IAP Handbook of Developmental and Behavioral Pediatrics Jeeson C Unni, Samir H Dalwai, Shabina Ahmed, Kawaljit Singh Multani, Leena Deshpande, Leena Srivastava
INDEX
Page numbers followed by b refer to box, f refer to figure, fc refer to flowchart, and t refer to table.
A
Abuse
and neglect, types of 253
impact of 254
physical 253
sexual 254, 295
substance 192, 273
Acupuncture 292
Addictive behaviors 281
ADHD See Attention deficit hyperactivity disorder
ADI-R See Autism diagnostic interview-revised
ADOS See Autism diagnostic observation schedule
Aggressive disorder 272
Agoraphobia 183
Airway and breathing 163
Akinesia 147
Alper's disease 155
Amino acid disorders 49
Ammonia 156
Anemia 68
management of 263
Aneuploidy 48
Angelman syndrome 92, 123, 152
clinical features 92
differential diagnosis 93
management 93
Angiomyolipomas 106
Anthropometry 56
Antibiotics decisions 35
Antiepileptic drugs 140
Anxiety 68, 82, 177, 180, 212, 233, 239, 272
clinical features 181
disorder 183
treatment of 184
type of 181, 183
evaluation for 225
risk for 282
Aortic stenosis, supravalvular 51
Applied behavior analysis 234, 266
Ariel Tison method 43t
Arrhythmias 116
Artificial intelligence 287
Asperger disorder 231
Asperger syndrome 231
Assessing development 42, 42t
ASSR See Auditory steady-state response
Asthma 120
chronic 254
Ataxia 147
Athetosis 148, 150
Atomoxetine 174, 194
Attention deficit 239, 258
Attention deficit hyperactivity disorder 55, 82, 86, 107, 123, 129, 149, 160, 169172, 172b, 172t, 176, 192194, 211, 228, 243, 250, 257, 272, 278
clinical diagnosis 170
management 173
subtypes of 170fc
symptoms of 170, 171fc
Audible block 221
Audiologic management 197
Audiological tests 198t
Auditory 215
integration therapy 292
steady-state response 199
Auditory-oral approach 200
Auditory-verbal approach 200
Autism 203, 236, 239, 267
classic 231
diagnostic interview-revised 258
diagnostic observation schedule 258
early infantile 231
intervention program for 235f
management of 235fc
social interaction of 237t
spectrum 258
tools for assessment of 233t
Autism spectrum disorder 67, 86, 123, 223, 227, 231, 250, 257, 273, 292
cause of 81
clinical diagnosis 228, 232
clinical features of 232fc
diagnosis of 233
differential diagnosis 233
learning disabilities 215
management 234
medical comorbidities in 227
symptomatology, prevalence of 67
symptoms of 232
Autistic disorder 231
Autistic spectrum disorder 75, 107, 140
Autoimmune
diseases 156
encephalitis 140
neuropsychiatric disorder 190
Autonomic function, deterioration of 116
Autosomal dominant inheritance
neurocutaneous disorder 99
pattern 49f
Autosomal recessive inheritance pattern 49f
Azoospermia 85
B
Balance disorders 205
causes of 206b
Basal ganglia 190
disorders 149
Bayley's infant neurodevelopmental screen 25
Bayley's scale 31
Behavior and temperament 11
Behavior modification 266
Behavior therapy 278
Behavioral difficulty 155, 258
Behavioral disorders, management of 272
Behavioral issues 65
Behavioral problems 283
range of 89
Behavioral regulation 233
Behavioral screening 27
Behavioral surveillance and screening 26
Behavioral symptoms 82
Behind the ear 197
Benzodiazepines 141
Beta-amyloid precursor protein 63
Binet Kamat test 31
Biological theories 14, 18
Biotinidase deficiency 31
Bipolar disorder 192
Bladder control, absence of 132
Blood pressure 103, 135
Bowel control 132
Bradykinesia 147
Brain
development 261
function 187
pathways 191f
structure 187
tissue, damaged 292
tumors 166, 168
Breath-holding spells 138
Breathing disorders, sleep-related 122
Bruxism 116
C
Carbamazepine 141
Cardiac conditions, treatment of 76
Cardiac rhabdomyomas 106
Cardiofaciocutaneous syndrome 76
Cardiovascular disorder 254
CARS See Childhood autism rating scale
Cataracts 73
Celiac disease 68
Central disorders 122
Central nervous system 6, 44, 77, 99, 106
infection 191
maturation of 7
Cerebral palsy 123, 143, 145, 257, 258, 269
classification of 143
clinical diagnosis 144
management 144
presentations of 145t
risk factors for 144
types of 145
Cerebrospinal fluid 156, 159
Ceruloplasmin 156
Charcot Marie tooth 206
CHARGE syndrome 152
Chemotherapeutic agents 167
Chemotherapy 167
Child abuse 253
incidence 253
risk factors for 254
Child development, theories on 13
Child Rights Commissions Act 295, 297
Child, prematurity of 10
Child's development, measurement of 8
Child's eyes 264
Child's program 58
Childhood autism 231
rating scale 258
Childhood cancer, treatment of 166
Children, development of 261
Children's behavior 3
Chiropractic care 292
Cholesterol metabolism 160
Chorea 148, 149, 153
Chromosomal disorders 248
Chromosomal karyotype, high-resolution 52
Chromosomal syndrome 29
Chromosome 48, 90
number of 48
Chronologic age 41
Circadian rhythm sleep-wake disorders 122
Clinical counseling 276
Clonazepam 126, 127
Clonidine 126, 127, 194
CNS See Central nervous system
Coagulation defects 75
Cochlear implant 197
Cognition 40
Cognitive ability 54
Cognitive behavior 102
therapy 135, 188, 247, 278
Cognitive development 16
Cognitive theories 16
Cognitive-adaptive disability, psychotropic management of 273
Cognitive-developmental theory 3, 18
Common movement disorders, characteristics of 147t
