Advancing Frontiers of Psychiatric Therapeutics PK Singh
INDEX
Page numbers followed by b refer to box, f refer to figure, fc refer to flowchart, and t refer to table.
A
Ablation 237
Ablative procedures 229, 235
Abnormal involuntary movements scale 71, 74
Acetylcholine 202
Acetylcholinesterase
enzyme 172
inhibitors 170, 172
Acyclovir 75
dose of 70
treatment 70
Addiction 147, 149, 237
Adjunctive valacyclovir 73
Adjuvant antiviral agents, clinical trials of 71t
Akathisia 28
Alcohol
abuse 171
intolerance 200
use disorders 114, 117
Alzheimer's dementia 205
Alzheimer's disease 169, 170
early-stage 31
American Academy of Child and Adolescent Psychiatry 115
American Psychiatric Association 134
guideline 110, 156, 158
American Psychological Association 158
Aminothiazole 174
Amnestic mild cognitive impairment 174
Amobarbital 53, 54
Ampakines 128
Amphetamines 128
Amygdala, basolateral nucleus of 237
Amyloid deposition 174t
modulation of 173
Amyotrophic lateral sclerosis 205
Angelman syndrome 192
Anorexia nervosa 237
Anti-amyloid aggregation agents 174
Antidepressants 5, 113, 128, 155, 157, 159, 164
molecules 160
tricyclic 110, 113, 117, 156
Antioxidant drugs 170, 174
Antipsychotic 29, 61, 102, 110, 192
atypical 156, 192
drugs 63, 69
Antiviral agents, effect of 72
Antiviral therapy 69
Anxiety 15, 200
disorders 44, 113, 135, 203
neurosis 53
related disorders 23
Aripiprazole 192
Arrhythmias 15
Artificial intelligence 6, 9, 12
based therapies 8
personalized treatment 11
requirements of 8
types of 9
Assertive community treatment 82, 86
Asthma 15
Attention deficit hyperactivity disorder 10, 19, 115, 117, 124
Attenuated positive symptom syndrome 87
Auditory hallucinations 65
Auditory verbal hallucinations 215
psychological interventions for 64b
Autism spectrum disorder 10, 189, 192, 193, 205
Autoimmune neuropsychiatric disorders, pediatric 205
Autonomic nervous system 32
Avatar therapy 64, 65, 81, 89
B
Bacillus 202
Bacopa monniera 136
Bacteria 202
Bad breath 200
Barbiturates 48, 49, 50, 53, 54
Barnes akathisia scale 71
Basal ganglia 228
Beck depression inventory 24, 227
Benzodiazepine 41, 4850, 54, 57, 58, 102, 113
assisted psychotherapy 50
Beta-N-methylamino-l-alanine 205
Bhastrika pranayama 26
Bhujangasana 26
Bifidobacterium 202, 205
animalis 204
infantis 206
longum 203
Biofeedback
recent advances in 16
therapy, recent advances in 14
Bipolar depression 112, 112t
Bipolar disorder 43, 111, 116, 171, 190192
Bleeding 3
Bloating 200
Blood
brain barrier 203
hemoglobin concentrations 19
oxygen level dependent 17
Bloodletting 4
Body mass index 237
Body odors 200
Bonferroni corrections 75
Borderline personality disorder 53
Brain
activity 17
contrast-enhanced computed tomography of 228
derived neurotrophic factor synthesis 148, 163, 203
functions of 6
gut
axis 144
connection 201
heart axis 144
magnetic resonance imaging of 228
scans 6
stimulation 212
technique 219
therapies 3, 212
waves 14, 16
British Association of Psychopharmacology guidelines 157, 158
Bupropion 112, 156
B-vitamins, synthesis of 200
C
Canadian Network for Mood and Anxiety Treatment 157, 158
Candida 200
Canmat guidelines 158
Capsulotomy 230
anterior 229
Cardiovascular disorders 15, 134
Catatonia 54, 55
Catechol-O-methyltransferase 132
Cathartic abreaction 49
Central nervous system 135, 199, 202
Cerebrolysin 174
Childhood autism rating scale scores 194
Chlorpromazine 5, 61, 192
Cholinesterase inhibitors 115, 128
Chronic depression
drug treatment of 155
management of 159
Chronic obstructive pulmonary disease 15
Chronic pain syndromes 10
Cingulate cortex, anterior 229, 232
