Quantitative Research Methods in Health Sciences Rajendra Karkee
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1Research Process
 
CHAPTERS
  • 1. What is Research?
  • 2. Health System Research
  • 3. Research Process and Research Integrity
Research is an organized quest for new knowledge based on curiosity or perceived needs. Research is about searching, testing, intervening, developing, reasoning etc. to give new knowledge. This section briefly describes about research and research proposal development with reference to health research.2

What is ResearchCHAPTER 1

How do you acquire knowledge and verify that the new acquired knowledge is true? You may resort to either of followings:
  • By the authority: You are told the ‘truth’ by someone you believe in or knowledge is derived from tradition. I did a research to write this book and as a reader, you believe it and follow it. As a student, you are likely to depend on your teachers. However, there can be contradictions among authorities. The solution to contradictions should be guided by criteria.
  • By the intuition: It is your judgement that or it seems to stand to reason that something is true after careful observations. Intuition is a kind of insights someone gains after experience.
  • By the scientific methods or research: You follow a systematic investigation that produces a generalizable knowledge. Not all investigations or studies can be termed as ‘research’. Firstly, a research is characterized by observations or experiments that take place in a known framework and can be replicated to generate the same evidences; and secondly, the results should be generalizable to a broader community, not restricted within a specific context.
A research refutes inadequate practices based solely on unscientific methods including tradition, authority, personal preferences, untested hypotheses or common sense. The research helps to generate evidence-based knowledge. Epidemiology provides an acceptable scientific method for public health and has been developed over a period of last few centuries, concomitantly with the growth of modern 4scientific researches. However, epidemiology is also criticised as being mainly confined to the biomedical or the clinical domain, focussing on the distribution and determinants of disease rather than having a broad community and ecologic perspective (Shy, 1997). Recently, efforts have broadened to include the social, economic, environmental and cultural determinants of health as a social epidemiology.
A research is often described as being theoretical research (i.e. developing, exploring or testing the theories or ideas) or empirical research (i.e. based on observations and measurements of reality) on the basis of philosophical approach (WHO, 2001). However, in reality, most researches are a blend of these two terms: a comparison of theories about how the world operates with observations of its operation. Many health researches are based on epidemiological designs and tend to be empirical.
The Epistemology is the philosophy of knowledge or of how you come to know, while a methodology is more focussed on the specific ways (i.e. methods) that you use to generate knowledge. That is why the methodology of a research can be broadly based on a theoretical framework. The theoretical framework should disclose the methods, methodology, theoretical perspective and epistemology. A research which is guided by behavioral, social, and organizational (or systems) paradigms and examines how individual, community and health system factors may affect the leprosy prevalence and leprosy control programs in a country, can be based on the theoretical framework of the Health Belief Model (Rosenstock et al., 1974). In fact, many researches related with preventive health behaviors including health promotion, with compliance with recommended medical regimens, and with health care visits are based on the Health Belief Model. Researches seeking to understand maternity service utilization can be based on the theoretical framework of Andersen's Behavior Model (Andersen, 1995; Karkee et al., 2014a; Titaley et al., 2009) or Ecological model, (Wild et al., 2010). A conceptual framework, such as the three delays framework for utilization of the institutional delivery services, has been drawn using such theoretical bases (Karkee et al., 2013a; Thaddeus and Maine, 1994).
Over the past centuries, the scientific method has refined itself and has made its base on: (i) Empiricism: the notion that enquiry ought to 5be conducted through observation and knowledge verified through evidence; (ii) Determinism: the notion that events in the world occur according to regular laws and causes.
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FIGURE 1.1: Logic of scientific reasoning
The aims of research are to discover these rules and causes; and (iii) Scepticism: the notion that any proposition or statement, even those by great authorities, is open to analysis and critique.
The reasoning or the inference is the main characteristic of a research. The logic of a scientific reasoning can be a deductive or an inductive. The deductive reasoning starts from a broader theory and narrow down to hypothesis, specific observations and a conclusion (top-down), while the inductive reasoning starts from a specific observation, pattern, tentative hypothesis and to a broader theory (bottom-up). Thus, the deductive and inductive approaches are complementary making a cyclic process (Figure 1.1): the deductive sets out from a theory and hypothesis to a conclusion while the inductive sets out from an observation to a tentative hypothesis and a theory. A scientific hypothesis is a statement that specifies the expected nature of the relationship between two or more sets of variables and plays an important role in science. Note that a hypothesis can be induced from the observations or the measurements or be deduced logically from the statements and/or the mathematical models which specify the causal relationships postulated by the theories.
The inductive process is more open-ended, exploratory and emphasizes on ‘observation’ (i.e. empiricism/naturalistic); while the deductive process starts with a preoccupation (i.e. hypotheses 6or positivistic/rationalism) and tests the hypotheses by making observations (i.e. whether the hypotheses are falsifiable). The inductive process suits a qualitative research while the deductive approach is applied usually in a quantitative research. Historically, the scientific enquiry was built on the philosophy of deductive logic (i.e. quantitative paradigm). Epidemiology, the base of public health research, is largely quantitative. The purpose is to find possible causal relationships between exposure and outcome and to generalize the findings to a population. However, public health issues can be complex in nature and quantitative research findings alone are insufficient to support practitioners and policy makers in making evidence-based decisions. Human behavior, thoughts, opinions, interactions, and perceptions (i.e. questions on why and how) may need detail qualitative investigation. So, both processes may be necessary to investigate in a ‘pragmatic way’.
Research is an important aspect of health sciences. The term ‘health research’ can denote a broad range of research in health sciences, which can be conceptually distinguished into four groups on the basis of object and level of analysis as shown in Table 1.1: biomedical research, clinical research, epidemiological research, and health systems research (Frenk, 1993).
TABLE 1.1   Classification of health research
Level of analysis
Object of analysis
Conditions (Health problems)
Health care responses
Individual and subindividual
Biomedical research Basic biological processes; structure and function of the human body; pathological mechanisms
Clinical research Efficacy of preventive, diagnostic, and therapeutic procedures; natural history of diseases
Population (Public Health Research)
Epidemiological research Frequency, distribution, and determinants of health needs
Health systems research Effectiveness, quality, and costs of services; development and distribution of resources for care
Source: Adapted from Frenk J, 1998
The object of analysis refers to conditions as the biological, psychological and social 7processes that constitute the levels of health. It also refers to the responses which the society organises for improving health conditions. There are two levels of analysis: first are individuals or parts of individuals (i.e. organs, cells, or subcellular elements); and second are aggregate levels of groups or populations. Since, public health has been recognized as a multidisciplinary and multisectoral discipline in the form of organized social response for sustained population-wide health improvement, the epidemiological and health system research usually fall under the domain of public health research. However, an interdependency and overlap can exists between various types of research, for example an epidemiological investigation of a disease can lead to health service research to prevent the disease.