Common neurodevelopmental disorders 123t
Communication
augmentative 118
behavior, and socialization, red flags for 263
disorders 220, 245
nonverbal 221
technology 287
verbal 221
Communication-related handicapped children 267
Community-based facilities and care 1
Complex molecules group 159
Consanguinity, history of 30
Constipation 61, 68, 136, 233
signs of 230
symptoms of 230
Constraint-induced movement 270
Control one's dysphoric feelings 281
Convulsive disorder 272
Coprolalia 191
Corencephalopathy 154
Cornelia de Lange syndrome 52
Cortical dysplasias 106
Cortical visual impairment 202
Costello syndrome 76
Counseling 276, 277
behavior therapy 277
COVID-19 4, 288
Cri du chat syndrome 48
D
Daily living, activities of 28
Deaf-blindness 59
Deafness, levels of 196f
Dental enamel pits 105
Deoxyribonucleic acid 82
Depression 68, 177, 82, 185, 187, 189, 192, 233, 239, 272
Depressive disorder 185
clinical features 185
major 185, 186
management 188
Depressive symptoms, chronicity of 186
Desmopressin 135
Development supportive care, implementation of 38
Development, principles of 7
Developmental and behavioral management 59
Developmental behavioral disorders 243
clinical features 245
management 246
treatment of 246
Developmental behavioral paediatrics, history of 1, 2
Developmental context, red flags in 11
Developmental coordination disorder 211
Developmental delay 28
Developmental disorder 25, 98, 291
Developmental dissociation 29
Developmental learning disorder 245
Developmental milestones 10
Developmental problems 25
Developmental quotient 42t
Developmental screening 25
step-wise approach 26
Developmental surveillance 24
and screening 24
program 26
Dietary supplementation 291
Direct observation card 262b
Disability, medical care of 297
Disabled persons 59
Disease manager 21
Disputing thoughts 279
Disruptive behavior 272
disorders 175
Disruptive mood dysregulation disorder 187
Dix-Hallpike test 208
Dizziness 205
causes of 206b
sensation of 205
Down syndrome 48, 51, 62, 63t, 123
developmental milestones 63
management 68
neurobiology of 62
relative strengths 64
Duchenne muscular dystrophy 206
Dyscalculia 250
Dysgraphia 250
Dyskinesia 147, 274
Dysmorphic facial features 75
Dyspraxias 86
Dysthymia 185, 186
Dystonia 148, 150, 153
medications for 145
Dystonic tremors 149
E
Ear, nose and throat 124
Early developmental impairment 28
Early intervention 44, 261
clinical features 261
management 263
Echopraxia 192
Eclectic therapy 280
Ecological systems 16
EDS See Enveloping distribution sampling
Education 295
Educational considerations 200
EEG See Electroencephalogram
Electrocardiogram, automated 288
Electroencephalogram 123
Electronic media and gadgets 281
clinical features 282
management 284
Elimination disorders 132, 272
clinical features 132
management 134
Emotional neglect 254
Emotional response 11
Empty chair technique 280
Encopresis 132, 134, 272
classification of 133f
Encourage language 222
Endocrine 106
disorders 75
dysfunction 156
Endotracheal tubes, displacement of 35
Energy medicine 292
Energy metabolism group 158
ENT See Ear, nose and throat
Enuresis 132, 133, 135, 272
classification of 134fc
treatment of 135
Enveloping distribution sampling 123
Enzyme activity, tests for 156
Epilepsy 93, 137, 139, 155, 206, 258
drug-resistant 140
focal 140, 141
management of 93
syndrome 139
Epileptic discharges 137
Episodes 133
Episodic ataxia 206
Episodic dyscontrol 82
Eye 101, 106
almond-shaped 90
coloboma of 152
evaluation 45
Eyelids, upper 100
F
Facial dysmorphism 96f
Faded bedtimes 126
Family-centered care 36
Fatigue, chronic 82
Fatty acid oxidation disorders 50, 158
FDA See Food and drug administration
Febrile seizures 137
Feeding behaviors’ rating scales 130
Feeding difficulty, prevalence of 128
Feeding disorder 61, 128
behavioral basis of 130fc
clinical features 128
management 129
neurological basis of 129fc
Feeding problems 75, 228
Fertility treatments 73
Fibroblasts 159
Fibrous cephalic plaque 104
Fluency disorders 221
Fluoxetine 184, 194
FMR1 gene 48
Focal abnormal signal intensity 102
Folate 263
Follicle-stimulating hormone 86
Food and drug administration 194
Fragile X syndrome 50, 81, 123, 151, 152, 239, 248
clinical features 81
management 82
phenotype 81
Freud's theory 2
Friedrich's ataxia 206
Frustration tolerance 67
Fundamental Rights and Penal Code 294
G
Gabapentin 127
Galactosemia 160
Gamma-aminobutyric acid 121
Gastroesophageal reflux 68
disease 124
Gastrointestinal tract 77
Gaucher disease 155
Gene activity, modification of 49
Generalized anxiety disorder 183
Genetic abnormalities 51
Genetic disorders 25, 48, 54, 229, 233
Genetic influences 248
Genetic predisposition 211
Genetic syndromes 29, 52
Genetic testing 56
Genitalia 135
Genome 48
GERD See Gastroesophageal reflux disease
Germ cells 70
Gesell's spiral 6f
Gesell's work 2
Gestalt therapy 279
GIT See Gastrointestinal tract
Global developmental delay 28
etiology of 29, 29t
Glutaric aciduria 155
Gluten-free-casein-free diets 291
Glycogen storage disorders 160
Glycolytic pathway affection 156
Glycosaminoglycans 156
Glycosylation, congenital disorders of 159
GMFM See Gross motor function measure