Cingulate gyrus, anterior 228
Cingulotomy 229, 230
anterior 232
procedure 230
Circulating proinflammatory cytokines, high levels of 203
Clinical global impression severity 30
Clozapine 63, 66, 111, 192
Cocaine 123
Cognitive behavior therapy 5, 12, 39, 40, 64, 8183, 87b, 103, 146, 227
model of 84fc
role of 88b
Cognitive disorders 23
minor 203
Cognitive dysfunction 72, 75
Cognitive enhancement therapy 85
Cognitive enhancers, current status of 169
Cognitive impairment, diagnosis of mild 31
Cognitive realignment therapy 88
Cognitive remediation 81, 82, 85
intervention 85
therapy 85, 91
computer-assisted 90
Cold sores 72
Collapsin response mediator protein-2 192
Colostrinin 174
Combinatorial gene testing 181
Committee on Research on Psychiatric Treatments of American Psychiatric Association 134
Communication skills 83
Computerized neurocognitive battery 74
Computer-web-based programs 90
Conducting group therapy 93
Consciousness 144
Constipation 200
chronic 16
Continuous positive airway pressure therapy 146
Conversion disorder 55
treatment for 56
Cortico-striato-thalamo-cortical loop 228
Cosmetic
medications 128
psychopharmacology 123, 124
Coumarin-Huperzine derivatives 172
Cravings, treatment of 102
Crisis management 83, 100
Crooked cells 6
Cybernetics theory 14
Cytokines 203
Cytomegalovirus 71, 72
D
Data search methodology 156
Deep brain stimulation 212, 219, 224, 230, 232, 234, 236, 238
Dehydroepiandrosterone sulfate 25
Delusions 62t
assessment of 62
scales for 62
Dementia 117
Deoxyribonucleic acid 178
Dephosphorylation 162
Depression 19, 23, 30, 33, 42, 58, 110, 116, 117, 148, 155, 159, 169, 191, 200, 205, 227, 231, 234
chronic major 155
indications for surgery in 232
long-term 213
major 171
severity of 157
study, treatment for adolescents with 42
treatment-resistant 117, 162, 233
Depressive disorder 134, 155
neurobiology of major 231
Detoxification 114
Dexamethasone nonsuppression 202
Dhanurasana 26
Dialectical behavior therapy 103
Diarrhea 159, 200
Diazepam 49, 50, 54
Disability
adjusted life years 155
years lived with 155
Disease-modifying agents 170, 173
Dissociative disorder 55, 57
Distress tolerance 104
Docosahexaenoic acid 134
Donepezil 170172
Dopamine 202, 203
D2 receptor 163
lower levels of 204
Dorsolateral prefrontal cortex 213
Dysbiosis 200
symptoms of 200t
Dysfunctional coping modes 106
Dysfunctional parent modes 106
Dystonia 28
E
Eczema 200
Eicosapentaenoic acid 134
Electrical stimulation, chronic 230
Electrocardiogram 15
Electroconvulsive therapy 3, 20, 65, 91, 156, 224, 232
Electrodermal activity 15
Electrodes, placement of 20
Electroencephalograph 16, 17
quantitative 16
Electromyogram 15
Encephalitis 72
Endophenotypes 5
Enteric nervous system 200
Enterococcus 202
Enzyme acetylcholinesterase 170
Epigenetics 179
Episode
medication 73
psychosis, nonpharmacological therapies in first 87
Epstein-Barr virus 71
infection 70
Equipment, types of 15
Escherichia 202
Euphoria 6
European Medicines Agency 170
Exercise 148, 149
External reward, role of 18
F
Facial emotion recognition deficits 26
Facial expression 12
Factitious disorder 55
Fatigue 133, 200
Federal Health Agency of Germany and British Herbal Compendium 136
Fetal stem cell 193
transplantation 193
Ficus platyphylla 136
First episode psychosis 88
Flumazenil 114
Fluoxetine 112, 128
Food and Drug Administration 170, 181, 213, 224
Forward-backward bending 26
Fragile X syndrome 192
Free radicals 204
Frequent colds 200
Frequent urination 200
G
Gabapentin 112
Galantamine 115, 170172
Gamma knife radiation surgery 227
Gamma-amino butyric acid 32, 132, 171, 202
