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Atlas of Neurology—A Case-based Approach
by Satish V Khadilkar, Kalyan B BhattacharyyaThis set of video clips shows familial orthostatic tremor in an unusually early age. Additionally, there is essential tremor in both the sides. Incidentally, the elder brother suffered from an attack of acute anterior poliomyelitis in the right lower limb in childhood. Surface EMG shows tremor in the range of 13 to 18 Hz and it is the fastest tremor in man. The 3rd video shows classical orthostatic tremor in an elderly subject. Orthostatic tremor has often been thought to be a variant of essential tremor and the two conditions may coexist. But orthostatic tremor does not respond to propranolol and is treated, albeit with frustrating results, with clonazepam and gabapentin. However, like in essential tremor, PET study shows increased cerebellar blood flow in orthostatic tremor, suggesting a common anatomical substrate.
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