Gross motor function
classification system 144
measure 258
Growing children, development in 23
Guanfacine 194
Gustatory 215
Gynecomastia 85, 86
H
Haloperidol 194
Hamartoma tumor syndrome 227
Hand function, early intervention for 265
Handwriting samples 249f
Head control, early intervention for 264
Head shaking nystagmus 208
Head thrust test 208
Health
apps 289
care, tools in 288f
concept of 21
provider 21
Hearing 40, 46
abnormalities, management 195
aid 197
types of 197
assessment 197
deficits 68
impairment 67, 195, 269
loss 143
profound congenital 195
monitoring 83
professionals 201
screening 196, 262
Heart defects 152
congenital 71
Hematopoietic stem cell transplantation 159
HIE See Hypoxic ischemic encephalopathy
High refractive errors 202
High-risk clinic, components of 41
Hormonal replacement therapy 86
Human social behavior 96
Hurler-Scheie syndrome 112
Hyperactivity 233
disorder 239
Hyperammonemia 49
Hyperbaric oxygen therapy and chelation 291
Hyperkinetic movement disorders 147
drug-induced 148t
Hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 155
Hyperphagia 90
Hypersomnolence 122
Hypertelorism 74
Hypertension, pregnancy-induced 30
Hypoglycemia 160
injury 60
Hypokinetic disorders 151
Hypomelanotic macules 104
Hyponatremia 136
Hypothyroidism, congenital 30
Hypotonia 228
Hypoxic ischemic encephalopathy 41
I
Imipramine 135
Immune disorders 140
Impaired adaptive functioning 56t
Individual education plan 269
Infants, high-risk 45t
Infection prevention 263
Inflammatory bowel disease 73
Insomnia 82
disorders 122
risk for 282
Intellectual ability 54
Intellectual disability 49, 54, 55t, 57t, 62, 107, 269, 296
Intellectual impairment 57t
Intelligence quotient 31, 62, 240, 241
averages 96
scores, traditional classification of 57t
Intention tremor 149
Interpersonal therapy 188
Interpreting observations 44t
Intoxication group 158
Intraoral fibromas 105
Intrauterine
growth restriction 263
infections 59
Intraventricular hemorrhage 41
Iodine 263
IQ See Intelligence quotient
Iron 263
deficiency anemia 30
Isotonic saline 163
IVH See Intraventricular haemorrhage
J
Juvenile Justice Act 295, 296
Juvenile myoclonic epilepsy 140
K
Kangaroo care 35, 38
Kanner's autism 231
Karyotype detects 48
Ketone body defects 158
Klinefelter syndrome 85, 87f, 239, 248
clinical diagnosis 85
diagnosis of 86
management 86
Klinefelter-Reifenstein-Albright syndrome 85
Krabbe's disease 155
L
Lactic acidemias, congenital 158
Lagging behind 54
Language
development 281
disorder 220
management of 221
expressive 64
Laws, kinds of 294
LD See Learning disability
Lead poisoning 233
Learning difficulty 258
Learning disability 86, 241, 248, 269
assessments for 251
clinical diagnosis 248
diagnosis of 250
family history of 248
functional consequences of 250
management of 251, 252fc
types of 250
Learning disorders 211, 245
Learning with visual supports 64
Leigh's disease 155
Leopard syndrome 76
Lesch-Nyhan disease 155
Leukocyte 159
Leukodystrophy 154
Leukomalacia, periventricular 41
Life skills modifications 188
Liver
angiomyolipomas 107
function tests 156
Low glycemic index treatment 93
Lower limbs 135
Lower urinary tract symptoms 134t
Luteinizing hormone 86
Lymphangioleiomyomatosis 106
Lymphatic dysplasias 75
Lysosomal storage disorders 109, 159
Lysosomes 109
M
Maple syrup urine disease 155
Massage 38, 292
Maturational theory 2
Measuring development 8
MECP2 gene 48
Medical problems 91
Medically-unexplained symptoms 187
Medicine
complementary and alternative 291
technology in 289
Melatonin 121, 126, 127, 229
Menke's disease 155
Menstrual irregularities 141
Mental disorders, diagnostic and statistical manual of 131b
Mental Health Act 295, 296
Mental health disorder 25
Mental retardation 54
Metabolic disorders 29
Metabolic syndrome 86
Metabolism
errors of 154
group of inborn errors of 109
inborn errors of 158
Metal disorders 161
Methylphenidate 173
Middle ear disease 67
Migraine, vestibular 207
Minimum developmental screening 23
Miscarriages, history of 30
Mitochondrial diseases 156
Mitochondrial disorders 160, 206
MNE See Monosymptomatic enuresis
Monosomy 71f
Monosymptomatic enuresis 134
Mood disturbances 67
Moro's reflex 7
Mosaic turner syndrome 72f
Motor development 64
Motor disorders, sensory-based 216
Motor tic 193
Mouth 105
Movement disorder 147, 149, 151, 155, 243
etiology of 148t
management of 152
sleep-related 122
treatment of 153t
type of 148
Mucopolysaccharides 109
Mucopolysaccharidosis 50, 110t
clinical features 109
developmental and behavioral 109
diagnosis 109
management 113
Multiple disability 59, 60
clinical features 60
management 60
Multiplex ligation-dependent probe amplification 52
Musculoskeletal disorders 75
Mutism
diagnostic criteria for selective 224b
elective 225
Myelination 121
Myelogenous leukemia, chronic 100
Myeloid leukemia, acute 108
Myoclonic movements 150
Myoclonic seizures 93
Myoclonic spasms 138
Myoclonus 148, 150
N
Narcolepsy 122
National Autism Center 266
National Trust Act 295, 297
NDDs See Neurodevelopmental disorders
Neglect, types of 254
Neonatal deaths, history of 30
Neonatal intensive care 10, 35, 40
unit environment 37
Neoplastic etiology 156