Gas 200
Gastrointestinal bleeds 159
Gastrointestinal function 14
Gastrointestinal system 200
Gastrointestinal upset 133
Generation antidepressants 156
GeneSight psychotropic test 183, 185
Gestures 12
Ginkgo biloba 128, 137, 174
Glutamate 203
system 163
Granulocyte-colony stimulating factor 193
H
Habenula, lateral 234
Hallucinations 62t
assessment of 62
focused integrative treatment 64
scales for 62
treatment strategies for 62
Hallucinogenic substances 48
Haloperidol 111, 192
Hamilton anxiety rating scale 227
Hamilton depression rating scale 30, 157, 227, 232, 234
Hand stretch breathing 26
Hatha yoga 24
effect of 30
Headache 15, 230
Healing hand 2
Health, management of 144
Heart rate 14, 15
Hemoencephalography 19
Heroin 123
Herpes simplex virus 71, 72, 75
Histocompatibility complexes, major 73
Human deoxyribonucleic acid 70
Human erythropoietin 128
Human genome project 201
Human immunodeficiency virus 69
Human intelligence 6, 8, 13
Human microbiome 205
Human studies 149
Humanitarian movement 4
Hypericum perforatum 132
Hypersomnia 200
Hypertension 15
Hyponatremia 159
Hypothalamic-pituitary-adrenal axis 32, 202
Hypothalamus, lateral 237
I
Ibogaine 49
Iliac spine, anterior superior 193
Illnesses, psychological model of 37
Imipramine 112
Immunization
active 174
passive 174
Immunoglobulin
G 72
M 72
Immunotherapy 174
Impulse control, loss of 97
Inadequate sphincter control 230
Indian Psychiatric Society 226
treatment guidelines 116t
Indian Scale for Assessment of Autism Scores 193
Indian Society of Stereotactic and Functional Neurosurgery 226
Individual-gene testing
advantages of 182
disadvantages of 182
Inflammation, chronic 203
Information and communication technology 89
use of 89
Initial randomized controlled studies 25
Injectable antipsychotics, long-acting 63
Inositol 112
Insane 4
Insomnia 146, 200
Insulin-like growth factor 128, 146
Intelligent agents, design of 9
Intermittent psychotic symptom syndrome 87
Internal capsule, anterior limb of 234
International Electroencephalogram 10–20 System 217
International personality disorder examination 99
International Yoga Day 23
Intracerebral hemorrhage 233
Intravenous amobarbital 56
Invasive brain stimulation techniques 218
Irrational polypharmacy, reduction of 115b
Irritable bowel syndrome, management of 206
Itching 200
J
Jogging 26
Joint aches 200
K
Ketamine 49, 5355, 162
Knowledge, power of 2
L
Lactobacillus 202, 205
bulgaricus 204
helveticus 203
rhamnosus 204
Lactococcus lactis 204
Lamotrigine 112
Laziness 230
Levomilnacipran 161
Limbic leucotomy 229, 230-233
Limbic system 201
Lipopolysaccharides 204
Lipoprotein, high-density 144
Lithium 112, 156, 192
Live microorganisms 199
Lorazepam 49, 50, 54
L-thyroxine 112
Lunatic asylums 6
Lysergic acid diethylamide 49, 51, 54, 57, 123
M
Magnetic resonance-guided focused ultrasound 227
Major depressive disorder 10, 25, 110, 155, 158t, 184, 224, 232, 232b
ablative procedures for 232
Makarasana 26
Mammals, microbial colonization of 199
Mania 111
Maprotiline 156
Matsyasana 26
Maudsley guidelines 158
Median forebrain bundle 232
Memantine 172, 175
Memory, poor 200
Menstrual disorders 32
Mental derangements 2
Mental disorders 3, 37, 38, 98
severe 25, 102
statistical manual of 98
treatment of 6
Mental faculties 1
Mental health 7, 8, 144
disorders 138
psychobiotic therapy for 6
rejuvenation of 7
review board 226
Mental Healthcare Act 226
Mental illness 3, 4
active 100
interventions for 5
medical model of 37
treatment of 37
Mental operations 6
Mental state 87
Mental tasks 6
Mentalization based therapy 104
Metabolic syndrome 145
