Series Editor
Nandita Palshetkar MD FCPS FICOG FRCOG (UK)
President FOGSI 2019 Scientific Director, Bloom IVF Professor Department of Obstetrics and Gynecology Dr DY Patil Medical College, Hospital and Research Center
Navi Mumbai, Maharashtra, India
Editors
Sunita Tandulwadkar MD (Obstetrics and Gynecology) FICS (Gyne-Endoscopy) FICOG
Head, Department of Obstetrics and Gynecology, Ruby Hall Clinic, Pune, Maharashtra, India Chief, Ruby Hall IVF and Endoscopy Center, Pune Director, Solo Clinic, Center of Excellence Infertility and Endoscopy Founder and Medical Advisor, Solo Stem Cells, Stem Cells Research and Application Center, Pune Chief, IVF and Endoscopy Department, Dr DY Patil Medical College, Pune, Maharashtra Co-Founder, Solo Research Foundation—Sponsor a Birth President, IAGE (2019-2020) Chairperson, Maharashtra Chapter ISAR (2018-2020) 2nd Vice President, Indian Society of Assisted Reproduction (ISAR) (2020-21) Founder Secretary, Maharashtra Chapter ISAR Vice-President, West Zone FOGSI (2017) Chairperson, FOGSI Infertility Committee (2011-2013) Elected Board Member, International Society of Gynecological Endoscopist (ISGE) (2013-2017) Advisor and Reviewer, Journal of Human Reproductive Sciences
Madhuri Patil MD DGO FCPS DFP FICOG (Mum)
Clinical Director, Dr Patil's Fertility and Endoscopy Clinic, Bengaluru, Karnataka, India Editor-in-Chief, Journal of Human Reproductive Sciences Associate Editor, The Onco Fertility Journal Editorial Board Member, Endocrine Society 2020 and 2021 Founder President, Karnataka Chapter of Indian Society for Assisted Reproduction Vice-President and Founder Member, Fertility Preservation Society (India) Vice-President and Founder Member, PCOS Society (India)
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_fm11Preface
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FOGSI Focus Use of Adjuvants in Infertility
First Edition: 2021
9789389587975
Printed at
_fm5Contributors
- Ameet S Patki
- Medical Director, Fertility Associates
- Mumbai, Maharashtra, India
- Hon Associate Professor
- K J Somaiya Medical College and Hospital
- Mumbai, Maharashtra, India
- Consultant
- Khar Hinduja Hospital and Surya Group of Hospital
- Mumbai, Maharashtra
- Past President, MOGS, 2014–15
- Chair, West Zone RCOG, 2015–19
- 2nd Vice President, ISAR, 2019–20
- General Secretary Maharashtra ISAR
- Bhavana Mittal
- Director, IVF Specialist
- Shivam IVF and Infertility Center
- Max Superspeciality Hospital
- New Delhi, India
- Dimple Atul Desai
- Embryologist
- DPU IVF and Endoscopy Center
- Pune, Maharashtra, India
- Gautam Khastgir
- Director
- BIRTH Fertility Clinic
- Kolkata, West Bengal, India
- Madhuri Patil
- Clinical Director, Dr Patil's Fertility and Endoscopy Clinic Bengaluru, Karnataka, India
- Editor-in-Chief, Journal of Human Reproductive Sciences
- Associate Editor, The Onco Fertility Journal
- Editorial Board Member, Endocrine Society 2020 and 2021
- Founder President, Karnataka Chapter of Indian Society for Assisted Reproduction
- Vice-President and Founder Member, Fertility Preservation Society (India)
- Vice-President and Founder Member, PCOS Society (India)
- Mayoukh Kumar Chakraborty
- Consultant in Gynecology, Obstetrics and Reproductive Medicine
- BIRTH Fertility Clinic
- Kolkata, West Bengal, India
- N Sanjeeva Reddy
- Professor and Head
- Department of Reproductive Medicine and Surgery
- Sri Ramachandra Institute of Higher Education and
- Research
- Chennai, Tamil Nadu, India
- Radha Vembu
- Associate Professor
- Sri Ramachandra Institute of Higher Education and
- Research
- Chennai, Tamil Nadu, India
- Ritu Hinduja
- Senior Consultant Fertility Specialist
- Nova IVF
- Mumbai, Maharashtra, India