Neurobehavior scoring 262
Neurodegenerative disorder 82, 206
Neurodevelopmental conditions 258t, 259fc
evaluation in 256, 257t
Neurodevelopmental disability 24, 257
Neurodevelopmental disorders 48, 121, 124, 129, 147, 151, 246
management of 272
spectrum of 296
Neurodevelopmental impairment 63
Neurodevelopmental problems 95
Neurodevelopmental profile 96
Neurodevelopmental screening, risk stratification for 40
Neurodevelopmental therapy 270
Neurofibromas 101
Neurofibromatosis 99, 248
clinical features 100
management 103
type 99
diagnostic criteria of 100b
Neurogenetic disorders 243
Neurological disorders 59, 75, 206
Neurometabolic disorders 243
Neuromuscular diseases 206
Neuronal ceroid lipofuscinosis 155
Neuronal migration 121
Neuropsychiatric syndrome, acute-onset 149
Neuroregressive disorders 154
clinical features 154
management 156
Neurotransmitter disorders 160
NF1 gene 49, 99
Niemann-Pick forms 160
NMNE See Nonmonosymptomatic enuresis
No-mobile-phobia 282
Nomophobia 282
Nonketotic hyperglycinemia 160
Nonmonosymptomatic enuresis 134
Nonpharmacologic interventions 169
Non-rapid eye movement 121, 123
Nonverbal skills 72
Noonan syndrome 51, 52, 74, 77t
clinical features 75
diagnosis and genetics 75
differential diagnosis 76
facial features in 76f
growth charts for 79f
management 76
Normal development and behavior 6
theories of 13
N-REM See Non-rapid eye movement
Nystagmus, vibration-induced 208
O
Obesity 283
Obscene gestures 191
Obsessive compulsive
behavior 193
disorder 192194, 272
symptoms 66
Obstructive sleep apnea 83, 120, 111, 123, 124
Occupational therapy 268
OCD See Obsessive compulsive disorder
Olfactory 215
Oligosaccharides 156
Omega-3-fatty acids 292
Oppositional defiant disorder 175
Optic atrophy 202
Optic pathway gliomas 100
Oral motor dysphagia 228
Organ system 109
Organic acids 156
OSA See Obstructive sleep apnea
Osteopenia 116
management of 119
Otitis media, recurrent 73
Ototoxicity 167
Oxcarbazepine 141
Oxybutynin 135
P
Pain, chronic 82
Painful procedures 37
Palilalia 191
Panic attacks 183
Parasomnias 122
Parental sleep education 125
Passive neglect 254
Perinatal brain injury 140
Perinatal causes 29
Perinatal complication 25
Peroxisomal biogenesis disorder 159
Persistent depressive disorder 186
Persons with Disabilities Act 295
Pharmacological interventions 169
Pharmacotherapy 188
principles of 272
Phelan-McDermid syndrome 227
Phenylalanine 156
Phenytoin 141
Phobia 181
Physical and mental challenges 294
Physical growth 40
Physical neglect 254
Physical problems 283
Physiotherapy 268
Pimozide 194
Pivotal response training 267
Play therapy 267
POCSO Act 255
Poliodystrophy 154
Polypharmacy 274
Polysaccharide 109
Positive bedtime routines 125
Posterior fossa syndrome 167
Postnatal causes 29
Postural tremor 149
Prader-Labhart-Willi syndrome 89
clinical features 89
diagnosis of 90
management 90
Prader-Willi and Angelman syndrome 227
Prader-Willi syndrome 48, 89, 92, 123
Pregnancy, high-risk 73
Prematurity
complication 25
correction for 41
Premonitory urges 190
Prenatal causes 29
Pressure-equalization tube 83
Preterm baby 10
brain 35
Primitive reflexes 7
Protein kinase, mitogen-activated 74
Psychiatric disorders 120
Psychoanalytical theories 13, 16
Psychogenic nonepileptic seizures 138
Psychological problems 91
Psychopharmacologic intervention 236t
Psychosexual development 2
Pubertal development 103
Pulmonary arteries 95
PVL See Periventricular leukomalacia
Pyramidal dysfunction 155
R
Rational emotive behavior therapy 279
Recklinghausens disease 99
Regular physical activity 24
Rehabilitation problem 259t
Renal cysts, multiple 106
Renal disorders 75
Renal malformations 52
Reproductive rights 295
Respiratory chain disorders 158
Respiratory problems, management of 119
Restricted diet 233
Retinal disorders 202
Rett syndrome 93, 115, 123, 151, 153
clinical features 116
diagnosis 116
differential diagnosis 118
management 118
medical management 119
stages of 116
Risperidone 194
Rubella vaccine 263
Russell-Silver syndrome 51
S
Saliva, thick 90
Saudubray's classification 158
Schizophrenias 273
Scholastic backwardness 239, 240, 241fc
clinical features 240
management 240
School absenteeism 239
Seizure 119, 137, 233
atypical 93
classification of 138f
clinical 229
diaries 141
disorders 228, 248
history of 241
provoked 137
treatment of 230
types, classification of 139f
Selective mutism 223
clinical diagnosis 224
management 225
prevalence of 223
Selective serotonin reuptake inhibitors 82, 184, 236
Self-injurious behavior 153
Self-injury 273
Sensorimotor stage 3
Sensorineural hearing loss 73
Sensory integration 268
and praxis tests 258
disorders 215
therapy 270, 292
Sensory modulation 216
disorder 216
Sensory motor approach 270
Sensory processing
measure 258
problems 218t
Sensory processing disorder 215
classification of 216fc
clinical features 216
management 217
Sensory seeking 216
Serotonin norepinephrine reuptake inhibitors 184
Sertraline 184, 194
Sexual violence 295
Shagreen patches 104
Shock, hypovolemic 163
Silent block 221
Single genes 49
Single-family room concept 36
SIPT See Sensory integration and praxis tests
Skeletal abnormality 51, 52
Skeletal disease 206