Metabotropic glutamate 163
Metacognitive
therapy 64
training 84
Methylene blue 173
Methylenedioxymethamphetamine 54, 123
Methylphenidate 56, 110, 128
Mianserin 156
Microbiome, potential role of 201
Midazolam 49, 50
Milieu therapy 89
Mindfulness
based interventions 65
based therapy 64
Mirtazapine 156
Modafinil 112, 128
Modified rush video rating scale 227
Monoamine oxidase 117
inhibitors 110, 159
Monoclonal antibodies 174
Mononuclear cells 193
Montgomery-Asberg depression rating scale 160, 227
Mood 146
altering agents 128
disorders 132, 134, 157
stabilizer 102, 111
swings 200
Multiple gene testing 182
advantages of 182
disadvantages of 182
Muscle 200
Musculoskeletal activity 14
Mycobacterium vaccae 206
N
N-acetylcysteine 112, 136
Nadanusandhana 26
Nadi Shuddhi Pranayama 26
Naloxone 114
Narcosuggestion 54
Natural language processing 10
Natural nootropics 170, 174
N-dimethyltryptamine 51
Near-infrared spectrography 16, 19
Neural circuitry 38
Neural progenitor cells 190
Neurocognitive enhancement therapy 85
Neurodevelopmental diseases 12
Neurofeedback 16, 20
connectivity-based 18
in disorders, use of 19
Neurogenesis 150
Neuroimaging biomarkers 10
Neuroinflammation 204
Neuroinflammatory hypothesis 203
Neuromodulation 204
field of 212
Society 226
Neuronal cells, types of 190
Neuropeptide
agonists 128
antagonists 128
Neuroplasticity 32
Neuropsychiatric disorders 212, 224
recognition of emotions in 26
scope of surgery in 226
treatment of 49
Neurotherapy 16
Neurotic reactions 56
Neurotransmitter 93
functioning of 37
synthesis of 202
systems 171
Newer theories 5
N-methyl D-aspartate 162, 205
receptors antagonists 170, 172
Noninvasive brain stimulation 62
techniques 65, 212, 213
Nonmentalizing modes 105
Nonpharmacological biological therapies 91
Nonpharmacological therapies 82t
principles of 81
Nonpsychiatric population 73
Nonsteroidal anti-inflammatory drugs 117, 163
Norepinephrine 202
Nucleus accumbens 229, 232
Nutraceuticals 131
Nutrition 131
O
Obesity 144, 145, 237
Obsessive-compulsive disorder 10, 113, 133, 205, 215, 224, 228, 229b, 230
indications for surgery in 228
pathophysiology of 228
Obstructive sleep apnea 145
Olanzapine 111, 112
Omega-3 fatty acids 112, 134
Online counseling 90
Opioid use disorders 114, 117
Oral medication 63
Orbitofrontal cortex 215, 228
Organic delirium 55
Organic mutism 55
Organophosphorus compounds 170
Oryza sativa 201
Outpatient psychiatrist 100
Oxoisoaporphine 172
P
Pains 200
Palpitations 200
Panic disorder 113
Parkinson's disease 224
Paroxetine 112
Passiflora incarnata 136
Patient-therapist interaction 5
Persistent depression, management of 159
Persistent depressive disorder 159
Personal purity 3
Personality
assessment schedule 99
diagnostic questionnaire 99
resist drug therapy 102
standardized assessment of 99
Personality disorder 20, 97, 101b, 106, 107
assessment of 98, 99
classification 98
development of 103
diagnosis of 99
interventions for 97
management of 98, 100
medication management 102
Pesticides 170
Pharmaceuticals 131
Pharmacogene, selection of 184
Pharmacogenetics 179, 180f
Pharmacogenomics 179, 180f, 185
disadvantages of 183
Pharmacological agents 38
Pharmacotherapy 20, 63, 224, 227
intervention 44
Phelan McDermid syndrome 192
Phenotype-behavior 5
Photodermatitis 133
Physical health 144
Physical pain 126
Physiological function 14
Piper methysticum 135
Placebo-controlled study 134
Pluripotent cells 6
Pluripotent stem cell 189
Pneumograph 15
Polypharmacy 109, 114
debate 109
rationalization of 115
Poor metabolizer 181
Positive and negative syndrome scale 26, 62
