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Atlas of Neurology—A Case-based Approach
by Satish V Khadilkar, Kalyan B BhattacharyyaThis patient of Parkinson’s disease, when asked to extend the left ankle joint, also lifts the right ankle. Mirror movements may persist as a physiological phenomenon in the first 2 years of life and disappears with myelination of the corpus callosum. Congenital mirror movements can be transmitted as an autosomal dominant trait and is caused by mutation in the DCC or RAD51 gene. This is thought to result from physiological cross-talk following formation of synkinetic or false synapses, or due to incomplete decussation of the corticospinal tracts in the medulla. It may be found in agenesis of corpus callosum, Parkinson’s disease, Kallmann’s syndrome (hypogonadotrophic hypogonadism with anosmia), and Klippel-Feil syndrome.
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