Skilled treatment 268
Skills, part of 5
Skin 104
disorders 75
to skin care 38
Sleep 67, 282
apnea 68
diary 124
disturbances 273
hormone 121
physiology of 121
problems 61, 120, 122, 123t
quiet 121
types of 121
wake pattern 121
Sleep disorders 120, 124fc
behavioral plan 125
clinical features 121
differential diagnosis 125
drug therapy 126
management 125
medications in 127t
miscellaneous drugs 126
nonpharmacological measures 125
treatment of 229
Sleep duration 124t
shortened 228
Sleep myoclonus 150
benign 138
Small lower jaw 71
Small testes 85
Smith-Magenis syndrome 123
Social anxiety disorder 223
Social deficits 82
Social development 64
Social phobia 223
Social skills 19
training 268
Somatosensory phenomena 190
Spastic quadriplegic cerebral palsy 294
Special educator, role of 268
Speech 40
and communication, early intervention in 265
clarity 64
memory, and learning, delays in 62
poor expressive 86
sounds 221
Speech and language
impairment 143
pathologists 228
therapy 269
Speech disorder 220
management of 221
Spine 135
SPM See Sensory processing measure
Stanford Binet test 31
Status epilepticus 138, 140, 141
Stem cell therapies 293
Stereotypy 148, 193t
Strabismus 73, 202
Stranger anxiety 22
Streptococcal infections 190
Subependymal giant cell astrocytomas 106
Subependymal nodules 106
Synapse formations 121
Synapse sculpting 121
Syndromic autism 151
Systematic stimulation programme 44
Systems theory 16, 19f
T
Target blood pressure 164
Technology and medical profession 288
Testicular sperm extraction 87
Testosterone 86
Thyroid function 68
Tic 148, 149, 153, 190
clinical features 191
comparing 193t
disorders 191f, 273
classification of 192fc
medications in 194t
management 193
Tonic-clonic seizures 138
Topiramate 194
Tourette's disorder 192
Tourette's syndrome 147, 190, 192, 193, 248
Traditional therapy 270
Transcutaneous electrical nerve stimulation 136
Traumatic brain injury 162
management 163
nonaccidental trauma 202
pathophysiology of 162
Tremor 148, 149
Trisomy 21 48
TSC1 gene 49
TSC2 gene 49
Tuberous sclerosis 48, 104
clinical features 104
complex 104, 107, 108, 151, 248
learning and behavior 107
management 107
treatment of complications 108
Tumor
factors related to 167
intracranial 206
Turner phenotype 74
Turner syndrome 51, 70, 71f, 248
clinical features 71
incidence of 70
management 73
U
Urinary tract
diverticula 97
infection 134
Urine 112
UTI See Urinary tract infection
V
Verbal short-term memory 65
Vertigo
benign positional 207
duration of 207
Vestibular diseases 206
Vestibular disorders 209
Vestibular function tests 209
Vestibulo-ocular reflex 205
tests 208
Vestibulospinal pathways 205
Vineland social maturity scale 118
Vision 40, 68, 103, 215
and hearing, assessing 43
deficits 143
functional 203
problems 213
screening 262
therapy 203
Visual acuity
dynamic 208
measurements 203
Visual aids, special 204
Visual field defects 202
Visual impairment 202, 203
causes for 202
clinical features 202
management of 203
Visual-spatial perception 250
Visuospatial skills 72
Vitamin B12 deficiency 30
Voice, disorders of 243
W
Well-baby nursery population 195
West syndrome 139, 140
Wide smiling mouth 92
Willful deprivation 254
William syndrome 48, 51, 95, 96f
clinical features 95
management 97
Wilson's disease 155
Wood's lamp 229
Writing disabilities 250
Written expression
difficulties in 249
disorder of 246
X
X chromosomes 70, 85
abnormal 85
X-linked inheritance pattern 50f
Z
Zinc 263
Ziprasidone 194
Zolpidem 126
×
Chapter Notes

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IAP Handbook of Developmental and Behavioral Pediatrics
IAP Handbook of Developmental and Behavioral Pediatrics
Editor-in-Chief Samir H Dalwai Developmental Behavioral Pediatrician New Horizons Child Development Centre and Research Foundation National Coordinator, IAP Fellowship in Developmental and Behavioral Pediatrics Nanavati Max Superspecialty Hospital, Mumbai, Maharashtra, India Chief Academic Editors Jeeson C Unni Senior Associate Consultant Aster Medcity Kochi, Kerala, India Editor-in-Chief, IAP Drug Formulary Shabina Ahmed Founder Director Assam Autism Foundation Guwahati, Assam, India Academic Editors Kawaljit Singh Multani Consultant Pediatrician 11 Air Force Hospital Ghaziabad, Uttar Pradesh, India Leena Deshpande Developmental and Behavioral Pediatrician iCAN Child Development Centre MGM Hospital, Apollo Hospital Navi Mumbai, Maharashtra, India Leena Srivastava Head, Division of Developmental and Behavioral Pediatrics Department of Pediatrics Bharati Vidyapeeth Medical College and Hospital Visiting Consultant, Developmental Pediatrics, CloudNine Hospital and LMCCH Pune, Maharashtra, India Forewords MKC Nair Piyush Gupta Remesh Kumar R Bakul Jayant Parekh Upendra Kinjawadekar Vineet Saxena
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IAP Handbook of Developmental and Behavioral Pediatrics
First Edition: 2022
9789389776485
Printed at
This book is dedicated to our parents and teachers who by their wisdom and patience continue to help us develop far beyond our childhood years and to our little patients who are the reason for the spring in our step every morning!