Positive placebo-controlled randomized controlled trials 112
Post-traumatic stress disorder 18, 40, 103, 113, 237
Posture 12
Potassium levels 192
Potent psychoactive substance 52
Potentiation, long-term 213
Pranayama 31
Preparatory psychotherapy 52
Probiotics 199
Prodrome 87
Promote neurotrophic growth 203
Prophylaxis 112
Propranolol 128
Pseudocholinesterase 178
Psilocybin 49, 51, 5355
Psoriasis 200
Psychedelic 49, 50, 52, 54, 55
mushrooms 49
psychotherapy 52
Psychiatric classificatory systems 109
Psychiatric diagnosis 9
artificial intelligence in 9
Psychiatric disorder 38, 58, 109, 127, 144, 189, 212, 213, 217
chronic 169
major 24
neurosurgery for 224
Psychiatric illnesses 48, 61, 189, 190
modeling of 190
symptoms of 48
Psychiatric rating scale 70, 71
Psychiatric therapeutics 2, 6
advancing frontiers of 2
Psychiatric treatment 39
artificial intelligence in 11
Psychiatrists, self-care for 107
Psychiatry 8, 23, 178, 189
artificial intelligence in 9
literature 57
nutraceuticals in 131
pharmacogenomics in 178
spiritual therapies in 23
Psychobiotic 199, 206, 207
therapy 199
Psychodynamic model 42
Psychodynamic psychotherapy 4, 89
Psychoeducation 39, 82, 83
Psychogenic amnesia 55
Psychological interventions 64
Psychologically-based disorders 39
Psychometric testing 17
Psychoneurosis 56
Psychopathology 4, 32, 39
Psychopharmacological agents 38
Psychopharmacology 5, 40, 44
interface of 37
Psychopharmacotherapeutic agents, development of 58
Psychosis 33, 55, 92, 117, 136
cognitive behavioral therapy for 82, 83
early 88
detection 10
psychotherapies for 82fc
severity of 102
Psychosocial intervention 44, 87, 88
Psychosocial rehabilitation 39
Psychosocial skills 39
Psychosurgery 238
history of 224
legal perspective of 226
preoperative evaluation for 227
Psychotherapeutic 57
interventions 37, 41
stage of 5
Psychotherapy 37, 40, 44, 52, 103, 224
biological underpinnings of 39
drug-assisted 49b, 52, 54t, 58
interface of 37
interventions 40
plan 100
process of drug-assisted 49f
psychedelic assisted 52, 53, 58
research evidence for drug-assisted 55
transference-focused 106
update on drug-assisted 48
uses 11
Psychotic disorders 79, 81
nonpharmacological therapies for 79, 80
Psychotic symptom 102
rating scale 62
Psychotropic drug 5, 38
clinical application of 54t
modeling 192
Purging 3, 4
Pyrazolopyridines 174
Q
Quetiapine 111
R
Randomized controlled
study 27
trials 73, 159, 173, 215
Reciprocal emotional response 99
Recovery-oriented treatment 39
Refractory delusions, treatment strategies for 62
Regional cerebral blood flow 213
Rehabilitation back 7
Relapse prevention 83
program for 42
Repetitive transcranial magnetic stimulation 92, 128, 212
Reptile brain 201
Residual and resistant auditory
delusions, management for 61
hallucinations, management for 61
Resistant anxiety disorders, treatment of 113t
Respiratory patterns 14
Restless legs syndrome 147
Rett syndrome 192
Ribonucleic acid 200
Risperidone 111, 192
Rivastigmine 170, 171
Rorschach test 100
Royal Australian and New Zealand College of Psychiatrists 157, 158
guidelines 158
S
S-adenosylmethionine 133
Schema-focused therapy 105
Schizoaffective disorder 79
Schizoid 102
Schizophrenia 10, 23, 27, 33, 42, 61, 69, 70, 71t, 79, 81, 87, 92, 93, 110, 111, 116, 149, 169, 171, 190, 203, 205
antiviral
medications in 69
therapy in 69
cytomegalovirus infection in 72
diagnosis of 33
infected 72
international pilot study on 61
interventions in 81
management of 28, 79
nonpharmacological therapies for 81
outpatients of 27
prevalence of 61
rehabilitation center 28
treatment of 79, 80, 92
acute 91