- Member of Managing Committee, Indian Society of Assisted Reproduction
- Rohan Krishnakumar
- ART and Endoscopic Consultant Gynecologist-Obstetrician
- J K Women Hospital
- Thane, Maharashtra
- Seema Pandey
- President, Azamgarh Obs Gyn Society
- Managing Committee Member, ISAR (2018–20)
- Secretary, UP ISPAT (2018)
- S Krishnakumar
- Endoscopic Surgeon, Gynecologist, Infertility Specialist
- JK Women Hospital
- Thane, Maharashtra, India
- Sonal Sagar Vaidya
- Chief Embryologist
- ISAR, ACE, IFS, ESHRE
- Ruby Hall Clinic
- Grant Medical Foundation
- Pune, Maharashtra, India
- Sujata Kar
- Consultant Gynecologist
- Kar Clinic and Hospital Pvt Ltd
- Sunita Tandulwadkar
- Head, Department of Obstetrics and Gynecology, Ruby Hall Clinic, Pune, Maharashtra, India
- Chief, Ruby Hall IVF and Endoscopy Center, Pune
- Director, Solo Clinic, Center of Excellence Infertility and Endoscopy
- Founder and Medical Advisor, Solo Stem Cells, Stem Cells Research and Application Center, Pune
- Chief, IVF and Endoscopy Department, Dr DY Patil Medical College, Pune, Maharashtra
- Co-Founder, Solo Research Foundation—Sponsor a Birth
- President, IAGE (2019–2020)
- Chairperson, Maharashtra Chapter ISAR (2018–2020)
- 2nd Vice President, Indian Society of Assisted Reproduction (ISAR) (2020–21)
- Founder Secretary, Maharashtra Chapter ISAR
- Vice-President, West Zone FOGSI (2017)
- Chairperson, FOGSI Infertility Committee (2011–2013)
- Elected Board Member, International Society of Gynecological Endoscopist (ISGE) (2013–2017)
- Advisor and Reviewer, Journal of Human Reproductive Sciences
- Swati Sandipan Ingale
- Senior Embryologist
- ISAR, ACE, IFS, ESHRE
- Ruby Hall Clinic, Grant Medical Foundation
- Pune, Maharashtra, India
- Teena Trivedi Desai
- Consulting Obstetrician Gynecologist
- Aviva Fertility Clinic
- Mumbai, Maharashtra, India
It gives me great pleasure to know that the FOGSI Focus Use of Adjuvants in Infertility is ready for release. The aim of this FOGSI Focus is to highlight a new emerging frontier in the area of pharmacotherapy, viz. the role of nutraceuticals, medical nutrition therapy and other medications to improve success rates in our field.
The chapters have been written by eminent experts in research and therapy areas including senior FOGSIans and faculty who are in teaching positions throughout the country. I hope this FOGSI Focus will help to improve your understanding of the role of antioxidants, micronutrients, reactive oxygen species, the scientific theories behind medical nutrition therapy and the growing evidence for adjuvant therapies.
The Presidential theme for my FOGSI year 2019 is “We for Stree—Safer, Stronger, Smarter”. During the year, we will attempt to focus on academic, social and community health initiatives aimed at improving the profile of women in India. I urge every single one of you to unite and stand with us and contribute to a series of initiatives which will refocus our contributions not only toward the health of Indian women, but also their social, financial and educational upliftment as well.
FOGSI is committed to delivering continuing medical education programs and also has a raft of initiatives to help women from poor socioeconomic areas receive appropriate care through our social and community healthcare initiatives, e.g., the FOGSI Saving Mothers Initiative. The FOGSI Manyata project also aims to bring a certain minimum standard of care to the women of India via accreditation and training of private nursing homes and healthcare personnel.
I congratulate the Editors of the book Dr Sunita Tandulwadkar and Madhuri Patil for their effort in helping to publish this FOGSI Focus and hope that it adds a new dimension in your practical approach to prescribing.