Contributors Foreword
I am happy to know that the IAP Chapter of Neurodevelopmental Pediatrics is publishing a Handbook of Developmental and Behavioral Pediatrics with contributions from eminent developmental pediatricians across the country and abroad. This comprehensive handbook covers all essential topics in the subject in 60 chapters. This handbook has come at a critical time, when we are looking for a simple user-friendly handbook for the personnel of District Early Intervention Centres under Rshtriya Bal Swasthya Karyakram (RBSK).
I do hope that this handbook would serve to initiate students of pediatrics into the field of developmental and behavioral pediatrics. It would also serve as a handy reference not only for practicing pediatricians but also for the developmental behavioral pediatricians—Developmental Therapist team at all levels. The DEIC therapy team of physiotherapists, occupational therapist, speech therapist, child psychologists, and special educators may find it handy. It could also be a textbook on Developmental Behavioral Pediatrics for the large number of community health personnel both in government and in private sector.
MKC Nair
DSc PhD MD MMedSc (NewCastle) MBA MA (Philosophy) MA (MC&J) FNNF FIAP FIACAM FAMS
Fomer Vice Chancellor and Professor Emeritus-Research Kerala University of Health Sciences
Founder Director and Professor Emeritus in Developmental Behavioral and Adolescent Pediatrics, CDC Kerala
Director, NIMS-Spectrum-Child Development Research Centre
Editor, IAP Textbook of Pediatrics and High-risk Newborn
Editor, Illingworth's The Development of the Infant and the Young Child (11th Edn)
Foreword
I am very much privileged to present the foreword for the Handbook of Developmental and Behavioral Pediatrics, which is being published by IAP to better equip practicing pediatricians to understand and assess developmental and behavioral problems in children. This book is a step forward in IAP's mission to continuously enlarge its scope to cover the entire spectrum of child health and child care. It is a comprehensive compilation of valuable information for the early detection of developmental and behavioral disorders in children, along with providing remedial measures.
Research into adult health issues and behavioral disorders clearly indicate that many such problems originate in childhood. It logically follows that these could have been better resolved with early intervention. As the saying goes, “Prevention is better than cure.” Hence, developmental and behavioral pediatrics has a special role to play in heralding a healthy society. This stream focuses on scientifically evaluating the child's physical, emotional and cognitive development to identify problem areas and prescribe corrective measures, which are designed to enable a transition to healthy adulthood. Judging by the important role this plays in child health, there can be no doubt that this domain of pediatrics will eventually take center stage in our profession.
Conventional wisdom holds that “Happy childhood leads to happy life”. However, with the advent of developmental pediatrics, we can confidently rephrase this as “Healthy childhood leads to healthy life”. However, as this his domain deals with the intangible “gray areas” of life, practitioners of this craft will need special qualities like sensitivity, observation, empathy and a helping nature to derive the best results. This handbook introduces the clinician to the fundamentals of developmental and behavioral issues and acquaints oneself to the new doors that are being opened in the field of pediatrics.
I congratulate the editorial team comprising Dr Samir H Dalwai as the Editor-in-Chief, Dr Jeeson Unni and Dr Shabina Ahmed as Chief Academic Editors, Dr Kawaljit Singh Multani, Dr Leena Srivastav and Dr Leena Deshpande as Academic Editors. They have taken pains to access the best brains in the field from across the country and abroad to produce an authoritative high quality publication which is worthy of the reader's attention. I wish them success in this venture and hope that the reader response will motivate them to continue updating this book with further inputs in the years to come.
Remesh Kumar R
National President 2022
Indian Academy of Pediatrics
Foreword
I am extremely happy to know that IAP has taken a very important initiative and is publishing a Handbook of Developmental and Behavioral Pediatrics. Neurodevelopmental disorders have a diverse influence on function, development, learning, behavior, mental health, and the child's capacity to meet the range of age-based expectations across a variety of settings.
What happens to children in the earliest years of their lives has a great impact on their immediate well-being and their future. Similarly, what does not happen for a child in their early years can be an impediment to their well-being and entire future. Any significant deviation in the behavior or the development of the child needs to be detected and addressed in the most comprehensive way. I am sure that this handbook will provide a collegiate and supportive structure for pediatricians and other medically trained professionals who work with children and families affected by eurodevelopmental and behavioral disorders, and share similar professional and related personal challenges.
In the last two years of the pandemic, while the entire medical fraternity irrespective of the field of their expertise was busy concentrating on prevention, control and cure of COVID-19, sadly, too many children around the world were denied the right to reach their full potential. And every year, some of them are held back, deprived, in one way or another, of the love, care, nurturing, health, nutrition and protection that they need to survive, grow and develop resulting in some behavioral and neurodevelopmental challenges.
The editorial team under the leadership of very talented Dr Samir H Dalwai and comprising of great academicians with huge experience in the field across the country like Dr Jeeson Unni, Dr Shabina Ahmed, Dr KS Multani, Dr Leena Shrivastava, Dr Leena Deshpande are aware about the advances in the field as well as the ground reality in regard to the current understanding of general pediatricians of behavioral and developmental pediatrics.
In acknowledgment of the complexity and uncertainty inherent to this area of developmental and behavioral pediatrics, the editors value the sharing of knowledge and experience towards the development of good clinical judgment. They have addressed dual goals of alleviating current distress, and working towards optimal outcomes, considering the fact that there is no magic bullet to treat or cure many of these disorders. This handbook has kept a highly practical focus, emphasizing evaluation, counseling, medical treatment, and follow-up with a single aim to promote and support the development of excellence in the practice of Neurodevelopmental and Behavioral Pediatrics.
I am sure this handbook will be a permanent companion of every medical practitioner working in the field of child health.
 Best Wishes
Upendra Kinjawadekar
National President Elect 2022
Indian Academy of Pediatrics
Foreword
I am very happy to know that the Indian Academy of Pediatrics is coming out with the first Handbook of Developmental and Behavioral Pediatrics!