treatment-resistant 61, 91
Schizotypal 102
personality disorder 79, 87
Second messenger systems 150
Seizures 230
Sensorimotor rhythm 16
Serotonin 202, 203
lower levels of 204
noradrenaline reuptake inhibitors 156
reuptake inhibitors, selective 102, 113, 117, 128, 132, 156, 159, 229
transporte 164
Sertraline 112, 159
Sexual dysfunction 159
Shalabhasana 26
Shashankasana breathing 26
Sheehan disability scale 161
Short message service 89
Single-gene testing 185
Skin rash 200
Skull, trephining of 3
Sleep 144147
apnea 145
disorders 145, 147
disturbances 145
quality 16
restriction 144
therapeutic role of 144
Smart devices use 90
Social anxiety 113
Social skills training 82, 86
Socio-occupational functioning scale 26
Socrates model 88
Sodium
amobarbital 49
thiopental 49
valproate 174
Somatic hyperpolarization 216
Somatoform
disorder 23, 53
pain disorder, diagnosis of 32
symptoms 32
Spiritual advancements, states of 32
Spiritual approaches 24
Spiritual dimensions 23
Spiritual therapies 23
Stem cell 189, 192, 194
generation 190
therapy 6, 189
Stigma avoidance 11
Stimulation 237
Streptococcal infections 205
Streptococcus 202
thermophiles 204
Stress 131, 202
hormone
cortisol 204
reduction of level of 202
management 12
reduction 15
Stria terminalis, bed nucleus of 229
Stroke 2
rehabilitation 20
Subcallosal cingulate gyrus 232
Subcaudate tractotomy 225, 229, 230, 232, 233
Subcortical component 231
Substance
abuse 102
use disorders 44, 114
withdrawal, treatment for 102
Sudarshan kriya 31
Superintelligence, artificial 9
Supported Employment Programs 85
Supportive psychotherapy 86
Surya Namaskar 26
Synaptogenesis 150
T
Tacrine 172
Tau deposition, modulation of 173
Technological sophistication 3
Technology, use of 89t
Telepsychiatry 89
Temporoparietal junction 215
Tenacious human curiosity 1
Texas medication algorithm 111
Thalamic peduncle, inferior 232
Thalamus 235
Thematic apperception test 100
Theoretical framework 103
Therapeutic loop 2
Therapeutic serious games 91
Therapy, principles of 103
Thermal biofeedback 15
Theta burst stimulation 214
Thyroid hormone 156
Tiger breathing 26
Timothy syndrome 192
Tolerate clozapine 63
Toll-like receptor 4 145
Topiramate 112
Tourette syndrome 224, 234, 235, 235b, 236
indications for surgery in 235
neurobiology of 234
surgery for 235b
Toxic carbamates 170
Traditional path 5
Trait loci, quantitative 195
Tramiprosate 174
Transcranial direct current stimulation 66, 92, 216
Transcranial magnetic stimulation 20, 65, 213
safety of repetitive 216
Transient memory loss 230
Tranylcypromine 112
Traumatic neurosis 53
Trazodone 156
Trihexyphenidyl 28
Trikonasana 26
U
Ultrarapid metabolizers 181
Urinary and fecal incontinence 15
Ushtrasana 26
V
Vaccination 174
Vagal modulation 204
Vagus nerve 204
stimulation 92, 93, 204, 218
Vakrasana 26
Valacyclovir 70
treatment 72
trials 72
trials 75
Valproate 112
Vancouver limbic surgery group 233
Venlafaxine 112
Ventral capsule 228
Ventral striatum 228, 232
Verbal memory 72
Videoconferencing gadgets 89
Vilazodone 162
Viparita karani 26
Virtual reality 90
Vitamin 174
A 174
B 133
group 133
B12 133, 174
deficiencies 133
B6 174
B8 133
B9 174
C 174
E 128
K 200
Vocational rehabilitation 85
Vomiting 3, 4
Vortioxetine 160
Voxel patterns 18
W
Water
boiling 3
ice-cold 3
Weight gain 159
Working memory 74
World Federation of Societies of Biological Psychiatry 158
guidelines 157
Y
Yale global tic severity scale 235, 236
Yale-brown obsessive compulsive score 227, 229
Yoga 23
current status of 23
for antipsychotic-induced side effects 28
for caregivers with schizophrenia 29