Nandita Palshetkar MD FCPS FICOG
President, FOGSI (2019)
President, IAGE (2017–18)
Chairperson, MSR (2017–18)
Vice President, AMOGS (2016–18)
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Office Bearers of Team FOGSI 2019 | |
President Secretary General Vice President (West Zone) Vice President (West Zone) Vice President (North Zone) Vice President (East Zone) Vice President (South Zone) Deputy Secretary General Treasurer Joint Treasurer Joint Secretary lmmediate Past President President Elect | Dr Nandita Palshetkar Dr Jaydeep Tank Dr Rajendrasingh Pardeshi Dr Haresh Doshi Dr Sudha Prasad Dr Rajat Mohanty Dr Aswath Kumar Dr Madhuri Patel Dr Suvarna Khadilkar Dr Parikshit Tank Dr Ameya Purandare Dr Jaideep Malhotra Dr Alpesh Gandhi |
Chairpersons of the Committees | |
Adolescent Health Clinical Research Endocrinology Endometriosis Endoscopic Surgery Ethics and Medicolegal Family Welfare Food Drugs Medico Surgical Equipment Genetics and Fetal Medicine HIV/AIDS Imaging Science Infertility International Academic Exchange MTP Medical Education Medical Disorders in Pregnancy Midlife Management Oncology Perinatology Practical Obstetrics Public Awareness Quiz Safe Motherhood Breast Sexual Medicine Urogynaecology Young Talent Promotion | Dr Girish Mane Dr Meena Samant Dr Pratik Tambe Dr Kuldeep Jain Dr B Ramesh Dr Geetendra Sharma Dr Shobha Gudi Dr Vidya Thobbi Dr Mandakini Pradhan Dr Mrutyunjay Mohapatra Dr Meenu Agarwal Dr Asha Baxi Dr Varsha Baste Dr Bharti Maheshwari Dr Abha Singh Dr Komal Chavan Dr Rajendra Nagarkatti Dr Bhagyalaxmi Nayak Dr Vaishali Chavan Dr Sanjay Das Dr Kalyan Barmade Dr Sebanti Goswami Dr N Palaniappan Dr Sneha Bhuyar Dr Sudha Tandon Dr Nita Thakre Dr Vinita Singh |
The last two decade has witnessed a striking progress in assisted reproductive technology (ART). There has also been a significant increase in the success rate of ART due to the introduction of adjuvant therapy in clinical practice, novel technologies and improved embryo culture systems. It is important that all ART clinicians keep abreast with all the newer tests, drugs, techniques and technology to implement them in their practice and provide optimal care to their patients.
This book brings fresh insights into the adjuvant therapy that can be used in clinical practice. It also provides up-to-date and practical information on the adjuvants that can be used in the laboratory management of subfertility. Every chapter lay stress on current advances in the potential strategies of various therapeutic options available to improve the management of the sub-fertile couple. Most of these adjuvants have a controversial evidence and this has been covered very well in all the chapters. This will enable each clinician depending on his/her practice conditions to adapt these newer techniques and technologies.
The preparation of this book was driven by a desire of our dear FOGSI president, Dr Nandita Palshetkar (2019) to provide a hands-on practical guide on the various add on treatments in assisted reproduction that would be accessible to those practising in this field. The contributing authors include nationally renowned clinicians and scientists actively involved in the field of reproductive medicine. We are most grateful to all who have made the publication of this “FOGSI Focus” possible.
We hope that you will enjoy reading this ready reckoner on adjuvants in ART as much as we did editing it.
_fm13Acknowledgments
We thank Nandita Palshetkar, President FOGSI (2019) for giving us the opportunity to publish the FOGSI Focus Use of Adjuvants in Infertility. We are extremely thankful to each and every author who has contributed to this edition of the FOGSI Focus. We are especially thankful to Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Mr MS Mani (Group President), Ms Chetna Malhotra Vohra (Associate Director—Content Strategy), Ms Pooja Bhandari (Production Head), Ms Kritika Dua (Development Editor) and the publishing staff at M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, for their work in completing this book successfully.