Developmental and Behavioral Pediatrics has traditionally been a subject, which has not received its due importance in the medical curriculum. Infectious diseases, intensive care, even growth and nutrition have been accorded much higher significance. However, as times have changed and pediatricians are faced with a larger proportion of concerns in the field of development and behavior in their practice, it is imperative for the practicing pediatrician to be well versed with basic clinical manifestations as well as primary intervention on these topics.
Indeed, the Indian Academy of Pediatrics has launched one of its most significant programs on Nurturing Care for Early Childhood Development; development and behavior is a very important component of the same. I am glad that this handbook is being released during these times, as this will add to the overall knowledge and practice of early child development.
I congratulate the Editor-in-Chief, Dr Samir Dalwai, the Chief Academic Editors, Dr Shabina Ahmed and Dr Jeeson Unni as well as the Academic Editors, Dr Leena Deshpande, Dr Leena Srivastava and Dr Kawaljit Singh Multani as well as all the esteemed authors who have contributed to this handbook.
I am sure this handbook will serve as an import source of knowledge to clinicians and academicians alike as well as residents and students and will stimulate a holistic interest in the subject.
Piyush Gupta MD FIAP FNNF FAMS
President, Indian Academy of Pediatrics, 2021
Foreword
Dear friends,
Greetings from the Indian Academy of Pediatrics!
In today's era, where the competition among children is rising at a fierce pace – a time when children are scoring more than 90 percent, the most common complaint heard from the parents are a few rather simple questions – Why is my child not able to study well? What is wrong with my child? Why is my child not attentive in class? Why is the teacher always complaining about my child? Why does my child get low marks in a certain subject, but excel in others? This has become more common today because of the COVID-19 pandemic scenario, wherein the schools were completely shut for more than a year. Unfortunately, the answer to these questions is not that simple, but the best person who can answer is from a comparatively new and upcoming field—Developmental and Behavioral Pediatrician.
Developmental and Behavioral Pediatrics is a specialized branch of pediatrics that deals with evaluation, counseling as well as providing treatment for children, adolescents, and their families with a wide range of developmental and behavioral difficulties including learning disorders, writing difficulties, math disorders, attention deficit/hyperactivity disorder, habit disorders, etc. to name a few. Unfortunately, the very mention of a behavioral and developmental pediatrician requirement often makes the parent rather defensive. They cannot accept that anything could be wrong with their child. However, we—the general pediatricians—can help the situation easily. By having a basic knowledge about the different issues, we can be the first point of contact and help in the correct diagnosis.
Since it is a specialized science, not all of us are trained in proper detection of the various scenarios that may lead to an actual visit to the specialist. This is where this book proves its usefulness. By having several problems faced by parents explained in a simple and lucid language, I am sure that it will help us in early and easy detection and provide the correct way forward. This book fills a void, which was felt regarding this specialized area of expertise, and I am certain that it will be very well received by all our colleagues.
With the schools on the verge of reopening once again and the concerns of parents regarding their child's scholastic performance, this handbook which was actually conceived pre-pandemic in 2020 and has dealt extensively with these topics as well, will aid the common pediatrician to guide the parents carefully in such situations. The book is very aptly named Handbook of Developmental and Behavioral Pediatrics. This handbook covers the most essential questions that have been asked by several parents during our practice and has been written by stalwarts in the field of Developmental and Behavioral Pediatrics. Since it is written by pediatricians, you can be assured that the contents are hundred percent proper and applicable in your day-to-day lives.
I would like to take this opportunity to thank all the editors and contributors in general and Dr Samir Dalwai in particular who have burnt the midnight oil and made the dream of mine and all pediatricians come true. It is without doubt an amazing handbook worth recommendation to be there in every parent and pediatrician's bookshelf. I am certain that the timing for the book and its contents could not have been better in any manner. Keep up the great work. Kudos to the entire team who has worked diligently on this project throughout the pandemic while fulfilling their duties at the same time.
 Happy Reading!
Bakul Jayant Parekh
President, Indian Academy of Pediatrics, 2020
Foreword
Dear Friends,
It gives me immense pleasure to introduce the ‘Handbook of Developmental and Behavioral Pediatrics’ by IAP. As we all know that Growth, Development and Behavioral Pediatrics is the most intriguing, interesting and unique aspect of our specialty. It is the real Pediatrics, which sets it apart from Medicine. It starts right from the time when the fetus is formed and especially how a newborn baby grows into a mature human being, passing through various milestones one after the other.
Even at the first glance, an astute pediatrician knows whether the baby is growing normally or if there is something amiss. Despite this skill which every pediatrician possesses by virtue of his/her training, it always needs to be honed and sharpened and approached in a systematic manner. I am sure that this handy book by IAP will stand out among all the available books on the subject of Development and Behavioral Pediatrics.
Each one of us needs to go through this book again and again so that the benefit of this fantastic book reaches to its final target—the little babies. Their growth and developmental assessment is our primary responsibility after all. Given the expertise of the Editorial Team and contributors, it will serve to be an indispensible tool for practicing pediatricians and postgraduates.
No words of appreciation are enough for Dr Jeeson Unni and Dr Shabina Ahmed who have worked so hard as Chief Academic Editors, and Dr Kawaljit Singh Multani, Dr Leena Srivastava and Dr Leena Deshpande, who have taken the responsibility of Academic Co-Editors and Dr Samir H Dalwai the Editor-in-Chief who has taken the mantle upon himself to bring out this gem for IAP. IAP is thankful to their yeoman service for the children as well as pediatricians.
