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First Edition: 2017

The past decade has witnessed an unprecedented interest in limbic system diseases and their treatments, as functional imaging and neuromodulation of limbic circuitry have gained sway diagnostically and therapeutically, and improvements in operative technique have made approaches to this region increasingly more feasible. Epilepsy, tumor, vascular, and stereotactic neurosurgeons need to understand thoroughly the complex regional anatomy and relationships of the limbic system with the brainstem, diencephalon, and associated vasculature, in order to navigate safely in this region. Unfortunately, and owing to the inherent complexity of this region, it is difficult to find a single compendium of practical surgical knowledge about the limbic system.

The limbic and paralimbic areas of the human brain hold profound fascination for both neuroscientists and neurosurgeons. The essential functions of the connections necessitate maintaining functions of the limbic and paralimbic structures, an important goal of surgery in this region. These critically important neuropsychological functional connections are often compromised by the pathology of the mesial temporal lobe, thus making surgery in this region safe, as the deficit created by the pathology is typically not worsened by surgery. The fact that much of the regional pathology is benign, but the conditions they cause, such as epilepsy are not, makes operating in this area a common challenge for neurosurgeons. The unique, obscure, and buried anatomy, the critical surrounding neurovascular structures of limbic and paralimbic archi- and paleo-cortex and the varied, complex pathology makes surgery of this region challenging in the best of circumstances for the most experienced surgeons. For these many reasons, we have dedicated a large portion of our practices, career and research to the mastery of surgery in this region.

The production of this book owes significant gratitude to the many who have shaped out interest and knowledge in the field of neurosurgery. We would like to thank Dr Andre Olivier who sparked the interest in limbic neurosurgery. Drs Walter Whisler and the late Roy AE Bakay who provided tremendous mentorship and serves as role models for excellence. The physical production of this work would not have been possible without the dedicated efforts of Anthony Serici at Rush University's department of Anatomy and Cell Biology.

The limbic and paralimbic areas of the human brain hold profound fascination for both neuroscientists and neurosurgeons. Maintaining the essential neuropsychological functions of the limbic and paralimbic structures is an important goal of surgery in this region. These critically important neuropsychological functional connections are often compromised by the pathology of the mesial temporal lobe, thus making surgery in this region safe, as the deficit created by the pathology is typically not worsened by surgery. The fact that much of the regional pathology is benign, but the conditions they cause, such as epilepsy are not, makes operating in this area a common challenge for neurosurgeons. The unique, obscure, and buried anatomy, the critical surrounding neurovascular structures of limbic and paralimbic archi- and paleo-cortex and the varied, complex pathology makes surgery of this region challenging in the best of circumstances for the most experienced surgeons. For these many reasons, we have dedicated a large portion of our practices, career and research to the mastery of surgery in this region.