About Video

This is the classical sign in progressive supranuclear palsy. It is a sign of motor preservation and is a form of apraxia. Though controversial, some studies have shown that it helps to differentiate between progressive supranuclear palsy from frontotemporal dementia and Alzheimer’s disease. Some studies have also shown positive results with corticobasal degeneration and diffuse Lewy body disease, while Alzheimer’s disease and posterior cortical atrophy do not show this sign. The second video shows the rare occurrence The second video shows the rare occurrence of improvement of applause sign following treatment with levodopa and pramipexole in another patient.