Vineet Saxena
Honorary Secretary General
Indian Academy of Pediatrics 2022-23
Preface
Over the past decade, interest in Developmental and Behavioral Pediatrics has shown a remarkable surge. A steady decline in infectious disorders, increased survival of high-risk neonates, smaller families, rising incomes and an overall increase in aspiration about the quality of life for the family has contributed to increasing awareness and increased care seeking for children and adolescents with neurodevelopmental and behavioral problems. The pediatrician who was content with a cursory look at motor milestones and weight gain is now being asked probing questions about the child's development and behavior. “Wait and watch”, worse—“Nothing can be done”—the earlier answers for most cases, is now neither acceptable assurance nor scientifically correct advice. A spiraling increase in autism and other neurobehavioral problems, coupled with insistence from schools, and indeed society, for perfection to fit the curriculum and expected norms are leading to increased consultancy for these issues.
The Indian Academy of Pediatrics has been at the forefront of training and coaching more than 30,000 pediatrician members to equip them with clinical skills. The demand for training on developmental and behavioral problems in children and adolescents has led to many of us having overbooked calendars. Often, the way this subject is practiced in the western world is far removed from the limitations and advantages of our family-oriented culture; teachers and authors that adapt with this important aspect are oft sought after. The IAP Fellowship in Developmental and Behavioral Pediatrics is now into its sixth successful year with an increased demand from Fellows for content of Indian origin. The thirst for such knowledge, albeit in a palatable dosage, has led to the birth of the first such Handbook of Developmental and Behavioral Pediatrics.
This handbook is organized into chapters that deal with basics of developmental and behavioral pediatrics and chapters that offer some in-depth knowledge about individual conditions. There are chapters on therapeutics as well various social aspects like digital exposure and medicolegal aspects, as well as a peek into the history of this subject. Each chapter has a brief introduction about the topic followed by simple to grasp clinical features often with key questions and a succinctly presented management of the condition. As such, the handbook can be read across at one go (for an examination, perhaps!) or can be used as a ready reference in the busy clinic. The authors have been invited nationally as well as overseas to present a swathe of clinical and academic aspects of the above. We are sure this will spur the uninitiated—the students and residents—into the subject, as well as the practicing pediatricians to spend a little more time with their patients with neurodevelopmental and behavioral disorders. Serious students of this subject will have to wait a little longer for a detailed textbook to follow this handbook soon. Meanwhile, if even a few families seen by each pediatrician receive a longer interaction about their child's concerns, we will be both delighted and relieved to have pulled off a difficult job well.
We will be happy to receive constructive criticism and suggestions about this handbook as we are sure it will help us “develop” the next edition better (Developmental Behavioral Pediatricians are an optimistic lot!). As blessed practitioners of this enchanting field, we are gratified by the fact that pursuit of no other subject or practice helps the practitioner to develop the self as much as this subject does. To this, we owe our emancipation! Long live the practice of Developmental Behavioral Pediatrics!
The despondency of earlier years where neurodevelopmental disorders were relegated to optional short notes in theory examinations and to asylums in real life gave way to Tennyson's “Tis better to have loved and lost than never to have loved at all” approach, when our earlier generation attempted forays into offering a more humane life to those affected. We hope coming generations of pediatricians will rather see most of these “disorders” for what they are in Ghalib's words, “Meherbaan ho ke bula lo mujhe chaho jis waqt, Main gaya waqt nahin hoon ke phir aa bhi na sakun!” (Your benevolent intervention is all that I seek for my resurrection; I am not time that I may never return once it passes.)
 It is never too late. It is only needed that we try!
Samir H Dalwai
Jeeson C Unni
Shabina Ahmed
Leena Deshpande
Leena Srivastava
Kawaljit Singh Multani
Acknowledgments
We wish to thank the Indian Academy of Pediatrics for the opportunity to contribute this handbook, which will serve to increase the knowledge of developmental and behavioral pediatrics.
We wish to thank the authors who have contributed their knowledge in a simple and lucid manner and complied with the (various) timelines.
We wish to thank our families who supported us through hours of being locked away in front of a screen interspersed with late night frantic phone discussions.
We wish to thank our individual staff and teams who accommodated our absence from our regular clinics.
We wish to thank Dr Bakul Parekh, who encouraged us when the idea for such a text was floated way back in 2020, Dr Piyush Gupta who helped us keep the momentum going through the COVID year, Dr Remesh Kumar R for always supporting us with this academic venture as well as our teachers, Dr YK Amdekar, Dr MKC Nair, Dr Rashid H Merchant and Dr Swati Bhave for their presence in this handbook.
We wish to thank Dr Waheeda Pagarkar, Dr Dilip R Patel, Dr Randi J Hagerman, Dr Ann M Neumeyer, Dr Patricia Osbourn, Dr Yamini Jagannath Howe, Dr MA Florita, Dr B Yambao-Dela Cruz, Dr Kaye M Napalinga, Dr Zahabiyah Bassi, Dr Shibani Kanungo and Dr Neelkamal Soares for their distinguished contribution in this field as well as adding an international flavor to this handbook.
We are forever grateful to our mentors Dr Sachidanand S Kamath and Dr Abraham K Paul for their guidance.
We are thankful to Shri Jitendar P Vij (Group Chairman), Mr. Ankit Vij (Managing Director), Ms Chetna Malhotra Vohra (Associate Director—Content Strategy) and Dr Rajul Jain (Development Editor) of Jaypee Brothers Medical Publishers (P) Ltd, New Delhi for their constant help in publishing the book.
Finally, we wish to formally thank each other—the editors! One remembers the concluding lines from the legendary Robbins and Kumar's Textbook of Pathology—“It is not that we always thought alike, but we were always happy to acknowledge each other's thoughts.”
We thank each other and all the authors for standing by us through all the unforeseen difficulties. This book is a conception of the COVID years as much a child of our years of study and work in this field.
Finally, we wish to thank the innumerable children and adolescents and their families who across the decades have taught us not just what little we know about this subject, but what it means to be human. We are but a product of their chisel.