for cognitive disorders 30
for somatoform disorders 32
in anxiety-related disorders 30
in depression 24
in psychiatry, role of 32
in psychosis 25
in substance use disorders 31
in therapy, role of 23
large effects of 30
programs, types of 31
role of 24
therapy 26, 33
treated for psychosis 29
Yogic philosophy 23
Z
Zinc 192
Ziprasidone 63
Zonisamide 112
×
Chapter Notes

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fm_1Advancing Frontiers of PSYCHIATRIC THERAPEUTICSfm_2
fm_3Advancing Frontiers of PSYCHIATRIC THERAPEUTICS
Indian Psychiatric Society Publication
Editor PK Singh MBBS (AIIMS) MD (PGIMER) Professor and Head Department of Psychiatry Patna Medical College Patna, Bihar, India
fm_4
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Advancing Frontiers of Psychiatric Therapeutics
First Edition: 2020
9789389776560
Printed at:
fm_5CONTRIBUTORS
fm_9
Health professionals are known for their healing touch. Their identity, authority, respectability and livelihood, all revolves around this healing touch. There used to be a time when healing touch was a simple touch, but advances of civilization and burgeoning power of science, this touch has evolved to include almost the universe. It has become more remote, multifaceted and complex. Despite all this the personal touch, however, have to be maintained.
The chapters embodied in this book Advancing Frontiers of Psychiatric Therapeutics are diverse and cover almost all aspects of current psychiatric therapeutics comprehensively. Our learned authors have tried intelligently and diligently to explore the different facets and interfaces of varied psychiatric therapeutics that have emerged in recent times. These newer paradigms and strategies will definitely empower mental health professional to become a more effective therapist. It is revealing to go through various chapters of this book to get a glimpse of the possibilities that are yet to be fully utilized for the care and help of people who are afflicted with mental disorders. This is of great practical and everyday importance. We are sure that all you will find it of great value.
The Publication Committee, especially Professor PK Singh needs to be appreciated for this novel update. We must put on record that his contributions as Chair of this committee are historic. The book has been beautifully produced and for this M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, deserves a big thank you.
Long live Indian Psychiatric Society (IPS).
Mrugesh Vaishnav
President, IPS
PK Dalal
President-elect, IPS
Vinay Kumar
Hon General Secretary, IPSfm_10
fm_11Preface
We, the mental health professionals, are constantly engaged in providing freedom from pain and suffering to all seekers of help for mental health issues through our armoury of varied therapeutic tools. This skill of inducting therapy is in fact the ultimate arbiter of our acceptance, respect and power in society as well as our source of livelihood. Different therapeutic paradigms are actually weapons in our hands for our adaptive struggle against all diseases and disorders that are integral part of our life. There immediate aim is freedom from suffering but larger aim is to increase the survival potential of human race as a member of the biosphere. Simultaneously, it also influences their quality of living as well as their productive and creative potentials. It is this linkage of therapy with life that provides justification and meaningfulness to all our related scientific and para-scientific activities, be it hard-core research or their applications in the community.
