. Then I got to know about your book. I can not express my gratitude and words enough to express the amount of confidence your notes in the book have instilled in me now. Thank you for the wonderful book”

“Mam exam was good. All from your book and updates in the facebook group”

“Hello mam. Someone suggest your book last year and may I just say that its brilliant. I have struggled with biochemistry, the book made so many concepts clear to me, even everything asked in PGI and AIIMs this year was mentioned in your book. So thanks a lot.”

“Thank you mam for this time in AIIMS biochemistry questions I was more confident in answering because I could recall the questions as direct lines from your book”

“Hi mam I would like to thank you for your guidance in TMCAA and your awesome book. I got rank 158 in AIIMS”

“Thank you for your wonderful lecture and book I got rank 78 in AIIMS in UR category”

All questions in DNB were direct from your book. Your lecture is the best of biochem I ever attended”

“Mam your book is too good. I like biochemistry and Harper a lot. Your book is no less than Harper “

“I read your book though not fully, but I attended all biochem question in Nov AIIMS 2015. I always felt I would not read biochem, but after buying your book things changed. Thanks a lot”FM16

“Mam I am your student in TMCAA. I am extremely to your ultimate teaching and your book. I could read whole biochemistry in just 2 and half days, and answer almost all the biochemistry questions correctly”

“All questions from your book mam. Me and Calicut Medical College is proud of you”

“Your book is an epic mam. I marked almost all questions right. I am happy because for the first time I could solve biochemistry”

“You are the best mam. Your words were questions. Mam biochem I felt so happy to answer because of you”

“Biochemistry was a dreaded subject for me. And in my previous attempt I did not even touch this subject as it looked scary. A friend of mine referred me your book. I bought it and read it. I must say “What an effort mam!!! I am so happy and satisfied with your book and it gave me confidence that ‘Yes, even I can attempt biochemistry’ questions.”