All systems in the universe, which includes our own species, have a natural tendency to move towards disorderliness. Even though there are naturally occurring, inbuilt homeostatic regulatory mechanisms to take care of this tendency, but often they prove to be inadequate and require to be supplemented by externally introduced, man-made interventions which require constant investment of time, energy and various other resources. There is a constant race and struggle between the order and the disorder. Therapeutic sciences play the role of tilting the balance in favor of orderliness.
The phenomenon of mind itself has hitherto remained inadequately unexplored and continues to remain a perpetual mystery. Mental disorders can be understood properly only when we are able to make some headway in understanding the true nature of mind. Complexity of human mind is reflected in the equally complex nature of its disorders which require varied inputs of a very wide spectrum to reclaim orderliness. Despite our ignorance about the primary order, the disorders of mind continue to be felt in everyday life because of the distress and dysfunctions associated with it and therefore need to be rectified. In fact, the insights gained through our attempts at successfully treating mental disorders, allow us to retrospectively extrapolate them in trying to understand the true nature of mind.
For last several years Indian Psychiatric Society (IPS) has been publishing a series of books annually under a generic heading of “Different Strokes” with varied themes and topics for internal circulation. Last year it was decided to focus on the theme of therapeutics where all knowledge seems to converge. In the book, we had tried to bring together some completely new and innovative therapeutic strategies along with the newer versions of older established treatment strategies. This ranges from spirituality to psychosurgery, from fm_12recent drugs to drug-assisted psychotherapy, from pharmacogenomics to stem-cell therapy, from cognitive enhancers to antiviral therapy, from issues related to integration of pharmacotherapy and psychotherapy to issues of polypharmacy, from nutraceuticals to psychobiotic therapy, from cosmetic psychopharmacology to therapeutic role of sleep and exercise, from management of resistant auditory hallucination to non-pharmacological management of psychotic disorders. There are a few more topics from the cutting edge interface of advancing frontier that has been included in the book. We are extremely thankful to all our esteemed and erudite authors for having spared enough time out of their extremely busy schedules, to write outstanding chapters on topics which are mostly unconventional.
Seeing the warm reception and also relevance of this theme, we decided to go for larger circulation of this book to a much wider audience. We are thankful to Jaypee Brothers Medical Publisher, a recognized and established name in the field of medical publishing in India and abroad, to come to our help for this venture. Without their forth-right cooperation and positive interest, this book in its present form would not have seen the light of the day. We express our gratitude to them for the same. Our colleagues at Publication Subcommittee of IPS, Dr Shahul Ameen and Dr Naresh Nebhinani have always been very supportive, helpful and encouraging. Higher leadership of Indian Psychiatric Society, the President, the President-elect, and the Hon General Secretary have been a constant source of strength and support. Especially Dr Vinay Kumar, the present Hon General Secretary, who also happens to be the immediate-past Chairperson of the Publication Subcommittee, has always been a great source of help, support, encouragement, and guidance. With his exemplary dynamism and resourcefulness, he has proved to be a great problem-buster at all stages of this project. At the end, having gone through the ordeal, we have been able to come up with a rich bouquet of rare flowers in the form of this unique book, which we are confident, shall prove a great asset for all, the researchers as well as the practitioners of science of mental health.
Long live Indian Psychiatric Society.
PK Singh
fm_13Acknowledgments
I would like to thank Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Mr MS Mani (Group President), Ms Chetna Malhotra Vohra (Associate Director—Content Strategy), Ms Pooja Bhandari (Production Head), Ms Nedup Denka Bhutia (Development Editor) and the publishing staff at M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, for their work in completing this book.fm_14fm_15fm_16